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UniProtKB - P19335 (MYF6_RAT)
Protein
Myogenic factor 6
Gene
Myf6
Organism
Rattus norvegicus (Rat)
Status
Functioni
Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein. May play a role in controlling terminal differentiation events.
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- muscle tissue morphogenesis Source: RGD
- negative regulation of transcription, DNA-templated Source: RGD
- positive regulation of myoblast differentiation Source: GO_Central
- positive regulation of skeletal muscle fiber development Source: GO_Central
- positive regulation of transcription, DNA-templated Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- skeletal muscle cell differentiation Source: RGD
- skeletal muscle tissue development Source: RGD
- skeletal muscle tissue regeneration Source: RGD
- somitogenesis Source: RGD
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Differentiation, Myogenesis |
Enzyme and pathway databases
Reactomei | R-RNO-525793, Myogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: Myogenic factor 6Short name: Myf-6 Alternative name(s): Muscle-specific regulatory factor 4 |
Gene namesi | Name:Myf6 Synonyms:Mrf4 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3134, Myf6 |
Subcellular locationi
Nucleus
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127354 | 1 – 242 | Myogenic factor 6Add BLAST | 242 |
Proteomic databases
PaxDbi | P19335 |
PTM databases
iPTMneti | P19335 |
PhosphoSitePlusi | P19335 |
Expressioni
Tissue specificityi
Skeletal muscle in late fetal and adult rats.
Gene expression databases
Bgeei | ENSRNOG00000004878, Expressed in skeletal muscle tissue and 12 other tissues |
Genevisiblei | P19335, RN |
Interactioni
Subunit structurei
Efficient DNA binding requires dimerization with another bHLH protein.
Interacts with CSRP3.
1 PublicationGO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
DIPi | DIP-485N |
IntActi | P19335, 1 interactor |
STRINGi | 10116.ENSRNOP00000006523 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 93 – 144 | bHLHPROSITE-ProRule annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 31 – 63 | DisorderedSequence analysisAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 38 – 54 | Polar residuesSequence analysisAdd BLAST | 17 |
Phylogenomic databases
eggNOGi | KOG3960, Eukaryota |
GeneTreei | ENSGT00950000182959 |
HOGENOMi | CLU_100258_0_0_1 |
InParanoidi | P19335 |
OMAi | SPCQDQI |
OrthoDBi | 1471470at2759 |
PhylomeDBi | P19335 |
TreeFami | TF316344 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR002546, MyoD_N IPR039704, Myogenic_factor |
PANTHERi | PTHR11534, PTHR11534, 1 hit |
Pfami | View protein in Pfam PF01586, Basic, 1 hit PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00520, BASIC, 1 hit SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P19335-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMMDLFETGS YFFYLDGENV TLQPLEVAEG SPLYPGSDGT LSPCQDQMPQ
60 70 80 90 100
EAGSDSSGEE HVLAPPGLQP PHCPGQCLIW ACKTCKRKSA PTDRRKAATL
110 120 130 140 150
RERRRLKKIN EAFEALKRRT VANPNQRLPK VEILRSAINY IERLQDLLHR
160 170 180 190 200
LDQQEKMQEL GVDPYSYKPK QEILEGADFL RTCSPQWPSV SDHSRGLVIT
210 220 230 240
AKEGGASVDA SASSSLQRLS SIVDSISSEE RKLPSVEEVV EK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A8I6A0M5 | A0A8I6A0M5_RAT | Myogenic factor 6 | Myf6 | 338 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M27151 mRNA Translation: AAA41636.1 M84685 Genomic DNA Translation: AAA41635.1 |
PIRi | JC1233 |
RefSeqi | NP_037304.1, NM_013172.2 |
Genome annotation databases
Ensembli | ENSRNOT00000006523; ENSRNOP00000006523; ENSRNOG00000004878 |
GeneIDi | 25714 |
KEGGi | rno:25714 |
UCSCi | RGD:3134, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M27151 mRNA Translation: AAA41636.1 M84685 Genomic DNA Translation: AAA41635.1 |
PIRi | JC1233 |
RefSeqi | NP_037304.1, NM_013172.2 |
3D structure databases
AlphaFoldDBi | P19335 |
SMRi | P19335 |
ModBasei | Search... |
Protein-protein interaction databases
DIPi | DIP-485N |
IntActi | P19335, 1 interactor |
STRINGi | 10116.ENSRNOP00000006523 |
PTM databases
iPTMneti | P19335 |
PhosphoSitePlusi | P19335 |
Proteomic databases
PaxDbi | P19335 |
Genome annotation databases
Ensembli | ENSRNOT00000006523; ENSRNOP00000006523; ENSRNOG00000004878 |
GeneIDi | 25714 |
KEGGi | rno:25714 |
UCSCi | RGD:3134, rat |
Organism-specific databases
CTDi | 4618 |
RGDi | 3134, Myf6 |
Phylogenomic databases
eggNOGi | KOG3960, Eukaryota |
GeneTreei | ENSGT00950000182959 |
HOGENOMi | CLU_100258_0_0_1 |
InParanoidi | P19335 |
OMAi | SPCQDQI |
OrthoDBi | 1471470at2759 |
PhylomeDBi | P19335 |
TreeFami | TF316344 |
Enzyme and pathway databases
Reactomei | R-RNO-525793, Myogenesis |
Miscellaneous databases
PROi | PR:P19335 |
Gene expression databases
Bgeei | ENSRNOG00000004878, Expressed in skeletal muscle tissue and 12 other tissues |
Genevisiblei | P19335, RN |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR002546, MyoD_N IPR039704, Myogenic_factor |
PANTHERi | PTHR11534, PTHR11534, 1 hit |
Pfami | View protein in Pfam PF01586, Basic, 1 hit PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00520, BASIC, 1 hit SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MYF6_RAT | |
Accessioni | P19335Primary (citable) accession number: P19335 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | November 1, 1990 | |
Last modified: | May 25, 2022 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |