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Entry version 222 (07 Apr 2021)
Sequence version 2 (07 Mar 2006)
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Protein

Glutathione hydrolase 1 proenzyme

Gene

GGT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates and other gamma-glutamyl compounds, such as leukotriene C4 (LTC4). The metabolism of glutathione by GGT1 releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound (PubMed:17924658, PubMed:7673200, PubMed:7759490, PubMed:8095045, PubMed:8827453, PubMed:21447318). Contributes to cysteine homeostasis, glutathione homeostasis and in the conversion of the leukotriene LTC4 to LTD4.8 Publications
Seems to be inactive.1 Publication

Miscellaneous

Cys-454 was thought to bind the gamma-glutamyl moiety, but mutagenesis of this residue had no effect on activity.1 Publication
Chloride ions bound in the active site cavity may contribute to stabilize the protein fold.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by autocatalytic cleavage (PubMed:23682772). Inhibited by serine-borate (PubMed:21447318).2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=11 mM for glycylglycine1 Publication
  2. KM=10.6 µM for glutathione1 Publication
  3. KM=8.8 µM for oxidized-glutathione1 Publication
  4. KM=1.3 mM for D-gamma-glutamyl-p-nitroanalide1 Publication
  5. KM=9.9 µM for S-methylglutathion1 Publication
  6. KM=33.4 µM for gamma-glutamyl leucine1 Publication
  7. KM=10.8 µM for leukotriene C41 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: leukotriene D4 biosynthesis

    This protein is involved in the pathway leukotriene D4 biosynthesis, which is part of Lipid metabolism.1 Publication
    View all proteins of this organism that are known to be involved in the pathway leukotriene D4 biosynthesis and in Lipid metabolism.

    Pathwayi: glutathione metabolism

    This protein is involved in the pathway glutathione metabolism, which is part of Sulfur metabolism.1 Publication
    View all proteins of this organism that are known to be involved in the pathway glutathione metabolism and in Sulfur metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei107Glutamate1 Publication1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei381Nucleophile2 Publications1
    Binding sitei423Glutamate1 Publication1
    Binding sitei474Glutamate; via amide nitrogen1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAcyltransferase, Hydrolase, Protease, Transferase
    Biological processGlutathione biosynthesis, Lipid metabolism
    LigandSialic acid

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:MONOMER66-34394

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    P19440

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-174403, Glutathione synthesis and recycling
    R-HSA-2142691, Synthesis of Leukotrienes (LT) and Eoxins (EX)
    R-HSA-5423646, Aflatoxin activation and detoxification
    R-HSA-5579022, Defective GGT1 causes Glutathionuria (GLUTH)
    R-HSA-9035968, Defective GGT1 causes Glutathionuria (GLUTH)
    R-HSA-9664535, LTC4-CYSLTR mediated IL4 production

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P19440

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00204
    UPA00880

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    T03.006

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000001454

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Glutathione hydrolase 1 proenzyme (EC:3.4.19.132 Publications)
    Alternative name(s):
    Gamma-glutamyltransferase 1
    Gamma-glutamyltranspeptidase 1 (EC:2.3.2.27 Publications)
    Short name:
    GGT 1
    Leukotriene-C4 hydrolase (EC:3.4.19.141 Publication)
    CD_antigen: CD224
    Cleaved into the following 2 chains:
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:GGT1
    Synonyms:GGT
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:4250, GGT1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    612346, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P19440

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...
    VEuPathDBi
    HostDB:ENSG00000100031.18

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 4CytoplasmicBy similarity4
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei5 – 26Helical; Signal-anchor for type II membrane proteinBy similarityAdd BLAST22
    Topological domaini27 – 569ExtracellularBy similarityAdd BLAST543

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Glutathionuria (GLUTH)1 Publication
    The disease is caused by variants affecting the gene represented in this entry. A large homozygous deletion that removes several exons of all isoforms of GGT1 has been found in one family affected by glutathionuria.1 Publication
    Disease descriptionA very rare, autosomal recessive metabolic disorder characterized by the presence of glutathione in the urine, due to generalized gamma-glutamyl transpeptidase deficiency. Most patients manifest mild to moderate mental retardation, and behavioral disturbance. Seizures, tremor, marfanoid features and strabismus are observed in some patients.
    Related information in OMIM

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi100K → N: No effect on gamma-glutamyltranspeptidase activity. 1 Publication1
    Mutagenesisi102E → Q: No effect on gamma-glutamyltranspeptidase activity. 1 Publication1
    Mutagenesisi107R → K: Reduces enzyme gamma-glutamyltranspeptidase activity by 99%. 1 Publication1
    Mutagenesisi107R → Q or H: Abolishes gamma-glutamyltranspeptidase activity. 1 Publication1
    Mutagenesisi108E → Q: Reduces gamma-glutamyltranspeptidase activity by 98%. 1 Publication1
    Mutagenesisi112R → Q: No effect on gamma-glutamyltranspeptidase activity. 1 Publication1
    Mutagenesisi139R → Q: No effect on gamma-glutamyltranspeptidase activity. 1 Publication1
    Mutagenesisi147R → Q: No effect on gamma-glutamyltranspeptidase activity. 1 Publication1
    Mutagenesisi150R → Q: No effect on gamma-glutamyltranspeptidase activity. 1 Publication1
    Mutagenesisi192C → W: Loss of autocatalytic cleavage, cell membrane localization and decrease in gamma-glutamyltranspeptidase activity; when associated with Y-193. 1 Publication1
    Mutagenesisi193E → Y: Loss of autocatalytic cleavage, cell membrane localization and decrease in gamma-glutamyltranspeptidase activity; when associated with W-192. 1 Publication1
    Mutagenesisi383H → A: Reduces gamma-glutamyltranspeptidase activity by 66%. 1 Publication1
    Mutagenesisi385S → A: No effect on gamma-glutamyltranspeptidase activity. 1 Publication1
    Mutagenesisi413S → A: No effect on gamma-glutamyltranspeptidase activity. 1 Publication1
    Mutagenesisi422D → A: Reduces enzyme gamma-glutamyltranspeptidase activity by 90%. 1 Publication1
    Mutagenesisi423D → A: Abolishes gamma-glutamyltranspeptidase activity. Increases KM for D-gamma-glutamyl-p-nitroanalide by over 1000-fold. 1 Publication1
    Mutagenesisi425S → A: No effect on gamma-glutamyltranspeptidase activity. 1 Publication1
    Mutagenesisi451S → A: Reduces gamma-glutamyltranspeptidase activity by 99%. Abolishes activity; when associated with A-452. 1 Publication1
    Mutagenesisi452S → A: Reduces gamma-glutamyltranspeptidase activity by 99%. Abolishes activity; when associated with A-451. 1 Publication1
    Mutagenesisi454C → A: No effect on gamma-glutamyltranspeptidase activity. 1 Publication1
    Mutagenesisi505H → A: Reduces gamma-glutamyltranspeptidase activity by 90%. 1 Publication1
    Mutagenesisi545Q → K: Reduces enzyme activity by 97%. 1 Publication1

    Keywords - Diseasei

    Mental retardation

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    2678

    GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

    More...
    GeneReviewsi
    GGT1

    MalaCards human disease database

    More...
    MalaCardsi
    GGT1
    MIMi231950, phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000100031

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    33573, Gamma-glutamyl transpeptidase deficiency

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA28662

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    P19440, Tbio

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL5696

    Drug and drug target database

    More...
    DrugBanki
    DB00143, Glutathione

    DrugCentral

    More...
    DrugCentrali
    P19440

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    GGT1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    93140064

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000110581 – 380Glutathione hydrolase 1 heavy chainAdd BLAST380
    ChainiPRO_0000011059381 – 569Glutathione hydrolase 1 light chain1 PublicationAdd BLAST189

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi50 ↔ 741 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi95N-linked (GlcNAc...) asparagine3 Publications1
    Glycosylationi120N-linked (GlcNAc...) asparagine6 Publications1
    Disulfide bondi192 ↔ 1961 Publication
    Glycosylationi230N-linked (GlcNAc...) asparagine4 Publications1
    Glycosylationi266N-linked (GlcNAc...) asparagine4 Publications1
    Glycosylationi297N-linked (GlcNAc...) asparagine1 Publication1
    Glycosylationi344N-linked (GlcNAc...) asparagine4 Publications1
    Glycosylationi511N-linked (GlcNAc...) asparagine6 Publications1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    N-glycosylated on both chains. Contains hexoses, hexosamines and sialic acid residues. Glycosylation profiles tested in kidney and liver tissues reveal the presence of tissue-specific and site-specific glycan composition, despite the overlap in composition among the N-glycans. A total of 36 glycan compositions, with 40 unique structures are observed. Up to 15 different glycans are observed at a single site, with site-specific variation in glycan composition. The difference in glycosylation profiles in the 2 tissues do not affect the enzyme activity.9 Publications
    Cleaved by autocatalysis into a large and a small subunit and the autocatalytic cleavage is essential to the functional activation of the enzyme.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    The CPTAC Assay portal

    More...
    CPTACi
    CPTAC-2217

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P19440

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P19440

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    P19440

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P19440

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P19440

    PeptideAtlas

    More...
    PeptideAtlasi
    P19440

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P19440

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    53662 [P19440-1]
    53663 [P19440-2]
    53664 [P19440-3]

    PTM databases

    GlyConnect protein glycosylation platform

    More...
    GlyConnecti
    1261, 27 N-Linked glycans (4 sites)

    GlyGen: Computational and Informatics Resources for Glycoscience

    More...
    GlyGeni
    P19440, 7 sites

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P19440

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P19440

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Detected in fetal and adult kidney and liver, adult pancreas, stomach, intestine, placenta and lung. There are several other tissue-specific forms that arise from alternative promoter usage but that produce the same protein.
    Lung-specific.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000100031, Expressed in adult mammalian kidney and 116 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P19440, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P19440, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000100031, Tissue enhanced (kidney, seminal vesicle)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Heterodimer composed of the light and heavy chains. The active site is located in the light chain.

    2 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Hide details

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    108946, 12 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    P19440, 11 interactors

    Molecular INTeraction database

    More...
    MINTi
    P19440

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000383232

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    P19440

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    P19440, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1569
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P19440

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni399 – 401Glutamate binding2 Publications3
    Regioni451 – 452Glutamate binding2 Publications2

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the gamma-glutamyltransferase family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2410, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000154601

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_014813_1_3_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P19440

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    KATKNMF

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P19440

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF313608

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.246.130, 1 hit
    3.60.20.40, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR043138, GGT_lsub_C
    IPR000101, GGT_peptidase
    IPR043137, GGT_ssub
    IPR029055, Ntn_hydrolases_N

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11686, PTHR11686, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF56235, SSF56235, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00066, g_glut_trans, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00462, G_GLU_TRANSPEPTIDASE, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 15 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: P19440-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MKKKLVVLGL LAVVLVLVIV GLCLWLPSAS KEPDNHVYTR AAVAADAKQC
    60 70 80 90 100
    SKIGRDALRD GGSAVDAAIA ALLCVGLMNA HSMGIGGGLF LTIYNSTTRK
    110 120 130 140 150
    AEVINAREVA PRLAFATMFN SSEQSQKGGL SVAVPGEIRG YELAHQRHGR
    160 170 180 190 200
    LPWARLFQPS IQLARQGFPV GKGLAAALEN KRTVIEQQPV LCEVFCRDRK
    210 220 230 240 250
    VLREGERLTL PQLADTYETL AIEGAQAFYN GSLTAQIVKD IQAAGGIVTA
    260 270 280 290 300
    EDLNNYRAEL IEHPLNISLG DVVLYMPSAP LSGPVLALIL NILKGYNFSR
    310 320 330 340 350
    ESVESPEQKG LTYHRIVEAF RFAYAKRTLL GDPKFVDVTE VVRNMTSEFF
    360 370 380 390 400
    AAQLRAQISD DTTHPISYYK PEFYTPDDGG TAHLSVVAED GSAVSATSTI
    410 420 430 440 450
    NLYFGSKVRS PVSGILFNNE MDDFSSPSIT NEFGVPPSPA NFIQPGKQPL
    460 470 480 490 500
    SSMCPTIMVG QDGQVRMVVG AAGGTQITTA TALAIIYNLW FGYDVKRAVE
    510 520 530 540 550
    EPRLHNQLLP NVTTVERNID QAVTAALETR HHHTQIASTF IAVVQAIVRT
    560
    AGGWAAASDS RKGGEPAGY
    Note: Produced by alternative promoter usage.
    Length:569
    Mass (Da):61,410
    Last modified:March 7, 2006 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i71AE12485239A69F
    GO
    Isoform 2 (identifier: P19440-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         341-366: VVRNMTSEFFAAQLRAQISDDTTHPI → ASSGVSAGGPQHDLRVLRCPAPGPDL
         367-569: Missing.

    Note: Produced by alternative splicing of isoform 1.Curated
    Show »
    Length:366
    Mass (Da):39,420
    Checksum:i726B492DEFA85BE2
    GO
    Isoform 3 (identifier: P19440-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-344: Missing.

    Note: Produced by alternative promoter usage.Curated
    Show »
    Length:225
    Mass (Da):24,080
    Checksum:i46765CED537C40C3
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    E7ETN1E7ETN1_HUMAN
    Glutathione hydrolase 1 proenzyme
    GGT1
    97Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    B5MC36B5MC36_HUMAN
    Glutathione hydrolase 1 proenzyme
    GGT1
    218Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E7ET76E7ET76_HUMAN
    Glutathione hydrolase 1 proenzyme
    GGT1
    463Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    B5MC34B5MC34_HUMAN
    Glutathione hydrolase 1 proenzyme
    GGT1
    252Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    C9JGF3C9JGF3_HUMAN
    Glutathione hydrolase 1 proenzyme
    GGT1
    30Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E7ETR7E7ETR7_HUMAN
    Glutathione hydrolase 1 proenzyme
    GGT1
    174Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E7ESL5E7ESL5_HUMAN
    Glutathione hydrolase 1 proenzyme
    GGT1
    108Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E7ETJ6E7ETJ6_HUMAN
    Glutathione hydrolase 1 proenzyme
    GGT1
    127Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PHP2E9PHP2_HUMAN
    Glutathione hydrolase 1 proenzyme
    GGT1
    67Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E7ENJ5E7ENJ5_HUMAN
    Glutathione hydrolase 1 proenzyme
    GGT1
    120Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    There are more potential isoformsShow all

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAA35899 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti30 – 31SK → KS AA sequence (PubMed:2896486).Curated2
    Sequence conflicti47A → K AA sequence (PubMed:2896486).Curated1
    Sequence conflicti139R → E in AAA35889 (PubMed:1968061).Curated1
    Sequence conflicti356A → S in AAI28240 (PubMed:15489334).Curated1
    Sequence conflicti361D → H in AAI28240 (PubMed:15489334).Curated1
    Sequence conflicti372E → D in AAA02886 (PubMed:7689219).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02554551S → L. Corresponds to variant dbSNP:rs2330837Ensembl.1
    Natural variantiVAR_01837352K → E. Corresponds to variant dbSNP:rs2330838Ensembl.1
    Natural variantiVAR_018374177A → V. Corresponds to variant dbSNP:rs3895576Ensembl.1
    Natural variantiVAR_018372272V → A6 PublicationsCorresponds to variant dbSNP:rs4049829Ensembl.1
    Natural variantiVAR_025546419N → D. Corresponds to variant dbSNP:rs17004876Ensembl.1
    Natural variantiVAR_049181435V → A. Corresponds to variant dbSNP:rs1062459Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0081321 – 344Missing in isoform 3. 2 PublicationsAdd BLAST344
    Alternative sequenceiVSP_001746341 – 366VVRNM…TTHPI → ASSGVSAGGPQHDLRVLRCP APGPDL in isoform 2. 1 PublicationAdd BLAST26
    Alternative sequenceiVSP_001747367 – 569Missing in isoform 2. 1 PublicationAdd BLAST203

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    J04131 mRNA Translation: AAA52547.1
    M24087 mRNA Translation: AAA35899.1 Different initiation.
    M24903 mRNA Translation: AAA52546.1
    J05235 mRNA Translation: AAA35889.1
    X60069 mRNA Translation: CAA42674.1
    L20490 mRNA Translation: AAA02884.1
    L20493 mRNA Translation: AAA02886.1
    CR456494 mRNA Translation: CAG30380.1
    AP000356 Genomic DNA No translation available.
    BC025927 mRNA Translation: AAH25927.1
    BC069473 mRNA Translation: AAH69473.1
    BC069504 mRNA Translation: AAH69504.1
    BC128238 mRNA Translation: AAI28239.1
    BC128239 mRNA Translation: AAI28240.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS42992.1 [P19440-1]

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A31253, EKHUEX
    A48987
    A60439
    JS0067
    PS0312

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001275762.1, NM_001288833.1 [P19440-1]
    NP_038265.2, NM_013421.2 [P19440-1]
    NP_038347.2, NM_013430.2 [P19440-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000400380; ENSP00000383231; ENSG00000100031 [P19440-1]
    ENST00000400382; ENSP00000383232; ENSG00000100031 [P19440-1]
    ENST00000401885; ENSP00000384381; ENSG00000100031 [P19440-3]
    ENST00000403838; ENSP00000384820; ENSG00000100031 [P19440-3]
    ENST00000404532; ENSP00000385445; ENSG00000100031 [P19440-3]
    ENST00000425895; ENSP00000387499; ENSG00000100031 [P19440-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    2678

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:2678

    UCSC genome browser

    More...
    UCSCi
    uc003aan.2, human [P19440-1]

    Keywords - Coding sequence diversityi

    Alternative promoter usage, Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    Wikipedia

    Gamma-glutamyl transpeptidase entry

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    J04131 mRNA Translation: AAA52547.1
    M24087 mRNA Translation: AAA35899.1 Different initiation.
    M24903 mRNA Translation: AAA52546.1
    J05235 mRNA Translation: AAA35889.1
    X60069 mRNA Translation: CAA42674.1
    L20490 mRNA Translation: AAA02884.1
    L20493 mRNA Translation: AAA02886.1
    CR456494 mRNA Translation: CAG30380.1
    AP000356 Genomic DNA No translation available.
    BC025927 mRNA Translation: AAH25927.1
    BC069473 mRNA Translation: AAH69473.1
    BC069504 mRNA Translation: AAH69504.1
    BC128238 mRNA Translation: AAI28239.1
    BC128239 mRNA Translation: AAI28240.1
    CCDSiCCDS42992.1 [P19440-1]
    PIRiA31253, EKHUEX
    A48987
    A60439
    JS0067
    PS0312
    RefSeqiNP_001275762.1, NM_001288833.1 [P19440-1]
    NP_038265.2, NM_013421.2 [P19440-1]
    NP_038347.2, NM_013430.2 [P19440-1]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    4GDXX-ray1.67A2-374[»]
    B375-569[»]
    4GG2X-ray2.21A28-380[»]
    B381-569[»]
    4Z9OX-ray2.30A28-380[»]
    B381-569[»]
    4ZBKX-ray2.18A28-380[»]
    B381-569[»]
    4ZC6X-ray2.10A28-380[»]
    B381-569[»]
    4ZCGX-ray2.22A28-380[»]
    B381-569[»]
    5V4QX-ray2.20A28-380[»]
    B381-569[»]
    SMRiP19440
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi108946, 12 interactors
    IntActiP19440, 11 interactors
    MINTiP19440
    STRINGi9606.ENSP00000383232

    Chemistry databases

    BindingDBiP19440
    ChEMBLiCHEMBL5696
    DrugBankiDB00143, Glutathione
    DrugCentraliP19440
    SwissLipidsiSLP:000001454

    Protein family/group databases

    MEROPSiT03.006

    PTM databases

    GlyConnecti1261, 27 N-Linked glycans (4 sites)
    GlyGeniP19440, 7 sites
    iPTMnetiP19440
    PhosphoSitePlusiP19440

    Genetic variation databases

    BioMutaiGGT1
    DMDMi93140064

    Proteomic databases

    CPTACiCPTAC-2217
    EPDiP19440
    jPOSTiP19440
    MassIVEiP19440
    MaxQBiP19440
    PaxDbiP19440
    PeptideAtlasiP19440
    PRIDEiP19440
    ProteomicsDBi53662 [P19440-1]
    53663 [P19440-2]
    53664 [P19440-3]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    24014, 454 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    2678

    Genome annotation databases

    EnsembliENST00000400380; ENSP00000383231; ENSG00000100031 [P19440-1]
    ENST00000400382; ENSP00000383232; ENSG00000100031 [P19440-1]
    ENST00000401885; ENSP00000384381; ENSG00000100031 [P19440-3]
    ENST00000403838; ENSP00000384820; ENSG00000100031 [P19440-3]
    ENST00000404532; ENSP00000385445; ENSG00000100031 [P19440-3]
    ENST00000425895; ENSP00000387499; ENSG00000100031 [P19440-2]
    GeneIDi2678
    KEGGihsa:2678
    UCSCiuc003aan.2, human [P19440-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    2678
    DisGeNETi2678

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    GGT1
    GeneReviewsiGGT1
    HGNCiHGNC:4250, GGT1
    HPAiENSG00000100031, Tissue enhanced (kidney, seminal vesicle)
    MalaCardsiGGT1
    MIMi231950, phenotype
    612346, gene
    neXtProtiNX_P19440
    OpenTargetsiENSG00000100031
    Orphaneti33573, Gamma-glutamyl transpeptidase deficiency
    PharmGKBiPA28662
    VEuPathDBiHostDB:ENSG00000100031.18

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG2410, Eukaryota
    GeneTreeiENSGT00940000154601
    HOGENOMiCLU_014813_1_3_1
    InParanoidiP19440
    OMAiKATKNMF
    PhylomeDBiP19440
    TreeFamiTF313608

    Enzyme and pathway databases

    UniPathwayiUPA00204
    UPA00880
    BioCyciMetaCyc:MONOMER66-34394
    PathwayCommonsiP19440
    ReactomeiR-HSA-174403, Glutathione synthesis and recycling
    R-HSA-2142691, Synthesis of Leukotrienes (LT) and Eoxins (EX)
    R-HSA-5423646, Aflatoxin activation and detoxification
    R-HSA-5579022, Defective GGT1 causes Glutathionuria (GLUTH)
    R-HSA-9035968, Defective GGT1 causes Glutathionuria (GLUTH)
    R-HSA-9664535, LTC4-CYSLTR mediated IL4 production
    SABIO-RKiP19440

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    2678, 96 hits in 926 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    GGT1, human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    GGT1

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    2678
    PharosiP19440, Tbio

    Protein Ontology

    More...
    PROi
    PR:P19440
    RNActiP19440, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000100031, Expressed in adult mammalian kidney and 116 other tissues
    ExpressionAtlasiP19440, baseline and differential
    GenevisibleiP19440, HS

    Family and domain databases

    Gene3Di1.10.246.130, 1 hit
    3.60.20.40, 1 hit
    InterProiView protein in InterPro
    IPR043138, GGT_lsub_C
    IPR000101, GGT_peptidase
    IPR043137, GGT_ssub
    IPR029055, Ntn_hydrolases_N
    PANTHERiPTHR11686, PTHR11686, 1 hit
    SUPFAMiSSF56235, SSF56235, 1 hit
    TIGRFAMsiTIGR00066, g_glut_trans, 1 hit
    PROSITEiView protein in PROSITE
    PS00462, G_GLU_TRANSPEPTIDASE, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGGT1_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P19440
    Secondary accession number(s): Q08247
    , Q14404, Q8TBS1, Q9UMK1
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: March 7, 2006
    Last modified: April 7, 2021
    This is version 222 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    3. Human entries with genetic variants
      List of human entries with genetic variants
    4. Human variants curated from literature reports
      Index of human variants curated from literature reports
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    7. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    8. SIMILARITY comments
      Index of protein domains and families
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