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Protein

Hexokinase-1

Gene

HK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase).

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Enzyme regulationi

Hexokinase is an allosteric enzyme inhibited by its product Glc-6-P.

Pathwayi: hexose metabolism

This protein is involved in the pathway hexose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway hexose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei30ATP 1Combined sources2 Publications1
Binding sitei155Substrate 1Combined sources3 Publications1
Binding sitei209Glucose-6-phosphate 1Combined sources3 Publications1
Binding sitei232Glucose-6-phosphate 1Combined sources3 Publications1
Binding sitei235Substrate 1Combined sources4 Publications1
Binding sitei260Substrate 1Combined sources4 Publications1
Binding sitei345ATP 1Combined sources1 Publication1
Binding sitei449Glucose-6-phosphate 1Combined sources3 Publications1
Binding sitei657Glucose-6-phosphate 2Combined sources3 Publications1
Binding sitei680ATP 2Combined sources2 Publications1
Binding sitei680Glucose-6-phosphate 2Combined sources3 Publications1
Binding sitei708Substrate 2Combined sources3 Publications1
Binding sitei742Substrate 2Combined sources3 Publications1
Binding sitei897Glucose-6-phosphate 2Combined sources3 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi84 – 89ATP 1Combined sources2 Publications6
Nucleotide bindingi425 – 426ATP 1Combined sources2 Publications2
Nucleotide bindingi532 – 537ATP 2Combined sources1 Publication6
Nucleotide bindingi747 – 748ATP 2Combined sources1 Publication2
Nucleotide bindingi784 – 788ATP 2Combined sources1 Publication5
Nucleotide bindingi863 – 867ATP 2Combined sources2 Publications5

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • fructokinase activity Source: GO_Central
  • glucokinase activity Source: GO_Central
  • glucose binding Source: InterPro
  • hexokinase activity Source: CAFA
  • identical protein binding Source: IntAct
  • mannokinase activity Source: GO_Central
  • peptidoglycan binding Source: CAFA

GO - Biological processi

  • canonical glycolysis Source: Reactome
  • carbohydrate phosphorylation Source: CAFA
  • cellular glucose homeostasis Source: GO_Central
  • establishment of protein localization to mitochondrion Source: ParkinsonsUK-UCL
  • glycolytic process Source: ProtInc
  • maintenance of protein location in mitochondrion Source: ParkinsonsUK-UCL

Keywordsi

Molecular functionAllosteric enzyme, Kinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS08136-MONOMER
BRENDAi2.7.1.1 2681
ReactomeiR-HSA-5619056 Defective HK1 causes hexokinase deficiency (HK deficiency)
R-HSA-70171 Glycolysis
SABIO-RKiP19367
SIGNORiP19367
UniPathwayiUPA00242

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase-1 (EC:2.7.1.1)
Alternative name(s):
Brain form hexokinase
Hexokinase type I
Short name:
HK I
Gene namesi
Name:HK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000156515.21
HGNCiHGNC:4922 HK1
MIMi142600 gene
neXtProtiNX_P19367

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Involvement in diseasei

Hexokinase deficiency (HK deficiency)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionRare autosomal recessive disease with nonspherocytic hemolytic anemia as the predominant clinical feature.
See also OMIM:235700
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_009878529L → S in HK deficiency. 1 PublicationCorresponds to variant dbSNP:rs137853249Ensembl.1
Natural variantiVAR_023780680T → S in HK deficiency; HK Utrecht. 1 PublicationCorresponds to variant dbSNP:rs398122379Ensembl.1
Neuropathy, hereditary motor and sensory, Russe type (HMSNR)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive progressive complex peripheral neuropathy characterized by onset in the first decade of distal lower limb weakness and muscle atrophy resulting in walking difficulties. Distal impairment of the upper limbs usually occurs later, as does proximal lower limb weakness. There is distal sensory impairment, with pes cavus and areflexia. Laboratory studies suggest that it is a myelinopathy resulting in reduced nerve conduction velocities in the demyelinating range as well as a length-dependent axonopathy.
See also OMIM:605285
Retinitis pigmentosa 79 (RP79)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of retinitis pigmentosa, a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP79 inheritance is autosomal dominant.
See also OMIM:617460
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_078923847E → K in RP79; unknown pathological significance; no effect on hexokinase activity; no effect on protein abundance. 2 PublicationsCorresponds to variant dbSNP:rs777849213Ensembl.1

Keywords - Diseasei

Charcot-Marie-Tooth disease, Disease mutation, Neurodegeneration, Neuropathy, Retinitis pigmentosa

Organism-specific databases

DisGeNETi3098
MalaCardsiHK1
MIMi235700 phenotype
605285 phenotype
617460 phenotype
OpenTargetsiENSG00000156515
Orphaneti99953 Charcot-Marie-Tooth disease type 4G
90031 Non-spherocytic hemolytic anemia due to hexokinase deficiency
PharmGKBiPA29300

Chemistry databases

ChEMBLiCHEMBL2688
DrugBankiDB02007 alpha-D-glucose 6-phosphate
DB02379 Beta-D-Glucose
DB09502 Fludeoxyglucose F-18
DB04395 Phosphoaminophosphonic Acid-Adenylate Ester

Polymorphism and mutation databases

BioMutaiHK1
DMDMi116242516

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001975851 – 917Hexokinase-1Add BLAST917

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei337PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP19367
MaxQBiP19367
PaxDbiP19367
PeptideAtlasiP19367
PRIDEiP19367
ProteomicsDBi53648
53649 [P19367-2]
53650 [P19367-3]
53651 [P19367-4]

PTM databases

CarbonylDBiP19367
iPTMnetiP19367
PhosphoSitePlusiP19367
SwissPalmiP19367

Expressioni

Tissue specificityi

Isoform 2 is erythrocyte specific. Isoform 3 and isoform 4 are testis-specific.

Gene expression databases

BgeeiENSG00000156515
CleanExiHS_HK1
ExpressionAtlasiP19367 baseline and differential
GenevisibleiP19367 HS

Organism-specific databases

HPAiCAB010052
HPA007043
HPA007044

Interactioni

Subunit structurei

Monomer. Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2 (By similarity). Interacts with VDAC1. The HK1-VDAC1 complex interacts with ATF2. Interacts (via N-terminal spermatogenic cell-specific region) with PFKM (via C-terminus) (By similarity).By similarity4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi109345, 51 interactors
DIPiDIP-56245N
IntActiP19367, 44 interactors
MINTiP19367
STRINGi9606.ENSP00000384774

Chemistry databases

BindingDBiP19367

Structurei

Secondary structure

1917
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi17 – 25Combined sources9
Helixi27 – 29Combined sources3
Helixi33 – 51Combined sources19
Turni53 – 55Combined sources3
Helixi56 – 58Combined sources3
Beta strandi78 – 100Combined sources23
Beta strandi103 – 112Combined sources10
Helixi116 – 119Combined sources4
Beta strandi120 – 122Combined sources3
Helixi123 – 141Combined sources19
Beta strandi144 – 146Combined sources3
Beta strandi150 – 154Combined sources5
Beta strandi161 – 164Combined sources4
Turni179 – 182Combined sources4
Helixi185 – 196Combined sources12
Beta strandi203 – 207Combined sources5
Helixi209 – 220Combined sources12
Beta strandi224 – 241Combined sources18
Helixi242 – 244Combined sources3
Beta strandi252 – 258Combined sources7
Helixi261 – 263Combined sources3
Turni264 – 273Combined sources10
Helixi276 – 283Combined sources8
Beta strandi285 – 287Combined sources3
Helixi294 – 297Combined sources4
Helixi299 – 315Combined sources17
Helixi320 – 322Combined sources3
Turni326 – 329Combined sources4
Helixi336 – 342Combined sources7
Turni345 – 347Combined sources3
Helixi348 – 358Combined sources11
Helixi365 – 401Combined sources37
Beta strandi404 – 413Combined sources10
Helixi415 – 419Combined sources5
Helixi423 – 434Combined sources12
Beta strandi438 – 444Combined sources7
Helixi449 – 475Combined sources27
Helixi481 – 499Combined sources19
Helixi501 – 504Combined sources4
Beta strandi526 – 546Combined sources21
Beta strandi548 – 550Combined sources3
Beta strandi552 – 560Combined sources9
Helixi564 – 567Combined sources4
Beta strandi568 – 570Combined sources3
Helixi571 – 589Combined sources19
Beta strandi597 – 602Combined sources6
Beta strandi606 – 610Combined sources5
Beta strandi613 – 616Combined sources4
Helixi633 – 644Combined sources12
Beta strandi650 – 655Combined sources6
Helixi657 – 666Combined sources10
Beta strandi672 – 689Combined sources18
Turni690 – 692Combined sources3
Beta strandi700 – 706Combined sources7
Helixi709 – 711Combined sources3
Turni712 – 715Combined sources4
Turni717 – 721Combined sources5
Helixi724 – 731Combined sources8
Turni734 – 737Combined sources4
Helixi742 – 744Combined sources3
Turni747 – 749Combined sources3
Helixi750 – 763Combined sources14
Helixi768 – 770Combined sources3
Turni774 – 777Combined sources4
Helixi784 – 790Combined sources7
Helixi797 – 807Combined sources11
Helixi813 – 848Combined sources36
Beta strandi852 – 861Combined sources10
Helixi863 – 867Combined sources5
Helixi871 – 882Combined sources12
Beta strandi886 – 892Combined sources7
Helixi898 – 912Combined sources15

3D structure databases

ProteinModelPortaliP19367
SMRiP19367
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19367

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 458Hexokinase 1PROSITE-ProRule annotationAdd BLAST443
Domaini464 – 906Hexokinase 2PROSITE-ProRule annotationAdd BLAST443

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 12HydrophobicAdd BLAST12
Regioni13 – 475RegulatoryAdd BLAST463
Regioni73 – 207Hexokinase small subdomain 1PROSITE-ProRule annotationAdd BLAST135
Regioni84 – 91Glucose-6-phosphate 1 bindingCombined sources3 Publications8
Regioni172 – 173Substrate 1 bindingCombined sources4 Publications2
Regioni208 – 447Hexokinase large subdomain 1PROSITE-ProRule annotationAdd BLAST240
Regioni208 – 209Substrate 1 bindingCombined sources4 Publications2
Regioni291 – 294Substrate 1 bindingCombined sources4 Publications4
Regioni413 – 415Glucose-6-phosphate 1 bindingCombined sources3 Publications3
Regioni476 – 917CatalyticAdd BLAST442
Regioni521 – 655Hexokinase small subdomain 2PROSITE-ProRule annotationAdd BLAST135
Regioni532 – 536Glucose-6-phosphate 2 bindingCombined sources2 Publications5
Regioni603 – 604Substrate 2 bindingCombined sources2 Publications2
Regioni620 – 621Substrate 2 bindingCombined sources3 Publications2
Regioni656 – 895Hexokinase large subdomain 2PROSITE-ProRule annotationAdd BLAST240
Regioni656 – 657Substrate 2 bindingCombined sources3 Publications2
Regioni682 – 683Substrate 2 bindingCombined sources3 Publications2
Regioni861 – 863Glucose-6-phosphate 2 bindingCombined sources3 Publications3

Domaini

The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus. Each domain can bind a single glucose and Gluc-6-P molecule.

Sequence similaritiesi

Belongs to the hexokinase family.PROSITE-ProRule annotationCurated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1369 Eukaryota
COG5026 LUCA
GeneTreeiENSGT00390000017159
HOVERGENiHBG005020
InParanoidiP19367
KOiK00844
OMAiYDDQQCE
PhylomeDBiP19367
TreeFamiTF314238

Family and domain databases

InterProiView protein in InterPro
IPR001312 Hexokinase
IPR019807 Hexokinase_BS
IPR022673 Hexokinase_C
IPR022672 Hexokinase_N
PANTHERiPTHR19443 PTHR19443, 4 hits
PfamiView protein in Pfam
PF00349 Hexokinase_1, 2 hits
PF03727 Hexokinase_2, 2 hits
PROSITEiView protein in PROSITE
PS00378 HEXOKINASE_1, 2 hits
PS51748 HEXOKINASE_2, 2 hits

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P19367-1) [UniParc]FASTAAdd to basket
Also known as: Common

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIAAQLLAYY FTELKDDQVK KIDKYLYAMR LSDETLIDIM TRFRKEMKNG
60 70 80 90 100
LSRDFNPTAT VKMLPTFVRS IPDGSEKGDF IALDLGGSSF RILRVQVNHE
110 120 130 140 150
KNQNVHMESE VYDTPENIVH GSGSQLFDHV AECLGDFMEK RKIKDKKLPV
160 170 180 190 200
GFTFSFPCQQ SKIDEAILIT WTKRFKASGV EGADVVKLLN KAIKKRGDYD
210 220 230 240 250
ANIVAVVNDT VGTMMTCGYD DQHCEVGLII GTGTNACYME ELRHIDLVEG
260 270 280 290 300
DEGRMCINTE WGAFGDDGSL EDIRTEFDRE IDRGSLNPGK QLFEKMVSGM
310 320 330 340 350
YLGELVRLIL VKMAKEGLLF EGRITPELLT RGKFNTSDVS AIEKNKEGLH
360 370 380 390 400
NAKEILTRLG VEPSDDDCVS VQHVCTIVSF RSANLVAATL GAILNRLRDN
410 420 430 440 450
KGTPRLRTTV GVDGSLYKTH PQYSRRFHKT LRRLVPDSDV RFLLSESGSG
460 470 480 490 500
KGAAMVTAVA YRLAEQHRQI EETLAHFHLT KDMLLEVKKR MRAEMELGLR
510 520 530 540 550
KQTHNNAVVK MLPSFVRRTP DGTENGDFLA LDLGGTNFRV LLVKIRSGKK
560 570 580 590 600
RTVEMHNKIY AIPIEIMQGT GEELFDHIVS CISDFLDYMG IKGPRMPLGF
610 620 630 640 650
TFSFPCQQTS LDAGILITWT KGFKATDCVG HDVVTLLRDA IKRREEFDLD
660 670 680 690 700
VVAVVNDTVG TMMTCAYEEP TCEVGLIVGT GSNACYMEEM KNVEMVEGDQ
710 720 730 740 750
GQMCINMEWG AFGDNGCLDD IRTHYDRLVD EYSLNAGKQR YEKMISGMYL
760 770 780 790 800
GEIVRNILID FTKKGFLFRG QISETLKTRG IFETKFLSQI ESDRLALLQV
810 820 830 840 850
RAILQQLGLN STCDDSILVK TVCGVVSRRA AQLCGAGMAA VVDKIRENRG
860 870 880 890 900
LDRLNVTVGV DGTLYKLHPH FSRIMHQTVK ELSPKCNVSF LLSEDGSGKG
910
AALITAVGVR LRTEASS
Length:917
Mass (Da):102,486
Last modified:October 17, 2006 - v3
Checksum:iF29A6837531C0594
GO
Isoform 2 (identifier: P19367-2) [UniParc]FASTAAdd to basket
Also known as: Erythrocyte, R

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MIAAQLLAYYFTELKDDQVKK → MDCEHSLSLPCRGAEAWEIG

Show »
Length:916
Mass (Da):102,201
Checksum:i6E528FC4BEC5100B
GO
Isoform 3 (identifier: P19367-3) [UniParc]FASTAAdd to basket
Also known as: TA, TB

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MIAAQLLAYYFTELKDDQVKK → MGQICQRESATAAEKPKLHLLAESE

Show »
Length:921
Mass (Da):102,738
Checksum:i329F41F87DF6E1D1
GO
Isoform 4 (identifier: P19367-4) [UniParc]FASTAAdd to basket
Also known as: TD

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MIAAQLLAYYFTELKDDQVKK → MAKRALHDF

Show »
Length:905
Mass (Da):101,085
Checksum:iAE1BC4A3D2604AB0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti730D → N in AAA52646 (PubMed:3207429).Curated1
Sequence conflicti730D → N in CAA47379 (PubMed:1637300).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_009878529L → S in HK deficiency. 1 PublicationCorresponds to variant dbSNP:rs137853249Ensembl.1
Natural variantiVAR_023780680T → S in HK deficiency; HK Utrecht. 1 PublicationCorresponds to variant dbSNP:rs398122379Ensembl.1
Natural variantiVAR_023781776L → M2 PublicationsCorresponds to variant dbSNP:rs1054203Ensembl.1
Natural variantiVAR_078923847E → K in RP79; unknown pathological significance; no effect on hexokinase activity; no effect on protein abundance. 2 PublicationsCorresponds to variant dbSNP:rs777849213Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0020711 – 21MIAAQ…DQVKK → MDCEHSLSLPCRGAEAWEIG in isoform 2. CuratedAdd BLAST21
Alternative sequenceiVSP_0020721 – 21MIAAQ…DQVKK → MGQICQRESATAAEKPKLHL LAESE in isoform 3. CuratedAdd BLAST21
Alternative sequenceiVSP_0020731 – 21MIAAQ…DQVKK → MAKRALHDF in isoform 4. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75126 mRNA Translation: AAA52646.1
AF016365
, AF016349, AF016351, AF016352, AF016353, AF016354, AF016355, AF016356, AF016357, AF016358, AF016359, AF016360, AF016361, AF016362, AF016363, AF016364 Genomic DNA Translation: AAC15862.1
AF016365
, AF016349, AF016351, AF016352, AF016353, AF016354, AF016355, AF016356, AF016357, AF016358, AF016359, AF016360, AF016361, AF016362, AF016363, AF016364 Genomic DNA Translation: AAC15863.1
AF016365
, AF163910, AF163911, AF016351, AF016352, AF016353, AF016354, AF016355, AF016356, AF016357, AF016358, AF016359, AF016360, AF016361, AF016362, AF016363, AF016364 Genomic DNA Translation: AAF82319.1
AF016365
, AF163912, AF016351, AF016352, AF016353, AF016354, AF016355, AF016356, AF016357, AF016358, AF016359, AF016360, AF016361, AF016362, AF016363, AF016364 Genomic DNA Translation: AAF82320.1
AC016821 Genomic DNA No translation available.
AL596223 Genomic DNA No translation available.
AL672126 Genomic DNA No translation available.
BC008730 mRNA Translation: AAH08730.1
AF073786 mRNA Translation: AAC25424.1
AF029306 Genomic DNA Translation: AAC00172.1
X66957 mRNA Translation: CAA47379.1
CCDSiCCDS7289.1 [P19367-3]
CCDS7290.1 [P19367-4]
CCDS7291.1 [P19367-2]
CCDS7292.1 [P19367-1]
PIRiA31869
RefSeqiNP_000179.2, NM_000188.2 [P19367-1]
NP_001309293.1, NM_001322364.1 [P19367-3]
NP_277031.1, NM_033496.2 [P19367-2]
NP_277032.1, NM_033497.2 [P19367-3]
NP_277033.1, NM_033498.2 [P19367-3]
NP_277035.2, NM_033500.2 [P19367-4]
XP_011538034.1, XM_011539732.1 [P19367-4]
UniGeneiHs.370365

Genome annotation databases

EnsembliENST00000298649; ENSP00000298649; ENSG00000156515 [P19367-2]
ENST00000359426; ENSP00000352398; ENSG00000156515 [P19367-1]
ENST00000360289; ENSP00000353433; ENSG00000156515 [P19367-4]
ENST00000436817; ENSP00000415949; ENSG00000156515 [P19367-3]
ENST00000448642; ENSP00000402103; ENSG00000156515 [P19367-3]
ENST00000643399; ENSP00000494664; ENSG00000156515 [P19367-3]
GeneIDi3098
KEGGihsa:3098
UCSCiuc001jpg.5 human [P19367-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHXK1_HUMAN
AccessioniPrimary (citable) accession number: P19367
Secondary accession number(s): E9PCK0
, O43443, O43444, O75574, Q5VTC3, Q96HC8, Q9NNZ4, Q9NNZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 17, 2006
Last modified: July 18, 2018
This is version 217 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

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