UniProtKB - P19388 (RPAB1_HUMAN)
Protein
DNA-directed RNA polymerases I, II, and III subunit RPABC1
Gene
POLR2E
Organism
Homo sapiens (Human)
Status
Functioni
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity).By similarity1 Publication
GO - Molecular functioni
- DNA binding Source: InterPro
- DNA-directed 5'-3' RNA polymerase activity Source: ProtInc
GO - Biological processi
- 7-methylguanosine mRNA capping Source: Reactome
- fibroblast growth factor receptor signaling pathway Source: Reactome
- mRNA splicing, via spliceosome Source: Reactome
- positive regulation of gene expression, epigenetic Source: Reactome
- positive regulation of type I interferon production Source: Reactome
- positive regulation of viral transcription Source: Reactome
- regulation of gene silencing by miRNA Source: Reactome
- RNA metabolic process Source: Reactome
- snRNA transcription by RNA polymerase II Source: Reactome
- somatic stem cell population maintenance Source: Reactome
- termination of RNA polymerase I transcription Source: Reactome
- transcription, DNA-templated Source: Reactome
- transcription by RNA polymerase II Source: UniProtKB
- transcription-coupled nucleotide-excision repair Source: Reactome
- transcription elongation from RNA polymerase II promoter Source: Reactome
- transcription elongation from RNA polymerase I promoter Source: Reactome
- transcription initiation from RNA polymerase II promoter Source: Reactome
- transcription initiation from RNA polymerase I promoter Source: Reactome
- viral process Source: UniProtKB-KW
Keywordsi
Biological process | Host-virus interaction, Transcription |
Enzyme and pathway databases
PathwayCommonsi | P19388 |
Reactomei | R-HSA-112382, Formation of RNA Pol II elongation complex R-HSA-113418, Formation of the Early Elongation Complex R-HSA-167152, Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167158, Formation of the HIV-1 Early Elongation Complex R-HSA-167160, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167161, HIV Transcription Initiation R-HSA-167162, RNA Polymerase II HIV Promoter Escape R-HSA-167172, Transcription of the HIV genome R-HSA-167200, Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167238, Pausing and recovery of Tat-mediated HIV elongation R-HSA-167242, Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167243, Tat-mediated HIV elongation arrest and recovery R-HSA-167246, Tat-mediated elongation of the HIV-1 transcript R-HSA-167287, HIV elongation arrest and recovery R-HSA-167290, Pausing and recovery of HIV elongation R-HSA-168325, Viral Messenger RNA Synthesis R-HSA-1834949, Cytosolic sensors of pathogen-associated DNA R-HSA-203927, MicroRNA (miRNA) biogenesis R-HSA-427413, NoRC negatively regulates rRNA expression R-HSA-5250924, B-WICH complex positively regulates rRNA expression R-HSA-5578749, Transcriptional regulation by small RNAs R-HSA-5601884, PIWI-interacting RNA (piRNA) biogenesis R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-674695, RNA Polymerase II Pre-transcription Events R-HSA-6781823, Formation of TC-NER Pre-Incision Complex R-HSA-6781827, Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6782135, Dual incision in TC-NER R-HSA-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6796648, TP53 Regulates Transcription of DNA Repair Genes R-HSA-6803529, FGFR2 alternative splicing R-HSA-6807505, RNA polymerase II transcribes snRNA genes R-HSA-72086, mRNA Capping R-HSA-72163, mRNA Splicing - Major Pathway R-HSA-72165, mRNA Splicing - Minor Pathway R-HSA-72203, Processing of Capped Intron-Containing Pre-mRNA R-HSA-73762, RNA Polymerase I Transcription Initiation R-HSA-73772, RNA Polymerase I Promoter Escape R-HSA-73776, RNA Polymerase II Promoter Escape R-HSA-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73780, RNA Polymerase III Chain Elongation R-HSA-73863, RNA Polymerase I Transcription Termination R-HSA-73980, RNA Polymerase III Transcription Termination R-HSA-749476, RNA Polymerase III Abortive And Retractive Initiation R-HSA-75953, RNA Polymerase II Transcription Initiation R-HSA-75955, RNA Polymerase II Transcription Elongation R-HSA-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76066, RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76071, RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-77075, RNA Pol II CTD phosphorylation and interaction with CE R-HSA-8851708, Signaling by FGFR2 IIIa TM R-HSA-9018519, Estrogen-dependent gene expression R-HSA-9670095, Inhibition of DNA recombination at telomere |
SIGNORi | P19388 |
Names & Taxonomyi
Protein namesi | Recommended name: DNA-directed RNA polymerases I, II, and III subunit RPABC1Short name: RNA polymerases I, II, and III subunit ABC1 Alternative name(s): DNA-directed RNA polymerase II 23 kDa polypeptide DNA-directed RNA polymerase II subunit E RPB5 homolog XAP4 |
Gene namesi | Name:POLR2E |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000099817.11 |
HGNCi | HGNC:9192, POLR2E |
MIMi | 180664, gene |
neXtProti | NX_P19388 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
- RNA polymerase I complex Source: GO_Central
- RNA polymerase II, core complex Source: UniProtKB
- RNA polymerase III complex Source: GO_Central
Keywords - Cellular componenti
DNA-directed RNA polymerase, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 5434 |
OpenTargetsi | ENSG00000099817 |
PharmGKBi | PA33512 |
Miscellaneous databases
Pharosi | P19388, Tbio |
Polymorphism and mutation databases
BioMutai | POLR2E |
DMDMi | 116242767 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000146075 | 1 – 210 | DNA-directed RNA polymerases I, II, and III subunit RPABC1Add BLAST | 210 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Cross-linki | 81 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Acetylation, Isopeptide bond, Ubl conjugationProteomic databases
EPDi | P19388 |
jPOSTi | P19388 |
MassIVEi | P19388 |
MaxQBi | P19388 |
PaxDbi | P19388 |
PeptideAtlasi | P19388 |
PRIDEi | P19388 |
ProteomicsDBi | 53653 |
TopDownProteomicsi | P19388 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00291093 |
SWISS-2DPAGEi | P19388 |
PTM databases
iPTMneti | P19388 |
MetOSitei | P19388 |
PhosphoSitePlusi | P19388 |
Expressioni
Gene expression databases
Bgeei | ENSG00000099817, Expressed in heart left ventricle and 251 other tissues |
ExpressionAtlasi | P19388, baseline and differential |
Genevisiblei | P19388, HS |
Organism-specific databases
HPAi | ENSG00000099817, Low tissue specificity |
Interactioni
Subunit structurei
Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively (By similarity). In RNA Pol II, this subunit is present in 2-fold molar excess over the other subunits.
Interacts with URI1.
By similarity3 Publications(Microbial infection) Interacts with HBV protein X.
1 PublicationBinary interactionsi
Hide detailsP19388
With | #Exp. | IntAct |
---|---|---|
IP6K3 [Q96PC2] | 6 | EBI-395189,EBI-10990676 |
UBE2D4 [Q9Y2X8] | 3 | EBI-395189,EBI-745527 |
URI1 [O94763] | 2 | EBI-395189,EBI-357067 |
Protein-protein interaction databases
BioGRIDi | 111430, 157 interactors |
CORUMi | P19388 |
DIPi | DIP-56N |
IntActi | P19388, 106 interactors |
MINTi | P19388 |
STRINGi | 9606.ENSP00000478303 |
Miscellaneous databases
RNActi | P19388, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family.Curated
Phylogenomic databases
eggNOGi | KOG3218, Eukaryota |
GeneTreei | ENSGT00390000013841 |
HOGENOMi | CLU_058320_0_1_1 |
InParanoidi | P19388 |
OMAi | MQMCHDR |
OrthoDBi | 1255823at2759 |
PhylomeDBi | P19388 |
Family and domain databases
Gene3Di | 3.40.1340.10, 1 hit 3.90.940.20, 1 hit |
HAMAPi | MF_00025, RNApol_RpoH_RPB5, 1 hit |
InterProi | View protein in InterPro IPR014381, DNA_RNA_pol_RPB5_euk/virus IPR005571, RNA_pol_Rpb5_N IPR036710, RNA_pol_Rpb5_N_sf IPR000783, RNA_pol_subH/Rpb5_C IPR020608, RNA_pol_subH/Rpb5_CS IPR039531, Rpb5-like IPR035913, RPB5-like_sf IPR020609, RpoH/RPB5 |
PANTHERi | PTHR10535, PTHR10535, 1 hit |
Pfami | View protein in Pfam PF01191, RNA_pol_Rpb5_C, 1 hit PF03871, RNA_pol_Rpb5_N, 1 hit |
PIRSFi | PIRSF000747, RPB5, 1 hit |
SUPFAMi | SSF53036, SSF53036, 1 hit SSF55287, SSF55287, 1 hit |
PROSITEi | View protein in PROSITE PS01110, RNA_POL_H_23KD, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
P19388-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDDEEETYRL WKIRKTIMQL CHDRGYLVTQ DELDQTLEEF KAQSGDKPSE
60 70 80 90 100
GRPRRTDLTV LVAHNDDPTD QMFVFFPEEP KVGIKTIKVY CQRMQEENIT
110 120 130 140 150
RALIVVQQGM TPSAKQSLVD MAPKYILEQF LQQELLINIT EHELVPEHVV
160 170 180 190 200
MTKEEVTELL ARYKLRENQL PRIQAGDPVA RYFGIKRGQV VKIIRPSETA
210
GRYITYRLVQ
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WVZ9 | A0A087WVZ9_HUMAN | DNA-directed RNA polymerase II subu... | POLR2E | 184 | Annotation score: | ||
A0A0A0MQR7 | A0A0A0MQR7_HUMAN | DNA-directed RNA polymerase II subu... | POLR2E | 204 | Annotation score: | ||
A0A087WWX0 | A0A087WWX0_HUMAN | DNA-directed RNA polymerases I, II,... | POLR2E | 134 | Annotation score: | ||
A0A087WVN5 | A0A087WVN5_HUMAN | DNA-directed RNA polymerases I, II,... | POLR2E | 83 | Annotation score: | ||
K7EJ87 | K7EJ87_HUMAN | DNA-directed RNA polymerases I, II,... | POLR2E | 68 | Annotation score: | ||
K7EQN2 | K7EQN2_HUMAN | DNA-directed RNA polymerases I, II,... | POLR2E | 51 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 132 | Q → E (PubMed:2753903).Curated | 1 | |
Sequence conflicti | 132 | Q → E (PubMed:7828586).Curated | 1 | |
Sequence conflicti | 157 | T → S in BAA07406 (PubMed:7828586).Curated | 1 | |
Sequence conflicti | 185 | I → V in AAH34144 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 186 | K → R in BAA07406 (PubMed:7828586).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028259 | 44 | S → F5 PublicationsCorresponds to variant dbSNP:rs12459404Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04965 mRNA Translation: AAA62401.1 Sequence problems. S42643 mRNA Translation: AAB19339.1 D38251 mRNA Translation: BAA07406.1 AK312625 mRNA Translation: BAG35511.1 AC004151 Genomic DNA Translation: AAC03238.1 CH471139 Genomic DNA Translation: EAW69548.1 CH471139 Genomic DNA Translation: EAW69549.1 BC004441 mRNA Translation: AAH04441.1 BC034144 mRNA Translation: AAH34144.1 |
CCDSi | CCDS12056.1 |
PIRi | S52002, A32618 |
RefSeqi | NP_002686.2, NM_002695.3 |
Genome annotation databases
Ensembli | ENST00000586746; ENSP00000464739; ENSG00000099817 ENST00000612655; ENSP00000485021; ENSG00000099817 ENST00000615234; ENSP00000478303; ENSG00000099817 |
GeneIDi | 5434 |
KEGGi | hsa:5434 |
UCSCi | uc002lre.5, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04965 mRNA Translation: AAA62401.1 Sequence problems. S42643 mRNA Translation: AAB19339.1 D38251 mRNA Translation: BAA07406.1 AK312625 mRNA Translation: BAG35511.1 AC004151 Genomic DNA Translation: AAC03238.1 CH471139 Genomic DNA Translation: EAW69548.1 CH471139 Genomic DNA Translation: EAW69549.1 BC004441 mRNA Translation: AAH04441.1 BC034144 mRNA Translation: AAH34144.1 |
CCDSi | CCDS12056.1 |
PIRi | S52002, A32618 |
RefSeqi | NP_002686.2, NM_002695.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5IY6 | electron microscopy | 7.20 | E | 1-210 | [»] | |
5IY7 | electron microscopy | 8.60 | E | 1-210 | [»] | |
5IY8 | electron microscopy | 7.90 | E | 1-210 | [»] | |
5IY9 | electron microscopy | 6.30 | E | 1-210 | [»] | |
5IYA | electron microscopy | 5.40 | E | 1-210 | [»] | |
5IYB | electron microscopy | 3.90 | E | 1-210 | [»] | |
5IYC | electron microscopy | 3.90 | E | 1-210 | [»] | |
5IYD | electron microscopy | 3.90 | E | 1-210 | [»] | |
6DRD | electron microscopy | 3.90 | E | 1-210 | [»] | |
6O9L | electron microscopy | 7.20 | E | 1-210 | [»] | |
SMRi | P19388 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111430, 157 interactors |
CORUMi | P19388 |
DIPi | DIP-56N |
IntActi | P19388, 106 interactors |
MINTi | P19388 |
STRINGi | 9606.ENSP00000478303 |
PTM databases
iPTMneti | P19388 |
MetOSitei | P19388 |
PhosphoSitePlusi | P19388 |
Polymorphism and mutation databases
BioMutai | POLR2E |
DMDMi | 116242767 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00291093 |
SWISS-2DPAGEi | P19388 |
Proteomic databases
EPDi | P19388 |
jPOSTi | P19388 |
MassIVEi | P19388 |
MaxQBi | P19388 |
PaxDbi | P19388 |
PeptideAtlasi | P19388 |
PRIDEi | P19388 |
ProteomicsDBi | 53653 |
TopDownProteomicsi | P19388 |
Protocols and materials databases
Antibodypediai | 22550, 295 antibodies |
DNASUi | 5434 |
Genome annotation databases
Ensembli | ENST00000586746; ENSP00000464739; ENSG00000099817 ENST00000612655; ENSP00000485021; ENSG00000099817 ENST00000615234; ENSP00000478303; ENSG00000099817 |
GeneIDi | 5434 |
KEGGi | hsa:5434 |
UCSCi | uc002lre.5, human |
Organism-specific databases
CTDi | 5434 |
DisGeNETi | 5434 |
EuPathDBi | HostDB:ENSG00000099817.11 |
GeneCardsi | POLR2E |
HGNCi | HGNC:9192, POLR2E |
HPAi | ENSG00000099817, Low tissue specificity |
MIMi | 180664, gene |
neXtProti | NX_P19388 |
OpenTargetsi | ENSG00000099817 |
PharmGKBi | PA33512 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3218, Eukaryota |
GeneTreei | ENSGT00390000013841 |
HOGENOMi | CLU_058320_0_1_1 |
InParanoidi | P19388 |
OMAi | MQMCHDR |
OrthoDBi | 1255823at2759 |
PhylomeDBi | P19388 |
Enzyme and pathway databases
PathwayCommonsi | P19388 |
Reactomei | R-HSA-112382, Formation of RNA Pol II elongation complex R-HSA-113418, Formation of the Early Elongation Complex R-HSA-167152, Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167158, Formation of the HIV-1 Early Elongation Complex R-HSA-167160, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection R-HSA-167161, HIV Transcription Initiation R-HSA-167162, RNA Polymerase II HIV Promoter Escape R-HSA-167172, Transcription of the HIV genome R-HSA-167200, Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167238, Pausing and recovery of Tat-mediated HIV elongation R-HSA-167242, Abortive elongation of HIV-1 transcript in the absence of Tat R-HSA-167243, Tat-mediated HIV elongation arrest and recovery R-HSA-167246, Tat-mediated elongation of the HIV-1 transcript R-HSA-167287, HIV elongation arrest and recovery R-HSA-167290, Pausing and recovery of HIV elongation R-HSA-168325, Viral Messenger RNA Synthesis R-HSA-1834949, Cytosolic sensors of pathogen-associated DNA R-HSA-203927, MicroRNA (miRNA) biogenesis R-HSA-427413, NoRC negatively regulates rRNA expression R-HSA-5250924, B-WICH complex positively regulates rRNA expression R-HSA-5578749, Transcriptional regulation by small RNAs R-HSA-5601884, PIWI-interacting RNA (piRNA) biogenesis R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-674695, RNA Polymerase II Pre-transcription Events R-HSA-6781823, Formation of TC-NER Pre-Incision Complex R-HSA-6781827, Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6782135, Dual incision in TC-NER R-HSA-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-6796648, TP53 Regulates Transcription of DNA Repair Genes R-HSA-6803529, FGFR2 alternative splicing R-HSA-6807505, RNA polymerase II transcribes snRNA genes R-HSA-72086, mRNA Capping R-HSA-72163, mRNA Splicing - Major Pathway R-HSA-72165, mRNA Splicing - Minor Pathway R-HSA-72203, Processing of Capped Intron-Containing Pre-mRNA R-HSA-73762, RNA Polymerase I Transcription Initiation R-HSA-73772, RNA Polymerase I Promoter Escape R-HSA-73776, RNA Polymerase II Promoter Escape R-HSA-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73780, RNA Polymerase III Chain Elongation R-HSA-73863, RNA Polymerase I Transcription Termination R-HSA-73980, RNA Polymerase III Transcription Termination R-HSA-749476, RNA Polymerase III Abortive And Retractive Initiation R-HSA-75953, RNA Polymerase II Transcription Initiation R-HSA-75955, RNA Polymerase II Transcription Elongation R-HSA-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76066, RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-76071, RNA Polymerase III Transcription Initiation From Type 3 Promoter R-HSA-77075, RNA Pol II CTD phosphorylation and interaction with CE R-HSA-8851708, Signaling by FGFR2 IIIa TM R-HSA-9018519, Estrogen-dependent gene expression R-HSA-9670095, Inhibition of DNA recombination at telomere |
SIGNORi | P19388 |
Miscellaneous databases
BioGRID-ORCSi | 5434, 762 hits in 851 CRISPR screens |
ChiTaRSi | POLR2E, human |
GeneWikii | POLR2E |
GenomeRNAii | 5434 |
Pharosi | P19388, Tbio |
PROi | PR:P19388 |
RNActi | P19388, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000099817, Expressed in heart left ventricle and 251 other tissues |
ExpressionAtlasi | P19388, baseline and differential |
Genevisiblei | P19388, HS |
Family and domain databases
Gene3Di | 3.40.1340.10, 1 hit 3.90.940.20, 1 hit |
HAMAPi | MF_00025, RNApol_RpoH_RPB5, 1 hit |
InterProi | View protein in InterPro IPR014381, DNA_RNA_pol_RPB5_euk/virus IPR005571, RNA_pol_Rpb5_N IPR036710, RNA_pol_Rpb5_N_sf IPR000783, RNA_pol_subH/Rpb5_C IPR020608, RNA_pol_subH/Rpb5_CS IPR039531, Rpb5-like IPR035913, RPB5-like_sf IPR020609, RpoH/RPB5 |
PANTHERi | PTHR10535, PTHR10535, 1 hit |
Pfami | View protein in Pfam PF01191, RNA_pol_Rpb5_C, 1 hit PF03871, RNA_pol_Rpb5_N, 1 hit |
PIRSFi | PIRSF000747, RPB5, 1 hit |
SUPFAMi | SSF53036, SSF53036, 1 hit SSF55287, SSF55287, 1 hit |
PROSITEi | View protein in PROSITE PS01110, RNA_POL_H_23KD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RPAB1_HUMAN | |
Accessioni | P19388Primary (citable) accession number: P19388 Secondary accession number(s): B2R6L4 Q9BT06 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | October 17, 2006 | |
Last modified: | December 2, 2020 | |
This is version 213 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations