Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosducin

Gene

PDC

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits the transcriptional activation activity of the cone-rod homeobox CRX (By similarity). May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism.By similarity

GO - Biological processi

Keywordsi

Biological processSensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Phosducin
Short name:
PHD
Alternative name(s):
33 kDa phototransducing protein
Protein MEKA
Gene namesi
Name:PDC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001637481 – 245PhosducinAdd BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei73Phosphoserine; by PKA1 Publication1

Post-translational modificationi

Light-induced changes in cyclic nucleotide levels modulate the phosphorylation of this protein by cAMP kinase.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP19632
PRIDEiP19632

PTM databases

iPTMnetiP19632

Interactioni

Subunit structurei

Interacts with CRX (By similarity). Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin.By similarity

Protein-protein interaction databases

CORUMiP19632
IntActiP19632, 2 interactors
MINTiP19632
STRINGi9913.ENSBTAP00000005468

Structurei

Secondary structure

1245
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP19632
SMRiP19632
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19632

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni111 – 245Thioredoxin foldBy similarityAdd BLAST135

Sequence similaritiesi

Belongs to the phosducin family.Curated

Phylogenomic databases

eggNOGiKOG3171 Eukaryota
ENOG4110DRD LUCA
HOGENOMiHOG000232010
HOVERGENiHBG003456
InParanoidiP19632

Family and domain databases

CDDicd02987 Phd_like_Phd, 1 hit
Gene3Di1.10.168.10, 1 hit
InterProiView protein in InterPro
IPR001200 Phosducin
IPR023196 Phosducin_N_dom_sf
IPR024253 Phosducin_thioredoxin-like_dom
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF02114 Phosducin, 1 hit
PRINTSiPR00677 PHOSDUCIN
SUPFAMiSSF52833 SSF52833, 1 hit

Sequencei

Sequence statusi: Complete.

P19632-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKAKSQSLE EDFEGQASHT GPKGVINDWR KFKLESEDSD SVAHSKKEIL
60 70 80 90 100
RQMSSPQSRD DKDSKERFSR KMSVQEYELI HKDKEDENCL RKYRRQCMQD
110 120 130 140 150
MHQKLSFGPR YGFVYELESG EQFLETIEKE QKITTIVVHI YEDGIKGCDA
160 170 180 190 200
LNSSLICLAA EYPMVKFCKI KASNTGAGDR FSSDVLPTLL VYKGGELLSN
210 220 230 240
FISVTEQLAE EFFTGDVESF LNEYGLLPEK EMHVLEQTNM EEDME
Length:245
Mass (Da):28,231
Last modified:May 1, 1991 - v2
Checksum:i5CA621610401D550
GO

Sequence cautioni

The sequence AAA62716 differs from that shown. Reason: Frameshift at position 231.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44H → P in AAA30349 (PubMed:2210381).Curated1
Sequence conflicti238 – 239TN → SK in AAA30349 (PubMed:2210381).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58170 mRNA Translation: AAA62716.1 Frameshift.
M33529 mRNA Translation: AAA30349.1
PIRiA38379
UniGeneiBt.12783

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58170 mRNA Translation: AAA62716.1 Frameshift.
M33529 mRNA Translation: AAA30349.1
PIRiA38379
UniGeneiBt.12783

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A0RX-ray2.80P1-245[»]
ProteinModelPortaliP19632
SMRiP19632
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiP19632
IntActiP19632, 2 interactors
MINTiP19632
STRINGi9913.ENSBTAP00000005468

PTM databases

iPTMnetiP19632

Proteomic databases

PaxDbiP19632
PRIDEiP19632

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3171 Eukaryota
ENOG4110DRD LUCA
HOGENOMiHOG000232010
HOVERGENiHBG003456
InParanoidiP19632

Miscellaneous databases

EvolutionaryTraceiP19632

Family and domain databases

CDDicd02987 Phd_like_Phd, 1 hit
Gene3Di1.10.168.10, 1 hit
InterProiView protein in InterPro
IPR001200 Phosducin
IPR023196 Phosducin_N_dom_sf
IPR024253 Phosducin_thioredoxin-like_dom
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF02114 Phosducin, 1 hit
PRINTSiPR00677 PHOSDUCIN
SUPFAMiSSF52833 SSF52833, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPHOS_BOVIN
AccessioniPrimary (citable) accession number: P19632
Secondary accession number(s): P20940, Q28160
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: May 1, 1991
Last modified: November 7, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again