UniProtKB - P19397 (CD53_HUMAN)
Protein
Leukocyte surface antigen CD53
Gene
CD53
Organism
Homo sapiens (Human)
Status
Functioni
Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity).By similarity
GO - Molecular functioni
- identical protein binding Source: IntAct
GO - Biological processi
- neutrophil degranulation Source: Reactome
- positive regulation of myoblast fusion Source: UniProtKB
- signal transduction Source: ProtInc
Enzyme and pathway databases
PathwayCommonsi | P19397 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
SignaLinki | P19397 |
Protein family/group databases
TCDBi | 8.A.40.1.18, the tetraspanin (tetraspanin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Leukocyte surface antigen CD53Alternative name(s): Cell surface glycoprotein CD53 Tetraspanin-25 Short name: Tspan-25 CD_antigen: CD53 |
Gene namesi | Name:CD53 Synonyms:MOX44, TSPAN25 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1686, CD53 |
MIMi | 151525, gene |
neXtProti | NX_P19397 |
VEuPathDBi | HostDB:ENSG00000143119.12 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity
Other locations
- Cell junction By similarity
- Membrane ; Multi-pass membrane protein
Note: Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes.By similarity
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- immunological synapse Source: UniProtKB
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: UniProtKB
Other locations
- cell surface Source: Ensembl
- cell-cell junction Source: UniProtKB
- specific granule membrane Source: Reactome
- tertiary granule membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 11 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 12 – 32 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 33 – 54 | ExtracellularSequence analysisAdd BLAST | 22 | |
Transmembranei | 55 – 69 | HelicalSequence analysisAdd BLAST | 15 | |
Topological domaini | 70 – 80 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 81 – 106 | HelicalSequence analysisAdd BLAST | 26 | |
Topological domaini | 107 – 181 | ExtracellularSequence analysisAdd BLAST | 75 | |
Transmembranei | 182 – 206 | HelicalSequence analysisAdd BLAST | 25 | |
Topological domaini | 207 – 219 | CytoplasmicSequence analysisAdd BLAST | 13 |
Keywords - Cellular componenti
Cell junction, Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 963 |
OpenTargetsi | ENSG00000143119 |
PharmGKBi | PA26225 |
Miscellaneous databases
Pharosi | P19397, Tbio |
Genetic variation databases
BioMutai | CD53 |
DMDMi | 116019 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219212 | 1 – 219 | Leukocyte surface antigen CD53Add BLAST | 219 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 129 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 148 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | P19397 |
MassIVEi | P19397 |
MaxQBi | P19397 |
PaxDbi | P19397 |
PeptideAtlasi | P19397 |
PRIDEi | P19397 |
ProteomicsDBi | 53654 |
PTM databases
GlyGeni | P19397, 2 sites |
iPTMneti | P19397 |
SwissPalmi | P19397 |
Expressioni
Tissue specificityi
B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes and peripheral T-cells.
Gene expression databases
Bgeei | ENSG00000143119, Expressed in blood and 230 other tissues |
Genevisiblei | P19397, HS |
Organism-specific databases
HPAi | ENSG00000143119, Tissue enhanced (blood, lymphoid tissue) |
Interactioni
Subunit structurei
Interacts with SCIMP.
1 PublicationBinary interactionsi
P19397
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 107401, 101 interactors |
CORUMi | P19397 |
IntActi | P19397, 76 interactors |
STRINGi | 9606.ENSP00000271324 |
Miscellaneous databases
RNActi | P19397, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the tetraspanin (TM4SF) family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3882, Eukaryota |
GeneTreei | ENSGT00940000159669 |
HOGENOMi | CLU_055524_4_3_1 |
InParanoidi | P19397 |
OMAi | SFLHCCG |
PhylomeDBi | P19397 |
TreeFami | TF352892 |
Family and domain databases
Gene3Di | 1.10.1450.10, 1 hit |
InterProi | View protein in InterPro IPR000301, Tetraspanin IPR018499, Tetraspanin/Peripherin IPR018503, Tetraspanin_CS IPR008952, Tetraspanin_EC2_sf |
Pfami | View protein in Pfam PF00335, Tetraspanin, 1 hit |
PIRSFi | PIRSF002419, Tetraspanin, 1 hit |
PRINTSi | PR00259, TMFOUR |
SUPFAMi | SSF48652, SSF48652, 1 hit |
PROSITEi | View protein in PROSITE PS00421, TM4_1, 1 hit |
i Sequence
Sequence statusi: Complete.
P19397-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGMSSLKLLK YVLFFFNLLF WICGCCILGF GIYLLIHNNF GVLFHNLPSL
60 70 80 90 100
TLGNVFVIVG SIIMVVAFLG CMGSIKENKC LLMSFFILLL IILLAEVTLA
110 120 130 140 150
ILLFVYEQKL NEYVAKGLTD SIHRYHSDNS TKAAWDSIQS FLQCCGINGT
160 170 180 190 200
SDWTSGPPAS CPSDRKVEGC YAKARLWFHS NFLYIGIITI CVCVIEVLGM
210
SFALTLNCQI DKTSQTIGL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M37033 mRNA Translation: AAA35663.1 M60871 mRNA Translation: AAA51951.1 BT019643 mRNA Translation: AAV38449.1 AK313582 mRNA Translation: BAG36352.1 AL391064 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56459.1 BC040693 mRNA Translation: AAH40693.1 |
CCDSi | CCDS829.1 |
PIRi | A37243 |
RefSeqi | NP_000551.1, NM_000560.3 NP_001035122.1, NM_001040033.1 |
Genome annotation databases
Ensembli | ENST00000271324; ENSP00000271324; ENSG00000143119 ENST00000648608; ENSP00000497382; ENSG00000143119 |
GeneIDi | 963 |
KEGGi | hsa:963 |
UCSCi | uc001dzx.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M37033 mRNA Translation: AAA35663.1 M60871 mRNA Translation: AAA51951.1 BT019643 mRNA Translation: AAV38449.1 AK313582 mRNA Translation: BAG36352.1 AL391064 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56459.1 BC040693 mRNA Translation: AAH40693.1 |
CCDSi | CCDS829.1 |
PIRi | A37243 |
RefSeqi | NP_000551.1, NM_000560.3 NP_001035122.1, NM_001040033.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6WVG | X-ray | 2.90 | A/B | 1-219 | [»] | |
SMRi | P19397 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107401, 101 interactors |
CORUMi | P19397 |
IntActi | P19397, 76 interactors |
STRINGi | 9606.ENSP00000271324 |
Protein family/group databases
TCDBi | 8.A.40.1.18, the tetraspanin (tetraspanin) family |
PTM databases
GlyGeni | P19397, 2 sites |
iPTMneti | P19397 |
SwissPalmi | P19397 |
Genetic variation databases
BioMutai | CD53 |
DMDMi | 116019 |
Proteomic databases
jPOSTi | P19397 |
MassIVEi | P19397 |
MaxQBi | P19397 |
PaxDbi | P19397 |
PeptideAtlasi | P19397 |
PRIDEi | P19397 |
ProteomicsDBi | 53654 |
Protocols and materials databases
Antibodypediai | 20101, 705 antibodies |
DNASUi | 963 |
Genome annotation databases
Ensembli | ENST00000271324; ENSP00000271324; ENSG00000143119 ENST00000648608; ENSP00000497382; ENSG00000143119 |
GeneIDi | 963 |
KEGGi | hsa:963 |
UCSCi | uc001dzx.4, human |
Organism-specific databases
CTDi | 963 |
DisGeNETi | 963 |
GeneCardsi | CD53 |
HGNCi | HGNC:1686, CD53 |
HPAi | ENSG00000143119, Tissue enhanced (blood, lymphoid tissue) |
MIMi | 151525, gene |
neXtProti | NX_P19397 |
OpenTargetsi | ENSG00000143119 |
PharmGKBi | PA26225 |
VEuPathDBi | HostDB:ENSG00000143119.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3882, Eukaryota |
GeneTreei | ENSGT00940000159669 |
HOGENOMi | CLU_055524_4_3_1 |
InParanoidi | P19397 |
OMAi | SFLHCCG |
PhylomeDBi | P19397 |
TreeFami | TF352892 |
Enzyme and pathway databases
PathwayCommonsi | P19397 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
SignaLinki | P19397 |
Miscellaneous databases
BioGRID-ORCSi | 963, 3 hits in 992 CRISPR screens |
ChiTaRSi | CD53, human |
GeneWikii | CD53 |
GenomeRNAii | 963 |
Pharosi | P19397, Tbio |
PROi | PR:P19397 |
RNActi | P19397, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143119, Expressed in blood and 230 other tissues |
Genevisiblei | P19397, HS |
Family and domain databases
Gene3Di | 1.10.1450.10, 1 hit |
InterProi | View protein in InterPro IPR000301, Tetraspanin IPR018499, Tetraspanin/Peripherin IPR018503, Tetraspanin_CS IPR008952, Tetraspanin_EC2_sf |
Pfami | View protein in Pfam PF00335, Tetraspanin, 1 hit |
PIRSFi | PIRSF002419, Tetraspanin, 1 hit |
PRINTSi | PR00259, TMFOUR |
SUPFAMi | SSF48652, SSF48652, 1 hit |
PROSITEi | View protein in PROSITE PS00421, TM4_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CD53_HUMAN | |
Accessioni | P19397Primary (citable) accession number: P19397 Secondary accession number(s): B2R905, Q5U0D6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | November 1, 1990 | |
Last modified: | April 7, 2021 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families