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Protein

ETS domain-containing protein Elk-1

Gene

ELK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi5 – 86ETSPROSITE-ProRule annotationAdd BLAST82

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-198753 ERK/MAPK targets

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P19419

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P19419

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ETS domain-containing protein Elk-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ELK1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000126767.17

Human Gene Nomenclature Database

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HGNCi
HGNC:3321 ELK1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
311040 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P19419

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi230K → R: 9-fold increase in transcriptional activator activity; when associated with R-249. Reduction in sumoylation. 2 Publications1
Mutagenesisi249K → R: 9-fold increase in transcriptional activator activity; when associated with R-230. Reduction in sumoylation. 2 Publications1
Mutagenesisi254K → R: Reduction in sumoylation. 1 Publication1
Mutagenesisi324S → A: No effect on ternary complex formation but loss of transcriptional activity positive regulation by MAD2L2. 1 Publication1
Mutagenesisi336T → A: No effect on ternary complex formation. 1 Publication1
Mutagenesisi353T → A: No effect on ternary complex formation. 1 Publication1
Mutagenesisi363T → A: No effect on ternary complex formation. 1 Publication1
Mutagenesisi368T → A: No effect on ternary complex formation. 1 Publication1
Mutagenesisi383S → A: 17% reduction in ternary complex formation. 2 Publications1
Mutagenesisi389S → A: 34% reduction in ternary complex formation. 1 Publication1
Mutagenesisi417T → A: No effect on ternary complex formation. 1 Publication1
Mutagenesisi422S → A: Slight reduction in ternary complex formation. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
2002

Open Targets

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OpenTargetsi
ENSG00000126767

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27749

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL4453

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ELK1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12643407

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002040951 – 428ETS domain-containing protein Elk-1Add BLAST428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki230Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Cross-linki249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)2 Publications
Cross-linki254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei324Phosphoserine; by MAPK1Combined sources1 Publication1
Modified residuei336Phosphothreonine; by MAPK11 Publication1
Modified residuei353Phosphothreonine; by MAPK11 Publication1
Modified residuei363Phosphothreonine; by MAPK11 Publication1
Modified residuei368Phosphothreonine; by MAPK11 Publication1
Modified residuei383Phosphoserine; by MAPK1 and MAPK83 Publications1
Modified residuei389Phosphoserine; by MAPK12 Publications1
Modified residuei417Phosphothreonine; by MAPK11 Publication1
Modified residuei422Phosphoserine; by MAPK1Combined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention.
On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-383 and Ser-389 are the preferred sites for MAPK1. In vitro, phosphorylation by MAPK1 potentiates ternary complex formation with the serum responses factors, SRE and SRF. Also phosphorylated on Ser-383 by MAPK8 and/or MAKP9. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity. Phosphorylated and activated by CAMK4, MAPK11, MAPK12 and MAPK14. Upon bFGF stimulus, phosphorylated by PAK1 (By similarity).By similarity5 Publications

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P19419

MaxQB - The MaxQuant DataBase

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MaxQBi
P19419

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P19419

PeptideAtlas

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PeptideAtlasi
P19419

PRoteomics IDEntifications database

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PRIDEi
P19419

ProteomicsDB human proteome resource

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ProteomicsDBi
53656
53657 [P19419-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P19419

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P19419

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Lung and testis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000126767 Expressed in 240 organ(s), highest expression level in cingulate cortex

CleanEx database of gene expression profiles

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CleanExi
HS_ELK1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P19419 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P19419 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB003808
HPA036084
HPA064381

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts in its sumoylated form with PIAS2/PIASX which enhances its transcriptional activator activity (PubMed:15920481). Interacts with MAD2L2; the interaction is direct and promotes phosphorylation by the kinases MAPK8 and/or MAPK9 (PubMed:17296730). Interacts with POU1F1 (PubMed:26612202).3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108317, 28 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P19419

Database of interacting proteins

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DIPi
DIP-36057N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P19419

Protein interaction database and analysis system

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IntActi
P19419, 10 interactors

Molecular INTeraction database

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MINTi
P19419

STRING: functional protein association networks

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STRINGi
9606.ENSP00000247161

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P19419

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1428
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P19419

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P19419

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P19419

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni349 – 399Sufficient for interaction with MAD2L21 PublicationAdd BLAST51

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3806 Eukaryota
ENOG410Z0ZF LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157571

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG004344

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P19419

KEGG Orthology (KO)

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KOi
K04375

Identification of Orthologs from Complete Genome Data

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OMAi
RRATHRF

Database of Orthologous Groups

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OrthoDBi
EOG091G0CL4

Database for complete collections of gene phylogenies

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PhylomeDBi
P19419

TreeFam database of animal gene trees

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TreeFami
TF317732

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000418 Ets_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF00178 Ets, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00454 ETSDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00413 ETS, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46785 SSF46785, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P19419-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPSVTLWQF LLQLLREQGN GHIISWTSRD GGEFKLVDAE EVARLWGLRK
60 70 80 90 100
NKTNMNYDKL SRALRYYYDK NIIRKVSGQK FVYKFVSYPE VAGCSTEDCP
110 120 130 140 150
PQPEVSVTST MPNVAPAAIH AAPGDTVSGK PGTPKGAGMA GPGGLARSSR
160 170 180 190 200
NEYMRSGLYS TFTIQSLQPQ PPPHPRPAVV LPSAAPAGAA APPSGSRSTS
210 220 230 240 250
PSPLEACLEA EEAGLPLQVI LTPPEAPNLK SEELNVEPGL GRALPPEVKV
260 270 280 290 300
EGPKEELEVA GERGFVPETT KAEPEVPPQE GVPARLPAVV MDTAGQAGGH
310 320 330 340 350
AASSPEISQP QKGRKPRDLE LPLSPSLLGG PGPERTPGSG SGSGLQAPGP
360 370 380 390 400
ALTPSLLPTH TLTPVLLTPS SLPPSIHFWS TLSPIAPRSP AKLSFQFPSS
410 420
GSAQVHIPSI SVDGLSTPVV LSPGPQKP
Length:428
Mass (Da):44,888
Last modified:January 24, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i68F71F8ADB9D38CA
GO
Isoform 2 (identifier: P19419-2) [UniParc]FASTAAdd to basket
Also known as: ELKV

The sequence of this isoform differs from the canonical sequence as follows:
     91-95: VAGCS → SHCAP
     96-428: Missing.

Show »
Length:95
Mass (Da):11,217
Checksum:i8347760EEE65634F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_017108144G → S. Corresponds to variant dbSNP:rs1997639Ensembl.1
Natural variantiVAR_017109183S → N1 PublicationCorresponds to variant dbSNP:rs1059579Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00146691 – 95VAGCS → SHCAP in isoform 2. Curated5
Alternative sequenceiVSP_00146796 – 428Missing in isoform 2. CuratedAdd BLAST333

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M25269 mRNA Translation: AAA52384.1
AF080616 Genomic DNA Translation: AAC82466.1
AF000672 mRNA Translation: AAD00862.1
AB016193 mRNA Translation: BAA36616.1
AB016194 Genomic DNA Translation: BAA36617.1
AK312984 mRNA Translation: BAG35821.1
AL009172 Genomic DNA No translation available.
CH471164 Genomic DNA Translation: EAW59321.1
BC056150 mRNA Translation: AAH56150.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS14283.1 [P19419-1]
CCDS59165.1 [P19419-2]

Protein sequence database of the Protein Information Resource

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PIRi
A41354 TVHUEK

NCBI Reference Sequences

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RefSeqi
NP_001107595.1, NM_001114123.2 [P19419-1]
NP_001244097.1, NM_001257168.1 [P19419-2]
NP_005220.2, NM_005229.4 [P19419-1]
XP_016884828.1, XM_017029339.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.181128
Hs.715039
Hs.740673

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000247161; ENSP00000247161; ENSG00000126767 [P19419-1]
ENST00000343894; ENSP00000345585; ENSG00000126767 [P19419-2]
ENST00000376983; ENSP00000366182; ENSG00000126767 [P19419-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2002

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2002

UCSC genome browser

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UCSCi
uc004dik.6 human [P19419-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25269 mRNA Translation: AAA52384.1
AF080616 Genomic DNA Translation: AAC82466.1
AF000672 mRNA Translation: AAD00862.1
AB016193 mRNA Translation: BAA36616.1
AB016194 Genomic DNA Translation: BAA36617.1
AK312984 mRNA Translation: BAG35821.1
AL009172 Genomic DNA No translation available.
CH471164 Genomic DNA Translation: EAW59321.1
BC056150 mRNA Translation: AAH56150.1
CCDSiCCDS14283.1 [P19419-1]
CCDS59165.1 [P19419-2]
PIRiA41354 TVHUEK
RefSeqiNP_001107595.1, NM_001114123.2 [P19419-1]
NP_001244097.1, NM_001257168.1 [P19419-2]
NP_005220.2, NM_005229.4 [P19419-1]
XP_016884828.1, XM_017029339.1
UniGeneiHs.181128
Hs.715039
Hs.740673

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DUXX-ray2.10C/F1-94[»]
5VVTX-ray2.80B/D378-385[»]
ProteinModelPortaliP19419
SMRiP19419
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108317, 28 interactors
CORUMiP19419
DIPiDIP-36057N
ELMiP19419
IntActiP19419, 10 interactors
MINTiP19419
STRINGi9606.ENSP00000247161

Chemistry databases

BindingDBiP19419
ChEMBLiCHEMBL4453

PTM databases

iPTMnetiP19419
PhosphoSitePlusiP19419

Polymorphism and mutation databases

BioMutaiELK1
DMDMi12643407

Proteomic databases

EPDiP19419
MaxQBiP19419
PaxDbiP19419
PeptideAtlasiP19419
PRIDEiP19419
ProteomicsDBi53656
53657 [P19419-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
2002
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247161; ENSP00000247161; ENSG00000126767 [P19419-1]
ENST00000343894; ENSP00000345585; ENSG00000126767 [P19419-2]
ENST00000376983; ENSP00000366182; ENSG00000126767 [P19419-1]
GeneIDi2002
KEGGihsa:2002
UCSCiuc004dik.6 human [P19419-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2002
DisGeNETi2002
EuPathDBiHostDB:ENSG00000126767.17

GeneCards: human genes, protein and diseases

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GeneCardsi
ELK1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0016766
HGNCiHGNC:3321 ELK1
HPAiCAB003808
HPA036084
HPA064381
MIMi311040 gene
neXtProtiNX_P19419
OpenTargetsiENSG00000126767
PharmGKBiPA27749

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
GeneTreeiENSGT00940000157571
HOVERGENiHBG004344
InParanoidiP19419
KOiK04375
OMAiRRATHRF
OrthoDBiEOG091G0CL4
PhylomeDBiP19419
TreeFamiTF317732

Enzyme and pathway databases

ReactomeiR-HSA-198753 ERK/MAPK targets
SignaLinkiP19419
SIGNORiP19419

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ELK1 human
EvolutionaryTraceiP19419

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ELK1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2002

Protein Ontology

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PROi
PR:P19419

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000126767 Expressed in 240 organ(s), highest expression level in cingulate cortex
CleanExiHS_ELK1
ExpressionAtlasiP19419 baseline and differential
GenevisibleiP19419 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiELK1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P19419
Secondary accession number(s): B2R7H4
, O75606, O95058, Q969X8, Q9UJM4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 24, 2001
Last modified: December 5, 2018
This is version 206 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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