Glutamate receptor 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• AMPA glutamate receptor activity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.18

    "Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors."
    Schwenk J., Harmel N., Zolles G., Bildl W., Kulik A., Heimrich B., Chisaka O., Jonas P., Schulte U., Fakler B., Kloecker N.
    Science 323:1313-1319(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
• G-protein alpha-subunit binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling."
    Joiner M.L., Lise M.F., Yuen E.Y., Kam A.Y., Zhang M., Hall D.D., Malik Z.A., Qian H., Chen Y., Ulrich J.D., Burette A.C., Weinberg R.J., Law P.Y., El-Husseini A., Yan Z., Hell J.W.
    EMBO J. 29:482-495(2010) [PubMed] [Europe PMC] [Abstract]
• G-protein beta-subunit binding Source: RGDInferred from direct assayⁱ
  • "Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling."
    Joiner M.L., Lise M.F., Yuen E.Y., Kam A.Y., Zhang M., Hall D.D., Malik Z.A., Qian H., Chen Y., Ulrich J.D., Burette A.C., Weinberg R.J., Law P.Y., El-Husseini A., Yan Z., Hell J.W.
    EMBO J. 29:482-495(2010) [PubMed] [Europe PMC] [Abstract]
• PDZ domain binding Source: RGDInferred from physical interactionⁱ
  • "Peptide binding and NMR analysis of the interaction between SAP97 PDZ2 and GluR-A: potential involvement of a disulfide bond."
    von Ossowski L., Tossavainen H., von Ossowski I., Cai C., Aitio O., Fredriksson K., Permi P., Annila A., Keinanen K.
    Biochemistry 45:5567-5575(2006) [PubMed] [Europe PMC] [Abstract]
• adenylate cyclase binding Source: RGDInferred from direct assayⁱ
  • "Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling."
    Joiner M.L., Lise M.F., Yuen E.Y., Kam A.Y., Zhang M., Hall D.D., Malik Z.A., Qian H., Chen Y., Ulrich J.D., Burette A.C., Weinberg R.J., Law P.Y., El-Husseini A., Yan Z., Hell J.W.
    EMBO J. 29:482-495(2010) [PubMed] [Europe PMC] [Abstract]
• amyloid-beta binding Source: ARUK-UCLInferred from physical interactionⁱ
  • "Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption."
    Zhao W.Q., Santini F., Breese R., Ross D., Zhang X.D., Stone D.J., Ferrer M., Townsend M., Wolfe A.L., Seager M.A., Kinney G.G., Shughrue P.J., Ray W.J.
    J. Biol. Chem. 285:7619-7632(2010) [PubMed] [Europe PMC] [Abstract]
• beta-2 adrenergic receptor binding Source: ARUK-UCLInferred from physical interactionⁱ
  • "Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity."
    Wang D., Govindaiah G., Liu R., De Arcangelis V., Cox C.L., Xiang Y.K.
    FASEB J. 24:3511-3521(2010) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: IntActInferred from physical interactionⁱ
  • "Crystal structure and association behaviour of the GluR2 amino-terminal domain."
    Jin R., Singh S.K., Gu S., Furukawa H., Sobolevsky A.I., Zhou J., Jin Y., Gouaux E.
    EMBO J. 28:1812-1823(2009) [PubMed] [Europe PMC] [Abstract]
  • "Subunit-selective N-terminal domain associations organize the formation of AMPA receptor heteromers."
    Rossmann M., Sukumaran M., Penn A.C., Veprintsev D.B., Babu M.M., Greger I.H.
    EMBO J. 30:959-971(2011) [PubMed] [Europe PMC] [Abstract]
• immunoglobulin binding Source: UniProtKBInferred from physical interactionⁱ
  • "Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity."
    Jang S., Oh D., Lee Y., Hosy E., Shin H., van Riesen C., Whitcomb D., Warburton J.M., Jo J., Kim D., Kim S.G., Um S.M., Kwon S.K., Kim M.H., Roh J.D., Woo J., Jun H., Lee D.

    , Mah W., Kim H., Kaang B.K., Cho K., Rhee J.S., Choquet D., Kim E.
    Nat. Neurosci. 19:84-93(2016) [PubMed] [Europe PMC] [Abstract]
• ionotropic glutamate receptor activity Source: RGDInferred from direct assayⁱ
  • "Electrophysiological properties of AMPA receptors are differentially modulated depending on the associated member of the TARP family."
    Kott S., Werner M., Korber C., Hollmann M.
    J. Neurosci. 27:3780-3789(2007) [PubMed] [Europe PMC] [Abstract]
• myosin V binding Source: RGDInferred from physical interactionⁱ
  • "Involvement of myosin Vb in glutamate receptor trafficking."
    Lise M.F., Wong T.P., Trinh A., Hines R.M., Liu L., Kang R., Hines D.J., Lu J., Goldenring J.R., Wang Y.T., El-Husseini A.
    J. Biol. Chem. 281:3669-3678(2006) [PubMed] [Europe PMC] [Abstract]
• neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein C-terminus binding Source: ARUK-UCLInferred from physical interactionⁱ
  • "Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity."
    Wang D., Govindaiah G., Liu R., De Arcangelis V., Cox C.L., Xiang Y.K.
    FASEB J. 24:3511-3521(2010) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: RGDInferred from physical interactionⁱ
  • "Neuronal proteins involved in synaptic targeting of AMPA receptors in rat hippocampus by antidepressant drugs."
    Martinez-Turrillas R., Del Rio J., Frechilla D.
    Biochem. Biophys. Res. Commun. 353:750-755(2007) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: UniProtKB <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons."
    Shi S., Hayashi Y., Esteban J.A., Malinow R.
    Cell 105:331-343(2001) [PubMed] [Europe PMC] [Abstract]
• protein kinase A binding Source: RGDInferred from direct assayⁱ
  • "Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling."
    Joiner M.L., Lise M.F., Yuen E.Y., Kam A.Y., Zhang M., Hall D.D., Malik Z.A., Qian H., Chen Y., Ulrich J.D., Burette A.C., Weinberg R.J., Law P.Y., El-Husseini A., Yan Z., Hell J.W.
    EMBO J. 29:482-495(2010) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: RGDInferred from physical interactionⁱ
  • "LTP inhibits LTD in the hippocampus via regulation of GSK3beta."
    Peineau S., Taghibiglou C., Bradley C., Wong T.P., Liu L., Lu J., Lo E., Wu D., Saule E., Bouschet T., Matthews P., Isaac J.T., Bortolotto Z.A., Wang Y.T., Collingridge G.L.
    Neuron 53:703-717(2007) [PubMed] [Europe PMC] [Abstract]
• scaffold protein binding Source: SynGO-UCLInferred from physical interactionⁱ
  • "Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex."
    Colledge M., Dean R.A., Scott G.K., Langeberg L.K., Huganir R.L., Scott J.D.
    Neuron 27:107-119(2000) [PubMed] [Europe PMC] [Abstract]
• small GTPase binding Source: RGDInferred from physical interactionⁱ
  • "Neuronal proteins involved in synaptic targeting of AMPA receptors in rat hippocampus by antidepressant drugs."
    Martinez-Turrillas R., Del Rio J., Frechilla D.
    Biochem. Biophys. Res. Commun. 353:750-755(2007) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cellular response to amine stimulus Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Nucleus accumbens neurons exhibit synaptic scaling that is occluded by repeated dopamine pre-exposure."
    Sun X., Wolf M.E.
    Eur. J. Neurosci. 30:539-550(2009) [PubMed] [Europe PMC] [Abstract]
• cellular response to amino acid stimulus Source: RGDInferred from expression patternⁱ
  • "Early exposure of cultured hippocampal neurons to excitatory amino acids protects from later excitotoxicity."
    Friedman L.K., Segal M.
    Int. J. Dev. Neurosci. 28:195-205(2010) [PubMed] [Europe PMC] [Abstract]
• cellular response to dsRNA Source: RGDInferred from expression patternⁱ
  • "Glucocorticoid attenuates brain-derived neurotrophic factor-dependent upregulation of glutamate receptors via the suppression of microRNA-132 expression."
    Kawashima H., Numakawa T., Kumamaru E., Adachi N., Mizuno H., Ninomiya M., Kunugi H., Hashido K.
    Neuroscience 165:1301-1311(2010) [PubMed] [Europe PMC] [Abstract]
• cellular response to growth factor stimulus Source: RGDInferred from expression patternⁱ
  • "Glucocorticoid attenuates brain-derived neurotrophic factor-dependent upregulation of glutamate receptors via the suppression of microRNA-132 expression."
    Kawashima H., Numakawa T., Kumamaru E., Adachi N., Mizuno H., Ninomiya M., Kunugi H., Hashido K.
    Neuroscience 165:1301-1311(2010) [PubMed] [Europe PMC] [Abstract]
• cellular response to organic cyclic compound Source: RGDInferred from expression patternⁱ
  • "SA4503, a sigma-1 receptor agonist, prevents cultured cortical neurons from oxidative stress-induced cell death via suppression of MAPK pathway activation and glutamate receptor expression."
    Tuerxun T., Numakawa T., Adachi N., Kumamaru E., Kitazawa H., Kudo M., Kunugi H.
    Neurosci. Lett. 469:303-308(2010) [PubMed] [Europe PMC] [Abstract]
• cellular response to peptide hormone stimulus Source: RGDInferred from expression patternⁱ
  • "Leptin regulates AMPA receptor trafficking via PTEN inhibition."
    Moult P.R., Cross A., Santos S.D., Carvalho A.L., Lindsay Y., Connolly C.N., Irving A.J., Leslie N.R., Harvey J.
    J. Neurosci. 30:4088-4101(2010) [PubMed] [Europe PMC] [Abstract]
• long-term memory Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "BDNF activates mTOR to regulate GluR1 expression required for memory formation."
    Slipczuk L., Bekinschtein P., Katche C., Cammarota M., Izquierdo I., Medina J.H.
    PLoS ONE 4:e6007-e6007(2009) [PubMed] [Europe PMC] [Abstract]
• modulation of chemical synaptic transmission Source: UniProtKBInferred from direct assayⁱ
  • "Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons."
    Shi S., Hayashi Y., Esteban J.A., Malinow R.
    Cell 105:331-343(2001) [PubMed] [Europe PMC] [Abstract]
• neuronal action potential Source: UniProtKBInferred from mutant phenotypeⁱ
  • "PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity."
    Esteban J.A., Shi S.H., Wilson C., Nuriya M., Huganir R.L., Malinow R.
    Nat. Neurosci. 6:136-143(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of membrane potential Source: RGDInferred from mutant phenotypeⁱ
  • "Regulation of AMPA receptor trafficking by O-glycosylation."
    Kanno T., Yaguchi T., Nagata T., Mukasa T., Nishizaki T.
    Neurochem. Res. 35:782-788(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of synaptic transmission Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons."
    Shi S., Hayashi Y., Esteban J.A., Malinow R.
    Cell 105:331-343(2001) [PubMed] [Europe PMC] [Abstract]
• receptor internalization Source: UniProtKBInferred from direct assayⁱ
  • "Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization."
    Lin J.W., Ju W., Foster K., Lee S.H., Ahmadian G., Wyszynski M., Wang Y.T., Sheng M.
    Nat. Neurosci. 3:1282-1290(2000) [PubMed] [Europe PMC] [Abstract]
• regulation of receptor recycling Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons."
    Shi S., Hayashi Y., Esteban J.A., Malinow R.
    Cell 105:331-343(2001) [PubMed] [Europe PMC] [Abstract]
• regulation of synaptic plasticity Source: UniProtKBInferred from mutant phenotypeⁱ
  • "PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity."
    Esteban J.A., Shi S.H., Wilson C., Nuriya M., Huganir R.L., Malinow R.
    Nat. Neurosci. 6:136-143(2003) [PubMed] [Europe PMC] [Abstract]
• response to arsenic-containing substance Source: RGDInferred from expression patternⁱ
  • "Fast, quantitative in situ hybridization of rare mRNAs using 14C-standards and phosphorus imaging."
    Cremer C.M., Cremer M., Escobar J.L., Speckmann E.J., Zilles K.
    J. Neurosci. Methods 185:56-61(2009) [PubMed] [Europe PMC] [Abstract]
• response to cocaine Source: RGDInferred from expression patternⁱ
  • "Electrical stimulation of the lateral habenula produces enduring inhibitory effect on cocaine seeking behavior."
    Friedman A., Lax E., Dikshtein Y., Abraham L., Flaumenhaft Y., Sudai E., Ben-Tzion M., Ami-Ad L., Yaka R., Yadid G.
    Neuropharmacology 59:452-459(2010) [PubMed] [Europe PMC] [Abstract]
• response to drug Source: RGDInferred from expression patternⁱ
  • "Cannabidiol, a nonpsychotropic component of cannabis, inhibits cue-induced heroin seeking and normalizes discrete mesolimbic neuronal disturbances."
    Ren Y., Whittard J., Higuera-Matas A., Morris C.V., Hurd Y.L.
    J. Neurosci. 29:14764-14769(2009) [PubMed] [Europe PMC] [Abstract]
• response to electrical stimulus Source: RGDInferred from expression patternⁱ
  • "Involvement of microglial P2X7 receptors and downstream signaling pathways in long-term potentiation of spinal nociceptive responses."
    Chu Y.X., Zhang Y., Zhang Y.Q., Zhao Z.Q.
    Brain Behav. Immun. 24:1176-1189(2010) [PubMed] [Europe PMC] [Abstract]
• response to estradiol Source: RGDInferred from expression patternⁱ
  • "Estrogen receptor alpha and beta specific agonists regulate expression of synaptic proteins in rat hippocampus."
    Waters E.M., Mitterling K., Spencer J.L., Mazid S., McEwen B.S., Milner T.A.
    Brain Res. 1290:1-11(2009) [PubMed] [Europe PMC] [Abstract]
• response to fungicide Source: RGDInferred from expression patternⁱ
  • "Long-term exposure to endogenous levels of tributyltin decreases GluR2 expression and increases neuronal vulnerability to glutamate."
    Nakatsu Y., Kotake Y., Takishita T., Ohta S.
    Toxicol. Appl. Pharmacol. 240:292-298(2009) [PubMed] [Europe PMC] [Abstract]
• response to lithium ion Source: UniProtKBInferred from expression patternⁱ
  • "Modulation of synaptic plasticity by antimanic agents: the role of AMPA glutamate receptor subunit 1 synaptic expression."
    Du J., Gray N.A., Falke C.A., Chen W., Yuan P., Szabo S.T., Einat H., Manji H.K.
    J. Neurosci. 24:6578-6589(2004) [PubMed] [Europe PMC] [Abstract]
• response to organic cyclic compound Source: RGDInferred from expression patternⁱ
  • "Cannabidiol, a nonpsychotropic component of cannabis, inhibits cue-induced heroin seeking and normalizes discrete mesolimbic neuronal disturbances."
    Ren Y., Whittard J., Higuera-Matas A., Morris C.V., Hurd Y.L.
    J. Neurosci. 29:14764-14769(2009) [PubMed] [Europe PMC] [Abstract]
• response to peptide hormone Source: RGDInferred from expression patternⁱ
  • "Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone."
    Sears R.M., Liu R.J., Narayanan N.S., Sharf R., Yeckel M.F., Laubach M., Aghajanian G.K., DiLeone R.J.
    J. Neurosci. 30:8263-8273(2010) [PubMed] [Europe PMC] [Abstract]
• response to toxic substance Source: RGDInferred from mutant phenotypeⁱ
  • "Regulation of AMPA receptor trafficking by O-glycosylation."
    Kanno T., Yaguchi T., Nagata T., Mukasa T., Nishizaki T.
    Neurochem. Res. 35:782-788(2010) [PubMed] [Europe PMC] [Abstract]
• spinal cord development Source: RGDInferred from expression patternⁱ
  • "The potential role of phrenic nucleus glutamate receptor subunits in mediating spontaneous crossed phrenic activity in neonatal rat."
    Huang Y., Goshgarian H.G.
    Int. J. Dev. Neurosci. 27:477-483(2009) [PubMed] [Europe PMC] [Abstract]
• synaptic transmission, glutamatergic Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "Modulation of synaptic plasticity by antimanic agents: the role of AMPA glutamate receptor subunit 1 synaptic expression."
    Du J., Gray N.A., Falke C.A., Chen W., Yuan P., Szabo S.T., Einat H., Manji H.K.
    J. Neurosci. 24:6578-6589(2004) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• G-protein alpha-subunit binding Source: RGDInferred from physical interactionⁱ
  • "Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling."
    Joiner M.L., Lise M.F., Yuen E.Y., Kam A.Y., Zhang M., Hall D.D., Malik Z.A., Qian H., Chen Y., Ulrich J.D., Burette A.C., Weinberg R.J., Law P.Y., El-Husseini A., Yan Z., Hell J.W.
    EMBO J. 29:482-495(2010) [PubMed] [Europe PMC] [Abstract]
• G-protein beta-subunit binding Source: RGDInferred from direct assayⁱ
  • "Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling."
    Joiner M.L., Lise M.F., Yuen E.Y., Kam A.Y., Zhang M., Hall D.D., Malik Z.A., Qian H., Chen Y., Ulrich J.D., Burette A.C., Weinberg R.J., Law P.Y., El-Husseini A., Yan Z., Hell J.W.
    EMBO J. 29:482-495(2010) [PubMed] [Europe PMC] [Abstract]
• PDZ domain binding Source: RGDInferred from physical interactionⁱ
  • "Peptide binding and NMR analysis of the interaction between SAP97 PDZ2 and GluR-A: potential involvement of a disulfide bond."
    von Ossowski L., Tossavainen H., von Ossowski I., Cai C., Aitio O., Fredriksson K., Permi P., Annila A., Keinanen K.
    Biochemistry 45:5567-5575(2006) [PubMed] [Europe PMC] [Abstract]
• adenylate cyclase binding Source: RGDInferred from direct assayⁱ
  • "Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling."
    Joiner M.L., Lise M.F., Yuen E.Y., Kam A.Y., Zhang M., Hall D.D., Malik Z.A., Qian H., Chen Y., Ulrich J.D., Burette A.C., Weinberg R.J., Law P.Y., El-Husseini A., Yan Z., Hell J.W.
    EMBO J. 29:482-495(2010) [PubMed] [Europe PMC] [Abstract]
• beta-2 adrenergic receptor binding Source: ARUK-UCLInferred from physical interactionⁱ
  • "Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity."
    Wang D., Govindaiah G., Liu R., De Arcangelis V., Cox C.L., Xiang Y.K.
    FASEB J. 24:3511-3521(2010) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: IntActInferred from physical interactionⁱ
  • "Crystal structure and association behaviour of the GluR2 amino-terminal domain."
    Jin R., Singh S.K., Gu S., Furukawa H., Sobolevsky A.I., Zhou J., Jin Y., Gouaux E.
    EMBO J. 28:1812-1823(2009) [PubMed] [Europe PMC] [Abstract]
  • "Subunit-selective N-terminal domain associations organize the formation of AMPA receptor heteromers."
    Rossmann M., Sukumaran M., Penn A.C., Veprintsev D.B., Babu M.M., Greger I.H.
    EMBO J. 30:959-971(2011) [PubMed] [Europe PMC] [Abstract]
• myosin V binding Source: RGDInferred from physical interactionⁱ
  • "Involvement of myosin Vb in glutamate receptor trafficking."
    Lise M.F., Wong T.P., Trinh A., Hines R.M., Liu L., Kang R., Hines D.J., Lu J., Goldenring J.R., Wang Y.T., El-Husseini A.
    J. Biol. Chem. 281:3669-3678(2006) [PubMed] [Europe PMC] [Abstract]
• protein C-terminus binding Source: ARUK-UCLInferred from physical interactionⁱ
  • "Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity."
    Wang D., Govindaiah G., Liu R., De Arcangelis V., Cox C.L., Xiang Y.K.
    FASEB J. 24:3511-3521(2010) [PubMed] [Europe PMC] [Abstract]
• protein domain specific binding Source: RGDInferred from physical interactionⁱ
  • "Neuronal proteins involved in synaptic targeting of AMPA receptors in rat hippocampus by antidepressant drugs."
    Martinez-Turrillas R., Del Rio J., Frechilla D.
    Biochem. Biophys. Res. Commun. 353:750-755(2007) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: UniProtKBTraceable author statementⁱ
  • "Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons."
    Shi S., Hayashi Y., Esteban J.A., Malinow R.
    Cell 105:331-343(2001) [PubMed] [Europe PMC] [Abstract]
• protein kinase A binding Source: RGDInferred from direct assayⁱ
  • "Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling."
    Joiner M.L., Lise M.F., Yuen E.Y., Kam A.Y., Zhang M., Hall D.D., Malik Z.A., Qian H., Chen Y., Ulrich J.D., Burette A.C., Weinberg R.J., Law P.Y., El-Husseini A., Yan Z., Hell J.W.
    EMBO J. 29:482-495(2010) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: RGDInferred from physical interactionⁱ
  • "LTP inhibits LTD in the hippocampus via regulation of GSK3beta."
    Peineau S., Taghibiglou C., Bradley C., Wong T.P., Liu L., Lu J., Lo E., Wu D., Saule E., Bouschet T., Matthews P., Isaac J.T., Bortolotto Z.A., Wang Y.T., Collingridge G.L.
    Neuron 53:703-717(2007) [PubMed] [Europe PMC] [Abstract]
• scaffold protein binding Source: SynGO-UCLInferred from physical interactionⁱ
  • "Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex."
    Colledge M., Dean R.A., Scott G.K., Langeberg L.K., Huganir R.L., Scott J.D.
    Neuron 27:107-119(2000) [PubMed] [Europe PMC] [Abstract]
• small GTPase binding Source: RGDInferred from physical interactionⁱ
  • "Neuronal proteins involved in synaptic targeting of AMPA receptors in rat hippocampus by antidepressant drugs."
    Martinez-Turrillas R., Del Rio J., Frechilla D.
    Biochem. Biophys. Res. Commun. 353:750-755(2007) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MPYIFAFFCT GFLGAVVGAN FPNNIQIGGL FPNQQSQEHA AFRFALSQLT 
        60         70         80         90        100
EPPKLLPQID IVNISDSFEM TYRFCSQFSK GVYAIFGFYE RRTVNMLTSF 
       110        120        130        140        150
CGALHVCFIT PSFPVDTSNQ FVLQLRPELQ EALISIIDHY KWQTFVYIYD 
       160        170        180        190        200
ADRGLSVLQR VLDTAAEKNW QVTAVNILTT TEEGYRMLFQ DLEKKKERLV 
       210        220        230        240        250
VVDCESERLN AILGQIVKLE KNGIGYHYIL ANLGFMDIDL NKFKESGANV 
       260        270        280        290        300
TGFQLVNYTD TIPARIMQQW RTSDSRDHTR VDWKRPKYTS ALTYDGVKVM 
       310        320        330        340        350
AEAFQSLRRQ RIDISRRGNA GDCLANPAVP WGQGIDIQRA LQQVRFEGLT 
       360        370        380        390        400
GNVQFNEKGR RTNYTLHVIE MKHDGIRKIG YWNEDDKFVP AATDAQAGGD 
       410        420        430        440        450
NSSVQNRTYI VTTILEDPYV MLKKNANQFE GNDRYEGYCV ELAAEIAKHV 
       460        470        480        490        500
GYSYRLEIVS DGKYGARDPD TKAWNGMVGE LVYGRADVAV APLTITLVRE 
       510        520        530        540        550
EVIDFSKPFM SLGISIMIKK PQKSKPGVFS FLDPLAYEIW MCIVFAYIGV 
       560        570        580        590        600
SVVLFLVSRF SPYEWHSEEF EEGRDQTTSD QSNEFGIFNS LWFSLGAFMQ 
       610        620        630        640        650
QGCDISPRSL SGRIVGGVWW FFTLIIISSY TANLAAFLTV ERMVSPIESA 
       660        670        680        690        700
EDLAKQTEIA YGTLEAGSTK EFFRRSKIAV FEKMWTYMKS AEPSVFVRTT 
       710        720        730        740        750
EEGMIRVRKS KGKYAYLLES TMNEYIEQRK PCDTMKVGGN LDSKGYGIAT 
       760        770        780        790        800
PKGSALRNPV NLAVLKLNEQ GLLDKLKNKW WYDKGECGSG GGDSKDKTSA 
       810        820        830        840        850
LSLSNVAGVF YILIGGLGLA MLVALIEFCY KSRSESKRMK GFCLIPQQSI 
       860        870        880        890        900
NEAIRTSTLP RNSGAGASGG GGSGENGRVV SQDFPKSMQS IPCMSHSSGM 

PLGATGL                                                

        10         20         30         40         50
MPYIFAFFCT GFLGAVVGAN FPNNIQIGGL FPNQQSQEHA AFRFALSQLT 
        60         70         80         90        100
EPPKLLPQID IVNISDSFEM TYRFCSQFSK GVYAIFGFYE RRTVNMLTSF 
       110        120        130        140        150
CGALHVCFIT PSFPVDTSNQ FVLQLRPELQ EALISIIDHY KWQTFVYIYD 
       160        170        180        190        200
ADRGLSVLQR VLDTAAEKNW QVTAVNILTT TEEGYRMLFQ DLEKKKERLV 
       210        220        230        240        250
VVDCESERLN AILGQIVKLE KNGIGYHYIL ANLGFMDIDL NKFKESGANV 
       260        270        280        290        300
TGFQLVNYTD TIPARIMQQW RTSDSRDHTR VDWKRPKYTS ALTYDGVKVM 
       310        320        330        340        350
AEAFQSLRRQ RIDISRRGNA GDCLANPAVP WGQGIDIQRA LQQVRFEGLT 
       360        370        380        390        400
GNVQFNEKGR RTNYTLHVIE MKHDGIRKIG YWNEDDKFVP AATDAQAGGD 
       410        420        430        440        450
NSSVQNRTYI VTTILEDPYV MLKKNANQFE GNDRYEGYCV ELAAEIAKHV 
       460        470        480        490        500
GYSYRLEIVS DGKYGARDPD TKAWNGMVGE LVYGRADVAV APLTITLVRE 
       510        520        530        540        550
EVIDFSKPFM SLGISIMIKK PQKSKPGVFS FLDPLAYEIW MCIVFAYIGV 
       560        570        580        590        600
SVVLFLVSRF SPYEWHSEEF EEGRDQTTSD QSNEFGIFNS LWFSLGAFMQ 
       610        620        630        640        650
QGCDISPRSL SGRIVGGVWW FFTLIIISSY TANLAAFLTV ERMVSPIESA 
       660        670        680        690        700
EDLAKQTEIA YGTLEAGSTK EFFRRSKIAV FEKMWTYMKS AEPSVFVRTT 
       710        720        730        740        750
EEGMIRVRKS KGKYAYLLES TMNEYIEQRK PCDTMKVGGN LDSKGYGIAT 
       760        770        780        790        800
PKGSALRGPV NLAVLKLSEQ GVLDKLKSKW WYDKGECGSK DSGSKDKTSA 
       810        820        830        840        850
LSLSNVAGVF YILIGGLGLA MLVALIEFCY KSRSESKRMK GFCLIPQQSI 
       860        870        880        890        900
NEAIRTSTLP RNSGAGASGG GGSGENGRVV SQDFPKSMQS IPCMSHSSGM 

PLGATGL                                                

Experimental Info

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismⁱ

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. SIMILARITY comments
   Index of protein domains and families