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Protein

Troponin I, slow skeletal muscle

Gene

TNNI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi106 – 117By similarityAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Muscle protein
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-390522 Striated Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin I, slow skeletal muscle
Alternative name(s):
Troponin I, slow-twitch isoform
Gene namesi
Name:TNNI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000159173.18
HGNCiHGNC:11945 TNNI1
MIMi191042 gene
neXtProtiNX_P19237

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi7135
OpenTargetsiENSG00000159173
PharmGKBiPA36634

Polymorphism and mutation databases

BioMutaiTNNI1
DMDMi1351298

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001861392 – 187Troponin I, slow skeletal muscleAdd BLAST186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylprolineBy similarity1
Modified residuei58PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP19237
PeptideAtlasiP19237
PRIDEiP19237
ProteomicsDBi53641

PTM databases

iPTMnetiP19237
PhosphoSitePlusiP19237

Expressioni

Tissue specificityi

Highest levels observed in human skeletal muscle (e.g. gastrocnemious muscle), differentiated cultures of primary human muscle cells and rhabdomyosarcoma cells cultured in low serum medium. Expressed in C2 muscle cell myoblasts and myotubes.2 Publications

Gene expression databases

BgeeiENSG00000159173
ExpressionAtlasiP19237 baseline and differential
GenevisibleiP19237 HS

Organism-specific databases

HPAiHPA028190

Interactioni

Subunit structurei

Binds to actin and tropomyosin.

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112989, 14 interactors
IntActiP19237, 31 interactors
STRINGi9606.ENSP00000337022

Structurei

3D structure databases

ProteinModelPortaliP19237
SMRiP19237
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 48Involved in binding TNCAdd BLAST47
Regioni97 – 118Involved in binding TNC and actinAdd BLAST22

Sequence similaritiesi

Belongs to the troponin I family.Curated

Phylogenomic databases

eggNOGiKOG3977 Eukaryota
ENOG410Y9IX LUCA
GeneTreeiENSGT00390000002746
HOVERGENiHBG052737
InParanoidiP19237
KOiK10371
PhylomeDBiP19237
TreeFamiTF313374

Family and domain databases

Gene3Di1.20.5.350, 1 hit
InterProiView protein in InterPro
IPR001978 Troponin
IPR038077 Troponin_sf
PfamiView protein in Pfam
PF00992 Troponin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEVERKPKI TASRKLLLKS LMLAKAKECW EQEHEEREAE KVRYLAERIP
60 70 80 90 100
TLQTRGLSLS ALQDLCRELH AKVEVVDEER YDIEAKCLHN TREIKDLKLK
110 120 130 140 150
VMDLRGKFKR PPLRRVRVSA DAMLRALLGS KHKVSMDLRA NLKSVKKEDT
160 170 180
EKERPVEVGD WRKNVEAMSG MEGRKKMFDA AKSPTSQ
Length:187
Mass (Da):21,692
Last modified:January 23, 2007 - v3
Checksum:i7A8363CC7559B962
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4 – 5VE → FQ in AC096677 (PubMed:16710414).Curated2
Sequence conflicti30W → R in CAG29297 (Ref. 4) Curated1
Sequence conflicti103D → A in CAD91135 (PubMed:17974005).Curated1
Sequence conflicti131K → R in CAC44240 (Ref. 3) Curated1
Sequence conflicti143K → T in CAG46793 (Ref. 4) Curated1
Sequence conflicti182 – 183KS → NA in AAA61228 (PubMed:2365354).Curated2
Sequence conflicti182 – 183KS → NA in CAG46827 (Ref. 4) Curated2
Sequence conflicti182 – 183KS → NA in CAG46793 (Ref. 4) Curated2
Sequence conflicti182 – 183KS → NA in CAG29297 (Ref. 4) Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05240367R → W. Corresponds to variant dbSNP:rs2296695Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04760 mRNA Translation: AAA61228.1
L21910
, L21906, L21908, L21909 Genomic DNA Translation: AAC14461.1
AJ315823 mRNA Translation: CAC44240.1
CR450301 mRNA Translation: CAG29297.1
CR541996 mRNA Translation: CAG46793.1
CR542030 mRNA Translation: CAG46827.1
AL831820 mRNA Translation: CAD38534.1
AL831975 mRNA Translation: CAH56221.1
BX510903 mRNA Translation: CAD91135.1
AK223588 mRNA Translation: BAD97308.1
AK311896 mRNA Translation: BAG34837.1
AC096677 Genomic DNA No translation available.
BC012600 mRNA Translation: AAH12600.1
BC012601 mRNA Translation: AAH12601.1
CCDSiCCDS1411.1
PIRiA53740 TPHUIW
RefSeqiNP_003272.3, NM_003281.3
UniGeneiHs.320890

Genome annotation databases

EnsembliENST00000336092; ENSP00000337022; ENSG00000159173
ENST00000361379; ENSP00000354488; ENSG00000159173
ENST00000367312; ENSP00000356281; ENSG00000159173
GeneIDi7135
KEGGihsa:7135
UCSCiuc057oib.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTNNI1_HUMAN
AccessioniPrimary (citable) accession number: P19237
Secondary accession number(s): A6NEH3
, A8MSJ0, Q659A5, Q6FGS7, Q6FGW1, Q6ICU2, Q86T57, Q96DT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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