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UniProtKB - P19320 (VCAM1_HUMAN)

Entry version 237 (26 Feb 2020)
Sequence version 1 (01 Nov 1990)
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Protein

Vascular cell adhesion protein 1

Gene

VCAM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-216083 Integrin cell surface interactions
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-877300 Interferon gamma signaling

SIGNOR Signaling Network Open Resource

More...SIGNORi		P19320

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vascular cell adhesion protein 1
Short name:
V-CAM 1
Short name:
VCAM-1
Alternative name(s):
INCAM-100
CD_antigen: CD106
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VCAM1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12663 VCAM1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		192225 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P19320

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 698ExtracellularSequence analysisAdd BLAST674
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei699 – 720HelicalSequence analysisAdd BLAST22
Topological domaini721 – 739CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		7412

Open Targets

More...OpenTargetsi		ENSG00000162692

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37286

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P19320 Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3735

Drug and drug target database

More...DrugBanki		DB01136 Carvedilol
DB11338 Clove oil
DB00898 Ethanol
DB05399 Succinobucol

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		VCAM1

Domain mapping of disease mutations (DMDM)

More...DMDMi		137560

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 241 PublicationAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001499725 – 739Vascular cell adhesion protein 1Add BLAST715

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi47 ↔ 951 Publication
Disulfide bondi52 ↔ 991 Publication
Disulfide bondi137 ↔ 1951 Publication
Disulfide bondi246 ↔ 291PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi273N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi335 ↔ 383PROSITE-ProRule annotation
Glycosylationi365N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi417N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi463N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi531N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi534 ↔ 579PROSITE-ProRule annotation
Glycosylationi561N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sialoglycoprotein.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P19320

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P19320

MaxQB - The MaxQuant DataBase

More...MaxQBi		P19320

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P19320

PeptideAtlas

More...PeptideAtlasi		P19320

PRoteomics IDEntifications database

More...PRIDEi		P19320

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		19636
53645 [P19320-1]
53646 [P19320-2]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1984

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P19320

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P19320

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By cytokines (e.g. IL-1, TNF-alpha).

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000162692 Expressed in tendon and 203 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P19320 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P19320 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB000154
HPA034796
HPA069867

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		113255, 452 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P19320

Protein interaction database and analysis system

More...IntActi		P19320, 638 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000294728

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P19320

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P19320 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1739
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P19320

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P19320

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 105Ig-like C2-type 1Add BLAST81
Domaini109 – 212Ig-like C2-type 2Add BLAST104
Domaini223 – 309Ig-like C2-type 3Add BLAST87
Domaini312 – 399Ig-like C2-type 4Add BLAST88
Domaini408 – 506Ig-like C2-type 5Add BLAST99
Domaini511 – 595Ig-like C2-type 6Add BLAST85
Domaini600 – 684Ig-like C2-type 7Add BLAST85

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IIKS Eukaryota
ENOG4111F4V LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156511

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P19320

KEGG Orthology (KO)

More...KOi		K06527

Identification of Orthologs from Complete Genome Data

More...OMAi		YLCTVIC

Database of Orthologous Groups

More...OrthoDBi		544376at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P19320

TreeFam database of animal gene trees

More...TreeFami		TF333571

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003987 ICAM_VCAM_N
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR008424 Ig_C2-set
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR013151 Immunoglobulin
IPR003989 VCAM-1

The PANTHER Classification System

More...PANTHERi		PTHR13771:SF14 PTHR13771:SF14, 3 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05790 C2-set, 2 hits
PF07679 I-set, 3 hits
PF00047 ig, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01472 ICAMVCAM1
PR01474 VCAM1

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409 IG, 5 hits
SM00408 IGc2, 5 hits
SM00406 IGv, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726 SSF48726, 7 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835 IG_LIKE, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P19320-1) [UniParc]FASTAAdd to basket
Also known as: Long, VCAM-7D

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPGKMVVILG ASNILWIMFA ASQAFKIETT PESRYLAQIG DSVSLTCSTT 
        60         70         80         90        100
GCESPFFSWR TQIDSPLNGK VTNEGTTSTL TMNPVSFGNE HSYLCTATCE 
       110        120        130        140        150
SRKLEKGIQV EIYSFPKDPE IHLSGPLEAG KPITVKCSVA DVYPFDRLEI 
       160        170        180        190        200
DLLKGDHLMK SQEFLEDADR KSLETKSLEV TFTPVIEDIG KVLVCRAKLH 
       210        220        230        240        250
IDEMDSVPTV RQAVKELQVY ISPKNTVISV NPSTKLQEGG SVTMTCSSEG 
       260        270        280        290        300
LPAPEIFWSK KLDNGNLQHL SGNATLTLIA MRMEDSGIYV CEGVNLIGKN 
       310        320        330        340        350
RKEVELIVQE KPFTVEISPG PRIAAQIGDS VMLTCSVMGC ESPSFSWRTQ 
       360        370        380        390        400
IDSPLSGKVR SEGTNSTLTL SPVSFENEHS YLCTVTCGHK KLEKGIQVEL 
       410        420        430        440        450
YSFPRDPEIE MSGGLVNGSS VTVSCKVPSV YPLDRLEIEL LKGETILENI 
       460        470        480        490        500
EFLEDTDMKS LENKSLEMTF IPTIEDTGKA LVCQAKLHID DMEFEPKQRQ 
       510        520        530        540        550
STQTLYVNVA PRDTTVLVSP SSILEEGSSV NMTCLSQGFP APKILWSRQL 
       560        570        580        590        600
PNGELQPLSE NATLTLISTK MEDSGVYLCE GINQAGRSRK EVELIIQVTP 
       610        620        630        640        650
KDIKLTAFPS ESVKEGDTVI ISCTCGNVPE TWIILKKKAE TGDTVLKSID 
       660        670        680        690        700
GAYTIRKAQL KDAGVYECES KNKVGSQLRS LTLDVQGREN NKDYFSPELL 
       710        720        730 
VLYFASSLII PAIGMIIYFA RKANMKGSYS LVEAQKSKV
Note: Major isoform.
Length:739
Mass (Da):81,276
Last modified:November 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i050E2EBD39AC2FF4
GO
Isoform 2 (identifier: P19320-2) [UniParc]FASTAAdd to basket
Also known as: Short, VCAM-6D

The sequence of this isoform differs from the canonical sequence as follows:
     310-402: EKPFTVEISP...EKGIQVELYS → A

Show »
Length:647
Mass (Da):71,255
Checksum:i7EA67DB70AC91EF8
GO
Isoform 3 (identifier: P19320-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-113: Missing.

Show »
Length:677
Mass (Da):74,346
Checksum:iCA0C2F8A7E51EC83
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PDD2E9PDD2_HUMAN
Vascular cell adhesion protein 1
VCAM1
540Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISS8A0A3B3ISS8_HUMAN
Vascular cell adhesion protein 1
VCAM1
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti182F → G (PubMed:1377228).Curated1
Sequence conflicti402S → T (PubMed:1707234).Curated1
Sequence conflicti728S → P in BAG59286 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04995118M → I. Corresponds to variant dbSNP:rs34228330Ensembl.1
Natural variantiVAR_014309318S → F1 PublicationCorresponds to variant dbSNP:rs3783611Ensembl.1
Natural variantiVAR_014310384T → A1 PublicationCorresponds to variant dbSNP:rs3783612Ensembl.1
Natural variantiVAR_014311413G → A1 PublicationCorresponds to variant dbSNP:rs3783613Ensembl.1
Natural variantiVAR_049952421V → I. Corresponds to variant dbSNP:rs34100871Ensembl.1
Natural variantiVAR_049953488H → R. Corresponds to variant dbSNP:rs34199378Ensembl.1
Natural variantiVAR_014312716I → L1 PublicationCorresponds to variant dbSNP:rs3783615Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04463652 – 113Missing in isoform 3. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_002580310 – 402EKPFT…VELYS → A in isoform 2. 1 PublicationAdd BLAST93

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M30257 mRNA Translation: AAA51917.1
X53051 mRNA Translation: CAA37218.1
M60335 mRNA Translation: AAA61269.1
M73255 Genomic DNA Translation: AAA61270.1
AF536818 Genomic DNA Translation: AAM96190.1
AK291732 mRNA Translation: BAF84421.1
AK296692 mRNA Translation: BAG59286.1
AC093428 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW72950.1
BC017276 mRNA Translation: AAH17276.3
BC068490 mRNA Translation: AAH68490.2
BC085003 mRNA Translation: AAH85003.1
M92431 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS55617.1 [P19320-3]
CCDS773.1 [P19320-1]
CCDS774.1 [P19320-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A41288
B41288

NCBI Reference Sequences

More...RefSeqi		NP_001069.1, NM_001078.3 [P19320-1]
NP_001186763.1, NM_001199834.1 [P19320-3]
NP_542413.1, NM_080682.2 [P19320-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000294728; ENSP00000294728; ENSG00000162692 [P19320-1]
ENST00000347652; ENSP00000304611; ENSG00000162692 [P19320-2]
ENST00000370119; ENSP00000359137; ENSG00000162692 [P19320-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7412

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7412

UCSC genome browser

More...UCSCi		uc001dti.5 human [P19320-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

VCAM1 entry

SeattleSNPs
Functional Glycomics Gateway - Glycan Binding

VCAM-1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30257 mRNA Translation: AAA51917.1
X53051 mRNA Translation: CAA37218.1
M60335 mRNA Translation: AAA61269.1
M73255 Genomic DNA Translation: AAA61270.1
AF536818 Genomic DNA Translation: AAM96190.1
AK291732 mRNA Translation: BAF84421.1
AK296692 mRNA Translation: BAG59286.1
AC093428 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW72950.1
BC017276 mRNA Translation: AAH17276.3
BC068490 mRNA Translation: AAH68490.2
BC085003 mRNA Translation: AAH85003.1
M92431 Genomic DNA No translation available.
CCDSiCCDS55617.1 [P19320-3]
CCDS773.1 [P19320-1]
CCDS774.1 [P19320-2]
PIRiA41288
B41288
RefSeqiNP_001069.1, NM_001078.3 [P19320-1]
NP_001186763.1, NM_001199834.1 [P19320-3]
NP_542413.1, NM_080682.2 [P19320-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IJ9X-ray3.00A25-220[»]
1VCAX-ray1.80A/B25-226[»]
1VSCX-ray1.90A/B25-219[»]
SMRiP19320
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi113255, 452 interactors
CORUMiP19320
IntActiP19320, 638 interactors
STRINGi9606.ENSP00000294728

Chemistry databases

BindingDBiP19320
ChEMBLiCHEMBL3735
DrugBankiDB01136 Carvedilol
DB11338 Clove oil
DB00898 Ethanol
DB05399 Succinobucol

PTM databases

GlyConnecti1984
iPTMnetiP19320
PhosphoSitePlusiP19320

Polymorphism and mutation databases

BioMutaiVCAM1
DMDMi137560

Proteomic databases

jPOSTiP19320
MassIVEiP19320
MaxQBiP19320
PaxDbiP19320
PeptideAtlasiP19320
PRIDEiP19320
ProteomicsDBi19636
53645 [P19320-1]
53646 [P19320-2]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		7412

Genome annotation databases

EnsembliENST00000294728; ENSP00000294728; ENSG00000162692 [P19320-1]
ENST00000347652; ENSP00000304611; ENSG00000162692 [P19320-2]
ENST00000370119; ENSP00000359137; ENSG00000162692 [P19320-3]
GeneIDi7412
KEGGihsa:7412
UCSCiuc001dti.5 human [P19320-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7412
DisGeNETi7412

GeneCards: human genes, protein and diseases

More...GeneCardsi		VCAM1
HGNCiHGNC:12663 VCAM1
HPAiCAB000154
HPA034796
HPA069867
MIMi192225 gene
neXtProtiNX_P19320
OpenTargetsiENSG00000162692
PharmGKBiPA37286

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IIKS Eukaryota
ENOG4111F4V LUCA
GeneTreeiENSGT00940000156511
InParanoidiP19320
KOiK06527
OMAiYLCTVIC
OrthoDBi544376at2759
PhylomeDBiP19320
TreeFamiTF333571

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-216083 Integrin cell surface interactions
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-877300 Interferon gamma signaling
SIGNORiP19320

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		VCAM1 human
EvolutionaryTraceiP19320

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		VCAM-1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7412
PharosiP19320 Tchem

Protein Ontology

More...PROi		PR:P19320
RNActiP19320 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000162692 Expressed in tendon and 203 other tissues
ExpressionAtlasiP19320 baseline and differential
GenevisibleiP19320 HS

Family and domain databases

Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR003987 ICAM_VCAM_N
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR008424 Ig_C2-set
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR013151 Immunoglobulin
IPR003989 VCAM-1
PANTHERiPTHR13771:SF14 PTHR13771:SF14, 3 hits
PfamiView protein in Pfam
PF05790 C2-set, 2 hits
PF07679 I-set, 3 hits
PF00047 ig, 1 hit
PRINTSiPR01472 ICAMVCAM1
PR01474 VCAM1
SMARTiView protein in SMART
SM00409 IG, 5 hits
SM00408 IGc2, 5 hits
SM00406 IGv, 2 hits
SUPFAMiSSF48726 SSF48726, 7 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVCAM1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P19320
Secondary accession number(s): A8K6R7
, B4DKS4, E9PDD1, Q6NUP8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: February 26, 2020
This is version 237 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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