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Protein

Alpha-2B adrenergic receptor

Gene

Adra2b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei97Implicated in ligand bindingBy similarity1
Sitei181Implicated in catechol agonist bindingBy similarity1
Sitei185Implicated in catechol agonist bindingBy similarity1

GO - Molecular functioni

  • adrenergic receptor activity Source: GO_Central
  • alpha2-adrenergic receptor activity Source: RGD
  • epinephrine binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-390696 Adrenoceptors
R-RNO-392023 Adrenaline signalling through Alpha-2 adrenergic receptor
R-RNO-418594 G alpha (i) signalling events
R-RNO-418597 G alpha (z) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2B adrenergic receptor
Alternative name(s):
Alpha-2B adrenoreceptor
Short name:
Alpha-2B adrenoceptor
Short name:
Alpha-2BAR
Gene namesi
Name:Adra2b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi2057 Adra2b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17ExtracellularBy similarityAdd BLAST17
Transmembranei18 – 42Helical; Name=1By similarityAdd BLAST25
Topological domaini43 – 54CytoplasmicBy similarityAdd BLAST12
Transmembranei55 – 80Helical; Name=2By similarityAdd BLAST26
Topological domaini81 – 90ExtracellularBy similarity10
Transmembranei91 – 113Helical; Name=3By similarityAdd BLAST23
Topological domaini114 – 135CytoplasmicBy similarityAdd BLAST22
Transmembranei136 – 158Helical; Name=4By similarityAdd BLAST23
Topological domaini159 – 174ExtracellularBy similarityAdd BLAST16
Transmembranei175 – 198Helical; Name=5By similarityAdd BLAST24
Topological domaini199 – 375CytoplasmicBy similarityAdd BLAST177
Transmembranei376 – 399Helical; Name=6By similarityAdd BLAST24
Topological domaini400 – 408ExtracellularBy similarity9
Transmembranei409 – 432Helical; Name=7By similarityAdd BLAST24
Topological domaini433 – 453CytoplasmicBy similarityAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL266
GuidetoPHARMACOLOGYi26

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691001 – 453Alpha-2B adrenergic receptorAdd BLAST453

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi90 ↔ 169PROSITE-ProRule annotation
Lipidationi445S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP19328
PRIDEiP19328

PTM databases

PhosphoSitePlusiP19328

Expressioni

Gene expression databases

BgeeiENSRNOG00000013887 Expressed in 7 organ(s), highest expression level in adult mammalian kidney
GenevisibleiP19328 RN

Interactioni

Subunit structurei

Interacts with RAB26. Interacts with PPP1R9B.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018584

Chemistry databases

BindingDBiP19328

Structurei

3D structure databases

ProteinModelPortaliP19328
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi300 – 314Asp/Glu-rich (acidic)Add BLAST15

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139331
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP19328
KOiK04139
OMAiTWCEVYL
OrthoDBiEOG091G06VI
PhylomeDBiP19328
TreeFamiTF316350

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR000207 ADRA2B_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00559 ADRENRGCA2BR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P19328-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGPTMDHQE PYSVQATAAI ASAITFLILF TIFGNALVIL AVLTSRSLRA
60 70 80 90 100
PQNLFLVSLA AADILVATLI IPFSLANELL GYWYFWRAWC EVYLALDVLF
110 120 130 140 150
CTSSIVHLCA ISLDRYWAVS RALEYNSKRT PRRIKCIILT VWLIAAVISL
160 170 180 190 200
PPLIYKGDQR PEPRGLPQCE LNQEAWYILA SSIGSFFAPC LIMILVYLRI
210 220 230 240 250
YVIAKRSHCR GLGAKRGSGE GESKKPQPVA GGVPTSAKVP TLVSPLSSVG
260 270 280 290 300
EANGHPKPPR EKEEGETPED PEARALPPTW SALPRSGQGQ KKGTSGATAE
310 320 330 340 350
EGDEEDEEEV EECEPQTLPA SPASVCNPPL QQPQTSRVLA TLRGQVLLGK
360 370 380 390 400
NVGVASGQWW RRRTQLSREK RFTFVLAVVI GVFVVCWFPF FFSYSLGAIC
410 420 430 440 450
PQHCKVPHGL FQFFFWIGYC NSSLNPVIYT VFNQDFRRAF RRILCRPWTQ

TGW
Length:453
Mass (Da):50,369
Last modified:October 10, 2003 - v2
Checksum:iCBA69CE23EACB511
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132R → C in AAA40635 (PubMed:2158103).Curated1
Sequence conflicti162 – 163EP → DA in AAA40635 (PubMed:2158103).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32061 mRNA Translation: AAA40635.1
AF366899 Genomic DNA Translation: AAK53388.1
X74400 Genomic DNA Translation: CAA52411.1
PIRiA35642
I51883
RefSeqiNP_612514.2, NM_138505.2
UniGeneiRn.10296

Genome annotation databases

EnsembliENSRNOT00000018584; ENSRNOP00000018584; ENSRNOG00000013887
GeneIDi24174
KEGGirno:24174
UCSCiRGD:2057 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32061 mRNA Translation: AAA40635.1
AF366899 Genomic DNA Translation: AAK53388.1
X74400 Genomic DNA Translation: CAA52411.1
PIRiA35642
I51883
RefSeqiNP_612514.2, NM_138505.2
UniGeneiRn.10296

3D structure databases

ProteinModelPortaliP19328
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018584

Chemistry databases

BindingDBiP19328
ChEMBLiCHEMBL266
GuidetoPHARMACOLOGYi26

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP19328

Proteomic databases

PaxDbiP19328
PRIDEiP19328

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018584; ENSRNOP00000018584; ENSRNOG00000013887
GeneIDi24174
KEGGirno:24174
UCSCiRGD:2057 rat

Organism-specific databases

CTDi151
RGDi2057 Adra2b

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139331
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP19328
KOiK04139
OMAiTWCEVYL
OrthoDBiEOG091G06VI
PhylomeDBiP19328
TreeFamiTF316350

Enzyme and pathway databases

ReactomeiR-RNO-390696 Adrenoceptors
R-RNO-392023 Adrenaline signalling through Alpha-2 adrenergic receptor
R-RNO-418594 G alpha (i) signalling events
R-RNO-418597 G alpha (z) signalling events

Miscellaneous databases

PROiPR:P19328

Gene expression databases

BgeeiENSRNOG00000013887 Expressed in 7 organ(s), highest expression level in adult mammalian kidney
GenevisibleiP19328 RN

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR000207 ADRA2B_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00559 ADRENRGCA2BR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADA2B_RAT
AccessioniPrimary (citable) accession number: P19328
Secondary accession number(s): Q63021, Q925E4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 10, 2003
Last modified: November 7, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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