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UniProtKB - P19397 (CD53_HUMAN)

Entry version 170 (17 Jun 2020)
Sequence version 1 (01 Nov 1990)
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Protein

Leukocyte surface antigen CD53

Gene

CD53

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6798695 Neutrophil degranulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P19397

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.40.1.18 the tetraspanin (tetraspanin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leukocyte surface antigen CD53
Alternative name(s):
Cell surface glycoprotein CD53
Tetraspanin-25
Short name:
Tspan-25
CD_antigen: CD53
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD53
Synonyms:MOX44, TSPAN25
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000143119.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:1686 CD53

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		151525 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P19397

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 54ExtracellularSequence analysisAdd BLAST22
Transmembranei55 – 69HelicalSequence analysisAdd BLAST15
Topological domaini70 – 80CytoplasmicSequence analysisAdd BLAST11
Transmembranei81 – 106HelicalSequence analysisAdd BLAST26
Topological domaini107 – 181ExtracellularSequence analysisAdd BLAST75
Transmembranei182 – 206HelicalSequence analysisAdd BLAST25
Topological domaini207 – 219CytoplasmicSequence analysisAdd BLAST13

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		963

Open Targets

More...OpenTargetsi		ENSG00000143119

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26225

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P19397 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CD53

Domain mapping of disease mutations (DMDM)

More...DMDMi		116019

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002192121 – 219Leukocyte surface antigen CD53Add BLAST219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P19397

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P19397

MaxQB - The MaxQuant DataBase

More...MaxQBi		P19397

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P19397

PeptideAtlas

More...PeptideAtlasi		P19397

PRoteomics IDEntifications database

More...PRIDEi		P19397

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53654

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P19397

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P19397

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes and peripheral T-cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000143119 Expressed in blood and 220 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P19397 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000143119 Tissue enhanced (blood, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SCIMP.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P19397
With#Exp.IntAct
AIG1 - isoform 2 [Q9NVV5-2]3EBI-6657396,EBI-11957045
APOD [P05090]3EBI-6657396,EBI-715495
ARL13B [Q3SXY8]3EBI-6657396,EBI-11343438
ASGR2 - isoform 3 [P07307-3]3EBI-6657396,EBI-12808270
ATP6V0C [P27449]3EBI-6657396,EBI-721179
BCL2L13 [Q9BXK5]3EBI-6657396,EBI-747430
BIK [Q13323]3EBI-6657396,EBI-700794
BTN2A2 [Q8WVV5]3EBI-6657396,EBI-8648738
C1QL4 [Q86Z23]3EBI-6657396,EBI-12062109
CD302 [Q8IX05]3EBI-6657396,EBI-14259393
CD37 [P11049]3EBI-6657396,EBI-6139068
itself3EBI-6657396,EBI-6657396
CLCN7 [P51798]3EBI-6657396,EBI-4402346
CLDN19 - isoform 2 [Q8N6F1-2]3EBI-6657396,EBI-12256978
CLDN7 [O95471]3EBI-6657396,EBI-740744
CLEC7A - isoform 6 [Q9BXN2-6]3EBI-6657396,EBI-11989440
CNIH1 [O95406]3EBI-6657396,EBI-12172273
CNIH2 [Q6PI25]3EBI-6657396,EBI-12815321
COL4A5 - isoform 2 [P29400-2]3EBI-6657396,EBI-12211159
CREB3L1 [Q96BA8]5EBI-6657396,EBI-6942903
CTXN3 [Q4LDR2]3EBI-6657396,EBI-12019274
CYBC1 [Q9BQA9]3EBI-6657396,EBI-2680384
ECE2 - isoform ECE2-3 [P0DPD6-3]3EBI-6657396,EBI-19128181
EFNA5 [P52803]3EBI-6657396,EBI-1753674
EMP1 [P54849]3EBI-6657396,EBI-4319440
ERG28 [Q9UKR5]3EBI-6657396,EBI-711490
FAM209A [Q5JX71]3EBI-6657396,EBI-18304435
GIMAP5 [Q96F15]3EBI-6657396,EBI-6166686
GJA8 [P48165]3EBI-6657396,EBI-17458373
GPR108 [Q9NPR9]3EBI-6657396,EBI-11343451
GPR152 [Q8TDT2]3EBI-6657396,EBI-13345167
GPX8 [Q8TED1]3EBI-6657396,EBI-11721746
IFITM3 [Q01628]3EBI-6657396,EBI-7932862
IGFBP5 [P24593]3EBI-6657396,EBI-720480
KIR3DL3 [Q8N743]3EBI-6657396,EBI-17272405
LAT - isoform 2 [O43561-2]3EBI-6657396,EBI-8070286
LHFPL5 [Q8TAF8]3EBI-6657396,EBI-2820517
LPAR3 [Q9UBY5]3EBI-6657396,EBI-12033434
LSMEM1 [Q8N8F7]3EBI-6657396,EBI-10200825
MAL [P21145]3EBI-6657396,EBI-3932027
MS4A3 [Q96HJ5]3EBI-6657396,EBI-12806656
MUC1 - isoform Y-LSP [P15941-11]3EBI-6657396,EBI-17263240
NKG7 [Q16617]3EBI-6657396,EBI-3919611
PLN [P26678]3EBI-6657396,EBI-692836
PLP2 [Q04941]3EBI-6657396,EBI-608347
PMP22 [Q01453]3EBI-6657396,EBI-2845982
RPRM [Q9NS64]3EBI-6657396,EBI-1052363
SAR1A [Q9NR31]3EBI-6657396,EBI-3920694
SERTM1 [A2A2V5]3EBI-6657396,EBI-17284533
SLC35A1 [P78382]3EBI-6657396,EBI-12870360
SLC7A14 [Q8TBB6]3EBI-6657396,EBI-5235586
SMAGP [Q0VAQ4]3EBI-6657396,EBI-10226799
SMIM3 [Q9BZL3]3EBI-6657396,EBI-741850
SNORC [Q6UX34]3EBI-6657396,EBI-11957067
ST6GAL2 - isoform 2 [Q96JF0-2]3EBI-6657396,EBI-12908338
STRIT1 [P0DN84]3EBI-6657396,EBI-12200293
STX2 - isoform 1 [P32856-2]3EBI-6657396,EBI-11956649
TMEM128 - isoform 2 [Q5BJH2-2]3EBI-6657396,EBI-10694905
TMEM140 [Q9NV12]3EBI-6657396,EBI-2844246
TMEM218 [A2RU14]3EBI-6657396,EBI-10173151
TMEM229B [Q8NBD8]3EBI-6657396,EBI-12195227
TMEM237 - isoform 2 [Q96Q45-2]3EBI-6657396,EBI-10982110
TMEM60 [Q9H2L4]3EBI-6657396,EBI-2852148
TMEM86B [Q8N661]3EBI-6657396,EBI-2548832
TMEM97 [Q5BJF2]3EBI-6657396,EBI-12111910
TRAM1L1 [Q8N609]3EBI-6657396,EBI-11996766
TSPO2 [Q5TGU0]3EBI-6657396,EBI-12195249
TUSC5 [A5PKU2]3EBI-6657396,EBI-11988865
UBIAD1 [Q9Y5Z9]3EBI-6657396,EBI-2819725
UPK1B [O75841]3EBI-6657396,EBI-12237619
VAMP5 [O95183]3EBI-6657396,EBI-10191195
VSTM1 - isoform 3 [Q6UX27-3]3EBI-6657396,EBI-12190699
WRB [O00258]3EBI-6657396,EBI-18908258

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107401, 26 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P19397

Protein interaction database and analysis system

More...IntActi		P19397, 75 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000271324

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P19397 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3882 Eukaryota
ENOG4111IRY LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159669

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_055524_4_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P19397

KEGG Orthology (KO)

More...KOi		K06489

Identification of Orthologs from Complete Genome Data

More...OMAi		SFLHCCG

Database for complete collections of gene phylogenies

More...PhylomeDBi		P19397

TreeFam database of animal gene trees

More...TreeFami		TF352892

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1450.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00335 Tetraspanin, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF002419 Tetraspanin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00259 TMFOUR

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48652 SSF48652, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00421 TM4_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P19397-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGMSSLKLLK YVLFFFNLLF WICGCCILGF GIYLLIHNNF GVLFHNLPSL 
        60         70         80         90        100
TLGNVFVIVG SIIMVVAFLG CMGSIKENKC LLMSFFILLL IILLAEVTLA 
       110        120        130        140        150
ILLFVYEQKL NEYVAKGLTD SIHRYHSDNS TKAAWDSIQS FLQCCGINGT 
       160        170        180        190        200
SDWTSGPPAS CPSDRKVEGC YAKARLWFHS NFLYIGIITI CVCVIEVLGM 
       210 
SFALTLNCQI DKTSQTIGL
Length:219
Mass (Da):24,341
Last modified:November 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i48D4633DBC9110B6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M37033 mRNA Translation: AAA35663.1
M60871 mRNA Translation: AAA51951.1
BT019643 mRNA Translation: AAV38449.1
AK313582 mRNA Translation: BAG36352.1
AL391064 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56459.1
BC040693 mRNA Translation: AAH40693.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS829.1

Protein sequence database of the Protein Information Resource

More...PIRi		A37243

NCBI Reference Sequences

More...RefSeqi		NP_000551.1, NM_000560.3
NP_001035122.1, NM_001040033.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000271324; ENSP00000271324; ENSG00000143119
ENST00000648608; ENSP00000497382; ENSG00000143119

Database of genes from NCBI RefSeq genomes

More...GeneIDi		963

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:963

UCSC genome browser

More...UCSCi		uc001dzx.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37033 mRNA Translation: AAA35663.1
M60871 mRNA Translation: AAA51951.1
BT019643 mRNA Translation: AAV38449.1
AK313582 mRNA Translation: BAG36352.1
AL391064 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56459.1
BC040693 mRNA Translation: AAH40693.1
CCDSiCCDS829.1
PIRiA37243
RefSeqiNP_000551.1, NM_000560.3
NP_001035122.1, NM_001040033.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi107401, 26 interactors
CORUMiP19397
IntActiP19397, 75 interactors
STRINGi9606.ENSP00000271324

Protein family/group databases

TCDBi8.A.40.1.18 the tetraspanin (tetraspanin) family

PTM databases

iPTMnetiP19397
SwissPalmiP19397

Polymorphism and mutation databases

BioMutaiCD53
DMDMi116019

Proteomic databases

jPOSTiP19397
MassIVEiP19397
MaxQBiP19397
PaxDbiP19397
PeptideAtlasiP19397
PRIDEiP19397
ProteomicsDBi53654

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		20101 650 antibodies

The DNASU plasmid repository

More...DNASUi		963

Genome annotation databases

EnsembliENST00000271324; ENSP00000271324; ENSG00000143119
ENST00000648608; ENSP00000497382; ENSG00000143119
GeneIDi963
KEGGihsa:963
UCSCiuc001dzx.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		963
DisGeNETi963
EuPathDBiHostDB:ENSG00000143119.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		CD53
HGNCiHGNC:1686 CD53
HPAiENSG00000143119 Tissue enhanced (blood, lymphoid tissue)
MIMi151525 gene
neXtProtiNX_P19397
OpenTargetsiENSG00000143119
PharmGKBiPA26225

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00940000159669
HOGENOMiCLU_055524_4_3_1
InParanoidiP19397
KOiK06489
OMAiSFLHCCG
PhylomeDBiP19397
TreeFamiTF352892

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
SignaLinkiP19397

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		963 2 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CD53 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CD53

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		963
PharosiP19397 Tbio

Protein Ontology

More...PROi		PR:P19397
RNActiP19397 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000143119 Expressed in blood and 220 other tissues
GenevisibleiP19397 HS

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspanin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD53_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P19397
Secondary accession number(s): B2R905, Q5U0D6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: June 17, 2020
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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