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Entry version 190 (08 May 2019)
Sequence version 1 (01 Nov 1990)
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Protein

Lymphocyte function-associated antigen 3

Gene

CD58

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • signaling receptor binding Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lymphocyte function-associated antigen 3
Short name:
Ag3
Alternative name(s):
Surface glycoprotein LFA-3
CD_antigen: CD58
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD58
Synonyms:LFA3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1688 CD58

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
153420 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P19256

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini29 – 215ExtracellularSequence analysisAdd BLAST187
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei216 – 238HelicalSequence analysisAdd BLAST23
Topological domaini239 – 250CytoplasmicSequence analysisAdd BLAST12

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi29F → S: No effect on CD2-binding. 1 Publication1
Mutagenesisi37V → K: No effect on CD2-binding. 1 Publication1
Mutagenesisi49V → Q: No effect on CD2-binding. 1 Publication1
Mutagenesisi86V → K: No effect on CD2-binding. 1 Publication1
Mutagenesisi113T → S: No effect on CD2-binding. 1 Publication1
Mutagenesisi121L → G: No effect on CD2-binding. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
965

Open Targets

More...
OpenTargetsi
ENSG00000116815

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26227

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3790

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CD58

Domain mapping of disease mutations (DMDM)

More...
DMDMi
126225

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Add BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001481429 – 250Lymphocyte function-associated antigen 3Add BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi40N-linked (GlcNAc...) asparagine1
Glycosylationi94N-linked (GlcNAc...) asparagine1
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi142 ↔ 187By similarity
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P19256

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P19256

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P19256

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P19256

PeptideAtlas

More...
PeptideAtlasi
P19256

PRoteomics IDEntifications database

More...
PRIDEi
P19256

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53642
53643 [P19256-2]
53644 [P19256-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P19256-1 [P19256-1]
P19256-2 [P19256-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1474

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P19256

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P19256

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P19256

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000116815 Expressed in 215 organ(s), highest expression level in bone marrow

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P19256 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P19256 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CD2 (PubMed:10380930, PubMed:3309127). Interacts with CMTM6 (PubMed:28813417).3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107403, 14 interactors

Protein interaction database and analysis system

More...
IntActi
P19256, 5 interactors

Molecular INTeraction database

More...
MINTi
P19256

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358501

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1250
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P19256

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P19256

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 121Ig-likeAdd BLAST92

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J1AA Eukaryota
ENOG410Z508 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000049596

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000013140

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P19256

KEGG Orthology (KO)

More...
KOi
K06492

Identification of Orthologs from Complete Genome Data

More...
OMAi
CFGFISC

Database of Orthologous Groups

More...
OrthoDBi
801938at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P19256

TreeFam database of animal gene trees

More...
TreeFami
TF341787

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR015714 Lymphocyte_func-assoc_Ag_3

The PANTHER Classification System

More...
PANTHERi
PTHR21063 PTHR21063, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P19256-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVAGSDAGRA LGVLSVVCLL HCFGFISCFS QQIYGVVYGN VTFHVPSNVP
60 70 80 90 100
LKEVLWKKQK DKVAELENSE FRAFSSFKNR VYLDTVSGSL TIYNLTSSDE
110 120 130 140 150
DEYEMESPNI TDTMKFFLYV LESLPSPTLT CALTNGSIEV QCMIPEHYNS
160 170 180 190 200
HRGLIMYSWD CPMEQCKRNS TSIYFKMEND LPQKIQCTLS NPLFNTTSSI
210 220 230 240 250
ILTTCIPSSG HSRHRYALIP IPLAVITTCI VLYMNGILKC DRKPDRTNSN
Length:250
Mass (Da):28,147
Last modified:November 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i34D635DF1D14FE2E
GO
Isoform 2 (identifier: P19256-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     236-237: GI → VL
     238-250: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.1 Publication
Show »
Length:237
Mass (Da):26,661
Checksum:i9FF77F81A224D8DC
GO
Isoform 3 (identifier: P19256-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     248-250: NSN → K

Show »
Length:248
Mass (Da):27,960
Checksum:iF2AF1D14FE2E6D57
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AMW1B1AMW1_HUMAN
CD58 antigen, (Lymphocyte function-...
CD58 hCG_37075
240Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDI1H0YDI1_HUMAN
Lymphocyte function-associated anti...
CD58
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04988515S → G. Corresponds to variant dbSNP:rs17426456Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_002522236 – 237GI → VL in isoform 2. 2 Publications2
Alternative sequenceiVSP_002523238 – 250Missing in isoform 2. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_038693248 – 250NSN → K in isoform 3. 1 Publication3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y00636 mRNA Translation: CAA68668.1
X06296 mRNA Translation: CAA29622.1
Y14780
, Y14781, Y14782, Y14783, Y14784 Genomic DNA Translation: CAA75083.1
Y14780
, Y14781, Y14782, Y14783, Y14784, Y14785 Genomic DNA Translation: CAA75084.1
AK291980 mRNA Translation: BAF84669.1
CR456939 mRNA Translation: CAG33220.1
BT019816 mRNA Translation: AAV38619.1
BT019817 mRNA Translation: AAV38620.1
AL390066 Genomic DNA No translation available.
AL355794 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56652.1
CH471122 Genomic DNA Translation: EAW56653.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44199.1 [P19256-3]
CCDS888.1 [P19256-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A28564

NCBI Reference Sequences

More...
RefSeqi
NP_001138294.1, NM_001144822.1 [P19256-3]
NP_001770.1, NM_001779.2 [P19256-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000369489; ENSP00000358501; ENSG00000116815 [P19256-1]
ENST00000457047; ENSP00000409080; ENSG00000116815 [P19256-3]
ENST00000464088; ENSP00000432773; ENSG00000116815 [P19256-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
965

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:965

UCSC genome browser

More...
UCSCi
uc001egm.4 human [P19256-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00636 mRNA Translation: CAA68668.1
X06296 mRNA Translation: CAA29622.1
Y14780
, Y14781, Y14782, Y14783, Y14784 Genomic DNA Translation: CAA75083.1
Y14780
, Y14781, Y14782, Y14783, Y14784, Y14785 Genomic DNA Translation: CAA75084.1
AK291980 mRNA Translation: BAF84669.1
CR456939 mRNA Translation: CAG33220.1
BT019816 mRNA Translation: AAV38619.1
BT019817 mRNA Translation: AAV38620.1
AL390066 Genomic DNA No translation available.
AL355794 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56652.1
CH471122 Genomic DNA Translation: EAW56653.1
CCDSiCCDS44199.1 [P19256-3]
CCDS888.1 [P19256-1]
PIRiA28564
RefSeqiNP_001138294.1, NM_001144822.1 [P19256-3]
NP_001770.1, NM_001779.2 [P19256-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CCZX-ray1.80A29-122[»]
1CI5NMR-A29-123[»]
1QA9X-ray3.20B/D30-123[»]
SMRiP19256
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107403, 14 interactors
IntActiP19256, 5 interactors
MINTiP19256
STRINGi9606.ENSP00000358501

Chemistry databases

ChEMBLiCHEMBL3790

PTM databases

GlyConnecti1474
iPTMnetiP19256
PhosphoSitePlusiP19256
SwissPalmiP19256

Polymorphism and mutation databases

BioMutaiCD58
DMDMi126225

Proteomic databases

EPDiP19256
jPOSTiP19256
MaxQBiP19256
PaxDbiP19256
PeptideAtlasiP19256
PRIDEiP19256
ProteomicsDBi53642
53643 [P19256-2]
53644 [P19256-3]
TopDownProteomicsiP19256-1 [P19256-1]
P19256-2 [P19256-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
965
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369489; ENSP00000358501; ENSG00000116815 [P19256-1]
ENST00000457047; ENSP00000409080; ENSG00000116815 [P19256-3]
ENST00000464088; ENSP00000432773; ENSG00000116815 [P19256-2]
GeneIDi965
KEGGihsa:965
UCSCiuc001egm.4 human [P19256-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
965
DisGeNETi965

GeneCards: human genes, protein and diseases

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GeneCardsi
CD58
HGNCiHGNC:1688 CD58
MIMi153420 gene
neXtProtiNX_P19256
OpenTargetsiENSG00000116815
PharmGKBiPA26227

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410J1AA Eukaryota
ENOG410Z508 LUCA
GeneTreeiENSGT00510000049596
HOGENOMiHOG000013140
InParanoidiP19256
KOiK06492
OMAiCFGFISC
OrthoDBi801938at2759
PhylomeDBiP19256
TreeFamiTF341787

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CD58 human
EvolutionaryTraceiP19256

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
965

Protein Ontology

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PROi
PR:P19256

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000116815 Expressed in 215 organ(s), highest expression level in bone marrow
ExpressionAtlasiP19256 baseline and differential
GenevisibleiP19256 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR015714 Lymphocyte_func-assoc_Ag_3
PANTHERiPTHR21063 PTHR21063, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLFA3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P19256
Secondary accession number(s): A8K7G5
, Q5U053, Q6IB65, Q96KI9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: May 8, 2019
This is version 190 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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