UniProtKB - P19438 (TNR1A_HUMAN)
Tumor necrosis factor receptor superfamily member 1A
TNFRSF1A
Functioni
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
GO - Molecular functioni
- tumor necrosis factor-activated receptor activity Source: GO_Central
- tumor necrosis factor binding Source: ARUK-UCL
GO - Biological processi
- aortic valve development Source: BHF-UCL
- cellular response to mechanical stimulus Source: UniProtKB
- cytokine-mediated signaling pathway Source: UniProtKB
- defense response to bacterium Source: Ensembl
- extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
- inflammatory response Source: UniProtKB
- intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
- negative regulation of cardiac muscle hypertrophy Source: Ensembl
- negative regulation of extracellular matrix constituent secretion Source: BHF-UCL
- negative regulation of inflammatory response Source: BHF-UCL
- positive regulation of apoptotic process involved in morphogenesis Source: BHF-UCL
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- positive regulation of inflammatory response Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
- prostaglandin metabolic process Source: InterPro
- protein localization to plasma membrane Source: UniProtKB
- pulmonary valve development Source: BHF-UCL
- regulation of establishment of endothelial barrier Source: UniProtKB
- regulation of tumor necrosis factor-mediated signaling pathway Source: Ensembl
- tumor necrosis factor-mediated signaling pathway Source: UniProtKB
Keywordsi
Molecular function | Receptor |
Biological process | Apoptosis, Host-virus interaction |
Enzyme and pathway databases
PathwayCommonsi | P19438 |
Reactomei | R-HSA-5357786, TNFR1-induced proapoptotic signaling R-HSA-5357905, Regulation of TNFR1 signaling R-HSA-5357956, TNFR1-induced NFkappaB signaling pathway R-HSA-5626978, TNFR1-mediated ceramide production R-HSA-5669034, TNFs bind their physiological receptors R-HSA-6783783, Interleukin-10 signaling R-HSA-75893, TNF signaling |
SignaLinki | P19438 |
SIGNORi | P19438 |
Names & Taxonomyi
Protein namesi | Recommended name: Tumor necrosis factor receptor superfamily member 1AAlternative name(s): Tumor necrosis factor receptor 1 Short name: TNF-R1 Tumor necrosis factor receptor type I Short name: TNF-RI Short name: TNFR-I p55 p60 CD_antigen: CD120a Cleaved into the following 2 chains: |
Gene namesi | Name:TNFRSF1A Synonyms:TNFAR, TNFR1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11916, TNFRSF1A |
MIMi | 191190, gene |
neXtProti | NX_P19438 |
VEuPathDBi | HostDB:ENSG00000067182 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Golgi apparatus
- Golgi apparatus membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Note: A secreted form is produced through proteolytic processing.
Extracellular region or secreted
Note: Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted.
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: BHF-UCL
Golgi apparatus
- Golgi membrane Source: UniProtKB
Mitochondrion
- mitochondrion Source: GO_Central
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
Other locations
- cell surface Source: Ensembl
- membrane Source: ARUK-UCL
- membrane raft Source: BHF-UCL
- receptor complex Source: MGI
- tumor necrosis factor receptor superfamily complex Source: ARUK-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 30 – 211 | ExtracellularSequence analysisAdd BLAST | 182 | |
Transmembranei | 212 – 232 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 233 – 455 | CytoplasmicSequence analysisAdd BLAST | 223 |
Keywords - Cellular componenti
Cell membrane, Golgi apparatus, Membrane, SecretedPathology & Biotechi
Involvement in diseasei
Periodic fever, familial, autosomal dominant (FPF)5 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019329 | 51 | H → Q in FPF. 1 PublicationCorresponds to variant dbSNP:rs104895254EnsemblClinVar. | 1 | |
Natural variantiVAR_013410 | 59 | C → R in FPF. 1 PublicationCorresponds to variant dbSNP:rs104895217EnsemblClinVar. | 1 | |
Natural variantiVAR_019302 | 59 | C → S in FPF. 2 PublicationsCorresponds to variant dbSNP:rs104895223EnsemblClinVar. | 1 | |
Natural variantiVAR_019303 | 62 | C → G in FPF. 1 PublicationCorresponds to variant dbSNP:rs104895225EnsemblClinVar. | 1 | |
Natural variantiVAR_013411 | 62 | C → Y in FPF. 1 PublicationCorresponds to variant dbSNP:rs104895218EnsemblClinVar. | 1 | |
Natural variantiVAR_019330 | 75 | P → L in FPF; benign variant. 2 PublicationsCorresponds to variant dbSNP:rs4149637EnsemblClinVar. | 1 | |
Natural variantiVAR_013412 | 79 | T → M in FPF. 1 PublicationCorresponds to variant dbSNP:rs104895219EnsemblClinVar. | 1 | |
Natural variantiVAR_013413 | 81 | C → F in FPF. 1 PublicationCorresponds to variant dbSNP:rs104895220EnsemblClinVar. | 1 | |
Natural variantiVAR_019304 | 99 | C → S in FPF. 2 PublicationsCorresponds to variant dbSNP:rs104895228EnsemblClinVar. | 1 | |
Natural variantiVAR_019331 | 115 | S → G in FPF. 1 Publication | 1 | |
Natural variantiVAR_013414 | 117 | C → R in FPF. 1 PublicationCorresponds to variant dbSNP:rs104895221EnsemblClinVar. | 1 | |
Natural variantiVAR_013415 | 117 | C → Y in FPF. 1 PublicationCorresponds to variant dbSNP:rs104895222EnsemblClinVar. | 1 | |
Natural variantiVAR_019305 | 121 | R → P in FPF. 1 PublicationCorresponds to variant dbSNP:rs4149584EnsemblClinVar. | 1 | |
Natural variantiVAR_019332 | 121 | R → Q in FPF; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs4149584EnsemblClinVar. | 1 |
Multiple sclerosis 5 (MS5)1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 376 | R → A: Abolished GlcNAcylation by E.coli NleB1. 1 Publication | 1 |
Keywords - Diseasei
Amyloidosis, Disease variantOrganism-specific databases
DisGeNETi | 7132 |
MalaCardsi | TNFRSF1A |
MIMi | 142680, phenotype 614810, phenotype |
OpenTargetsi | ENSG00000067182 |
Orphaneti | 329967, Intermittent hydrarthrosis 802, NON RARE IN EUROPE: Multiple sclerosis 32960, Tumor necrosis factor receptor 1 associated periodic syndrome |
PharmGKBi | PA36609 |
Miscellaneous databases
Pharosi | P19438, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3378 |
DrugBanki | DB03507, 6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2',3':4,5]Pyrrolo[1,2-C]Imidazol-7-One DB11626, Tasonermin |
Genetic variation databases
BioMutai | TNFRSF1A |
DMDMi | 135959 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | 1 PublicationAdd BLAST | 29 | |
ChainiPRO_0000034543 | 30 – 455 | Tumor necrosis factor receptor superfamily member 1A, membrane formAdd BLAST | 426 | |
ChainiPRO_0000034544 | 41 – 201 | Tumor necrosis factor-binding protein 1Add BLAST | 161 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 44 ↔ 58 | |||
Glycosylationi | 54 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 59 ↔ 72 | |||
Disulfide bondi | 62 ↔ 81 | |||
Disulfide bondi | 84 ↔ 99 | |||
Disulfide bondi | 102 ↔ 117 | |||
Disulfide bondi | 105 ↔ 125 | |||
Disulfide bondi | 127 ↔ 143 | |||
Glycosylationi | 145 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 146 ↔ 158 | |||
Disulfide bondi | 149 ↔ 166 | |||
Glycosylationi | 151 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 168 ↔ 179 | |||
Disulfide bondi | 182 ↔ 195 | |||
Disulfide bondi | 185 ↔ 191 | |||
Glycosylationi | 376 | (Microbial infection) N-beta-linked (GlcNAc) arginine1 Publication1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinProteomic databases
EPDi | P19438 |
jPOSTi | P19438 |
MassIVEi | P19438 |
MaxQBi | P19438 |
PaxDbi | P19438 |
PeptideAtlasi | P19438 |
PRIDEi | P19438 |
ProteomicsDBi | 53659 [P19438-1] 53660 [P19438-2] 53661 [P19438-3] 5939 |
PTM databases
GlyGeni | P19438, 3 sites |
iPTMneti | P19438 |
PhosphoSitePlusi | P19438 |
SwissPalmi | P19438 |
Expressioni
Gene expression databases
Bgeei | ENSG00000067182, Expressed in tendon of biceps brachii and 238 other tissues |
ExpressionAtlasi | P19438, baseline and differential |
Genevisiblei | P19438, HS |
Organism-specific databases
HPAi | ENSG00000067182, Low tissue specificity |
Interactioni
Subunit structurei
Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling.
Interacts with BAG4, BABAM2, FEM1B, GRB2, SQSTM1 and TRPC4AP (PubMed:10356400, PubMed:10359574, PubMed:10542291, PubMed:15465831, PubMed:8387891, PubMed:9915703).
Interacts directly with NOL3 (via CARD domain); inhibits TNF-signaling pathway (By similarity).
Interacts with SH3RF2, TRADD and RIPK1. SH3RF2 facilitates the recruitment of RIPK1 and TRADD to TNFRSF1A in a TNF-alpha-dependent process (PubMed:24130170).
Interacts with PGLYRP1; this interaction is important for cell death induction (PubMed:26183779).
Interacts (via death domain) with MADD (via death domain) (PubMed:9115275).
By similarity9 Publications(Microbial infection) Interacts with mumps virus protein SH; this interaction inhibits downstream NF-kappa-B pathway activation.
1 Publication(Microbial infection) Interacts with HCV core protein.
1 Publication(Microbial infection) Interacts with human cytomegalovirus/HHV-5 protein UL138.
1 Publication(Microbial infection) Interacts with host TNFRSF1A; this interaction leads to the stimulation of both surface expression and shedding of TNFRSF1A.
2 PublicationsBinary interactionsi
P19438
With | #Exp. | IntAct |
---|---|---|
GRN [P28799] | 4 | EBI-299451,EBI-747754 |
RFK [Q969G6] | 4 | EBI-299451,EBI-716872 |
RIPK1 [Q13546] | 6 | EBI-299451,EBI-358507 |
TNF [P01375] | 15 | EBI-299451,EBI-359977 |
TRADD [Q15628] | 13 | EBI-299451,EBI-359215 |
Isoform 1 [P19438-1]
With | #Exp. | IntAct |
---|---|---|
RFK [Q969G6] | 2 | EBI-15795644,EBI-716872 |
GO - Molecular functioni
- tumor necrosis factor binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 112986, 201 interactors |
CORUMi | P19438 |
DIPi | DIP-407N |
IntActi | P19438, 98 interactors |
MINTi | P19438 |
STRINGi | 9606.ENSP00000162749 |
Chemistry databases
BindingDBi | P19438 |
Miscellaneous databases
RNActi | P19438, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P19438 |
BMRBi | P19438 |
SMRi | P19438 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P19438 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 43 – 82 | TNFR-Cys 1Add BLAST | 40 | |
Repeati | 83 – 125 | TNFR-Cys 2Add BLAST | 43 | |
Repeati | 126 – 166 | TNFR-Cys 3Add BLAST | 41 | |
Repeati | 167 – 196 | TNFR-Cys 4Add BLAST | 30 | |
Domaini | 356 – 441 | DeathPROSITE-ProRule annotationAdd BLAST | 86 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 254 – 273 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 338 – 348 | N-SMase activation domain (NSD)Add BLAST | 11 |
Domaini
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S050, Eukaryota |
GeneTreei | ENSGT00940000159540 |
HOGENOMi | CLU_050864_0_0_1 |
InParanoidi | P19438 |
OMAi | ICRCKPQ |
OrthoDBi | 976094at2759 |
PhylomeDBi | P19438 |
TreeFami | TF333916 |
Family and domain databases
CDDi | cd08313, Death_TNFR1, 1 hit cd10576, TNFRSF1A, 1 hit |
Gene3Di | 1.10.533.10, 1 hit |
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR001368, TNFR/NGFR_Cys_rich_reg IPR020419, TNFR_1A IPR033994, TNFRSF1A_death IPR033993, TNFRSF1A_N |
Pfami | View protein in Pfam PF00531, Death, 1 hit PF00020, TNFR_c6, 3 hits |
PRINTSi | PR01918, TNFACTORR1A |
SMARTi | View protein in SMART SM00005, DEATH, 1 hit SM00208, TNFR, 4 hits |
SUPFAMi | SSF47986, SSF47986, 1 hit |
PROSITEi | View protein in PROSITE PS50017, DEATH_DOMAIN, 1 hit PS00652, TNFR_NGFR_1, 3 hits PS50050, TNFR_NGFR_2, 3 hits |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGLSTVPDLL LPLVLLELLV GIYPSGVIGL VPHLGDREKR DSVCPQGKYI
60 70 80 90 100
HPQNNSICCT KCHKGTYLYN DCPGPGQDTD CRECESGSFT ASENHLRHCL
110 120 130 140 150
SCSKCRKEMG QVEISSCTVD RDTVCGCRKN QYRHYWSENL FQCFNCSLCL
160 170 180 190 200
NGTVHLSCQE KQNTVCTCHA GFFLRENECV SCSNCKKSLE CTKLCLPQIE
210 220 230 240 250
NVKGTEDSGT TVLLPLVIFF GLCLLSLLFI GLMYRYQRWK SKLYSIVCGK
260 270 280 290 300
STPEKEGELE GTTTKPLAPN PSFSPTPGFT PTLGFSPVPS STFTSSSTYT
310 320 330 340 350
PGDCPNFAAP RREVAPPYQG ADPILATALA SDPIPNPLQK WEDSAHKPQS
360 370 380 390 400
LDTDDPATLY AVVENVPPLR WKEFVRRLGL SDHEIDRLEL QNGRCLREAQ
410 420 430 440 450
YSMLATWRRR TPRREATLEL LGRVLRDMDL LGCLEDIEEA LCGPAALPPA
PSLLR
The sequence of this isoform differs from the canonical sequence as follows:
184-455: NCKKSLECTK...ALPPAPSLLR → KHHSAVAPGH...LLHCLWEIDT
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H8A6 | F5H8A6_HUMAN | Tumor necrosis factor receptor supe... | TNFRSF1A | 298 | Annotation score: | ||
F5H061 | F5H061_HUMAN | Tumor necrosis factor receptor supe... | TNFRSF1A | 412 | Annotation score: | ||
F5H6V7 | F5H6V7_HUMAN | Tumor necrosis factor receptor supe... | TNFRSF1A | 254 | Annotation score: | ||
F5H6Z2 | F5H6Z2_HUMAN | Tumor necrosis factor receptor supe... | TNFRSF1A | 118 | Annotation score: | ||
F5H4T5 | F5H4T5_HUMAN | Tumor necrosis factor receptor supe... | TNFRSF1A | 71 | Annotation score: | ||
F5H7N1 | F5H7N1_HUMAN | Tumor necrosis factor receptor supe... | TNFRSF1A | 72 | Annotation score: | ||
F5GWJ4 | F5GWJ4_HUMAN | Tumor necrosis factor receptor supe... | TNFRSF1A | 122 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 13 | L → LILPQ in BAG51763 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 255 | K → E in BAG37891 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 286 | S → G in BAG51763 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 394 | R → L in BAF83777 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 412 | Missing in AAA36756 (PubMed:2170974).Curated | 1 | |
Sequence conflicti | 443 – 446 | GPAA → APP in AAA36756 (PubMed:2170974).Curated | 4 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019329 | 51 | H → Q in FPF. 1 PublicationCorresponds to variant dbSNP:rs104895254EnsemblClinVar. | 1 | |
Natural variantiVAR_013410 | 59 | C → R in FPF. 1 PublicationCorresponds to variant dbSNP:rs104895217EnsemblClinVar. | 1 | |
Natural variantiVAR_019302 | 59 | C → S in FPF. 2 PublicationsCorresponds to variant dbSNP:rs104895223EnsemblClinVar. | 1 | |
Natural variantiVAR_019303 | 62 | C → G in FPF. 1 PublicationCorresponds to variant dbSNP:rs104895225EnsemblClinVar. | 1 | |
Natural variantiVAR_013411 | 62 | C → Y in FPF. 1 PublicationCorresponds to variant dbSNP:rs104895218EnsemblClinVar. | 1 | |
Natural variantiVAR_019330 | 75 | P → L in FPF; benign variant. 2 PublicationsCorresponds to variant dbSNP:rs4149637EnsemblClinVar. | 1 | |
Natural variantiVAR_013412 | 79 | T → M in FPF. 1 PublicationCorresponds to variant dbSNP:rs104895219EnsemblClinVar. | 1 | |
Natural variantiVAR_013413 | 81 | C → F in FPF. 1 PublicationCorresponds to variant dbSNP:rs104895220EnsemblClinVar. | 1 | |
Natural variantiVAR_019304 | 99 | C → S in FPF. 2 PublicationsCorresponds to variant dbSNP:rs104895228EnsemblClinVar. | 1 | |
Natural variantiVAR_019331 | 115 | S → G in FPF. 1 Publication | 1 | |
Natural variantiVAR_013414 | 117 | C → R in FPF. 1 PublicationCorresponds to variant dbSNP:rs104895221EnsemblClinVar. | 1 | |
Natural variantiVAR_013415 | 117 | C → Y in FPF. 1 PublicationCorresponds to variant dbSNP:rs104895222EnsemblClinVar. | 1 | |
Natural variantiVAR_019305 | 121 | R → P in FPF. 1 PublicationCorresponds to variant dbSNP:rs4149584EnsemblClinVar. | 1 | |
Natural variantiVAR_019332 | 121 | R → Q in FPF; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs4149584EnsemblClinVar. | 1 | |
Natural variantiVAR_011813 | 305 | P → T. Corresponds to variant dbSNP:rs1804532Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037154 | 1 – 232 | Missing in isoform 3. 1 PublicationAdd BLAST | 232 | |
Alternative sequenceiVSP_037153 | 1 – 108 | Missing in isoform 2. 1 PublicationAdd BLAST | 108 | |
Alternative sequenceiVSP_044949 | 184 – 455 | NCKKS…PSLLR → KHHSAVAPGHFLWSLPFIPP LHWFNVSLPTVEVQALLHCL WEIDT in isoform 4. CuratedAdd BLAST | 272 | |
Alternative sequenceiVSP_047613 | 184 – 218 | NCKKS…LPLVI → KVLLCRPGWNAVARSRLTAT SASQIQAILLLQPPK in isoform 5. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_047614 | 219 – 455 | Missing in isoform 5. 1 PublicationAdd BLAST | 237 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M58286 mRNA Translation: AAA36753.1 M33294 mRNA Translation: AAA03210.1 M63121 mRNA Translation: AAA36754.1 X55313 mRNA Translation: CAA39021.1 M60275 mRNA Translation: AAA36756.1 M75866, M75864, M75865 Genomic DNA Translation: AAA61201.1 AY131997 Genomic DNA Translation: AAM77802.1 AK056611 mRNA Translation: BAG51763.1 AK291088 mRNA Translation: BAF83777.1 AK298729 mRNA Translation: BAG60879.1 AK304517 mRNA Translation: BAG65321.1 AK315509 mRNA Translation: BAG37891.1 EU927389 mRNA Translation: ACH57451.1 AC006057 Genomic DNA No translation available. CH471116 Genomic DNA Translation: EAW88805.1 CH471116 Genomic DNA Translation: EAW88806.1 BC010140 mRNA Translation: AAH10140.1 |
CCDSi | CCDS8542.1 [P19438-1] |
PIRi | A38208, GQHUT1 |
RefSeqi | NP_001056.1, NM_001065.3 [P19438-1] NP_001333020.1, NM_001346091.1 [P19438-2] NP_001333021.1, NM_001346092.1 |
Genome annotation databases
Ensembli | ENST00000162749.7; ENSP00000162749.2; ENSG00000067182.8 ENST00000366159.8; ENSP00000380389.3; ENSG00000067182.8 [P19438-5] |
GeneIDi | 7132 |
KEGGi | hsa:7132 |
MANE-Selecti | ENST00000162749.7; ENSP00000162749.2; NM_001065.4; NP_001056.1 |
UCSCi | uc001qnu.4, human [P19438-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
INFEVERS Repertory of FMF and hereditary autoinflammatory disorders mutations |
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M58286 mRNA Translation: AAA36753.1 M33294 mRNA Translation: AAA03210.1 M63121 mRNA Translation: AAA36754.1 X55313 mRNA Translation: CAA39021.1 M60275 mRNA Translation: AAA36756.1 M75866, M75864, M75865 Genomic DNA Translation: AAA61201.1 AY131997 Genomic DNA Translation: AAM77802.1 AK056611 mRNA Translation: BAG51763.1 AK291088 mRNA Translation: BAF83777.1 AK298729 mRNA Translation: BAG60879.1 AK304517 mRNA Translation: BAG65321.1 AK315509 mRNA Translation: BAG37891.1 EU927389 mRNA Translation: ACH57451.1 AC006057 Genomic DNA No translation available. CH471116 Genomic DNA Translation: EAW88805.1 CH471116 Genomic DNA Translation: EAW88806.1 BC010140 mRNA Translation: AAH10140.1 |
CCDSi | CCDS8542.1 [P19438-1] |
PIRi | A38208, GQHUT1 |
RefSeqi | NP_001056.1, NM_001065.3 [P19438-1] NP_001333020.1, NM_001346091.1 [P19438-2] NP_001333021.1, NM_001346092.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1EXT | X-ray | 1.85 | A/B | 41-201 | [»] | |
1FT4 | X-ray | 2.90 | A/B | 41-201 | [»] | |
1ICH | NMR | - | A | 345-455 | [»] | |
1NCF | X-ray | 2.25 | A/B | 41-201 | [»] | |
1TNR | X-ray | 2.85 | R | 44-182 | [»] | |
7K7A | NMR | - | A/B/C | 209-238 | [»] | |
7KP7 | X-ray | 2.65 | D/E/F | 42-184 | [»] | |
7KP8 | X-ray | 3.15 | E/F | 43-184 | [»] | |
7KPB | X-ray | 3.00 | E/F | 42-184 | [»] | |
AlphaFoldDBi | P19438 | |||||
BMRBi | P19438 | |||||
SMRi | P19438 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112986, 201 interactors |
CORUMi | P19438 |
DIPi | DIP-407N |
IntActi | P19438, 98 interactors |
MINTi | P19438 |
STRINGi | 9606.ENSP00000162749 |
Chemistry databases
BindingDBi | P19438 |
ChEMBLi | CHEMBL3378 |
DrugBanki | DB03507, 6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2',3':4,5]Pyrrolo[1,2-C]Imidazol-7-One DB11626, Tasonermin |
PTM databases
GlyGeni | P19438, 3 sites |
iPTMneti | P19438 |
PhosphoSitePlusi | P19438 |
SwissPalmi | P19438 |
Genetic variation databases
BioMutai | TNFRSF1A |
DMDMi | 135959 |
Proteomic databases
EPDi | P19438 |
jPOSTi | P19438 |
MassIVEi | P19438 |
MaxQBi | P19438 |
PaxDbi | P19438 |
PeptideAtlasi | P19438 |
PRIDEi | P19438 |
ProteomicsDBi | 53659 [P19438-1] 53660 [P19438-2] 53661 [P19438-3] 5939 |
Protocols and materials databases
ABCDi | P19438, 8 sequenced antibodies |
Antibodypediai | 1320, 1506 antibodies from 51 providers |
DNASUi | 7132 |
Genome annotation databases
Ensembli | ENST00000162749.7; ENSP00000162749.2; ENSG00000067182.8 ENST00000366159.8; ENSP00000380389.3; ENSG00000067182.8 [P19438-5] |
GeneIDi | 7132 |
KEGGi | hsa:7132 |
MANE-Selecti | ENST00000162749.7; ENSP00000162749.2; NM_001065.4; NP_001056.1 |
UCSCi | uc001qnu.4, human [P19438-1] |
Organism-specific databases
CTDi | 7132 |
DisGeNETi | 7132 |
GeneCardsi | TNFRSF1A |
HGNCi | HGNC:11916, TNFRSF1A |
HPAi | ENSG00000067182, Low tissue specificity |
MalaCardsi | TNFRSF1A |
MIMi | 142680, phenotype 191190, gene 614810, phenotype |
neXtProti | NX_P19438 |
OpenTargetsi | ENSG00000067182 |
Orphaneti | 329967, Intermittent hydrarthrosis 802, NON RARE IN EUROPE: Multiple sclerosis 32960, Tumor necrosis factor receptor 1 associated periodic syndrome |
PharmGKBi | PA36609 |
VEuPathDBi | HostDB:ENSG00000067182 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S050, Eukaryota |
GeneTreei | ENSGT00940000159540 |
HOGENOMi | CLU_050864_0_0_1 |
InParanoidi | P19438 |
OMAi | ICRCKPQ |
OrthoDBi | 976094at2759 |
PhylomeDBi | P19438 |
TreeFami | TF333916 |
Enzyme and pathway databases
PathwayCommonsi | P19438 |
Reactomei | R-HSA-5357786, TNFR1-induced proapoptotic signaling R-HSA-5357905, Regulation of TNFR1 signaling R-HSA-5357956, TNFR1-induced NFkappaB signaling pathway R-HSA-5626978, TNFR1-mediated ceramide production R-HSA-5669034, TNFs bind their physiological receptors R-HSA-6783783, Interleukin-10 signaling R-HSA-75893, TNF signaling |
SignaLinki | P19438 |
SIGNORi | P19438 |
Miscellaneous databases
BioGRID-ORCSi | 7132, 16 hits in 1084 CRISPR screens |
ChiTaRSi | TNFRSF1A, human |
EvolutionaryTracei | P19438 |
GeneWikii | TNFRSF1A |
GenomeRNAii | 7132 |
Pharosi | P19438, Tchem |
PROi | PR:P19438 |
RNActi | P19438, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000067182, Expressed in tendon of biceps brachii and 238 other tissues |
ExpressionAtlasi | P19438, baseline and differential |
Genevisiblei | P19438, HS |
Family and domain databases
CDDi | cd08313, Death_TNFR1, 1 hit cd10576, TNFRSF1A, 1 hit |
Gene3Di | 1.10.533.10, 1 hit |
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR001368, TNFR/NGFR_Cys_rich_reg IPR020419, TNFR_1A IPR033994, TNFRSF1A_death IPR033993, TNFRSF1A_N |
Pfami | View protein in Pfam PF00531, Death, 1 hit PF00020, TNFR_c6, 3 hits |
PRINTSi | PR01918, TNFACTORR1A |
SMARTi | View protein in SMART SM00005, DEATH, 1 hit SM00208, TNFR, 4 hits |
SUPFAMi | SSF47986, SSF47986, 1 hit |
PROSITEi | View protein in PROSITE PS50017, DEATH_DOMAIN, 1 hit PS00652, TNFR_NGFR_1, 3 hits PS50050, TNFR_NGFR_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | TNR1A_HUMAN | |
Accessioni | P19438Primary (citable) accession number: P19438 Secondary accession number(s): A8K4X3 Q9UCA4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | February 1, 1991 | |
Last modified: | May 25, 2022 | |
This is version 253 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references