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Protein

Troponin I, cardiac muscle

Gene

TNNI3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei80Involved in TNI-TNT interactions1
Sitei97Involved in TNI-TNT interactions1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi137 – 148By similarityAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Muscle protein
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-390522 Striated Muscle Contraction
R-HSA-5578775 Ion homeostasis

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P19429

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Troponin I, cardiac muscle
Alternative name(s):
Cardiac troponin I
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNNI3
Synonyms:TNNC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000129991.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11947 TNNI3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
191044 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P19429

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cardiomyopathy, familial hypertrophic 7 (CMH7)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
See also OMIM:613690
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019872141R → Q in CMH7. 1 PublicationCorresponds to variant dbSNP:rs397516347EnsemblClinVar.1
Natural variantiVAR_007603145R → G in CMH7. 1 PublicationCorresponds to variant dbSNP:rs104894724EnsemblClinVar.1
Natural variantiVAR_019873157A → V in CMH7. 1 PublicationCorresponds to variant dbSNP:rs397516353EnsemblClinVar.1
Natural variantiVAR_019874162R → P in CMH7. 2 PublicationsCorresponds to variant dbSNP:rs397516354EnsemblClinVar.1
Natural variantiVAR_042745162R → Q in CMH7. 1 PublicationCorresponds to variant dbSNP:rs397516354EnsemblClinVar.1
Natural variantiVAR_029454166S → F in CMH7. 1 PublicationCorresponds to variant dbSNP:rs727504242EnsemblClinVar.1
Natural variantiVAR_019875177Missing in CMH7. 1 Publication1
Natural variantiVAR_019876186R → Q in CMH7. 1 PublicationCorresponds to variant dbSNP:rs397516357EnsemblClinVar.1
Natural variantiVAR_016085196D → N in CMH7. 2 PublicationsCorresponds to variant dbSNP:rs104894727EnsemblClinVar.1
Natural variantiVAR_042746204R → H in CMH7. 1 PublicationCorresponds to variant dbSNP:rs727504275EnsemblClinVar.1
Natural variantiVAR_007604206K → Q in CMH7. 1 PublicationCorresponds to variant dbSNP:rs104894725EnsemblClinVar.1
Cardiomyopathy, familial restrictive 1 (RCM1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA heart disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function.
See also OMIM:115210
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016079144L → Q in RCM1. 1 PublicationCorresponds to variant dbSNP:rs121917760EnsemblClinVar.1
Natural variantiVAR_016080145R → W in RCM1. 1 PublicationCorresponds to variant dbSNP:rs104894724EnsemblClinVar.1
Natural variantiVAR_016081171A → T in RCM1. 1 PublicationCorresponds to variant dbSNP:rs121917761EnsemblClinVar.1
Natural variantiVAR_016082178K → E in RCM1. 1 PublicationCorresponds to variant dbSNP:rs104894730EnsemblClinVar.1
Natural variantiVAR_016084192R → H in RCM1. 1 PublicationCorresponds to variant dbSNP:rs104894729EnsemblClinVar.1
Cardiomyopathy, dilated 2A (CMD2A)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
See also OMIM:611880
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0439892A → V in CMD2A. 1 PublicationCorresponds to variant dbSNP:rs397516359EnsemblClinVar.1
Cardiomyopathy, dilated 1FF (CMD1FF)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
See also OMIM:613286
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06354836K → Q in CMD1FF. 1 PublicationCorresponds to variant dbSNP:rs267607130EnsemblClinVar.1
Natural variantiVAR_067264116A → G in CMD1FF. 1 PublicationCorresponds to variant dbSNP:rs777177571EnsemblClinVar.1
Natural variantiVAR_063549185N → K in CMD1FF. 1 PublicationCorresponds to variant dbSNP:rs267607129EnsemblClinVar.1

Keywords - Diseasei

Cardiomyopathy, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
7137

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
TNNI3

MalaCards human disease database

More...
MalaCardsi
TNNI3
MIMi115210 phenotype
611880 phenotype
613286 phenotype
613690 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000129991

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
154 Familial isolated dilated cardiomyopathy
75249 Familial isolated restrictive cardiomyopathy
155 NON RARE IN EUROPE: Familial isolated hypertrophic cardiomyopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36636

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2095202

Drug and drug target database

More...
DrugBanki
DB04513 N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TNNI3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
136213

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001861512 – 210Troponin I, cardiac muscleAdd BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanine1 Publication1
Modified residuei5Phosphoserine1 Publication1
Modified residuei6Phosphoserine1 Publication1
Modified residuei23Phosphoserine; by PKA and PKD/PRKD14 Publications1
Modified residuei24Phosphoserine; by PKA and PKD/PRKD14 Publications1
Modified residuei26Phosphotyrosine1 Publication1
Modified residuei31Phosphothreonine; by STK4/MST11 Publication1
Modified residuei42Phosphoserine; by PKC/PRKCEBy similarity1
Modified residuei44Phosphoserine; by PKC/PRKCEBy similarity1
Modified residuei51Phosphothreonine; by STK4/MST12 Publications1
Modified residuei77Phosphoserine1 Publication1
Modified residuei78Phosphothreonine1 Publication1
Modified residuei129Phosphothreonine; by STK4/MST11 Publication1
Modified residuei143Phosphothreonine; by STK4/MST12 Publications1
Modified residuei150Phosphoserine; by PAK31 Publication1
Modified residuei166Phosphoserine1 Publication1
Modified residuei181Phosphothreonine1 Publication1
Modified residuei199Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at Ser-42 and Ser-44 by PRKCE; phosphorylation increases myocardium contractile dysfunction (By similarity). Phosphorylated at Ser-23 and Ser-24 by PRKD1; phosphorylation reduces myofilament calcium sensitivity. Phosphorylated preferentially at Thr-31. Phosphorylation by STK4/MST1 alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T).By similarity6 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P19429

PeptideAtlas

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PeptideAtlasi
P19429

PRoteomics IDEntifications database

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PRIDEi
P19429

ProteomicsDB human proteome resource

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ProteomicsDBi
53658

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P19429

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P19429

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000129991 Expressed in 113 organ(s), highest expression level in apex of heart

CleanEx database of gene expression profiles

More...
CleanExi
HS_TNNC1
HS_TNNI3

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P19429 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P19429 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB009349
HPA046428

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112991, 16 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-3280 Cardiac Troponin complex

Database of interacting proteins

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DIPi
DIP-34065N

Protein interaction database and analysis system

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IntActi
P19429, 19 interactors

Molecular INTeraction database

More...
MINTi
P19429

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000341838

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1210
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Database of protein disorder

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DisProti
DP00166

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P19429

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P19429

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P19429

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni32 – 79Involved in binding TNCAdd BLAST48
Regioni129 – 149Involved in binding TNC and actinAdd BLAST21

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the troponin I family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3977 Eukaryota
ENOG410Y9IX LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158518

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293300

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052737

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P19429

KEGG Orthology (KO)

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KOi
K12044

Identification of Orthologs from Complete Genome Data

More...
OMAi
HTRVDKV

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0NOD

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P19429

TreeFam database of animal gene trees

More...
TreeFami
TF313374

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.5.350, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001978 Troponin
IPR021666 Troponin-I_N
IPR038077 Troponin_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00992 Troponin, 1 hit
PF11636 Troponin-I_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P19429-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADGSSDAAR EPRPAPAPIR RRSSNYRAYA TEPHAKKKSK ISASRKLQLK
60 70 80 90 100
TLLLQIAKQE LEREAEERRG EKGRALSTRC QPLELAGLGF AELQDLCRQL
110 120 130 140 150
HARVDKVDEE RYDIEAKVTK NITEIADLTQ KIFDLRGKFK RPTLRRVRIS
160 170 180 190 200
ADAMMQALLG ARAKESLDLR AHLKQVKKED TEKENREVGD WRKNIDALSG
210
MEGRKKKFES
Length:210
Mass (Da):24,008
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i20A804F8C24AE1B0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EN02K7EN02_HUMAN
Troponin I, cardiac muscle
TNNI3
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJP0K7EJP0_HUMAN
Troponin I, cardiac muscle
TNNI3
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0439892A → V in CMD2A. 1 PublicationCorresponds to variant dbSNP:rs397516359EnsemblClinVar.1
Natural variantiVAR_06354836K → Q in CMD1FF. 1 PublicationCorresponds to variant dbSNP:rs267607130EnsemblClinVar.1
Natural variantiVAR_02945379R → C. Corresponds to variant dbSNP:rs3729712EnsemblClinVar.1
Natural variantiVAR_01607882P → S Polymorphism; risk factor for CMH7. 1 PublicationCorresponds to variant dbSNP:rs77615401EnsemblClinVar.1
Natural variantiVAR_067264116A → G in CMD1FF. 1 PublicationCorresponds to variant dbSNP:rs777177571EnsemblClinVar.1
Natural variantiVAR_019872141R → Q in CMH7. 1 PublicationCorresponds to variant dbSNP:rs397516347EnsemblClinVar.1
Natural variantiVAR_016079144L → Q in RCM1. 1 PublicationCorresponds to variant dbSNP:rs121917760EnsemblClinVar.1
Natural variantiVAR_007603145R → G in CMH7. 1 PublicationCorresponds to variant dbSNP:rs104894724EnsemblClinVar.1
Natural variantiVAR_016080145R → W in RCM1. 1 PublicationCorresponds to variant dbSNP:rs104894724EnsemblClinVar.1
Natural variantiVAR_019873157A → V in CMH7. 1 PublicationCorresponds to variant dbSNP:rs397516353EnsemblClinVar.1
Natural variantiVAR_019874162R → P in CMH7. 2 PublicationsCorresponds to variant dbSNP:rs397516354EnsemblClinVar.1
Natural variantiVAR_042745162R → Q in CMH7. 1 PublicationCorresponds to variant dbSNP:rs397516354EnsemblClinVar.1
Natural variantiVAR_029454166S → F in CMH7. 1 PublicationCorresponds to variant dbSNP:rs727504242EnsemblClinVar.1
Natural variantiVAR_016081171A → T in RCM1. 1 PublicationCorresponds to variant dbSNP:rs121917761EnsemblClinVar.1
Natural variantiVAR_019875177Missing in CMH7. 1 Publication1
Natural variantiVAR_016082178K → E in RCM1. 1 PublicationCorresponds to variant dbSNP:rs104894730EnsemblClinVar.1
Natural variantiVAR_063549185N → K in CMD1FF. 1 PublicationCorresponds to variant dbSNP:rs267607129EnsemblClinVar.1
Natural variantiVAR_019876186R → Q in CMH7. 1 PublicationCorresponds to variant dbSNP:rs397516357EnsemblClinVar.1
Natural variantiVAR_016083190D → H in CMH7 and RCM1. 1 Publication1
Natural variantiVAR_016084192R → H in RCM1. 1 PublicationCorresponds to variant dbSNP:rs104894729EnsemblClinVar.1
Natural variantiVAR_016085196D → N in CMH7. 2 PublicationsCorresponds to variant dbSNP:rs104894727EnsemblClinVar.1
Natural variantiVAR_042746204R → H in CMH7. 1 PublicationCorresponds to variant dbSNP:rs727504275EnsemblClinVar.1
Natural variantiVAR_007604206K → Q in CMH7. 1 PublicationCorresponds to variant dbSNP:rs104894725EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X54163 mRNA Translation: CAA38102.1
M64247 mRNA Translation: AAA16157.1
X90780 Genomic DNA Translation: CAA62301.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS42628.1

Protein sequence database of the Protein Information Resource

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PIRi
A61229 TPHUIC

NCBI Reference Sequences

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RefSeqi
NP_000354.4, NM_000363.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.709179

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000344887; ENSP00000341838; ENSG00000129991

Database of genes from NCBI RefSeq genomes

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GeneIDi
7137

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7137

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54163 mRNA Translation: CAA38102.1
M64247 mRNA Translation: AAA16157.1
X90780 Genomic DNA Translation: CAA62301.1
CCDSiCCDS42628.1
PIRiA61229 TPHUIC
RefSeqiNP_000354.4, NM_000363.4
UniGeneiHs.709179

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J1DX-ray2.61C/F31-163[»]
1J1EX-ray3.30C/F31-210[»]
1LXFNMR-I148-164[»]
1MXLNMR-I148-164[»]
1OZSNMR-B129-148[»]
2KGBNMR-I145-164[»]
2KRDNMR-I148-164[»]
2L1RNMR-B145-164[»]
2MZPNMR-I145-171[»]
2N7LNMR-C145-174[»]
4Y99X-ray2.00C1-210[»]
5VLNNMR-A139-164[»]
5W88NMR-A133-164[»]
5WCLNMR-A139-164[»]
DisProtiDP00166
ProteinModelPortaliP19429
SMRiP19429
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112991, 16 interactors
ComplexPortaliCPX-3280 Cardiac Troponin complex
DIPiDIP-34065N
IntActiP19429, 19 interactors
MINTiP19429
STRINGi9606.ENSP00000341838

Chemistry databases

ChEMBLiCHEMBL2095202
DrugBankiDB04513 N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide

PTM databases

iPTMnetiP19429
PhosphoSitePlusiP19429

Polymorphism and mutation databases

BioMutaiTNNI3
DMDMi136213

Proteomic databases

PaxDbiP19429
PeptideAtlasiP19429
PRIDEiP19429
ProteomicsDBi53658

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
7137
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344887; ENSP00000341838; ENSG00000129991
GeneIDi7137
KEGGihsa:7137

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7137
DisGeNETi7137
EuPathDBiHostDB:ENSG00000129991.12

GeneCards: human genes, protein and diseases

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GeneCardsi
TNNI3
GeneReviewsiTNNI3
HGNCiHGNC:11947 TNNI3
HPAiCAB009349
HPA046428
MalaCardsiTNNI3
MIMi115210 phenotype
191044 gene
611880 phenotype
613286 phenotype
613690 phenotype
neXtProtiNX_P19429
OpenTargetsiENSG00000129991
Orphaneti154 Familial isolated dilated cardiomyopathy
75249 Familial isolated restrictive cardiomyopathy
155 NON RARE IN EUROPE: Familial isolated hypertrophic cardiomyopathy
PharmGKBiPA36636

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3977 Eukaryota
ENOG410Y9IX LUCA
GeneTreeiENSGT00940000158518
HOGENOMiHOG000293300
HOVERGENiHBG052737
InParanoidiP19429
KOiK12044
OMAiHTRVDKV
OrthoDBiEOG091G0NOD
PhylomeDBiP19429
TreeFamiTF313374

Enzyme and pathway databases

ReactomeiR-HSA-390522 Striated Muscle Contraction
R-HSA-5578775 Ion homeostasis
SIGNORiP19429

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TNNI3 human
EvolutionaryTraceiP19429

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TNNI3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7137

Protein Ontology

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PROi
PR:P19429

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000129991 Expressed in 113 organ(s), highest expression level in apex of heart
CleanExiHS_TNNC1
HS_TNNI3
ExpressionAtlasiP19429 baseline and differential
GenevisibleiP19429 HS

Family and domain databases

Gene3Di1.20.5.350, 1 hit
InterProiView protein in InterPro
IPR001978 Troponin
IPR021666 Troponin-I_N
IPR038077 Troponin_sf
PfamiView protein in Pfam
PF00992 Troponin, 1 hit
PF11636 Troponin-I_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNNI3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P19429
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 188 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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