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UniProtKB - P19360 (ASCL2_RAT)
Protein
Achaete-scute homolog 2
Gene
Ascl2
Organism
Rattus norvegicus (Rat)
Status
Functioni
AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.
GO - Molecular functioni
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
- E-box binding Source: RGD
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- cell differentiation Source: RGD
- in utero embryonic development Source: RGD
- negative regulation of Schwann cell proliferation Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- neuron differentiation Source: GO_Central
- placenta development Source: RGD
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of neurogenesis Source: GO_Central
- regulation of transcription by RNA polymerase II Source: RGD
- response to hypoxia Source: RGD
- sensory organ development Source: GO_Central
- somatic stem cell population maintenance Source: RGD
- spongiotrophoblast differentiation Source: RGD
- spongiotrophoblast layer development Source: RGD
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Differentiation, Neurogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: Achaete-scute homolog 2Alternative name(s): Mash2 |
Gene namesi | Name:Ascl2 Synonyms:Ash2, Mash-2, Mash2 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2159, Ascl2 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: RGD
- RNA polymerase II transcription regulator complex Source: GO_Central
Other locations
- cytoplasm Source: RGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127132 | 1 – 260 | Achaete-scute homolog 2Add BLAST | 260 |
Proteomic databases
PaxDbi | P19360 |
PRIDEi | P19360 |
Expressioni
Tissue specificityi
Neuronal precursor cells.
Gene expression databases
Bgeei | ENSRNOG00000020434, Expressed in testis and 20 other tissues |
Genevisiblei | P19360, RN |
Interactioni
Subunit structurei
Efficient DNA binding requires dimerization with another bHLH protein.
Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity (By similarity).
By similarityGO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000027688 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 118 – 170 | bHLHPROSITE-ProRule annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 85 – 126 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 191 – 239 | DisorderedSequence analysisAdd BLAST | 49 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 194 – 239 | Polar residuesSequence analysisAdd BLAST | 46 |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000163041 |
HOGENOMi | CLU_063523_3_0_1 |
InParanoidi | P19360 |
OMAi | ACPRESC |
OrthoDBi | 1131543at2759 |
PhylomeDBi | P19360 |
TreeFami | TF322889 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR015660, MASH1/Ascl1a-like |
PANTHERi | PTHR13935, PTHR13935, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
P19360-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MESHFNWYGV PRLQKASDAC PRESCSSALP EAREGANVHF PPHPVPREHF
60 70 80 90 100
SCGAPKPVAG APALNASLMD GGALPRLVPT SSGVAGACTA RRRPPSPELL
110 120 130 140 150
RCSRRRRSGA TEASSSSAAV ARRNERERNR VKLVNLGFQA LRQHVPHGGA
160 170 180 190 200
NKKLSKVETL RSAVEYIRAL QRLLAEHDAV RAALSGGLLT PATRPSDVCT
210 220 230 240 250
QPSASPASAS LSCTSTSPDR LGCSEPASPR SAYSSEDSSC EGETYPMGQM
260
FDFSNWLGGY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53724 mRNA Translation: CAA37759.1 |
PIRi | S11562 |
RefSeqi | NP_113691.1, NM_031503.2 |
Genome annotation databases
Ensembli | ENSRNOT00000027688; ENSRNOP00000027688; ENSRNOG00000020434 |
GeneIDi | 24209 |
KEGGi | rno:24209 |
UCSCi | RGD:2159, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53724 mRNA Translation: CAA37759.1 |
PIRi | S11562 |
RefSeqi | NP_113691.1, NM_031503.2 |
3D structure databases
AlphaFoldDBi | P19360 |
SMRi | P19360 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000027688 |
Proteomic databases
PaxDbi | P19360 |
PRIDEi | P19360 |
Genome annotation databases
Ensembli | ENSRNOT00000027688; ENSRNOP00000027688; ENSRNOG00000020434 |
GeneIDi | 24209 |
KEGGi | rno:24209 |
UCSCi | RGD:2159, rat |
Organism-specific databases
CTDi | 430 |
RGDi | 2159, Ascl2 |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000163041 |
HOGENOMi | CLU_063523_3_0_1 |
InParanoidi | P19360 |
OMAi | ACPRESC |
OrthoDBi | 1131543at2759 |
PhylomeDBi | P19360 |
TreeFami | TF322889 |
Miscellaneous databases
PROi | PR:P19360 |
Gene expression databases
Bgeei | ENSRNOG00000020434, Expressed in testis and 20 other tissues |
Genevisiblei | P19360, RN |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR015660, MASH1/Ascl1a-like |
PANTHERi | PTHR13935, PTHR13935, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ASCL2_RAT | |
Accessioni | P19360Primary (citable) accession number: P19360 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | November 1, 1990 | |
Last modified: | May 25, 2022 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |