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UniProtKB - P19544 (WT1_HUMAN)

>sp|P19544|WT1_HUMAN Wilms tumor protein OS=Homo sapiens OX=9606 GN=WT1 PE=1 SV=2
MGSDVRDLNALLPAVPSLGGGGGCALPVSGAAQWAPVLDFAPPGASAYGSLGGPAPPPAP
PPPPPPPPHSFIKQEPSWGGAEPHEEQCLSAFTVHFSGQFTGTAGACRYGPFGPPPPSQA
SSGQARMFPNAPYLPSCLESQPAIRNQGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHED
PMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQ
MNLGATLKGVAAGSSSSVKWTEGQSNHSTGYESDNHTTPILCGAQYRIHTHGVFRGIQDV
RRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDC
ERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGKTSEKPFSCRWPS
CQKKFARSDELVRHHNMHQRNMTKLQLAL

Entry version 243 (02 Dec 2020)
Sequence version 2 (01 Aug 1991)
Previous versions | rss

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Protein

Wilms tumor protein

Gene

WT1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:7862533, PubMed:17716689, PubMed:25258363). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921).7 Publications

Miscellaneous

Presence of the KTS motif hinders interactions between DNA and zinc-finger 4.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	424	Important for interaction with target DNA		1
Siteⁱ	430	Important for interaction with target DNA		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	323 – 347	C2H2-type 1PROSITE-ProRule annotationAdd BLAST		25
Zinc fingerⁱ	353 – 377	C2H2-type 2PROSITE-ProRule annotationAdd BLAST		25
Zinc fingerⁱ	383 – 405	C2H2-type 3PROSITE-ProRule annotationAdd BLAST		23
Zinc fingerⁱ	414 – 438	C2H2-type 4PROSITE-ProRule annotationAdd BLAST		25

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, RNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

PathwayCommonsⁱ	P19544
SignaLinkⁱ	P19544
SIGNORⁱ	P19544

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Wilms tumor protein Alternative name(s): WT33
Gene namesⁱ	Name:WT1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000184937.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12796, WT1
MIMⁱ	607102, gene
neXtProtⁱ	NX_P19544

Subcellular locationⁱ

UniProt annotation
GO - Cellular component

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Frasier syndrome (FS)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionCharacterized by a slowly progressing nephropathy leading to renal failure in adolescence or early adulthood, male pseudohermaphroditism, and no Wilms tumor. As for histological findings of the kidneys, focal glomerular sclerosis is often observed. There is phenotypic overlap with Denys-Drash syndrome. Inheritance is autosomal dominant.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_015060	392	F → L in FS. 1 Publication		1

Wilms tumor 1 (WT1)4 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionEmbryonal malignancy of the kidney that affects approximately 1 in 10'000 infants and young children. It occurs both in sporadic and hereditary forms.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_007739	181	P → S in WT1. 2 PublicationsCorresponds to variant dbSNP:rs2234584Ensembl.		1
Natural variantⁱVAR_007740	223	S → N in WT1. 1 Publication		1
Natural variantⁱVAR_007741	253	G → A in WT1. 1 Publication		1
Natural variantⁱVAR_043799	355	C → G in WT1. 1 Publication		1
Natural variantⁱVAR_007745	366	R → C in WT1, DDS and MEACHS. 4 Publications		1
Natural variantⁱVAR_007746	366	R → H in DDS and WT1. 4 Publications		1
Natural variantⁱVAR_007747	373	H → Q in DDS and WT1. 1 Publication		1
Natural variantⁱVAR_043807	394	R → L in WT1. 1 Publication		1

Denys-Drash syndrome (DDS)17 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionTypical nephropathy characterized by diffuse mesangial sclerosis, genital abnormalities, and/or Wilms tumor. There is phenotypic overlap with WAGR syndrome and Frasier syndrome. Inheritance is autosomal dominant, but most cases are sporadic.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_007743	330	C → Y in DDS. 1 Publication		1
Natural variantⁱVAR_015054	342	M → R in DDS. 1 Publication		1
Natural variantⁱVAR_015055	355	C → Y in DDS. 2 Publications		1
Natural variantⁱVAR_007744	360	C → G in DDS.		1
Natural variantⁱVAR_043800	360	C → Y in DDS. 1 Publication		1
Natural variantⁱVAR_007746	366	R → H in DDS and WT1. 4 Publications		1
Natural variantⁱVAR_043802	366	R → L in DDS. 1 Publication		1
Natural variantⁱVAR_043803	369	Q → P in DDS. 1 Publication		1
Natural variantⁱVAR_007747	373	H → Q in DDS and WT1. 1 Publication		1
Natural variantⁱVAR_015056	373	H → Y in DDS. 1 Publication		1
Natural variantⁱVAR_015057	377	H → R in DDS. 1 Publication		1
Natural variantⁱVAR_015058	385	C → R in DDS. 3 Publications		1
Natural variantⁱVAR_015059	388	C → F in DDS. 1 Publication		1
Natural variantⁱVAR_043806	388	C → Y in DDS. 1 Publication		1
Natural variantⁱVAR_043808	394	R → P in DDS. 1 Publication		1
Natural variantⁱVAR_015061	394	R → Q in DDS and NPHS4. 3 Publications		1
Natural variantⁱVAR_007750	394	R → W in DDS, WT1, MEACHS and NPHS4. 9 Publications		1
Natural variantⁱVAR_007752	396	D → G in DDS.		1
Natural variantⁱVAR_007751	396	D → N in DDS and NPHS4. 3 Publications		1
Natural variantⁱVAR_043809	396	D → Y in DDS. 1 Publication		1
Natural variantⁱVAR_015062	398	L → P in DDS. 2 Publications		1
Natural variantⁱVAR_043811	401	H → Y in DDS. 1 Publication		1
Natural variantⁱVAR_043812	405	H → R in DDS. 1 Publication		1

Nephrotic syndrome 4 (NPHS4)5 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure. Most patients with NPHS4 show diffuse mesangial sclerosis on renal biopsy, which is a pathologic entity characterized by mesangial matrix expansion with no mesangial hypercellularity, hypertrophy of the podocytes, vacuolized podocytes, thickened basement membranes, and diminished patency of the capillary lumen.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_015053	312	R → Q in NPHS4. 1 Publication		1
Natural variantⁱVAR_043801	364	F → L in NPHS4. 1 Publication		1
Natural variantⁱVAR_007748	377	H → Y in NPHS4. 1 Publication		1
Natural variantⁱVAR_043804	379	G → C in NPHS4. 1 Publication		1
Natural variantⁱVAR_007749	383	F → L in NPHS4. 1 Publication		1
Natural variantⁱVAR_043805	388	C → R in NPHS4. 2 Publications		1
Natural variantⁱVAR_015061	394	R → Q in DDS and NPHS4. 3 Publications		1
Natural variantⁱVAR_007750	394	R → W in DDS, WT1, MEACHS and NPHS4. 9 Publications		1
Natural variantⁱVAR_007751	396	D → N in DDS and NPHS4. 3 Publications		1
Natural variantⁱVAR_043810	397	H → P in NPHS4. 2 Publications		1

Meacham syndrome (MEACHS)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionRare sporadically occurring multiple malformation syndrome characterized by male pseudohermaphroditism with abnormal internal female genitalia comprising a uterus and double or septate vagina, complex congenital heart defect and diaphragmatic abnormalities.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_007745	366	R → C in WT1, DDS and MEACHS. 4 Publications		1

A chromosomal aberration involving WT1 may be a cause of desmoplastic small round cell tumor (DSRCT). Translocation t(11;22)(p13;q12) with EWSR1.

Mesothelioma, malignant (MESOM)1 Publication

The disease may be caused by mutations affecting the gene represented in this entry.

Disease descriptionAn aggressive neoplasm of the serosal lining of the chest. It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos.

Related information in OMIM

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	73	K → R: Abolishes sumoylation; when associated with R-177. 1 Publication		1
Mutagenesisⁱ	177	K → R: Abolishes sumoylation; when associated with R-77. 1 Publication		1
Mutagenesisⁱ	343	H → A: Reduced RNA binding. 1 Publication		1
Mutagenesisⁱ	366	R → A: Strongly reduced binding of DNA and RNA. 1 Publication		1
Mutagenesisⁱ	372	R → A: Strongly reduced binding of DNA and RNA. 1 Publication		1
Mutagenesisⁱ	394	R → A or S: Strongly reduced binding of DNA and RNA. 1 Publication		1
Mutagenesisⁱ	434	H → A: Reduced RNA binding. 1 Publication		1

Keywords - Diseaseⁱ

Disease mutation, Tumor suppressor

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7490
GeneReviewsⁱ	WT1
MalaCards human disease database More...MalaCardsⁱ	WT1
MIMⁱ	136680, phenotype 156240, phenotype 194070, phenotype 194080, phenotype 256370, phenotype 608978, phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000184937
Orphanetⁱ	242, 46,XY complete gonadal dysgenesis 251510, 46,XY partial gonadal dysgenesis 220, Denys-Drash syndrome 83469, Desmoplastic small round cell tumor 347, Frasier syndrome 656, Genetic steroid-resistant nephrotic syndrome 3097, Meacham syndrome 654, Nephroblastoma 893, WAGR syndrome
PharmGKBⁱ	PA37395

Miscellaneous databases

Pharosⁱ

P19544, Tbio

Polymorphism and mutation databases

BioMutaⁱ	WT1
DMDMⁱ	139778

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047131	1 – 449	Wilms tumor proteinAdd BLAST		449

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	73	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Cross-linkⁱ	177	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Cross-linkⁱ	444	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

jPOSTⁱ	P19544
MassIVEⁱ	P19544
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P19544
PaxDbⁱ	P19544
PeptideAtlas More...PeptideAtlasⁱ	P19544
PRIDEⁱ	P19544
ProteomicsDBⁱ	53673 [P19544-1] 53674 [P19544-2] 53675 [P19544-3] 53676 [P19544-4] 53677 [P19544-6] 53678 [P19544-7] 53679 [P19544-8] 53680 [P19544-9]

PTM databases

iPTMnetⁱ	P19544
PhosphoSitePlusⁱ	P19544

Expressionⁱ

Tissue specificityⁱ

Expressed in the kidney and a subset of hematopoietic cells.

Gene expression databases

Bgeeⁱ	ENSG00000184937, Expressed in germinal epithelium of ovary and 130 other tissues
ExpressionAtlasⁱ	P19544, baseline and differential
Genevisibleⁱ	P19544, HS

Organism-specific databases

HPAⁱ

ENSG00000184937, Tissue enhanced (endometrium, fallopian tube, ovary)

Interactionⁱ

Subunit structureⁱ

Homodimer.

Interacts with WTIP.

Interacts with actively translating polysomes. Detected in nuclear ribonucleoprotein (mRNP) particles.

Interacts with HNRNPU via the zinc-finger region.

Interacts with U2AF2.

Interacts with CITED2 (By similarity).

Interacts with ZNF224 via the zinc-finger region.

Interacts with WTAP and SRY.

Interacts with AMER1.

Interacts with RBM4.

By similarity7 Publications

Binary interactionsⁱ

P19544

With	#Exp.	IntAct
KRT40 [Q6A162]	4	EBI-2320534,EBI-10171697
KRTAP10-8 [P60410]	3	EBI-2320534,EBI-10171774
TET2 [Q6N021]	9	EBI-2320534,EBI-310727

Isoform 6 [P19544-6]

With	#Exp.	IntAct
BHLHE40 [O14503]	3	EBI-11745701,EBI-711810
CYSRT1 [A8MQ03]	3	EBI-11745701,EBI-3867333
HMBOX1 [Q6NT76]	3	EBI-11745701,EBI-2549423
IPO8 [O15397]	3	EBI-11745701,EBI-358808
KRTAP10-6 [P60371]	3	EBI-11745701,EBI-12012928
KRTAP10-7 [P60409]	3	EBI-11745701,EBI-10172290
OSBPL3 [Q9H4L5]	3	EBI-11745701,EBI-1051317
PICK1 [Q9NRD5]	3	EBI-11745701,EBI-79165
WTAP [Q15007]	3	EBI-11745701,EBI-751647
ZRANB1 [Q9UGI0]	3	EBI-11745701,EBI-527853

GO - Molecular functionⁱ

C2H2 zinc finger domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- "The Wilms' tumor suppressor gene WT1 is negatively autoregulated."
  Rupprecht H.D., Drummond I.A., Madden S.L., Rauscher F.J., Sukhatme V.P.
  J Biol Chem 269:6198-6206(1994) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	113327, 63 interactors
IntActⁱ	P19544, 27 interactors
Molecular INTeraction database More...MINTⁱ	P19544
STRINGⁱ	9606.ENSP00000331327

Miscellaneous databases

RNActⁱ

P19544, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

3D structure databases

BMRBⁱ	P19544
SMRⁱ	P19544
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	367 – 381	Important for interaction with target DNAAdd BLAST		15
Regionⁱ	393 – 401	Important for interaction with target DNA		9

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	236 – 244	9aaTAD1 Publication		9
Motifⁱ	408 – 410	KTS motif		3

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	27 – 83	Pro-richAdd BLAST		57

Domainⁱ

Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3' via its C2H2-type zinc fingers. Starting from the N-terminus, the second zinc finger binds to the 3'-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5'-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine, 5-formylcytosine or 5-carboxylcytosine.1 Publication

The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.1 Publication

Sequence similaritiesⁱ

Belongs to the EGR C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	323 – 347	C2H2-type 1PROSITE-ProRule annotationAdd BLAST		25
Zinc fingerⁱ	353 – 377	C2H2-type 2PROSITE-ProRule annotationAdd BLAST		25
Zinc fingerⁱ	383 – 405	C2H2-type 3PROSITE-ProRule annotationAdd BLAST		23
Zinc fingerⁱ	414 – 438	C2H2-type 4PROSITE-ProRule annotationAdd BLAST		25

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000156734
InParanoidⁱ	P19544
Database of Orthologous Groups More...OrthoDBⁱ	1318335at2759
PhylomeDBⁱ	P19544

Family and domain databases

InterProⁱ	View protein in InterPro IPR017987, Wilms_tumour IPR000976, Wilms_tumour_N IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type
PANTHERⁱ	PTHR23235:SF49, PTHR23235:SF49, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02165, WT1, 1 hit PF00096, zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00355, ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF57667, SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits

Sequences (8+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 8 isoformsⁱ produced by alternative splicing and alternative initiation. Align Add to basket

This entry has 8 described isoforms and 8 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P19544-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

        10         20         30         40         50
MGSDVRDLNA LLPAVPSLGG GGGCALPVSG AAQWAPVLDF APPGASAYGS 
        60         70         80         90        100
LGGPAPPPAP PPPPPPPPHS FIKQEPSWGG AEPHEEQCLS AFTVHFSGQF 
       110        120        130        140        150
TGTAGACRYG PFGPPPPSQA SSGQARMFPN APYLPSCLES QPAIRNQGYS 
       160        170        180        190        200
TVTFDGTPSY GHTPSHHAAQ FPNHSFKHED PMGQQGSLGE QQYSVPPPVY 
       210        220        230        240        250
GCHTPTDSCT GSQALLLRTP YSSDNLYQMT SQLECMTWNQ MNLGATLKGV 
       260        270        280        290        300
AAGSSSSVKW TEGQSNHSTG YESDNHTTPI LCGAQYRIHT HGVFRGIQDV 
       310        320        330        340        350
RRVPGVAPTL VRSASETSEK RPFMCAYPGC NKRYFKLSHL QMHSRKHTGE 
       360        370        380        390        400
KPYQCDFKDC ERRFSRSDQL KRHQRRHTGV KPFQCKTCQR KFSRSDHLKT 
       410        420        430        440 
HTRTHTGKTS EKPFSCRWPS CQKKFARSDE LVRHHNMHQR NMTKLQLAL

Note: Detected in nucleus speckle, may bind mRNA.

Length:449

Mass (Da):49,188

Last modified:August 1, 1991 - v2

Checksum:ⁱ11C7FA3D485096B2

Isoform 2 (identifier: P19544-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
250-266: Missing.
408-410: Missing.

        10         20         30         40         50
MGSDVRDLNA LLPAVPSLGG GGGCALPVSG AAQWAPVLDF APPGASAYGS 
        60         70         80         90        100
LGGPAPPPAP PPPPPPPPHS FIKQEPSWGG AEPHEEQCLS AFTVHFSGQF 
       110        120        130        140        150
TGTAGACRYG PFGPPPPSQA SSGQARMFPN APYLPSCLES QPAIRNQGYS 
       160        170        180        190        200
TVTFDGTPSY GHTPSHHAAQ FPNHSFKHED PMGQQGSLGE QQYSVPPPVY 
       210        220        230        240        250
GCHTPTDSCT GSQALLLRTP YSSDNLYQMT SQLECMTWNQ MNLGATLKGH 
       260        270        280        290        300
STGYESDNHT TPILCGAQYR IHTHGVFRGI QDVRRVPGVA PTLVRSASET 
       310        320        330        340        350
SEKRPFMCAY PGCNKRYFKL SHLQMHSRKH TGEKPYQCDF KDCERRFSRS 
       360        370        380        390        400
DQLKRHQRRH TGVKPFQCKT CQRKFSRSDH LKTHTRTHTG EKPFSCRWPS 
       410        420 
CQKKFARSDE LVRHHNMHQR NMTKLQLAL

Length:429

Mass (Da):47,195

Checksum:ⁱC2F9912E0A4DA3DB

Isoform 3 (identifier: P19544-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
250-266: Missing.

        10         20         30         40         50
MGSDVRDLNA LLPAVPSLGG GGGCALPVSG AAQWAPVLDF APPGASAYGS 
        60         70         80         90        100
LGGPAPPPAP PPPPPPPPHS FIKQEPSWGG AEPHEEQCLS AFTVHFSGQF 
       110        120        130        140        150
TGTAGACRYG PFGPPPPSQA SSGQARMFPN APYLPSCLES QPAIRNQGYS 
       160        170        180        190        200
TVTFDGTPSY GHTPSHHAAQ FPNHSFKHED PMGQQGSLGE QQYSVPPPVY 
       210        220        230        240        250
GCHTPTDSCT GSQALLLRTP YSSDNLYQMT SQLECMTWNQ MNLGATLKGH 
       260        270        280        290        300
STGYESDNHT TPILCGAQYR IHTHGVFRGI QDVRRVPGVA PTLVRSASET 
       310        320        330        340        350
SEKRPFMCAY PGCNKRYFKL SHLQMHSRKH TGEKPYQCDF KDCERRFSRS 
       360        370        380        390        400
DQLKRHQRRH TGVKPFQCKT CQRKFSRSDH LKTHTRTHTG KTSEKPFSCR 
       410        420        430 
WPSCQKKFAR SDELVRHHNM HQRNMTKLQL AL

Length:432

Mass (Da):47,511

Checksum:ⁱ1ACA6CE3563DA9D2

Isoform 4 (identifier: P19544-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
408-410: Missing.

        10         20         30         40         50
MGSDVRDLNA LLPAVPSLGG GGGCALPVSG AAQWAPVLDF APPGASAYGS 
        60         70         80         90        100
LGGPAPPPAP PPPPPPPPHS FIKQEPSWGG AEPHEEQCLS AFTVHFSGQF 
       110        120        130        140        150
TGTAGACRYG PFGPPPPSQA SSGQARMFPN APYLPSCLES QPAIRNQGYS 
       160        170        180        190        200
TVTFDGTPSY GHTPSHHAAQ FPNHSFKHED PMGQQGSLGE QQYSVPPPVY 
       210        220        230        240        250
GCHTPTDSCT GSQALLLRTP YSSDNLYQMT SQLECMTWNQ MNLGATLKGV 
       260        270        280        290        300
AAGSSSSVKW TEGQSNHSTG YESDNHTTPI LCGAQYRIHT HGVFRGIQDV 
       310        320        330        340        350
RRVPGVAPTL VRSASETSEK RPFMCAYPGC NKRYFKLSHL QMHSRKHTGE 
       360        370        380        390        400
KPYQCDFKDC ERRFSRSDQL KRHQRRHTGV KPFQCKTCQR KFSRSDHLKT 
       410        420        430        440 
HTRTHTGEKP FSCRWPSCQK KFARSDELVR HHNMHQRNMT KLQLAL

Length:446

Mass (Da):48,872

Checksum:ⁱ8CE7FC116A41DA04

Isoform 6 (identifier: P19544-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-144: Missing.
     145-147: RNQ → MEK
     408-410: Missing.

        10         20         30         40         50
MEKGYSTVTF DGTPSYGHTP SHHAAQFPNH SFKHEDPMGQ QGSLGEQQYS 
        60         70         80         90        100
VPPPVYGCHT PTDSCTGSQA LLLRTPYSSD NLYQMTSQLE CMTWNQMNLG 
       110        120        130        140        150
ATLKGVAAGS SSSVKWTEGQ SNHSTGYESD NHTTPILCGA QYRIHTHGVF 
       160        170        180        190        200
RGIQDVRRVP GVAPTLVRSA SETSEKRPFM CAYPGCNKRY FKLSHLQMHS 
       210        220        230        240        250
RKHTGEKPYQ CDFKDCERRF SRSDQLKRHQ RRHTGVKPFQ CKTCQRKFSR 
       260        270        280        290        300
SDHLKTHTRT HTGEKPFSCR WPSCQKKFAR SDELVRHHNM HQRNMTKLQL 

AL

Length:302

Mass (Da):34,447

Checksum:ⁱ715B121077C0991D

Isoform 7 (identifier: P19544-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MDFLLLQDPASTCVPEPASQHTLRSGPGCLQQPEQQGVRDPGGIWAKLGAAEASAERLQGRRSRGASGSEPQQM

        10         20         30         40         50
MDFLLLQDPA STCVPEPASQ HTLRSGPGCL QQPEQQGVRD PGGIWAKLGA 
        60         70         80         90        100
AEASAERLQG RRSRGASGSE PQQMGSDVRD LNALLPAVPS LGGGGGCALP 
       110        120        130        140        150
VSGAAQWAPV LDFAPPGASA YGSLGGPAPP PAPPPPPPPP PHSFIKQEPS 
       160        170        180        190        200
WGGAEPHEEQ CLSAFTVHFS GQFTGTAGAC RYGPFGPPPP SQASSGQARM 
       210        220        230        240        250
FPNAPYLPSC LESQPAIRNQ GYSTVTFDGT PSYGHTPSHH AAQFPNHSFK 
       260        270        280        290        300
HEDPMGQQGS LGEQQYSVPP PVYGCHTPTD SCTGSQALLL RTPYSSDNLY 
       310        320        330        340        350
QMTSQLECMT WNQMNLGATL KGVAAGSSSS VKWTEGQSNH STGYESDNHT 
       360        370        380        390        400
TPILCGAQYR IHTHGVFRGI QDVRRVPGVA PTLVRSASET SEKRPFMCAY 
       410        420        430        440        450
PGCNKRYFKL SHLQMHSRKH TGEKPYQCDF KDCERRFSRS DQLKRHQRRH 
       460        470        480        490        500
TGVKPFQCKT CQRKFSRSDH LKTHTRTHTG KTSEKPFSCR WPSCQKKFAR 
       510        520 
SDELVRHHNM HQRNMTKLQL AL

Note: Produced by alternative initiation of isoform 1. Extended N-terminus.Curated

Length:522

Mass (Da):56,883

Checksum:ⁱFB30F6E34A60EC04

Isoform 8 (identifier: P19544-8) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MDFLLLQDPASTCVPEPASQHTLRSGPGCLQQPEQQGVRDPGGIWAKLGAAEASAERLQGRRSRGASGSEPQQM
250-266: Missing.

        10         20         30         40         50
MDFLLLQDPA STCVPEPASQ HTLRSGPGCL QQPEQQGVRD PGGIWAKLGA 
        60         70         80         90        100
AEASAERLQG RRSRGASGSE PQQMGSDVRD LNALLPAVPS LGGGGGCALP 
       110        120        130        140        150
VSGAAQWAPV LDFAPPGASA YGSLGGPAPP PAPPPPPPPP PHSFIKQEPS 
       160        170        180        190        200
WGGAEPHEEQ CLSAFTVHFS GQFTGTAGAC RYGPFGPPPP SQASSGQARM 
       210        220        230        240        250
FPNAPYLPSC LESQPAIRNQ GYSTVTFDGT PSYGHTPSHH AAQFPNHSFK 
       260        270        280        290        300
HEDPMGQQGS LGEQQYSVPP PVYGCHTPTD SCTGSQALLL RTPYSSDNLY 
       310        320        330        340        350
QMTSQLECMT WNQMNLGATL KGHSTGYESD NHTTPILCGA QYRIHTHGVF 
       360        370        380        390        400
RGIQDVRRVP GVAPTLVRSA SETSEKRPFM CAYPGCNKRY FKLSHLQMHS 
       410        420        430        440        450
RKHTGEKPYQ CDFKDCERRF SRSDQLKRHQ RRHTGVKPFQ CKTCQRKFSR 
       460        470        480        490        500
SDHLKTHTRT HTGKTSEKPF SCRWPSCQKK FARSDELVRH HNMHQRNMTK 

LQLAL

Note: Produced by alternative initiation of isoform 1. Extended N-terminus.Curated

Length:505

Mass (Da):55,206

Checksum:ⁱC7CE98CE8B83C250

Isoform 9 (identifier: P19544-9) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-144: Missing.
     145-147: RNQ → MEK
     250-266: Missing.

        10         20         30         40         50
MEKGYSTVTF DGTPSYGHTP SHHAAQFPNH SFKHEDPMGQ QGSLGEQQYS 
        60         70         80         90        100
VPPPVYGCHT PTDSCTGSQA LLLRTPYSSD NLYQMTSQLE CMTWNQMNLG 
       110        120        130        140        150
ATLKGHSTGY ESDNHTTPIL CGAQYRIHTH GVFRGIQDVR RVPGVAPTLV 
       160        170        180        190        200
RSASETSEKR PFMCAYPGCN KRYFKLSHLQ MHSRKHTGEK PYQCDFKDCE 
       210        220        230        240        250
RRFSRSDQLK RHQRRHTGVK PFQCKTCQRK FSRSDHLKTH TRTHTGKTSE 
       260        270        280 
KPFSCRWPSC QKKFARSDEL VRHHNMHQRN MTKLQLAL

Length:288

Mass (Da):33,086

Checksum:ⁱ9526D02081619728

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H0Y7K5	H0Y7K5_HUMAN		Wilms tumor protein Wilms tumor protein	WT1	519	Annotation score:
	J3KNN9	J3KNN9_HUMAN		Wilms tumor protein Wilms tumor protein	WT1	502	Annotation score:
	A0A0A0MT54	A0A0A0MT54_HUMAN		Wilms tumor protein Wilms tumor protein	WT1	522	Annotation score:
	A0A1W2PR07	A0A1W2PR07_HUMAN		Wilms tumor protein Wilms tumor protein	WT1	297	Annotation score:
	A0A1W2PQQ0	A0A1W2PQQ0_HUMAN		Wilms tumor protein Wilms tumor protein	WT1	505	Annotation score:
	H0YED9	H0YED9_HUMAN		Wilms tumor protein Wilms tumor protein	WT1	178	Annotation score:
	H0Y3F0	H0Y3F0_HUMAN		Wilms tumor protein Wilms tumor protein	WT1	322	Annotation score:
	A0A494C0I9	A0A494C0I9_HUMAN		Wilms tumor protein Wilms tumor protein	WT1	43	Annotation score:

Sequence cautionⁱ

The sequence AAB33443 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

The sequence CAA35956 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.Curated

The sequence CAA35956 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

The sequence CAC39220 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

The sequence CAI95758 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

The sequence CAI95759 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	288	I → M in AAH32861 (PubMed:15489334).Curated		1
Sequence conflictⁱ	365	S → F in AAA36810 (PubMed:2154335).Curated		1
Sequence conflictⁱ	365	S → F in AAB33443 (PubMed:7862533).Curated		1
Sequence conflictⁱ	387	T → A in CAA43819 (PubMed:1572653).Curated		1

RNA editingⁱ

Edited at position 281.1 Publication
Partially edited.

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_043798	131	A → T in a patient with hypospadias. 1 Publication		1
Natural variantⁱVAR_007739	181	P → S in WT1. 2 PublicationsCorresponds to variant dbSNP:rs2234584Ensembl.		1
Natural variantⁱVAR_007740	223	S → N in WT1. 1 Publication		1
Natural variantⁱVAR_007741	253	G → A in WT1. 1 Publication		1
Natural variantⁱVAR_007742	273	S → G Found in a mesothelioma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121907908Ensembl.		1
Natural variantⁱVAR_058021	281	L → P in RNA edited version.		1
Natural variantⁱVAR_015053	312	R → Q in NPHS4. 1 Publication		1
Natural variantⁱVAR_007743	330	C → Y in DDS. 1 Publication		1
Natural variantⁱVAR_015054	342	M → R in DDS. 1 Publication		1
Natural variantⁱVAR_043799	355	C → G in WT1. 1 Publication		1
Natural variantⁱVAR_015055	355	C → Y in DDS. 2 Publications		1
Natural variantⁱVAR_007744	360	C → G in DDS.		1
Natural variantⁱVAR_043800	360	C → Y in DDS. 1 Publication		1
Natural variantⁱVAR_043801	364	F → L in NPHS4. 1 Publication		1
Natural variantⁱVAR_007745	366	R → C in WT1, DDS and MEACHS. 4 Publications		1
Natural variantⁱVAR_007746	366	R → H in DDS and WT1. 4 Publications		1
Natural variantⁱVAR_043802	366	R → L in DDS. 1 Publication		1
Natural variantⁱVAR_043803	369	Q → P in DDS. 1 Publication		1
Natural variantⁱVAR_007747	373	H → Q in DDS and WT1. 1 Publication		1
Natural variantⁱVAR_015056	373	H → Y in DDS. 1 Publication		1
Natural variantⁱVAR_015057	377	H → R in DDS. 1 Publication		1
Natural variantⁱVAR_007748	377	H → Y in NPHS4. 1 Publication		1
Natural variantⁱVAR_043804	379	G → C in NPHS4. 1 Publication		1
Natural variantⁱVAR_007749	383	F → L in NPHS4. 1 Publication		1
Natural variantⁱVAR_015058	385	C → R in DDS. 3 Publications		1
Natural variantⁱVAR_015059	388	C → F in DDS. 1 Publication		1
Natural variantⁱVAR_043805	388	C → R in NPHS4. 2 Publications		1
Natural variantⁱVAR_043806	388	C → Y in DDS. 1 Publication		1
Natural variantⁱVAR_015060	392	F → L in FS. 1 Publication		1
Natural variantⁱVAR_043807	394	R → L in WT1. 1 Publication		1
Natural variantⁱVAR_043808	394	R → P in DDS. 1 Publication		1
Natural variantⁱVAR_015061	394	R → Q in DDS and NPHS4. 3 Publications		1
Natural variantⁱVAR_007750	394	R → W in DDS, WT1, MEACHS and NPHS4. 9 Publications		1
Natural variantⁱVAR_007752	396	D → G in DDS.		1
Natural variantⁱVAR_007751	396	D → N in DDS and NPHS4. 3 Publications		1
Natural variantⁱVAR_043809	396	D → Y in DDS. 1 Publication		1
Natural variantⁱVAR_043810	397	H → P in NPHS4. 2 Publications		1
Natural variantⁱVAR_015062	398	L → P in DDS. 2 Publications		1
Natural variantⁱVAR_043811	401	H → Y in DDS. 1 Publication		1
Natural variantⁱVAR_043812	405	H → R in DDS. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_037582	1 – 144	Missing in isoform 6 and isoform 9. 2 PublicationsAdd BLAST		144
Alternative sequenceⁱVSP_037583	1	M → MDFLLLQDPASTCVPEPASQ HTLRSGPGCLQQPEQQGVRD PGGIWAKLGAAEASAERLQG RRSRGASGSEPQQM in isoform 7 and isoform 8. 1 Publication		1
Alternative sequenceⁱVSP_037584	145 – 147	RNQ → MEK in isoform 6 and isoform 9. 2 Publications		3
Alternative sequenceⁱVSP_006866	250 – 266	Missing in isoform 2, isoform 3, isoform 8 and isoform 9. 2 PublicationsAdd BLAST		17
Alternative sequenceⁱVSP_006867	408 – 410	Missing in isoform 2, isoform 4 and isoform 6. 3 Publications		3

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X51630 mRNA Translation: CAA35956.1 Sequence problems. M80232 M80231 Genomic DNA Translation: AAA61299.1 X61631 X61638 Genomic DNA Translation: CAA43819.1 AK093168 mRNA Translation: BAG52667.1 AK291736 mRNA Translation: BAF84425.1 AY245105 Genomic DNA Translation: AAO61088.1 AL049692 Genomic DNA Translation: CAC39220.3 Different initiation. AL049692 Genomic DNA Translation: CAI95758.2 Different initiation. AL049692 Genomic DNA Translation: CAI95759.2 Different initiation. AL049692 Genomic DNA Translation: CAI95760.1 CH471064 Genomic DNA Translation: EAW68220.1 CH471064 Genomic DNA Translation: EAW68223.1 CH471064 Genomic DNA Translation: EAW68224.1 BC032861 mRNA Translation: AAH32861.1 M30393 mRNA Translation: AAA36810.1 S75264 mRNA Translation: AAB33443.1 Sequence problems. S61515 Genomic DNA Translation: AAB20110.1 S61522 Genomic DNA Translation: AAB20111.1 S61524 Genomic DNA Translation: AAB20112.1 S60755 Genomic DNA Translation: AAC60605.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS55750.1 [P19544-9] CCDS55751.1 [P19544-6] CCDS7878.2 [P19544-7]
PIRⁱ	A38080
NCBI Reference Sequences More...RefSeqⁱ	NP_000369.3, NM_000378.4 NP_001185480.1, NM_001198551.1 [P19544-6] NP_001185481.1, NM_001198552.1 [P19544-9] NP_077742.2, NM_024424.3 NP_077744.3, NM_024426.4 [P19544-7]

Genome annotation databases

Ensemblⁱ	ENST00000379079; ENSP00000368370; ENSG00000184937 [P19544-6] ENST00000530998; ENSP00000435307; ENSG00000184937 [P19544-9]
GeneIDⁱ	7490
KEGGⁱ	hsa:7490
UCSC genome browser More...UCSCⁱ	uc001mtl.3, human [P19544-1]

Keywords - Coding sequence diversityⁱ

Alternative initiation, Alternative splicing, Chromosomal rearrangement, RNA editing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X51630 mRNA Translation: CAA35956.1 Sequence problems. M80232 M80231 Genomic DNA Translation: AAA61299.1 X61631 X61638 Genomic DNA Translation: CAA43819.1 AK093168 mRNA Translation: BAG52667.1 AK291736 mRNA Translation: BAF84425.1 AY245105 Genomic DNA Translation: AAO61088.1 AL049692 Genomic DNA Translation: CAC39220.3 Different initiation. AL049692 Genomic DNA Translation: CAI95758.2 Different initiation. AL049692 Genomic DNA Translation: CAI95759.2 Different initiation. AL049692 Genomic DNA Translation: CAI95760.1 CH471064 Genomic DNA Translation: EAW68220.1 CH471064 Genomic DNA Translation: EAW68223.1 CH471064 Genomic DNA Translation: EAW68224.1 BC032861 mRNA Translation: AAH32861.1 M30393 mRNA Translation: AAA36810.1 S75264 mRNA Translation: AAB33443.1 Sequence problems. S61515 Genomic DNA Translation: AAB20110.1 S61522 Genomic DNA Translation: AAB20111.1 S61524 Genomic DNA Translation: AAB20112.1 S60755 Genomic DNA Translation: AAC60605.1
CCDSⁱ	CCDS55750.1 [P19544-9] CCDS55751.1 [P19544-6] CCDS7878.2 [P19544-7]
PIRⁱ	A38080
RefSeqⁱ	NP_000369.3, NM_000378.4 NP_001185480.1, NM_001198551.1 [P19544-6] NP_001185481.1, NM_001198552.1 [P19544-9] NP_077742.2, NM_024424.3 NP_077744.3, NM_024426.4 [P19544-7]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1LU6	model	-	A	310-449	[»]
	1XF7	NMR	-	A	381-407	[»]
	2G7T	model	-	A	310-449	[»]
	2G7V	model	-	A	310-449	[»]
	2G7W	model	-	A	310-449	[»]
	2G7X	model	-	A	310-449	[»]
	2JP9	NMR	-	A	318-438	[»]
	2JPA	NMR	-	A	318-438	[»]
	2PRT	X-ray	3.15	A	318-438	[»]
	3HPJ	X-ray	2.00	C/F	126-134	[»]
	3MYJ	X-ray	1.89	C/F	126-134	[»]
	4R2E	X-ray	1.84	A	350-440	[»]
	4R2P	X-ray	1.79	A	350-440	[»]
	4R2Q	X-ray	1.54	A	350-440	[»]
	4R2R	X-ray	2.09	A	350-440	[»]
	4R2S	X-ray	2.49	A	350-440	[»]
	4WUU	X-ray	3.05	C	126-134	[»]
	5KL2	X-ray	1.69	A	350-440	[»]
	5KL3	X-ray	1.45	A	350-440	[»]
	5KL4	X-ray	1.78	A/D	350-440	[»]
	5KL5	X-ray	2.29	A	350-440	[»]
	5KL6	X-ray	1.64	A	350-440	[»]
	5KL7	X-ray	1.58	A	350-440	[»]
	6B0O	X-ray	1.55	A/D	321-440	[»]
	6B0P	X-ray	2.08	A/D	321-440	[»]
	6B0Q	X-ray	2.79	A/D	321-440	[»]
	6B0R	X-ray	1.82	A/D	321-440	[»]
	6BLW	X-ray	1.83	A	319-440	[»]
	6RSY	X-ray	2.95	C/H	126-134	[»]
BMRBⁱ	P19544
SMRⁱ	P19544
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	113327, 63 interactors
IntActⁱ	P19544, 27 interactors
MINTⁱ	P19544
STRINGⁱ	9606.ENSP00000331327

PTM databases

iPTMnetⁱ	P19544
PhosphoSitePlusⁱ	P19544

Polymorphism and mutation databases

BioMutaⁱ	WT1
DMDMⁱ	139778

Proteomic databases

jPOSTⁱ	P19544
MassIVEⁱ	P19544
MaxQBⁱ	P19544
PaxDbⁱ	P19544
PeptideAtlasⁱ	P19544
PRIDEⁱ	P19544
ProteomicsDBⁱ	53673 [P19544-1] 53674 [P19544-2] 53675 [P19544-3] 53676 [P19544-4] 53677 [P19544-6] 53678 [P19544-7] 53679 [P19544-8] 53680 [P19544-9]

Protocols and materials databases

ABCDⁱ	P19544, 1 sequenced antibody
Antibodypediaⁱ	3523, 1083 antibodies
The DNASU plasmid repository More...DNASUⁱ	7490

Genome annotation databases

Ensemblⁱ	ENST00000379079; ENSP00000368370; ENSG00000184937 [P19544-6] ENST00000530998; ENSP00000435307; ENSG00000184937 [P19544-9]
GeneIDⁱ	7490
KEGGⁱ	hsa:7490
UCSCⁱ	uc001mtl.3, human [P19544-1]

Organism-specific databases

CTDⁱ	7490
DisGeNETⁱ	7490
EuPathDBⁱ	HostDB:ENSG00000184937.12
GeneCardsⁱ	WT1
GeneReviewsⁱ	WT1
HGNCⁱ	HGNC:12796, WT1
HPAⁱ	ENSG00000184937, Tissue enhanced (endometrium, fallopian tube, ovary)
MalaCardsⁱ	WT1
MIMⁱ	136680, phenotype 156240, phenotype 194070, phenotype 194080, phenotype 256370, phenotype 607102, gene 608978, phenotype
neXtProtⁱ	NX_P19544
OpenTargetsⁱ	ENSG00000184937
Orphanetⁱ	242, 46,XY complete gonadal dysgenesis 251510, 46,XY partial gonadal dysgenesis 220, Denys-Drash syndrome 83469, Desmoplastic small round cell tumor 347, Frasier syndrome 656, Genetic steroid-resistant nephrotic syndrome 3097, Meacham syndrome 654, Nephroblastoma 893, WAGR syndrome
PharmGKBⁱ	PA37395
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721, Eukaryota
GeneTreeⁱ	ENSGT00940000156734
InParanoidⁱ	P19544
OrthoDBⁱ	1318335at2759
PhylomeDBⁱ	P19544

Enzyme and pathway databases

PathwayCommonsⁱ	P19544
SignaLinkⁱ	P19544
SIGNORⁱ	P19544

Miscellaneous databases

BioGRID-ORCSⁱ	7490, 16 hits in 872 CRISPR screens
ChiTaRSⁱ	WT1, human
EvolutionaryTraceⁱ	P19544
GeneWikiⁱ	WT1
GenomeRNAiⁱ	7490
Pharosⁱ	P19544, Tbio
Protein Ontology More...PROⁱ	PR:P19544
RNActⁱ	P19544, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000184937, Expressed in germinal epithelium of ovary and 130 other tissues
ExpressionAtlasⁱ	P19544, baseline and differential
Genevisibleⁱ	P19544, HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR017987, Wilms_tumour IPR000976, Wilms_tumour_N IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type
PANTHERⁱ	PTHR23235:SF49, PTHR23235:SF49, 1 hit
Pfamⁱ	View protein in Pfam PF02165, WT1, 1 hit PF00096, zf-C2H2, 2 hits
SMARTⁱ	View protein in SMART SM00355, ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF57667, SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	WT1_HUMAN
Accessionⁱ	P19544Primary (citable) accession number: P19544 Secondary accession number(s): A8K6S1 Q8IYZ5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
	Last sequence update:	August 1, 1991
	Last modified:	December 2, 2020
	This is version 243 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations

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