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Entry version 216 (22 Apr 2020)
Sequence version 2 (07 Mar 2006)
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Protein

Glutathione hydrolase 1 proenzyme

Gene

GGT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Isoform 3 seems to be inactive.6 Publications

Miscellaneous

Cys-454 was thought to bind the gamma-glutamyl moiety, but mutagenesis of this residue had no effect on activity.
Chloride ions bound in the active site cavity may contribute to stabilize the protein fold.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by autocatalytic cleavage.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glutathione metabolism

This protein is involved in the pathway glutathione metabolism, which is part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the pathway glutathione metabolism and in Sulfur metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei107Glutamate1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei381Nucleophile1 Publication1
Binding sitei399Glutamate1 Publication1
Binding sitei420Glutamate1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Hydrolase, Protease, Transferase
Biological processGlutathione biosynthesis
LigandSialic acid

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:MONOMER66-34394

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-174403 Glutathione synthesis and recycling
R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-HSA-5423646 Aflatoxin activation and detoxification
R-HSA-5579022 Defective GGT1 causes Glutathionuria (GLUTH)
R-HSA-9035968 Defective GGT1 causes Glutathionuria (GLUTH)

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P19440

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00204

Protein family/group databases

MEROPS protease database

More...
MEROPSi
T03.006

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001454

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutathione hydrolase 1 proenzyme (EC:3.4.19.131 Publication)
Alternative name(s):
Gamma-glutamyltransferase 1
Gamma-glutamyltranspeptidase 11 Publication (EC:2.3.2.25 Publications)
Short name:
GGT 1
Leukotriene-C4 hydrolase (EC:3.4.19.14By similarity)
CD_antigen: CD224
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GGT1
Synonyms:GGT
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4250 GGT1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612346 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P19440

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 4CytoplasmicSequence analysis4
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei5 – 26Helical; Signal-anchor for type II membrane proteinCuratedAdd BLAST22
Topological domaini27 – 569ExtracellularSequence analysisAdd BLAST543

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Glutathionuria (GLUTH)1 Publication
The disease is caused by mutations affecting the gene represented in this entry. A large homozygous deletion that removes several exons of all isoforms of GGT1 has been found in one family affected by glutathionuria.1 Publication
Disease descriptionA very rare, autosomal recessive metabolic disorder characterized by the presence of glutathione in the urine, due to generalized gamma-glutamyl transpeptidase deficiency. Most patients manifest mild to moderate mental retardation, and behavioral disturbance. Seizures, tremor, marfanoid features and strabismus are observed in some patients.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi100K → N: No effect on activity. 1 Publication1
Mutagenesisi102E → Q: No effect on activity. 1 Publication1
Mutagenesisi107R → K: Reduces enzyme activity by 99%. 1 Publication1
Mutagenesisi107R → Q or H: Abolishes enzyme activity. 1 Publication1
Mutagenesisi108E → Q: Reduces enzyme activity by 98%. 1 Publication1
Mutagenesisi112R → Q: No effect on activity. 1 Publication1
Mutagenesisi139R → Q: No effect on activity. 1 Publication1
Mutagenesisi147R → Q: No effect on activity. 1 Publication1
Mutagenesisi150R → Q: No effect on activity. 1 Publication1
Mutagenesisi192C → W: Loss of autocatalytic cleavage, cell membrane localization and decrease in catalytic activity; when associated with Y-193. 1 Publication1
Mutagenesisi193E → Y: Loss of autocatalytic cleavage, cell membrane localization and decrease in catalytic activity; when associated with W-192. 1 Publication1
Mutagenesisi383H → A: Reduces enzyme activity by 66%. 1 Publication1
Mutagenesisi385S → A: No effect on activity. 1 Publication1
Mutagenesisi413S → A: No effect on activity. 1 Publication1
Mutagenesisi422D → A: Reduces enzyme activity by 90%. 1 Publication1
Mutagenesisi423D → A: Abolishes enzyme activity. Increases KM by over 1000-fold. 1 Publication1
Mutagenesisi425S → A: No effect on activity. 1 Publication1
Mutagenesisi451S → A: Reduces enzyme activity by 99%. Abolishes activity; when associated with A-452. 1 Publication1
Mutagenesisi452S → A: Reduces enzyme activity by 99%. Abolishes activity; when associated with A-451. 1 Publication1
Mutagenesisi454C → A: No effect on activity. 1 Publication1
Mutagenesisi505H → A: Reduces enzyme activity by 90%. 1 Publication1
Mutagenesisi545Q → K: Reduces enzyme activity by 97%. 1 Publication1

Keywords - Diseasei

Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
2678

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
GGT1

MalaCards human disease database

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MalaCardsi
GGT1
MIMi231950 phenotype

Open Targets

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OpenTargetsi
ENSG00000100031

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
33573 Gamma-glutamyl transpeptidase deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA28662

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P19440 Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL5696

Drug and drug target database

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DrugBanki
DB00143 Glutathione

DrugCentral

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DrugCentrali
P19440

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
GGT1

Domain mapping of disease mutations (DMDM)

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DMDMi
93140064

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000110581 – 380Glutathione hydrolase 1 heavy chainAdd BLAST380
ChainiPRO_0000011059381 – 569Glutathione hydrolase 1 light chainAdd BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi50 ↔ 741 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi95N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi120N-linked (GlcNAc...) asparagine5 Publications1
Disulfide bondi192 ↔ 1961 Publication
Glycosylationi230N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi266N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi297N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi344N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi511N-linked (GlcNAc...) asparagine5 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated on both chains. Contains hexoses, hexosamines and sialic acid residues. Glycosylation profiles tested in kidney and liver tissues reveal the presence of tissue-specific and site-specific glycan composition, despite the overlap in composition among the N-glycans. A total of 36 glycan compositions, with 40 unique structures are observed. Up to 15 different glycans are observed at a single site, with site-specific variation in glycan composition. The difference in glycosylation profiles in the 2 tissues do not affect the enzyme activity.9 Publications
Cleaved by autocatalysis into a large and a small subunit and the autocatalytic cleavage is essential to the functional activation of the enzyme.

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

The CPTAC Assay portal

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CPTACi
CPTAC-2217

Encyclopedia of Proteome Dynamics

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EPDi
P19440

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P19440

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P19440

MaxQB - The MaxQuant DataBase

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MaxQBi
P19440

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P19440

PeptideAtlas

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PeptideAtlasi
P19440

PRoteomics IDEntifications database

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PRIDEi
P19440

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
53662 [P19440-1]
53663 [P19440-2]
53664 [P19440-3]

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1261

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P19440

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P19440

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in fetal and adult kidney and liver, adult pancreas, stomach, intestine, placenta and lung. Isoform 3 is lung-specific. There are several other tissue-specific forms that arise from alternative promoter usage but that produce the same protein.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000100031 Expressed in adult mammalian kidney and 88 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P19440 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P19440 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000100031 Tissue enhanced (kidney, seminal vesicle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer composed of the light and heavy chains. The active site is located in the light chain.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108946, 9 interactors

Protein interaction database and analysis system

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IntActi
P19440, 3 interactors

Molecular INTeraction database

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MINTi
P19440

STRING: functional protein association networks

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STRINGi
9606.ENSP00000383232

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P19440

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P19440 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1569
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P19440

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni451 – 452Glutamate binding2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the gamma-glutamyltransferase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2410 Eukaryota
COG0405 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154601

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_014813_1_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P19440

KEGG Orthology (KO)

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KOi
K18592

Identification of Orthologs from Complete Genome Data

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OMAi
KATKNMF

Database for complete collections of gene phylogenies

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PhylomeDBi
P19440

TreeFam database of animal gene trees

More...
TreeFami
TF313608

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000101 GGT_peptidase
IPR029055 Ntn_hydrolases_N

The PANTHER Classification System

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PANTHERi
PTHR11686 PTHR11686, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56235 SSF56235, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00066 g_glut_trans, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00462 G_GLU_TRANSPEPTIDASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 16 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P19440-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKKKLVVLGL LAVVLVLVIV GLCLWLPSAS KEPDNHVYTR AAVAADAKQC
60 70 80 90 100
SKIGRDALRD GGSAVDAAIA ALLCVGLMNA HSMGIGGGLF LTIYNSTTRK
110 120 130 140 150
AEVINAREVA PRLAFATMFN SSEQSQKGGL SVAVPGEIRG YELAHQRHGR
160 170 180 190 200
LPWARLFQPS IQLARQGFPV GKGLAAALEN KRTVIEQQPV LCEVFCRDRK
210 220 230 240 250
VLREGERLTL PQLADTYETL AIEGAQAFYN GSLTAQIVKD IQAAGGIVTA
260 270 280 290 300
EDLNNYRAEL IEHPLNISLG DVVLYMPSAP LSGPVLALIL NILKGYNFSR
310 320 330 340 350
ESVESPEQKG LTYHRIVEAF RFAYAKRTLL GDPKFVDVTE VVRNMTSEFF
360 370 380 390 400
AAQLRAQISD DTTHPISYYK PEFYTPDDGG TAHLSVVAED GSAVSATSTI
410 420 430 440 450
NLYFGSKVRS PVSGILFNNE MDDFSSPSIT NEFGVPPSPA NFIQPGKQPL
460 470 480 490 500
SSMCPTIMVG QDGQVRMVVG AAGGTQITTA TALAIIYNLW FGYDVKRAVE
510 520 530 540 550
EPRLHNQLLP NVTTVERNID QAVTAALETR HHHTQIASTF IAVVQAIVRT
560
AGGWAAASDS RKGGEPAGY
Note: Produced by alternative promoter usage.
Length:569
Mass (Da):61,410
Last modified:March 7, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i71AE12485239A69F
GO
Isoform 2 (identifier: P19440-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     341-366: VVRNMTSEFFAAQLRAQISDDTTHPI → ASSGVSAGGPQHDLRVLRCPAPGPDL
     367-569: Missing.

Note: Produced by alternative splicing of isoform 1.Curated
Show »
Length:366
Mass (Da):39,420
Checksum:i726B492DEFA85BE2
GO
Isoform 3 (identifier: P19440-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-344: Missing.

Note: Produced by alternative promoter usage.Curated
Show »
Length:225
Mass (Da):24,080
Checksum:i46765CED537C40C3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BT13H3BT13_HUMAN
Small nuclear ribonucleoprotein Sm ...
SNRPD3 GGT1
62Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ETN1E7ETN1_HUMAN
Glutathione hydrolase 1 proenzyme
GGT1
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JGF3C9JGF3_HUMAN
Glutathione hydrolase 1 proenzyme
GGT1
30Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ET76E7ET76_HUMAN
Glutathione hydrolase 1 proenzyme
GGT1
463Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MC36B5MC36_HUMAN
Glutathione hydrolase 1 proenzyme
GGT1
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ETR7E7ETR7_HUMAN
Glutathione hydrolase 1 proenzyme
GGT1
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MC34B5MC34_HUMAN
Glutathione hydrolase 1 proenzyme
GGT1
252Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ESL5E7ESL5_HUMAN
Glutathione hydrolase 1 proenzyme
GGT1
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ETJ6E7ETJ6_HUMAN
Glutathione hydrolase 1 proenzyme
GGT1
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PHP2E9PHP2_HUMAN
Glutathione hydrolase 1 proenzyme
GGT1
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA35899 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti30 – 31SK → KS AA sequence (PubMed:2896486).Curated2
Sequence conflicti47A → K AA sequence (PubMed:2896486).Curated1
Sequence conflicti139R → E in AAA35889 (PubMed:1968061).Curated1
Sequence conflicti356A → S in AAI28240 (PubMed:15489334).Curated1
Sequence conflicti361D → H in AAI28240 (PubMed:15489334).Curated1
Sequence conflicti372E → D in AAA02886 (PubMed:7689219).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02554551S → L. Corresponds to variant dbSNP:rs2330837Ensembl.1
Natural variantiVAR_01837352K → E. Corresponds to variant dbSNP:rs2330838Ensembl.1
Natural variantiVAR_018374177A → V. Corresponds to variant dbSNP:rs3895576Ensembl.1
Natural variantiVAR_018372272V → A6 PublicationsCorresponds to variant dbSNP:rs4049829Ensembl.1
Natural variantiVAR_025546419N → D. Corresponds to variant dbSNP:rs17004876Ensembl.1
Natural variantiVAR_049181435V → A. Corresponds to variant dbSNP:rs1062459Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0081321 – 344Missing in isoform 3. 2 PublicationsAdd BLAST344
Alternative sequenceiVSP_001746341 – 366VVRNM…TTHPI → ASSGVSAGGPQHDLRVLRCP APGPDL in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_001747367 – 569Missing in isoform 2. 1 PublicationAdd BLAST203

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J04131 mRNA Translation: AAA52547.1
M24087 mRNA Translation: AAA35899.1 Different initiation.
M24903 mRNA Translation: AAA52546.1
J05235 mRNA Translation: AAA35889.1
X60069 mRNA Translation: CAA42674.1
L20490 mRNA Translation: AAA02884.1
L20493 mRNA Translation: AAA02886.1
CR456494 mRNA Translation: CAG30380.1
AP000356 Genomic DNA No translation available.
BC025927 mRNA Translation: AAH25927.1
BC069473 mRNA Translation: AAH69473.1
BC069504 mRNA Translation: AAH69504.1
BC128238 mRNA Translation: AAI28239.1
BC128239 mRNA Translation: AAI28240.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42992.1 [P19440-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A31253 EKHUEX
A48987
A60439
JS0067
PS0312

NCBI Reference Sequences

More...
RefSeqi
NP_001275762.1, NM_001288833.1 [P19440-1]
NP_038265.2, NM_013421.2 [P19440-1]
NP_038347.2, NM_013430.2 [P19440-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000248923; ENSP00000248923; ENSG00000286070 [P19440-1]
ENST00000400380; ENSP00000383231; ENSG00000100031 [P19440-1]
ENST00000400382; ENSP00000383232; ENSG00000100031 [P19440-1]
ENST00000401885; ENSP00000384381; ENSG00000100031 [P19440-3]
ENST00000403838; ENSP00000384820; ENSG00000100031 [P19440-3]
ENST00000404532; ENSP00000385445; ENSG00000100031 [P19440-3]
ENST00000425895; ENSP00000387499; ENSG00000100031 [P19440-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2678

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2678

UCSC genome browser

More...
UCSCi
uc003aan.2 human [P19440-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Gamma-glutamyl transpeptidase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04131 mRNA Translation: AAA52547.1
M24087 mRNA Translation: AAA35899.1 Different initiation.
M24903 mRNA Translation: AAA52546.1
J05235 mRNA Translation: AAA35889.1
X60069 mRNA Translation: CAA42674.1
L20490 mRNA Translation: AAA02884.1
L20493 mRNA Translation: AAA02886.1
CR456494 mRNA Translation: CAG30380.1
AP000356 Genomic DNA No translation available.
BC025927 mRNA Translation: AAH25927.1
BC069473 mRNA Translation: AAH69473.1
BC069504 mRNA Translation: AAH69504.1
BC128238 mRNA Translation: AAI28239.1
BC128239 mRNA Translation: AAI28240.1
CCDSiCCDS42992.1 [P19440-1]
PIRiA31253 EKHUEX
A48987
A60439
JS0067
PS0312
RefSeqiNP_001275762.1, NM_001288833.1 [P19440-1]
NP_038265.2, NM_013421.2 [P19440-1]
NP_038347.2, NM_013430.2 [P19440-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4GDXX-ray1.67A2-374[»]
B375-569[»]
4GG2X-ray2.21A28-380[»]
B381-569[»]
4Z9OX-ray2.30A28-380[»]
B381-569[»]
4ZBKX-ray2.18A28-380[»]
B381-569[»]
4ZC6X-ray2.10A28-380[»]
B381-569[»]
4ZCGX-ray2.22A28-380[»]
B381-569[»]
5V4QX-ray2.20A28-380[»]
B381-569[»]
SMRiP19440
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi108946, 9 interactors
IntActiP19440, 3 interactors
MINTiP19440
STRINGi9606.ENSP00000383232

Chemistry databases

BindingDBiP19440
ChEMBLiCHEMBL5696
DrugBankiDB00143 Glutathione
DrugCentraliP19440
SwissLipidsiSLP:000001454

Protein family/group databases

MEROPSiT03.006

PTM databases

GlyConnecti1261
iPTMnetiP19440
PhosphoSitePlusiP19440

Polymorphism and mutation databases

BioMutaiGGT1
DMDMi93140064

Proteomic databases

CPTACiCPTAC-2217
EPDiP19440
jPOSTiP19440
MassIVEiP19440
MaxQBiP19440
PaxDbiP19440
PeptideAtlasiP19440
PRIDEiP19440
ProteomicsDBi53662 [P19440-1]
53663 [P19440-2]
53664 [P19440-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
24014 431 antibodies

The DNASU plasmid repository

More...
DNASUi
2678

Genome annotation databases

EnsembliENST00000248923; ENSP00000248923; ENSG00000286070 [P19440-1]
ENST00000400380; ENSP00000383231; ENSG00000100031 [P19440-1]
ENST00000400382; ENSP00000383232; ENSG00000100031 [P19440-1]
ENST00000401885; ENSP00000384381; ENSG00000100031 [P19440-3]
ENST00000403838; ENSP00000384820; ENSG00000100031 [P19440-3]
ENST00000404532; ENSP00000385445; ENSG00000100031 [P19440-3]
ENST00000425895; ENSP00000387499; ENSG00000100031 [P19440-2]
GeneIDi2678
KEGGihsa:2678
UCSCiuc003aan.2 human [P19440-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2678
DisGeNETi2678

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GGT1
GeneReviewsiGGT1
HGNCiHGNC:4250 GGT1
HPAiENSG00000100031 Tissue enhanced (kidney, seminal vesicle)
MalaCardsiGGT1
MIMi231950 phenotype
612346 gene
neXtProtiNX_P19440
OpenTargetsiENSG00000100031
Orphaneti33573 Gamma-glutamyl transpeptidase deficiency
PharmGKBiPA28662

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2410 Eukaryota
COG0405 LUCA
GeneTreeiENSGT00940000154601
HOGENOMiCLU_014813_1_3_1
InParanoidiP19440
KOiK18592
OMAiKATKNMF
PhylomeDBiP19440
TreeFamiTF313608

Enzyme and pathway databases

UniPathwayiUPA00204
BioCyciMetaCyc:MONOMER66-34394
ReactomeiR-HSA-174403 Glutathione synthesis and recycling
R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-HSA-5423646 Aflatoxin activation and detoxification
R-HSA-5579022 Defective GGT1 causes Glutathionuria (GLUTH)
R-HSA-9035968 Defective GGT1 causes Glutathionuria (GLUTH)
SABIO-RKiP19440

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GGT1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GGT1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2678
PharosiP19440 Tbio

Protein Ontology

More...
PROi
PR:P19440
RNActiP19440 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100031 Expressed in adult mammalian kidney and 88 other tissues
ExpressionAtlasiP19440 baseline and differential
GenevisibleiP19440 HS

Family and domain databases

InterProiView protein in InterPro
IPR000101 GGT_peptidase
IPR029055 Ntn_hydrolases_N
PANTHERiPTHR11686 PTHR11686, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR00066 g_glut_trans, 1 hit
PROSITEiView protein in PROSITE
PS00462 G_GLU_TRANSPEPTIDASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGGT1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P19440
Secondary accession number(s): Q08247
, Q14404, Q8TBS1, Q9UMK1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: March 7, 2006
Last modified: April 22, 2020
This is version 216 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  8. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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