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Protein

60S ribosomal protein L13a

Gene

Rpl13a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex.By similarity1 Publication

GO - Molecular functioni

  • mRNA binding Source: MGI
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

  • cellular response to interferon-gamma Source: UniProtKB
  • homeostatic process Source: MGI
  • lung morphogenesis Source: MGI
  • macrophage chemotaxis Source: MGI
  • negative regulation of formation of translation preinitiation complex Source: MGI
  • negative regulation of translation Source: UniProtKB
  • response to lipopolysaccharide Source: MGI
  • translation Source: InterPro

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, Tumor antigen
Biological processTranslation regulation

Enzyme and pathway databases

ReactomeiR-MMU-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L13a
Alternative name(s):
Transplantation antigen P198
Tum-P198 antigen
Gene namesi
Name:Rpl13a
Synonyms:P198, Tstap198-7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1351455 Rpl13a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi77S → A: Loss of interferon-gamma induced phosphorylation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001337702 – 20360S ribosomal protein L13aAdd BLAST202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei59Citrulline1 Publication1
Modified residuei77Phosphoserine; by ZIPK/DAPK31 Publication1
Modified residuei140Citrulline1 Publication1
Modified residuei191N6-acetyllysineBy similarity1

Post-translational modificationi

Phosphorylation at Ser-77 upon interferon-gamma treatment in macrophages involves a DAPK1-DAPK3 kinase cascade and is causing release from the ribosome, association with the GAIT complex and subsequent involvement in transcript-selective translation inhibition.1 Publication
Citrullinated by PADI4.1 Publication

Keywords - PTMi

Acetylation, Citrullination, Phosphoprotein

Proteomic databases

EPDiP19253
PaxDbiP19253
PeptideAtlasiP19253
PRIDEiP19253

PTM databases

iPTMnetiP19253
PhosphoSitePlusiP19253
SwissPalmiP19253

Expressioni

Gene expression databases

BgeeiENSMUSG00000074129
CleanExiMM_RPL13A
ExpressionAtlasiP19253 baseline and differential
GenevisibleiP19253 MM

Interactioni

Subunit structurei

Component of the 60S ribosome. Component of the GAIT complex. Interacts with EIF4G1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi204356, 4 interactors
CORUMiP19253
IntActiP19253, 6 interactors
MINTiP19253
STRINGi10090.ENSMUSP00000115722

Structurei

3D structure databases

ProteinModelPortaliP19253
SMRiP19253
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3204 Eukaryota
COG0102 LUCA
GeneTreeiENSGT00390000010799
HOGENOMiHOG000225289
HOVERGENiHBG062176
InParanoidiP19253
KOiK02872
TreeFamiTF300159

Family and domain databases

CDDicd00392 Ribosomal_L13, 1 hit
Gene3Di3.90.1180.10, 1 hit
HAMAPiMF_01366 Ribosomal_L13, 1 hit
InterProiView protein in InterPro
IPR005822 Ribosomal_L13
IPR023563 Ribosomal_L13_CS
IPR005755 Ribosomal_L13_euk/arc
IPR036899 Ribosomal_L13_sf
PANTHERiPTHR11545 PTHR11545, 1 hit
PTHR11545:SF3 PTHR11545:SF3, 1 hit
PfamiView protein in Pfam
PF00572 Ribosomal_L13, 1 hit
PIRSFiPIRSF002181 Ribosomal_L13, 1 hit
SUPFAMiSSF52161 SSF52161, 1 hit
TIGRFAMsiTIGR01077 L13_A_E, 1 hit
PROSITEiView protein in PROSITE
PS00783 RIBOSOMAL_L13, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19253-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEGQVLVLD GRGHLLGRLA AIVAKQVLLG RKVVVVRCEG INISGNFYRN
60 70 80 90 100
KLKYLAFLRK RMNTNPSRGP YHFRAPSRIF WRTVRGMLPH KTKRGQAALE
110 120 130 140 150
RLKVLDGIPP PYDKKKRMVV PAALKVVRLK PTRKFAYLGR LAHEVGWKYQ
160 170 180 190 200
AVTATLEEKR KEKAKMHYRK KKQILRLRKQ AEKNVEKKIC KFTEVLKTNG

LLV
Length:203
Mass (Da):23,464
Last modified:January 23, 2007 - v4
Checksum:i967AEAE3362E02CC
GO

Polymorphismi

The antigenic allele of P198 differs from the normal allele by a single mutation. The TUM- mutation P198 generates a new epitope recognized by syngeneic T-cells.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti154A → T in allele TUM-. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51528 Genomic DNA Translation: CAA35908.1
BC082289 mRNA Translation: AAH82289.1
CCDSiCCDS21230.1
PIRiJL0149
RefSeqiNP_033464.2, NM_009438.5
UniGeneiMm.180458

Genome annotation databases

EnsembliENSMUST00000150350; ENSMUSP00000115722; ENSMUSG00000074129
GeneIDi22121
KEGGimmu:22121
UCSCiuc009gtj.2 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRL13A_MOUSE
AccessioniPrimary (citable) accession number: P19253
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 169 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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