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Entry version 190 (02 Dec 2020)
Sequence version 3 (02 May 2006)
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Protein

Neurofilament heavy polypeptide

Gene

Nefh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (PubMed:22723690).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neurofilament heavy polypeptide
Short name:
NF-H
Alternative name(s):
200 kDa neurofilament protein
Neurofilament triplet H protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nefh
Synonyms:Kiaa0845, Nfh
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:97309, Nefh

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Intermediate filament

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000638011 – 1090Neurofilament heavy polypeptideAdd BLAST1090

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei74PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei345PhosphoserineBy similarity1
Modified residuei416PhosphoserineCombined sources1
Modified residuei419PhosphoserineCombined sources1
Modified residuei508PhosphoserineBy similarity1
Modified residuei523PhosphoserineBy similarity1
Modified residuei529PhosphoserineCombined sources1
Modified residuei535PhosphoserineCombined sources1
Modified residuei541PhosphoserineCombined sources1
Modified residuei547PhosphoserineCombined sources1
Modified residuei553PhosphoserineCombined sources1
Modified residuei559PhosphoserineCombined sources1
Modified residuei565PhosphoserineCombined sources1
Modified residuei571PhosphoserineCombined sources1
Modified residuei577PhosphoserineCombined sources1
Modified residuei583PhosphoserineCombined sources1
Modified residuei589PhosphoserineCombined sources1
Modified residuei595PhosphoserineCombined sources1
Modified residuei601PhosphoserineCombined sources1
Modified residuei607PhosphoserineCombined sources1
Modified residuei613PhosphoserineCombined sources1
Modified residuei619PhosphoserineCombined sources1
Modified residuei625PhosphoserineCombined sources1
Modified residuei631PhosphoserineCombined sources1
Modified residuei637PhosphoserineCombined sources1
Modified residuei643PhosphoserineCombined sources1
Modified residuei649PhosphoserineCombined sources1
Modified residuei655PhosphoserineCombined sources1
Modified residuei661PhosphoserineCombined sources1
Modified residuei667PhosphoserineCombined sources1
Modified residuei673PhosphoserineCombined sources1
Modified residuei679PhosphoserineCombined sources1
Modified residuei685PhosphoserineCombined sources1
Modified residuei691PhosphoserineCombined sources1
Modified residuei697PhosphoserineCombined sources1
Modified residuei703PhosphoserineCombined sources1
Modified residuei709PhosphoserineCombined sources1
Modified residuei715PhosphoserineCombined sources1
Modified residuei721PhosphoserineBy similarity1
Modified residuei727PhosphoserineCombined sources1
Modified residuei733PhosphoserineCombined sources1
Modified residuei739PhosphoserineCombined sources1
Modified residuei745PhosphoserineCombined sources1
Modified residuei751PhosphoserineCombined sources1
Modified residuei757PhosphoserineCombined sources1
Modified residuei763PhosphoserineCombined sources1
Modified residuei769PhosphoserineCombined sources1
Modified residuei783PhosphoserineCombined sources1
Modified residuei789PhosphoserineCombined sources1
Modified residuei795PhosphoserineCombined sources1
Modified residuei809PhosphoserineBy similarity1
Modified residuei815PhosphoserineCombined sources1
Modified residuei834PhosphoserineCombined sources1
Modified residuei839PhosphothreonineBy similarity1
Modified residuei859PhosphoserineCombined sources1
Modified residuei867PhosphoserineCombined sources1
Modified residuei888PhosphoserineCombined sources1
Modified residuei947PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

There are a number of repeats of the tripeptide K-S-P, NFH is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFH results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber.
Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincidentally with a change in the neurofilament function.
Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P19246

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P19246

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P19246

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P19246

PeptideAtlas

More...
PeptideAtlasi
P19246

PRoteomics IDEntifications database

More...
PRIDEi
P19246

2D gel databases

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P19246

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P19246

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P19246

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the sciatic nerve (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000020396, Expressed in ventral horn of spinal cord and 189 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P19246, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms heterodimers with NEFL; which can further hetero-oligomerize (in vitro) (By similarity). Forms heterodimers with INA (in vitro) (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
237594, 12 interactors

Protein interaction database and analysis system

More...
IntActi
P19246, 5 interactors

Molecular INTeraction database

More...
MINTi
P19246

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000091061

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P19246, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P19246

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini95 – 411IF rodPROSITE-ProRule annotationAdd BLAST317
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati522 – 52716
Repeati528 – 53326
Repeati534 – 53936
Repeati540 – 54546
Repeati546 – 55156
Repeati552 – 55766
Repeati558 – 56376
Repeati564 – 56986
Repeati570 – 57596
Repeati576 – 581106
Repeati582 – 587116
Repeati588 – 593126
Repeati594 – 599136
Repeati600 – 605146
Repeati606 – 611156
Repeati612 – 617166
Repeati618 – 623176
Repeati624 – 629186
Repeati630 – 635196
Repeati636 – 641206
Repeati642 – 647216
Repeati648 – 653226
Repeati654 – 659236
Repeati660 – 665246
Repeati666 – 671256
Repeati672 – 677266
Repeati678 – 683276
Repeati684 – 689286
Repeati690 – 695296
Repeati696 – 701306
Repeati702 – 707316
Repeati708 – 713326
Repeati714 – 719336
Repeati720 – 725346
Repeati726 – 731356
Repeati732 – 737366
Repeati738 – 743376
Repeati744 – 749386
Repeati750 – 755396
Repeati756 – 761406
Repeati762 – 767416
Repeati768 – 773426
Repeati774 – 77943; approximate6
Repeati782 – 787446
Repeati788 – 793456
Repeati794 – 799466
Repeati808 – 813476
Repeati814 – 819486
Repeati833 – 838496
Repeati858 – 863506
Repeati866 – 871516
Repeati887 – 892526

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 98HeadAdd BLAST97
Regioni99 – 130Coil 1AAdd BLAST32
Regioni131 – 143Linker 1Add BLAST13
Regioni144 – 242Coil 1BAdd BLAST99
Regioni243 – 264Linker 12Add BLAST22
Regioni265 – 286Coil 2AAdd BLAST22
Regioni287 – 290Linker 24
Regioni291 – 411Coil 2BAdd BLAST121
Regioni412 – 1090TailAdd BLAST679
Regioni522 – 89252 X 6 AA approximate tandem repeats of K-S-P-[AGISV]-[EATK]-[APVQ]Add BLAST371

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi439 – 520Glu-rich (acidic)Add BLAST82
Compositional biasi890 – 1090Glu/Lys-richAdd BLAST201

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QYDU, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161893

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012560_7_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P19246

Identification of Orthologs from Complete Genome Data

More...
OMAi
IKMVEKS

Database of Orthologous Groups

More...
OrthoDBi
898483at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P19246

TreeFam database of animal gene trees

More...
TreeFami
TF330122

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.5.1160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010790, DUF1388
IPR018039, IF_conserved
IPR039008, IF_rod_dom
IPR042180, IF_rod_dom_coil1B
IPR033183, NF-H

The PANTHER Classification System

More...
PANTHERi
PTHR23214, PTHR23214, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07142, DUF1388, 14 hits
PF00038, Filament, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01391, Filament, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00226, IF_ROD_1, 1 hit
PS51842, IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P19246-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMSFGSADAL LGAPFAPLHG GGSLHYSLSR KAGPGGTRSA AGSSSGFHSW
60 70 80 90 100
ARTSVSSVSA SPSRFRGAAS STDSLDTLSN GPEGCVVAAV AARSEKEQLQ
110 120 130 140 150
ALNDRFAGYI DKVRQLEAHN RSLEGEAAAL RQQQAGRAAM GELYEREVRE
160 170 180 190 200
MRGAVLRLGA ARGQLRLEQE HLLEDIAHVR QRLDEEARQR EEAEAAARAL
210 220 230 240 250
ARFAQEAEAA RVELQKKAQA LQEECGYLRR HHQEEVGELL GQIQGCGAAQ
260 270 280 290 300
AQAQAEARDA LKCDVTSALR EIRAQLEGHA VQSTLQSEEW FRVRLDRLSE
310 320 330 340 350
AAKVNTDAMR SAQEEITEYR RQLQARTTEL EALKSTKESL ERQRSELEDR
360 370 380 390 400
HQADIASYQD AIQQLDSELR NTKWEMAAQL REYQDLLNVK MALDIEIAAY
410 420 430 440 450
RKLLEGEECR IGFGPSPFSL TEGLPKIPSI STHIKVKSEE MIKVVEKSEK
460 470 480 490 500
ETVIVEGQTE EIRVTEGVTE EEDKEAQGQE GEEAEEGEEK EEEEGAAATS
510 520 530 540 550
PPAEEAASPE KETKSRVKEE AKSPGEAKSP GEAKSPAEAK SPGEAKSPGE
560 570 580 590 600
AKSPGEAKSP AEPKSPAEPK SPAEAKSPAE PKSPATVKSP GEAKSPSEAK
610 620 630 640 650
SPAEAKSPAE AKSPAEAKSP AEAKSPAEAK SPAEAKSPAT VKSPGEAKSP
660 670 680 690 700
SEAKSPAEAK SPAEAKSPAE AKSPAEVKSP GEAKSPAEPK SPAEAKSPAE
710 720 730 740 750
VKSPAEAKSP AEVKSPGEAK SPAAVKSPAE AKSPAAVKSP GEAKSPGEAK
760 770 780 790 800
SPAEAKSPAE AKSPIEVKSP EKAKTPVKEG AKSPAEAKSP EKAKSPVKED
810 820 830 840 850
IKPPAEAKSP EKAKSPVKEG AKPPEKAKPL DVKSPEAQTP VQEEAKHPTD
860 870 880 890 900
IRPPEQVKSP AKEKAKSPEK EEAKTSEKVA PKKEEVKSPV KEEVKAKEPP
910 920 930 940 950
KKVEEEKTLP TPKTEAKESK KDEAPKEAPK PKVEEKKETP TEKPKDSTAE
960 970 980 990 1000
AKKEEAGEKK KAVASEEETP AKLGVKEEAK PKEKTETTKT EAEDTKAKEP
1010 1020 1030 1040 1050
SKPTETEKPK KEEMPAAPEK KDTKEEKTTE SRKPEEKPKM EAKVKEDDKS
1060 1070 1080 1090
LSKEPSKPKT EKAEKSSSTD QKESQPPEKT TEDKATKGEK
Length:1,090
Mass (Da):116,994
Last modified:May 2, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2A7D7D36FF2F448
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA39813 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAA83229 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti134 – 135QA → K in AAA39813 (PubMed:3220257).Curated2
Sequence conflicti202Missing in AAA39813 (PubMed:3220257).Curated1
Sequence conflicti284T → S in AAA39813 (PubMed:3220257).Curated1
Sequence conflicti495G → L in AAA39813 (PubMed:3220257).Curated1
Sequence conflicti519E → EEAKSPG in AAA39809 (PubMed:3145094).Curated1
Sequence conflicti519E → EEAKSPG in CAA83229 (Ref. 3) Curated1
Sequence conflicti549G → R in AAA39809 (PubMed:3145094).Curated1
Sequence conflicti549G → R in CAA83229 (Ref. 3) Curated1
Sequence conflicti694 – 717Missing in AAA39809 (PubMed:3145094).CuratedAdd BLAST24
Sequence conflicti694 – 717Missing in CAA83229 (Ref. 3) CuratedAdd BLAST24
Sequence conflicti817V → M in AAA39809 (PubMed:3145094).Curated1
Sequence conflicti817V → M in CAA83229 (Ref. 3) Curated1
Sequence conflicti817V → M in ABK96805 (Ref. 6) Curated1
Sequence conflicti846 – 847KH → ND in AAA39809 (PubMed:3145094).Curated2
Sequence conflicti846 – 847KH → ND in CAA83229 (Ref. 3) Curated2
Sequence conflicti846 – 847KH → ND in ABK96805 (Ref. 6) Curated2
Sequence conflicti846 – 847KH → TV in AAA39813 (PubMed:3220257).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M35131 mRNA Translation: AAA39809.1
M24496 M24495 Genomic DNA Translation: AAA39813.1 Different initiation.
Z31012 Genomic DNA Translation: CAA83229.1 Different initiation.
AL645522 Genomic DNA No translation available.
EF101556 mRNA Translation: ABK96805.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS36099.1

Protein sequence database of the Protein Information Resource

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PIRi
JT0368, QFMSH

NCBI Reference Sequences

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RefSeqi
NP_035034.2, NM_010904.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000093369; ENSMUSP00000091061; ENSMUSG00000020396

Database of genes from NCBI RefSeq genomes

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GeneIDi
380684

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:380684

UCSC genome browser

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UCSCi
uc007hvm.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35131 mRNA Translation: AAA39809.1
M24496 M24495 Genomic DNA Translation: AAA39813.1 Different initiation.
Z31012 Genomic DNA Translation: CAA83229.1 Different initiation.
AL645522 Genomic DNA No translation available.
EF101556 mRNA Translation: ABK96805.1
CCDSiCCDS36099.1
PIRiJT0368, QFMSH
RefSeqiNP_035034.2, NM_010904.3

3D structure databases

SMRiP19246
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi237594, 12 interactors
IntActiP19246, 5 interactors
MINTiP19246
STRINGi10090.ENSMUSP00000091061

PTM databases

iPTMnetiP19246
PhosphoSitePlusiP19246

2D gel databases

UCD-2DPAGEiP19246

Proteomic databases

EPDiP19246
jPOSTiP19246
MaxQBiP19246
PaxDbiP19246
PeptideAtlasiP19246
PRIDEiP19246

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
3579, 1650 antibodies

The DNASU plasmid repository

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DNASUi
380684

Genome annotation databases

EnsembliENSMUST00000093369; ENSMUSP00000091061; ENSMUSG00000020396
GeneIDi380684
KEGGimmu:380684
UCSCiuc007hvm.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4744
MGIiMGI:97309, Nefh

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiENOG502QYDU, Eukaryota
GeneTreeiENSGT00940000161893
HOGENOMiCLU_012560_7_2_1
InParanoidiP19246
OMAiIKMVEKS
OrthoDBi898483at2759
PhylomeDBiP19246
TreeFamiTF330122

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
380684, 3 hits in 17 CRISPR screens

Protein Ontology

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PROi
PR:P19246
RNActiP19246, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000020396, Expressed in ventral horn of spinal cord and 189 other tissues
GenevisibleiP19246, MM

Family and domain databases

Gene3Di1.20.5.1160, 1 hit
InterProiView protein in InterPro
IPR010790, DUF1388
IPR018039, IF_conserved
IPR039008, IF_rod_dom
IPR042180, IF_rod_dom_coil1B
IPR033183, NF-H
PANTHERiPTHR23214, PTHR23214, 2 hits
PfamiView protein in Pfam
PF07142, DUF1388, 14 hits
PF00038, Filament, 1 hit
SMARTiView protein in SMART
SM01391, Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226, IF_ROD_1, 1 hit
PS51842, IF_ROD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNFH_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P19246
Secondary accession number(s): A1E2H9, Q5SVF6, Q61959
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: May 2, 2006
Last modified: December 2, 2020
This is version 190 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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