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Protein

Protein Mpv17

Gene

Mpv17

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in mitochondria homeostasis. May be involved in the metabolism of reactive oxygen species and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance (Probable).1 Publication

Caution

Was initially thought to be a peroxisomal protein (PubMed:7957077). However, it was later shown in human that it is a mitochondrial protein (PubMed:16582907 and PubMed:16582910).1 Publication

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-9033241 Peroxisomal protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Mpv17
Short name:
Mpv-17
Gene namesi
Name:Mpv17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:97138 Mpv17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Mice lack expression of this protein resulting in the development of adult onset nephrotic syndrome and chronic renal failure. They also develop severe morphological degeneration of the inner ear. In the inner ear, mice lacking Mpv17 display degenerative changes of the cochlear structures already at the age of 2 months. The degenerative changes are patchy arranged throughout the entire length of the cochlea and involved the organ of Corti as well as the stria vascularis epithelia with alterations of the basement membrane of the capillaries.2 Publications

Keywords - Diseasei

Deafness

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002189281 – 176Protein Mpv17Add BLAST176

Proteomic databases

MaxQBiP19258
PaxDbiP19258
PRIDEiP19258

PTM databases

PhosphoSitePlusiP19258

Expressioni

Tissue specificityi

High levels in heart, kidney, and brain, intermediate levels in testis, and low levels in liver and spleen.

Gene expression databases

BgeeiENSMUSG00000107283 Expressed in 273 organ(s), highest expression level in brown adipose tissue
CleanExiMM_MPV17
ExpressionAtlasiP19258 baseline and differential
GenevisibleiP19258 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110278

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1944 Eukaryota
ENOG4111SYH LUCA
GeneTreeiENSGT00530000063005
HOGENOMiHOG000039675
HOVERGENiHBG105417
InParanoidiP19258
KOiK13348
OMAiNYYLWPP
TreeFamiTF324070

Family and domain databases

InterProiView protein in InterPro
IPR007248 Mpv17_PMP22
PANTHERiPTHR11266 PTHR11266, 1 hit
PfamiView protein in Pfam
PF04117 Mpv17_PMP22, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P19258-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALWRAYQRA LAAHPWKVQV LTAGSLMGVG DMISQQLVER RGLQQHQAGR
60 70 80 90 100
TLTMVSLGCG FVGPVVGGWY KVLDHLIPGT TKVHALKKML LDQGGFAPCF
110 120 130 140 150
LGCFLPLVGI LNGMSAQDNW AKLKRDYPDA LITNYYLWPA VQLANFYLVP
160 170
LHYRLAVVQC VAIVWNSYLS WKAHQF
Length:176
Mass (Da):19,686
Last modified:November 1, 1990 - v1
Checksum:i7060A7B122F77DB1
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UVW1G3UVW1_MOUSE
Mpv17 transgene, kidney disease mut...
Mpv17 mCG_126791
178Annotation score:
A0A0J9YVC7A0A0J9YVC7_MOUSE
Protein Mpv17
Mpv17
105Annotation score:
E9Q1I6E9Q1I6_MOUSE
Protein Mpv17
Mpv17
165Annotation score:
D3YWI4D3YWI4_MOUSE
Protein Mpv17
Mpv17
162Annotation score:
F8WHT5F8WHT5_MOUSE
Protein Mpv17
Mpv17
170Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36411 mRNA Translation: AAA39736.1
BC013452 mRNA Translation: AAH13452.1
CCDSiCCDS19175.1
PIRiS29031
RefSeqiNP_001281253.1, NM_001294324.1
NP_001297456.1, NM_001310527.1
NP_032648.1, NM_008622.6
UniGeneiMm.271923
Mm.435472

Genome annotation databases

EnsembliENSMUST00000154241; ENSMUSP00000115292; ENSMUSG00000107283
ENSMUST00000200864; ENSMUSP00000144331; ENSMUSG00000107283
ENSMUST00000201353; ENSMUSP00000144198; ENSMUSG00000107283
GeneIDi17527
KEGGimmu:17527
UCSCiuc008wxf.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36411 mRNA Translation: AAA39736.1
BC013452 mRNA Translation: AAH13452.1
CCDSiCCDS19175.1
PIRiS29031
RefSeqiNP_001281253.1, NM_001294324.1
NP_001297456.1, NM_001310527.1
NP_032648.1, NM_008622.6
UniGeneiMm.271923
Mm.435472

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110278

PTM databases

PhosphoSitePlusiP19258

Proteomic databases

MaxQBiP19258
PaxDbiP19258
PRIDEiP19258

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000154241; ENSMUSP00000115292; ENSMUSG00000107283
ENSMUST00000200864; ENSMUSP00000144331; ENSMUSG00000107283
ENSMUST00000201353; ENSMUSP00000144198; ENSMUSG00000107283
GeneIDi17527
KEGGimmu:17527
UCSCiuc008wxf.3 mouse

Organism-specific databases

CTDi4358
MGIiMGI:97138 Mpv17

Phylogenomic databases

eggNOGiKOG1944 Eukaryota
ENOG4111SYH LUCA
GeneTreeiENSGT00530000063005
HOGENOMiHOG000039675
HOVERGENiHBG105417
InParanoidiP19258
KOiK13348
OMAiNYYLWPP
TreeFamiTF324070

Enzyme and pathway databases

ReactomeiR-MMU-9033241 Peroxisomal protein import

Miscellaneous databases

PROiPR:P19258
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000107283 Expressed in 273 organ(s), highest expression level in brown adipose tissue
CleanExiMM_MPV17
ExpressionAtlasiP19258 baseline and differential
GenevisibleiP19258 MM

Family and domain databases

InterProiView protein in InterPro
IPR007248 Mpv17_PMP22
PANTHERiPTHR11266 PTHR11266, 1 hit
PfamiView protein in Pfam
PF04117 Mpv17_PMP22, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMPV17_MOUSE
AccessioniPrimary (citable) accession number: P19258
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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