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Protein

Myogenic factor 6

Gene

Myf6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein. May play a role in controlling terminal differentiation events.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Myogenesis

Enzyme and pathway databases

ReactomeiR-RNO-375170 CDO in myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Myogenic factor 6
Short name:
Myf-6
Alternative name(s):
Muscle-specific regulatory factor 4
Gene namesi
Name:Myf6
Synonyms:Mrf4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi3134 Myf6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001273541 – 242Myogenic factor 6Add BLAST242

Proteomic databases

PaxDbiP19335
PRIDEiP19335

PTM databases

iPTMnetiP19335
PhosphoSitePlusiP19335

Expressioni

Tissue specificityi

Skeletal muscle in late fetal and adult rats.

Gene expression databases

BgeeiENSRNOG00000004878 Expressed in 2 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiP19335 RN

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Interacts with CSRP3.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-485N
IntActiP19335, 1 interactor
STRINGi10116.ENSRNOP00000006523

Structurei

3D structure databases

ProteinModelPortaliP19335
SMRiP19335
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 144bHLHPROSITE-ProRule annotationAdd BLAST52

Phylogenomic databases

eggNOGiKOG3960 Eukaryota
ENOG4111SED LUCA
GeneTreeiENSGT00530000063004
HOGENOMiHOG000234799
HOVERGENiHBG006429
InParanoidiP19335
KOiK18485
OMAiDQQDKMQ
OrthoDBiEOG091G0GKD
PhylomeDBiP19335
TreeFamiTF316344

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR002546 Basic
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF01586 Basic, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00520 BASIC, 1 hit
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

P19335-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMMDLFETGS YFFYLDGENV TLQPLEVAEG SPLYPGSDGT LSPCQDQMPQ
60 70 80 90 100
EAGSDSSGEE HVLAPPGLQP PHCPGQCLIW ACKTCKRKSA PTDRRKAATL
110 120 130 140 150
RERRRLKKIN EAFEALKRRT VANPNQRLPK VEILRSAINY IERLQDLLHR
160 170 180 190 200
LDQQEKMQEL GVDPYSYKPK QEILEGADFL RTCSPQWPSV SDHSRGLVIT
210 220 230 240
AKEGGASVDA SASSSLQRLS SIVDSISSEE RKLPSVEEVV EK
Length:242
Mass (Da):26,987
Last modified:November 1, 1990 - v1
Checksum:i4EFD739BB6C4F6C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27151 mRNA Translation: AAA41636.1
M84685 Genomic DNA Translation: AAA41635.1
PIRiJC1233
RefSeqiNP_037304.1, NM_013172.2
UniGeneiRn.2236

Genome annotation databases

EnsembliENSRNOT00000006523; ENSRNOP00000006523; ENSRNOG00000004878
GeneIDi25714
KEGGirno:25714
UCSCiRGD:3134 rat

Similar proteinsi

Entry informationi

Entry nameiMYF6_RAT
AccessioniPrimary (citable) accession number: P19335
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: September 12, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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