VCAM1

Functionⁱ

Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.

GO - Molecular functionⁱ

cell adhesion molecule binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 1377228
integrin binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 1377228
- 15220135
primary amine oxidase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 23474851

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

acute inflammatory response Source: Ensembl
aging Source: Ensembl
amine metabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 23474851
B cell differentiation
Source: BHF-UCL
Inferred by curatorⁱ
- 1715889
calcium-mediated signaling using intracellular calcium source
Source: UniProtKB
Inferred from genetic interactionⁱ
- 15879141
cardiac neuron differentiation Source: Ensembl
cell adhesion
Source: BHF-UCL
Inferred from direct assayⁱ
- 16809613
cell chemotaxis Source: Ensembl
cell-matrix adhesion
Source: UniProtKB
Inferred from direct assayⁱ
- 18308860
cellular response to tumor necrosis factor Source: Ensembl
cellular response to vascular endothelial growth factor stimulus Source: Ensembl
chronic inflammatory response Source: Ensembl
cytokine-mediated signaling pathway Source: Reactome
extracellular matrix organization Source: Reactome
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
Source: BHF-UCL
Inferred from direct assayⁱ
- 1715889
innervation Source: Ensembl
interferon-gamma-mediated signaling pathway Source: Reactome
leukocyte cell-cell adhesion
Source: BHF-UCL
Inferred from direct assayⁱ
leukocyte tethering or rolling
Source: UniProtKB
Inferred from direct assayⁱ
- 18308860
membrane to membrane docking
Source: BHF-UCL
Inferred from expression patternⁱ
- 12082081
positive regulation of T cell proliferation
Source: BHF-UCL
Inferred from direct assayⁱ
- 1381355
regulation of immune response Source: Reactome
response to ethanol Source: Ensembl
response to hypoxia Source: Ensembl
response to ionizing radiation Source: Ensembl
response to lipopolysaccharide Source: Ensembl
response to nicotine Source: Ensembl
response to nutrient Source: Ensembl
response to zinc ion Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell adhesion

Biological process

Cell adhesion

Enzyme and pathway databases

Reactomeⁱ	R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-216083 Integrin cell surface interactions R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling R-HSA-877300 Interferon gamma signaling
SIGNORⁱ	P19320

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Vascular cell adhesion protein 1 Short name: V-CAM 1 Short name: VCAM-1 Alternative name(s): INCAM-100 CD_antigen: CD106
Gene namesⁱ	Name:VCAM1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000162692.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12663 VCAM1
MIMⁱ	192225 gene
neXtProtⁱ	NX_P19320

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	25 – 698	ExtracellularSequence analysisAdd BLAST	674
Transmembraneⁱ	699 – 720	HelicalSequence analysisAdd BLAST	22
Topological domainⁱ	721 – 739	CytoplasmicSequence analysisAdd BLAST	19

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7412
Open Targets More...OpenTargetsⁱ	ENSG00000162692
PharmGKBⁱ	PA37286

Chemistry databases

ChEMBLⁱ	CHEMBL3735
Drug and drug target database More...DrugBankⁱ	DB05399 AGI-1067 DB01136 Carvedilol DB00898 Ethanol

Polymorphism and mutation databases

BioMutaⁱ	VCAM1
DMDMⁱ	137560

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 24	1 PublicationAdd BLAST		24
ChainⁱPRO_0000014997	25 – 739	Vascular cell adhesion protein 1Add BLAST		715

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	47 ↔ 95	1 Publication
Disulfide bondⁱ	52 ↔ 99	1 Publication
Disulfide bondⁱ	137 ↔ 195	1 Publication
Disulfide bondⁱ	246 ↔ 291	PROSITE-ProRule annotation
Glycosylationⁱ	273	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	335 ↔ 383	PROSITE-ProRule annotation
Glycosylationⁱ	365	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	417	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	463	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	531	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	534 ↔ 579	PROSITE-ProRule annotation
Glycosylationⁱ	561	N-linked (GlcNAc...) asparagine1 Publication	1

Post-translational modificationⁱ

Sialoglycoprotein.

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P19320
PaxDbⁱ	P19320
PeptideAtlas More...PeptideAtlasⁱ	P19320
PRIDEⁱ	P19320
ProteomicsDBⁱ	53645 53646 [P19320-2]

PTM databases

iPTMnetⁱ	P19320
PhosphoSitePlusⁱ	P19320

Miscellaneous databases

PMAP-CutDBⁱ	P19320

PMAP-CutDBⁱ

P19320

Expressionⁱ

Tissue specificityⁱ

Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.

Inductionⁱ

By cytokines (e.g. IL-1, TNF-alpha).

Gene expression databases

Bgeeⁱ	ENSG00000162692 Expressed in 204 organ(s), highest expression level in tendon
CleanExⁱ	HS_L1CAM HS_VCAM1
ExpressionAtlasⁱ	P19320 baseline and differential
Genevisibleⁱ	P19320 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB000154 HPA034796 HPA069867

HPAⁱ

CAB000154
HPA034796
HPA069867

Interactionⁱ

GO - Molecular functionⁱ

cell adhesion molecule binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 1377228
integrin binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 1377228
- 15220135

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113255, 452 interactors
CORUMⁱ	P19320
IntActⁱ	P19320, 630 interactors
STRINGⁱ	9606.ENSP00000294728

Chemistry databases

BindingDBⁱ

P19320

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	26 – 38	Combined sources	13
Beta strandⁱ	43 – 51	Combined sources	9
Beta strandⁱ	56 – 61	Combined sources	6
Beta strandⁱ	68 – 74	Combined sources	7
Beta strandⁱ	77 – 84	Combined sources	8
Helixⁱ	87 – 89	Combined sources	3
Beta strandⁱ	91 – 99	Combined sources	9
Beta strandⁱ	102 – 114	Combined sources	13
Beta strandⁱ	120 – 125	Combined sources	6
Beta strandⁱ	133 – 144	Combined sources	12
Helixⁱ	145 – 147	Combined sources	3
Beta strandⁱ	148 – 154	Combined sources	7
Beta strandⁱ	157 – 163	Combined sources	7
Beta strandⁱ	169 – 171	Combined sources	3
Beta strandⁱ	174 – 182	Combined sources	9
Helixⁱ	186 – 188	Combined sources	3
Beta strandⁱ	192 – 199	Combined sources	8
Beta strandⁱ	209 – 216	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	P19320
SMRⁱ	P19320
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P19320

EvolutionaryTraceⁱ

P19320

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	25 – 105	Ig-like C2-type 1Add BLAST	81
Domainⁱ	109 – 212	Ig-like C2-type 2Add BLAST	104
Domainⁱ	223 – 309	Ig-like C2-type 3Add BLAST	87
Domainⁱ	312 – 399	Ig-like C2-type 4Add BLAST	88
Domainⁱ	408 – 506	Ig-like C2-type 5Add BLAST	99
Domainⁱ	511 – 595	Ig-like C2-type 6Add BLAST	85
Domainⁱ	600 – 684	Ig-like C2-type 7Add BLAST	85

Domainⁱ

Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IIKS Eukaryota ENOG4111F4V LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00830000128299
HOGENOMⁱ	HOG000004820
HOVERGENⁱ	HBG053965
InParanoidⁱ	P19320
KEGG Orthology (KO) More...KOⁱ	K06527
OMAⁱ	ECESKNE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0590
PhylomeDBⁱ	P19320
TreeFamⁱ	TF333571

Family and domain databases

Gene3Dⁱ	2.60.40.10, 7 hits
InterProⁱ	View protein in InterPro IPR003987 ICAM_VCAM_N IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR008424 Ig_C2-set IPR013098 Ig_I-set IPR003599 Ig_sub IPR003598 Ig_sub2 IPR013106 Ig_V-set IPR013151 Immunoglobulin IPR003989 VCAM-1
PANTHERⁱ	PTHR44644 PTHR44644, 3 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05790 C2-set, 2 hits PF07679 I-set, 3 hits PF00047 ig, 1 hit
PRINTSⁱ	PR01472 ICAMVCAM1 PR01474 VCAM1
SMARTⁱ	View protein in SMART SM00409 IG, 5 hits SM00408 IGc2, 5 hits SM00406 IGv, 2 hits
SUPFAMⁱ	SSF48726 SSF48726, 7 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 5 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist.

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P19320-1) [UniParc]FASTA Add to basket

Also known as: Long, VCAM-7D

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGKMVVILG ASNILWIMFA ASQAFKIETT PESRYLAQIG DSVSLTCSTT 
        60         70         80         90        100
GCESPFFSWR TQIDSPLNGK VTNEGTTSTL TMNPVSFGNE HSYLCTATCE 
       110        120        130        140        150
SRKLEKGIQV EIYSFPKDPE IHLSGPLEAG KPITVKCSVA DVYPFDRLEI 
       160        170        180        190        200
DLLKGDHLMK SQEFLEDADR KSLETKSLEV TFTPVIEDIG KVLVCRAKLH 
       210        220        230        240        250
IDEMDSVPTV RQAVKELQVY ISPKNTVISV NPSTKLQEGG SVTMTCSSEG 
       260        270        280        290        300
LPAPEIFWSK KLDNGNLQHL SGNATLTLIA MRMEDSGIYV CEGVNLIGKN 
       310        320        330        340        350
RKEVELIVQE KPFTVEISPG PRIAAQIGDS VMLTCSVMGC ESPSFSWRTQ 
       360        370        380        390        400
IDSPLSGKVR SEGTNSTLTL SPVSFENEHS YLCTVTCGHK KLEKGIQVEL 
       410        420        430        440        450
YSFPRDPEIE MSGGLVNGSS VTVSCKVPSV YPLDRLEIEL LKGETILENI 
       460        470        480        490        500
EFLEDTDMKS LENKSLEMTF IPTIEDTGKA LVCQAKLHID DMEFEPKQRQ 
       510        520        530        540        550
STQTLYVNVA PRDTTVLVSP SSILEEGSSV NMTCLSQGFP APKILWSRQL 
       560        570        580        590        600
PNGELQPLSE NATLTLISTK MEDSGVYLCE GINQAGRSRK EVELIIQVTP 
       610        620        630        640        650
KDIKLTAFPS ESVKEGDTVI ISCTCGNVPE TWIILKKKAE TGDTVLKSID 
       660        670        680        690        700
GAYTIRKAQL KDAGVYECES KNKVGSQLRS LTLDVQGREN NKDYFSPELL 
       710        720        730 
VLYFASSLII PAIGMIIYFA RKANMKGSYS LVEAQKSKV

Note: Major isoform.

Length:739

Mass (Da):81,276

Last modified:November 1, 1990 - v1

Checksum:ⁱ050E2EBD39AC2FF4

GO

Isoform 2 (identifier: P19320-2) [UniParc]FASTA Add to basket

Also known as: Short, VCAM-6D

The sequence of this isoform differs from the canonical sequence as follows:
310-402: EKPFTVEISP...EKGIQVELYS → A

« Hide

        10         20         30         40         50
MPGKMVVILG ASNILWIMFA ASQAFKIETT PESRYLAQIG DSVSLTCSTT 
        60         70         80         90        100
GCESPFFSWR TQIDSPLNGK VTNEGTTSTL TMNPVSFGNE HSYLCTATCE 
       110        120        130        140        150
SRKLEKGIQV EIYSFPKDPE IHLSGPLEAG KPITVKCSVA DVYPFDRLEI 
       160        170        180        190        200
DLLKGDHLMK SQEFLEDADR KSLETKSLEV TFTPVIEDIG KVLVCRAKLH 
       210        220        230        240        250
IDEMDSVPTV RQAVKELQVY ISPKNTVISV NPSTKLQEGG SVTMTCSSEG 
       260        270        280        290        300
LPAPEIFWSK KLDNGNLQHL SGNATLTLIA MRMEDSGIYV CEGVNLIGKN 
       310        320        330        340        350
RKEVELIVQA FPRDPEIEMS GGLVNGSSVT VSCKVPSVYP LDRLEIELLK 
       360        370        380        390        400
GETILENIEF LEDTDMKSLE NKSLEMTFIP TIEDTGKALV CQAKLHIDDM 
       410        420        430        440        450
EFEPKQRQST QTLYVNVAPR DTTVLVSPSS ILEEGSSVNM TCLSQGFPAP 
       460        470        480        490        500
KILWSRQLPN GELQPLSENA TLTLISTKME DSGVYLCEGI NQAGRSRKEV 
       510        520        530        540        550
ELIIQVTPKD IKLTAFPSES VKEGDTVIIS CTCGNVPETW IILKKKAETG 
       560        570        580        590        600
DTVLKSIDGA YTIRKAQLKD AGVYECESKN KVGSQLRSLT LDVQGRENNK 
       610        620        630        640 
DYFSPELLVL YFASSLIIPA IGMIIYFARK ANMKGSYSLV EAQKSKV

Show »

Length:647

Mass (Da):71,255

Checksum:ⁱ7EA67DB70AC91EF8

GO

Isoform 3 (identifier: P19320-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
52-113: Missing.

« Hide

        10         20         30         40         50
MPGKMVVILG ASNILWIMFA ASQAFKIETT PESRYLAQIG DSVSLTCSTT 
        60         70         80         90        100
GSFPKDPEIH LSGPLEAGKP ITVKCSVADV YPFDRLEIDL LKGDHLMKSQ 
       110        120        130        140        150
EFLEDADRKS LETKSLEVTF TPVIEDIGKV LVCRAKLHID EMDSVPTVRQ 
       160        170        180        190        200
AVKELQVYIS PKNTVISVNP STKLQEGGSV TMTCSSEGLP APEIFWSKKL 
       210        220        230        240        250
DNGNLQHLSG NATLTLIAMR MEDSGIYVCE GVNLIGKNRK EVELIVQEKP 
       260        270        280        290        300
FTVEISPGPR IAAQIGDSVM LTCSVMGCES PSFSWRTQID SPLSGKVRSE 
       310        320        330        340        350
GTNSTLTLSP VSFENEHSYL CTVTCGHKKL EKGIQVELYS FPRDPEIEMS 
       360        370        380        390        400
GGLVNGSSVT VSCKVPSVYP LDRLEIELLK GETILENIEF LEDTDMKSLE 
       410        420        430        440        450
NKSLEMTFIP TIEDTGKALV CQAKLHIDDM EFEPKQRQST QTLYVNVAPR 
       460        470        480        490        500
DTTVLVSPSS ILEEGSSVNM TCLSQGFPAP KILWSRQLPN GELQPLSENA 
       510        520        530        540        550
TLTLISTKME DSGVYLCEGI NQAGRSRKEV ELIIQVTPKD IKLTAFPSES 
       560        570        580        590        600
VKEGDTVIIS CTCGNVPETW IILKKKAETG DTVLKSIDGA YTIRKAQLKD 
       610        620        630        640        650
AGVYECESKN KVGSQLRSLT LDVQGRENNK DYFSPELLVL YFASSLIIPA 
       660        670 
IGMIIYFARK ANMKGSYSLV EAQKSKV

Note: No experimental confirmation available.

Show »

Length:677

Mass (Da):74,346

Checksum:ⁱCA0C2F8A7E51EC83

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	E9PDD2	E9PDD2_HUMAN		Vascular cell adhesion protein 1 Vascular cell adhesion protein 1	VCAM1	540	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	182	F → G (PubMed:1377228).Curated	1
Sequence conflictⁱ	402	S → T (PubMed:1707234).Curated	1
Sequence conflictⁱ	728	S → P in BAG59286 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_049951	18	M → I. Corresponds to variant dbSNP:rs34228330Ensembl.	1
Natural variantⁱVAR_014309	318	S → F1 PublicationCorresponds to variant dbSNP:rs3783611Ensembl.	1
Natural variantⁱVAR_014310	384	T → A1 PublicationCorresponds to variant dbSNP:rs3783612Ensembl.	1
Natural variantⁱVAR_014311	413	G → A1 PublicationCorresponds to variant dbSNP:rs3783613Ensembl.	1
Natural variantⁱVAR_049952	421	V → I. Corresponds to variant dbSNP:rs34100871Ensembl.	1
Natural variantⁱVAR_049953	488	H → R. Corresponds to variant dbSNP:rs34199378Ensembl.	1
Natural variantⁱVAR_014312	716	I → L1 PublicationCorresponds to variant dbSNP:rs3783615Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_044636	52 – 113	Missing in isoform 3. 1 PublicationAdd BLAST		62
Alternative sequenceⁱVSP_002580	310 – 402	EKPFT…VELYS → A in isoform 2. 1 PublicationAdd BLAST		93

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M30257 mRNA Translation: AAA51917.1 X53051 mRNA Translation: CAA37218.1 M60335 mRNA Translation: AAA61269.1 M73255 Genomic DNA Translation: AAA61270.1 AF536818 Genomic DNA Translation: AAM96190.1 AK291732 mRNA Translation: BAF84421.1 AK296692 mRNA Translation: BAG59286.1 AC093428 Genomic DNA No translation available. CH471097 Genomic DNA Translation: EAW72950.1 BC017276 mRNA Translation: AAH17276.3 BC068490 mRNA Translation: AAH68490.2 BC085003 mRNA Translation: AAH85003.1 M92431 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS55617.1 [P19320-3] CCDS773.1 [P19320-1] CCDS774.1 [P19320-2]
PIRⁱ	A41288 B41288
NCBI Reference Sequences More...RefSeqⁱ	NP_001069.1, NM_001078.3 [P19320-1] NP_001186763.1, NM_001199834.1 [P19320-3] NP_542413.1, NM_080682.2 [P19320-2]
UniGeneⁱ	Hs.109225

Genome annotation databases

Ensemblⁱ	ENST00000294728; ENSP00000294728; ENSG00000162692 [P19320-1] ENST00000347652; ENSP00000304611; ENSG00000162692 [P19320-2] ENST00000370119; ENSP00000359137; ENSG00000162692 [P19320-3]
GeneIDⁱ	7412
KEGGⁱ	hsa:7412
UCSC genome browser More...UCSCⁱ	uc001dti.5 human [P19320-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P19320	Vascular cell adhesion molecule 1 (Fragment)		HUMAN		180	UniRef100_P19320
Vascular cell adhesion molecule 1 (Fragment)		HUMAN		195
Uncharacterized protein DKFZp779G2333 (Fragment)		HUMAN		53
Vascular cell adhesion molecule 1 (Fragment)		HUMAN		198
Vascular cell adhesion molecule 1 (Fragment)		HUMAN		141
+3

Protein	Similar proteins		Species	Score	Length	Source
P19320	Vascular cell adhesion molecule 1 (Fragment)		HUMAN		180	UniRef90_P19320
Vascular cell adhesion molecule 1		MACMU		739
Vascular cell adhesion molecule-1 (Fragment)		MACFA		82
VCAM1 isoform 2		PONAB		739
Vascular cell adhesion molecule 1		SAIBB		739
+28
P19320-2	Uncharacterized protein		CERAT		647	UniRef90_P19320-2
Uncharacterized protein		RHIRO		647
Uncharacterized protein		PAPAN		647
Uncharacterized protein		MANLE		647
Uncharacterized protein		NOMLE		647
+6

Protein	Similar proteins		Species	Score	Length	Source
P19320	Vascular cell adhesion protein 1		RAT		739	UniRef50_P19320
Vascular cell adhesion protein 1		CANLF		739
Vascular cell adhesion protein 1		MOUSE		739
Vascular cell adhesion molecule 1 (Fragment)		HUMAN		180
Uncharacterized protein		MANLE		739
+205
P19320-2	Vascular cell adhesion molecule 1		GORGO		647	UniRef50_P19320-2
Uncharacterized protein		MACNE		647
Uncharacterized protein		MACFA		647
Uncharacterized protein		RHIRO		647
Uncharacterized protein		MANLE		647
+66

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

VCAM1 entry

SeattleSNPs

Functional Glycomics Gateway - Glycan Binding

VCAM-1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M30257 mRNA Translation: AAA51917.1 X53051 mRNA Translation: CAA37218.1 M60335 mRNA Translation: AAA61269.1 M73255 Genomic DNA Translation: AAA61270.1 AF536818 Genomic DNA Translation: AAM96190.1 AK291732 mRNA Translation: BAF84421.1 AK296692 mRNA Translation: BAG59286.1 AC093428 Genomic DNA No translation available. CH471097 Genomic DNA Translation: EAW72950.1 BC017276 mRNA Translation: AAH17276.3 BC068490 mRNA Translation: AAH68490.2 BC085003 mRNA Translation: AAH85003.1 M92431 Genomic DNA No translation available.
CCDSⁱ	CCDS55617.1 [P19320-3] CCDS773.1 [P19320-1] CCDS774.1 [P19320-2]
PIRⁱ	A41288 B41288
RefSeqⁱ	NP_001069.1, NM_001078.3 [P19320-1] NP_001186763.1, NM_001199834.1 [P19320-3] NP_542413.1, NM_080682.2 [P19320-2]
UniGeneⁱ	Hs.109225

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1IJ9	X-ray	3.00	A	25-220	[»]
	1VCA	X-ray	1.80	A/B	25-226	[»]
	1VSC	X-ray	1.90	A/B	25-219	[»]
ProteinModelPortalⁱ	P19320
SMRⁱ	P19320
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113255, 452 interactors
CORUMⁱ	P19320
IntActⁱ	P19320, 630 interactors
STRINGⁱ	9606.ENSP00000294728

Chemistry databases

BindingDBⁱ	P19320
ChEMBLⁱ	CHEMBL3735
DrugBankⁱ	DB05399 AGI-1067 DB01136 Carvedilol DB00898 Ethanol

PTM databases

iPTMnetⁱ	P19320
PhosphoSitePlusⁱ	P19320

Polymorphism and mutation databases

BioMutaⁱ	VCAM1
DMDMⁱ	137560

Proteomic databases

MaxQBⁱ	P19320
PaxDbⁱ	P19320
PeptideAtlasⁱ	P19320
PRIDEⁱ	P19320
ProteomicsDBⁱ	53645 53646 [P19320-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7412
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000294728; ENSP00000294728; ENSG00000162692 [P19320-1] ENST00000347652; ENSP00000304611; ENSG00000162692 [P19320-2] ENST00000370119; ENSP00000359137; ENSG00000162692 [P19320-3]
GeneIDⁱ	7412
KEGGⁱ	hsa:7412
UCSCⁱ	uc001dti.5 human [P19320-1]

Organism-specific databases

CTDⁱ	7412
DisGeNETⁱ	7412
EuPathDBⁱ	HostDB:ENSG00000162692.10
GeneCardsⁱ	VCAM1
HGNCⁱ	HGNC:12663 VCAM1
HPAⁱ	CAB000154 HPA034796 HPA069867
MIMⁱ	192225 gene
neXtProtⁱ	NX_P19320
OpenTargetsⁱ	ENSG00000162692
PharmGKBⁱ	PA37286
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IIKS Eukaryota ENOG4111F4V LUCA
GeneTreeⁱ	ENSGT00830000128299
HOGENOMⁱ	HOG000004820
HOVERGENⁱ	HBG053965
InParanoidⁱ	P19320
KOⁱ	K06527
OMAⁱ	ECESKNE
OrthoDBⁱ	EOG091G0590
PhylomeDBⁱ	P19320
TreeFamⁱ	TF333571

Enzyme and pathway databases

Reactomeⁱ	R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-216083 Integrin cell surface interactions R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling R-HSA-877300 Interferon gamma signaling
SIGNORⁱ	P19320

Miscellaneous databases

ChiTaRSⁱ	VCAM1 human
EvolutionaryTraceⁱ	P19320
GeneWikiⁱ	VCAM-1
GenomeRNAiⁱ	7412
PMAP-CutDBⁱ	P19320
Protein Ontology More...PROⁱ	PR:P19320
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000162692 Expressed in 204 organ(s), highest expression level in tendon
CleanExⁱ	HS_L1CAM HS_VCAM1
ExpressionAtlasⁱ	P19320 baseline and differential
Genevisibleⁱ	P19320 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 7 hits
InterProⁱ	View protein in InterPro IPR003987 ICAM_VCAM_N IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR008424 Ig_C2-set IPR013098 Ig_I-set IPR003599 Ig_sub IPR003598 Ig_sub2 IPR013106 Ig_V-set IPR013151 Immunoglobulin IPR003989 VCAM-1
PANTHERⁱ	PTHR44644 PTHR44644, 3 hits
Pfamⁱ	View protein in Pfam PF05790 C2-set, 2 hits PF07679 I-set, 3 hits PF00047 ig, 1 hit
PRINTSⁱ	PR01472 ICAMVCAM1 PR01474 VCAM1
SMARTⁱ	View protein in SMART SM00409 IG, 5 hits SM00408 IGc2, 5 hits SM00406 IGv, 2 hits
SUPFAMⁱ	SSF48726 SSF48726, 7 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 5 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	VCAM1_HUMAN
Accessionⁱ	P19320Primary (citable) accession number: P19320 Secondary accession number(s): A8K6R7 , B4DKS4, E9PDD1, Q6NUP8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
	Last sequence update:	November 1, 1990
	Last modified:	November 7, 2018
	This is version 227 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

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UniProtKB - P19320 (VCAM1_HUMAN)

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Vascular cell adhesion protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ