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Protein

L-lactate dehydrogenase C chain

Gene

Ldhc

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possible role in sperm motility.By similarity

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (Ldha), L-lactate dehydrogenase (Ldhc), L-lactate dehydrogenase, L-lactate dehydrogenase (Ldhal6b), L-lactate dehydrogenase B chain (Ldhb), L-lactate dehydrogenase A chain (Ldha), L-lactate dehydrogenase C chain (Ldhc)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99NADBy similarity1
Binding sitei106SubstrateBy similarity1
Binding sitei138NAD or substrateBy similarity1
Binding sitei169SubstrateBy similarity1
Active sitei193Proton acceptorBy similarity1
Binding sitei248SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 57NADBy similarityAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

UniPathwayi
UPA00554;UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenase C chain (EC:1.1.1.27)
Short name:
LDH-C
Alternative name(s):
LDH testis subunit
LDH-X
Gene namesi
Name:Ldhc
Synonyms:Ldh-3, Ldh3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69366 Ldhc

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001684822 – 332L-lactate dehydrogenase C chainAdd BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2Blocked amino end (Ser)1

Proteomic databases

PaxDbiP19629
PRIDEiP19629

PTM databases

iPTMnetiP19629
PhosphoSitePlusiP19629

Interactioni

Subunit structurei

Homotetramer. Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017851

Structurei

3D structure databases

ProteinModelPortaliP19629
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.Curated

Phylogenomic databases

eggNOGiKOG1495 Eukaryota
COG0039 LUCA
HOGENOMiHOG000213793
HOVERGENiHBG000462
InParanoidiP19629
PhylomeDBiP19629

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.iShow all

P19629-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTVKEQLIQ NLAPDEKQSR CKITVVGVGN VGMACAISIL LKGLADELAL
60 70 80 90 100
VDADENKLKG EALDLLHGSL FLSTPKIVFG KDYSVSANSK LVIITAGARM
110 120 130 140 150
VSGESRLALL QRNVTSMKAI VPGVIQNSPD CKIMIVTNPV DILTYVVWKI
160 170 180 190 200
SGLPVSSVIG SGCNLDSARF RYLIGEKLGV NPSSCHGWVL GEHGDSSVPI
210 220 230 240 250
WSGVNIAGVT LKSLNPAIGS DSDKEQWKTV HKQVVDGGYE VLNLKGYTSW
260 270 280 290 300
AIALSVTDIA ASILKNLKRV HAVTTLVKGL YGIKEEIFLS IPCVLGQSGI
310 320 330
TDLVKVNMNT EEEALFKKSC DILWNIQKDL QL
Length:332
Mass (Da):35,687
Last modified:January 23, 2007 - v3
Checksum:i7D4C818B7D40B822
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6AYX2Q6AYX2_RAT
L-lactate dehydrogenase
Ldhc rCG_53562
332Annotation score:
H9N9H4H9N9H4_RAT
L-lactate dehydrogenase C chain
Ldhc LDHC
274Annotation score:
I1VWN1I1VWN1_RAT
L-lactate dehydrogenase C chain
Ldhc
119Annotation score:
I1VWM9I1VWM9_RAT
L-lactate dehydrogenase C chain
Ldhc
115Annotation score:
I1VWN0I1VWN0_RAT
L-lactate dehydrogenase C chain
Ldhc
103Annotation score:
A0A0G2K3B9A0A0G2K3B9_RAT
L-lactate dehydrogenase C chain
Ldhc
113Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7Q → E AA sequence (PubMed:6343385).Curated1
Sequence conflicti16Missing AA sequence (PubMed:6343385).Curated1
Sequence conflicti30N → D AA sequence (PubMed:6343385).Curated1
Sequence conflicti56N → D AA sequence (PubMed:6343385).Curated1
Sequence conflicti104E → Q AA sequence (PubMed:6343385).Curated1
Sequence conflicti116S → I AA sequence (PubMed:6343385).Curated1
Sequence conflicti183S → T AA sequence (PubMed:6343385).Curated1
Sequence conflicti200I → V AA sequence (PubMed:6343385).Curated1
Sequence conflicti206I → V AA sequence (PubMed:6343385).Curated1
Sequence conflicti223 – 226DKEQ → NKQE AA sequence (PubMed:6343385).Curated4
Sequence conflicti243N → D AA sequence (PubMed:6343385).Curated1
Sequence conflicti253A → G AA sequence (PubMed:6343385).Curated1
Sequence conflicti259 – 261IAA → LAE AA sequence (PubMed:6343385).Curated3
Sequence conflicti297Q → E AA sequence (PubMed:6343385).Curated1
Sequence conflicti329 – 331DLQ → NLE AA sequence (PubMed:6343385).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07177 mRNA Translation: AAA50435.1
PIRiI84639
UniGeneiRn.9984

Genome annotation databases

UCSCiRGD:69366 rat

Similar proteinsi

Entry informationi

Entry nameiLDHC_RAT
AccessioniPrimary (citable) accession number: P19629
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 137 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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