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Entry version 189 (08 May 2019)
Sequence version 2 (25 Nov 2002)
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Protein

Transcriptional activator cubitus interruptus

Gene

ci

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has a dual function as a transcriptional activator and a repressor of the hedgehog (Hh) pathway. The full-length ci form (ciFL), acts as an activator (ciA) while ciR, its C-terminally truncated form, acts as a repressor. Involved in segment polarity. Required for the normal development of the posterior half of each embryonic segment. Engrailed protein directly represses ci expression in posterior compartment cells. Essential component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required to activate Cad99C-dependent endosome formation, norpA-dependent Ca2+ mobilization and p38 MAPK, which are essential steps in the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri451 – 476C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri484 – 511C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri517 – 541C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri547 – 572C2H2-type 4PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri578 – 603C2H2-type 5PROSITE-ProRule annotationAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Repressor, Segmentation polarity protein
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-209159 Assembly of the CI containing complexes
R-DME-209190 Phosphorylation of CI
R-DME-209214 Phosphorylation of SMO
R-DME-209338 Assembly of the 'signalling complexes'
R-DME-209360 Ubiquitination and proteolysis of phosphorylated CI
R-DME-209446 N-HH ligand not bound to PTC receptor complex
R-DME-216119 Activation of CI
R-DME-216167 Nuclear CI is degraded
R-DME-216217 Activation of SMO
R-DME-5610780 Degradation of GLI1 by the proteasome
R-DME-5610785 GLI3 is processed to GLI3R by the proteasome
R-DME-5610787 Hedgehog 'off' state
R-DME-5632684 Hedgehog 'on' state

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P19538

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcriptional activator cubitus interruptus
Short name:
Transcriptional activator ci
Alternative name(s):
ci form of 155 kDa
Short name:
ci-155
ci full-length protein
Short name:
ciFL
Cleaved into the following chain:
Transcriptional repressor cubitus interruptus
Short name:
Transcriptional repressor ci
Alternative name(s):
ci C-terminally truncated form
ci form of 75 kDa
Short name:
ci-75
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ci
Synonyms:ci-D
ORF Names:CG2125
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0004859 ci

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown severely reduces adult survival following the ingestion of E.carotovora. Abolishes Cad99C-dependent formation of endosomes and DUOX-dependent up-regulation of reactive oxygen species (ROS) in the intestines of adults fed bacteria-derived uracil.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000469171 – 1397Transcriptional activator cubitus interruptusAdd BLAST1397
ChainiPRO_00004062171 – ?Transcriptional repressor cubitus interruptus

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Polyubiquitinated by RDX in the presence of CUL3, which results in proteasomal degradation.1 Publication
Phosphorylated on multiple sites by protein kinase A (PKA) and phosphorylation by PKA primes further phosphorylation by CK1 and GSK3. Phosphorylation is essential for its proteolytic processing. cos recruits multiple kinases to promote efficient phosphorylation of ci while Hh signaling inhibits phosphorylation by restricting the accessibility of ci to the kinases (PubMed:15691767). Phosphorylation by CkIalpha and dco enhances binding to Slmb, the F-box recognition component of the SCF(slmb) E3 ubiquitin-protein ligase required for ci processing (PubMed:16326393).2 Publications
Transcriptional repressor ciR, a C-terminally truncated form, is generated from the full-length ci (ciFL/ci-155) through proteolytic processing. Hh suppresses the formation of ci75 and promotes the conversion of ci155 into a transcriptional activator (ci155A).1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P19538

PRoteomics IDEntifications database

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PRIDEi
P19538

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P19538

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In embryos, expressed uniformly throughout the blastoderm stage and gastrulation (from stage 5). During stage 10, ci is eliminated from the posterior compartment of each segment forming 15 segmentally repeating stripes at the end of the short phase of germ-band extension.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
FBgn0004859 Expressed in 62 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P19538 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P19538 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RDX (PubMed:16740475). Interacts with cos (PubMed:9244298, PubMed:15691767). Interacts with slmb; the interaction is enhanced by phosphorylation by CkIalpha and dco (PubMed:16326393).4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
68605, 190 interactors

Database of interacting proteins

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DIPi
DIP-121N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P19538

Protein interaction database and analysis system

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IntActi
P19538, 8 interactors

STRING: functional protein association networks

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STRINGi
7227.FBpp0088245

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HQMX-ray1.74C/D1356-1367[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P19538

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P19538

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 440Interaction with RDX1 PublicationAdd BLAST440
Regioni1161 – 1397Interaction with RDX1 PublicationAdd BLAST237

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri451 – 476C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri484 – 511C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri517 – 541C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri547 – 572C2H2-type 4PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri578 – 603C2H2-type 5PROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000169506

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000038200

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P19538

KEGG Orthology (KO)

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KOi
K16799

Database for complete collections of gene phylogenies

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PhylomeDBi
P19538

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 5 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57667 SSF57667, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P19538-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAYALPTYF PLAYSELQFL ASRRAAAVAA AATVLPGSPC INQHHPTDVS
60 70 80 90 100
SSVTVPSIIP TGGTSDSIKT SIQPQICNEN TLLGNAGHQH NHQPQHVHNI
110 120 130 140 150
NVTGQPHDFH PAYRIPGYME QLYSLQRTNS ASSFHDPYVN CASAFHLAGL
160 170 180 190 200
GLGSADFLGS RGLSSLGELH NAAVAAAAAG SLASTDFHFS VDGNRRLGSP
210 220 230 240 250
RPPGGSIRAS ISRKRALSSS PYSDSFDINS MIRFSPNSLA TIMNGSRGSS
260 270 280 290 300
AASGSYGHIS ATALNPMSHV HSTRLQQIQA HLLRASAGLL NPMTPQQVAA
310 320 330 340 350
SGFSIGHMPT SASLRVNDVH PNLSDSHIQI TTSPTVTKDV SQVPAAAFSL
360 370 380 390 400
KNLDDAREKK GPFKDVVPEQ PSSTSGGVAQ VEADSASSQL SDRCYNNVVN
410 420 430 440 450
NITGIPGDVK VNSRLDEYIN CGSISIPSNE YDCANADTTD IKDEPGDFIE
460 470 480 490 500
TNCHWRSCRI EFITQDELVK HINNDHIQTN KKAFVCRWED CTRGEKPFKA
510 520 530 540 550
QYMLVVHMRR HTGEKPHKCT FEGCFKAYSR LENLKTHLRS HTGEKPYTCE
560 570 580 590 600
YPGCSKAFSN ASDRAKHQNR THSNEKPYIC KAPGCTKRYT DPSSLRKHVK
610 620 630 640 650
TVHGAEFYAN KKHKGLPLND ANSRLQQNNS RHNLQEHNID SSPCSEDSHL
660 670 680 690 700
GKMLGTSSPS IKSESDISSS NHHLVNGVRA SDSLLTYSPD DLAENLNLDD
710 720 730 740 750
GWNCDDDVDV ADLPIVLRAM VNIGNGNASA STIGGSVLAR QRFRGRLQTK
760 770 780 790 800
GINSSTIMLC NIPESNRTFG ISELNQRITE LKMEPGTDAE IKIPKLPNTT
810 820 830 840 850
IGGYTEDPLQ NQTSFRNTVS NKQGTVSGSI QGQFRRDSQN STASTYYGSM
860 870 880 890 900
QSRRSSQSSQ VSSIPTMRPN PSCNSTASFY DPISPGCSRR SSQMSNGANC
910 920 930 940 950
NSFTSTSGLP VLNKESNKSL NACINKPNIG VQGVGIYNSS LPPPPSSHLI
960 970 980 990 1000
ATNLKRLQRK DSEYHNFTSG RFSVPSYMHS LHIKNNKPVG ENEFDKAIAS
1010 1020 1030 1040 1050
NARRQTDPVP NINLDPLTNI SRFSTTPHSF DINVGKTNNI ASSINKDNLR
1060 1070 1080 1090 1100
KDLFTVSIKA DMAMTSDQHP NERINLDEVE ELILPDEMLQ YLNLVKDDTN
1110 1120 1130 1140 1150
HLEKEHQAVP VGSNVSETIA SNHYREQSNI YYTNKQILTP PSNVDIQPNT
1160 1170 1180 1190 1200
TKFTVQDKFA MTAVGGSFSQ RELSTLAVPN EHGHAKCESF HHQSQKYMNT
1210 1220 1230 1240 1250
DIGSKQQSAL PSAHQRQTEK SNYNQIIDSS MTSLPELNVD SIYPRNETEN
1260 1270 1280 1290 1300
IFKVHGDHDN EIQCGIISQS QMSPSTNLNN DGQFSTVNMQ PITTSKLFPP
1310 1320 1330 1340 1350
EPQKIVCDTQ ASNTSVMHLD TYQRTLEYVQ SCQNWMETNN TSTNQIQSLP
1360 1370 1380 1390
GMPVNNTLFP DVSSSTHPYH GTNMVINDMT TSLTSLLEEN RYLQMMQ
Length:1,397
Mass (Da):153,280
Last modified:November 25, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC3232A71EF9B8004
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H9XVL7H9XVL7_DROME
Cubitus interruptus, isoform B
ci Ce, CI, Ci, ci-D, Ci155
1,279Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H9XVL6H9XVL6_DROME
Cubitus interruptus, isoform C
ci Ce, CI, Ci, ci-D, Ci155
572Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti403T → K in AAC47752 (PubMed:9332387).Curated1
Sequence conflicti457S → R (PubMed:2166702).Curated1
Sequence conflicti457S → R (PubMed:1686006).Curated1
Sequence conflicti804 – 805YT → IS (PubMed:2166702).Curated2
Sequence conflicti804 – 805YT → IS (PubMed:1686006).Curated2
Sequence conflicti968T → S (PubMed:2166702).Curated1
Sequence conflicti968T → S (PubMed:1686006).Curated1
Sequence conflicti1043S → L (PubMed:2166702).Curated1
Sequence conflicti1043S → L (PubMed:1686006).Curated1
Sequence conflicti1152Missing (PubMed:2166702).Curated1
Sequence conflicti1152Missing (PubMed:1686006).Curated1
Sequence conflicti1155V → L in AAC47752 (PubMed:9332387).Curated1
Sequence conflicti1378 – 1397DMTTS…LQMMQ → V (PubMed:2166702).CuratedAdd BLAST20
Sequence conflicti1378 – 1397DMTTS…LQMMQ → V (PubMed:1686006).CuratedAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X54360 mRNA Translation: CAA38244.1
U66884 Genomic DNA Translation: AAC47752.1
AE014135 Genomic DNA Translation: AAF59373.2
AH003430 Genomic DNA Translation: AAG15271.1
AF433680 Genomic DNA Translation: AAM17953.1

Protein sequence database of the Protein Information Resource

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PIRi
A38926

NCBI Reference Sequences

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RefSeqi
NP_524617.3, NM_079878.5

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0089178; FBpp0088245; FBgn0004859

Database of genes from NCBI RefSeq genomes

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GeneIDi
43767

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG2125

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54360 mRNA Translation: CAA38244.1
U66884 Genomic DNA Translation: AAC47752.1
AE014135 Genomic DNA Translation: AAF59373.2
AH003430 Genomic DNA Translation: AAG15271.1
AF433680 Genomic DNA Translation: AAM17953.1
PIRiA38926
RefSeqiNP_524617.3, NM_079878.5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HQMX-ray1.74C/D1356-1367[»]
SMRiP19538
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi68605, 190 interactors
DIPiDIP-121N
ELMiP19538
IntActiP19538, 8 interactors
STRINGi7227.FBpp0088245

PTM databases

iPTMnetiP19538

Proteomic databases

PaxDbiP19538
PRIDEiP19538

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0089178; FBpp0088245; FBgn0004859
GeneIDi43767
KEGGidme:Dmel_CG2125

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
12679
FlyBaseiFBgn0004859 ci

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000169506
HOGENOMiHOG000038200
InParanoidiP19538
KOiK16799
PhylomeDBiP19538

Enzyme and pathway databases

ReactomeiR-DME-209159 Assembly of the CI containing complexes
R-DME-209190 Phosphorylation of CI
R-DME-209214 Phosphorylation of SMO
R-DME-209338 Assembly of the 'signalling complexes'
R-DME-209360 Ubiquitination and proteolysis of phosphorylated CI
R-DME-209446 N-HH ligand not bound to PTC receptor complex
R-DME-216119 Activation of CI
R-DME-216167 Nuclear CI is degraded
R-DME-216217 Activation of SMO
R-DME-5610780 Degradation of GLI1 by the proteasome
R-DME-5610785 GLI3 is processed to GLI3R by the proteasome
R-DME-5610787 Hedgehog 'off' state
R-DME-5632684 Hedgehog 'on' state
SignaLinkiP19538

Miscellaneous databases

EvolutionaryTraceiP19538

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
43767

Protein Ontology

More...
PROi
PR:P19538

Gene expression databases

BgeeiFBgn0004859 Expressed in 62 organ(s), highest expression level in embryo
ExpressionAtlasiP19538 differential
GenevisibleiP19538 DM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCI_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P19538
Secondary accession number(s): O18525, Q8T6T1, Q9V4A8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: November 25, 2002
Last modified: May 8, 2019
This is version 189 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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