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Entry version 135 (02 Jun 2021)
Sequence version 2 (01 Aug 1991)
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Protein

Polyprotein P3

Gene
N/A
Organism
Commelina yellow mottle virus (CoYMV)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Capsid protein self assembles to form a bacilliform capsid about 90-900 nm in length. The capsid encapsulates the genomic dsDNA. Following virus entry into host cell, provides nuclear import of the viral genome. Virus particles do not enter the nucleus, but are targeted to the nuclear membrane through the interaction with host importins (By similarity).

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1220For protease activityPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri879 – 896CCHC-typePROSITE-ProRule annotationAdd BLAST18

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAspartyl protease, Endonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Protease, RNA-directed DNA polymerase, Transferase, Viral movement protein
Biological processTransport, Viral penetration into host nucleus, Virus entry into host cell
LigandMetal-binding, Zinc

Protein family/group databases

MEROPS protease database

More...
MEROPSi
A03.004

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polyprotein P3
Including the following 5 domains:
Putative movement protein
Short name:
MP
Capsid protein
Alternative name(s):
Coat protein
Short name:
CP
Protease (EC:3.4.23.-)
Short name:
PR
Reverse transcriptase (EC:2.7.7.49)
Short name:
RT
Ribonuclease H (EC:3.1.26.4)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCommelina yellow mottle virus (CoYMV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10653 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaPararnaviraeArtverviricotaRevtraviricetesOrterviralesCaulimoviridaeBadnavirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiCommelina [TaxID: 4743]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002243 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001995691 – 1886Polyprotein P3Add BLAST1886

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Polyprotein P3 is presumably proteolytically cleaved into several chains by viral protease.Curated

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P19199

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1215 – 1292Peptidase A2PROSITE-ProRule annotationAdd BLAST78
Domaini1425 – 1615Reverse transcriptasePROSITE-ProRule annotationAdd BLAST191
Domaini1736 – 1841RNase HPROSITE-ProRule annotationAdd BLAST106

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 24DisorderedSequence analysisAdd BLAST24
Regioni420 – 466DisorderedSequence analysisAdd BLAST47
Regioni478 – 529DisorderedSequence analysisAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 19Polar residuesSequence analysisAdd BLAST19
Compositional biasi502 – 529Basic and acidic residuesSequence analysisAdd BLAST28

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri879 – 896CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Zinc-finger

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.70.10, 1 hit
3.30.70.270, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001969, Aspartic_peptidase_AS
IPR043502, DNA/RNA_pol_sf
IPR001995, Peptidase_A2_cat
IPR021109, Peptidase_aspartic_dom_sf
IPR018061, Retropepsins
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR002156, RNaseH_domain
IPR000477, RT_dom
IPR041577, RT_RNaseH_2
IPR001878, Znf_CCHC
IPR036875, Znf_CCHC_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17919, RT_RNaseH_2, 1 hit
PF00077, RVP, 1 hit
PF00078, RVT_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00343, ZnF_C2HC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56672, SSF56672, 1 hit
SSF57756, SSF57756, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50175, ASP_PROT_RETROV, 1 hit
PS00141, ASP_PROTEASE, 1 hit
PS50879, RNASE_H, 1 hit
PS50878, RT_POL, 1 hit
PS50158, ZF_CCHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P19199-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATRRLPAVT QTDGSRTATE SGVPEYEDQI RSYRNDQRRR HIWAGRGRRL
60 70 80 90 100
LSIMPGVSSS ERTLEMQMNP EVQLQRSMNH RAEAVPAEVL YRTFHGSVNH
110 120 130 140 150
RVYSHRSEER MMVVNGSQVD RSFIQESSFE VLSRTGIEFI HIGVMLVRIQ
160 170 180 190 200
ILHRKFAGTM ALIVFRDTRW SDDRAVLAAM EIDLSEGNQI VYVLPDIMMT
210 220 230 240 250
IKSFYRHIQI CVMTKGYDGW QGEDNLLITR GLTGRLSNTS NVGFAYDVKA
260 270 280 290 300
MVEHLQSNGV KAIKGEKWDA KRFHNGQWNI EPSKVVVPMQ PTEMKAVSNY
310 320 330 340 350
DGTTSLRFSN YAAASTSKPP QYNEKDEEIN EDEQEINHSL NLILNDEEST
360 370 380 390 400
DEDEEYYQYQ RYAWSQVGDS TFYYDTDGVW EEIDRCNDLP EYVPSETSTP
410 420 430 440 450
TIDESEAIID EFLEHAYEQR CDSDESLQSG DPRKYEYPTP QSSPEHLDNE
460 470 480 490 500
SRSRSSSASS TSMQDDVEEI VRLMKEMRMK KQKKKKAQQA LSSQAQEEPI
510 520 530 540 550
IEENIEENKQ AQEEPTQEEI PTHKENQPEE IQNEEIHVFE EEPAFKHLAA
560 570 580 590 600
QLSELVNMAE SSGQSGVGFQ PPVNAQPDVN MEGPAGYAPA TSQATWSNGV
610 620 630 640 650
NIPVKSANFR WKGPVGNFQL PSAQGKDGAM LVFGMNYSPE VFDRWASITR
660 670 680 690 700
NYISSFNFND GGDKIAWMED LLGETERKIF VSWRMRFKDE YQNLAKIANQ
710 720 730 740 750
DGGTQAILSQ IRRIFLGEDP VLGQNTVQNI AFRKLKQLVC PNYQSIRRYL
760 770 780 790 800
MDYLTLAAET GLMWSETEGP AISEELFTKM PAAIGERVAQ AYKIMDPTSA
810 820 830 840 850
VNLPSRVYFT INYLTEQCKE ASYMRSLKAL DFCRDFPIEG YYGRSGEKKK
860 870 880 890 900
YTARKATKYT GKAHDNHIRV TKAKYQRKCK CYICGQEGHY ANQCRNKHKD
910 920 930 940 950
QQRVAILQSL DLKENEEVVS ADDKEEEDDE IFSVLGEEDY QEETIMVLEE
960 970 980 990 1000
DDIQQIIKEF SKFGDLSRRN VGPNFPGPAE VQMGVLKPKS SWRRPIQATL
1010 1020 1030 1040 1050
EEINCHHNWT AISTGQLACR SCKQFLAGVQ CHHCHAVYCF MCAEAYHDVQ
1060 1070 1080 1090 1100
AEKILSKDYS FSARGKKGKA VIIEEDEIEG EFLISQLQQE NQRLQKQVER
1110 1120 1130 1140 1150
LQEELMKLHR EKDEALKHSE KASRVFSTIQ ESDEAELNLI KEELRQFKEE
1160 1170 1180 1190 1200
TRMAIAQLKE AIIVQEEDTI EERCAMILEE KHTENIYSAT AKAEYNGLYN
1210 1220 1230 1240 1250
VKVGIKPDNM EPYYINAIVD TGATACLIQI SAIPENYYED AKVTVNFRSV
1260 1270 1280 1290 1300
LGIGTSTQMI KAGRILIGEQ YFRMPVTYVM NMGLSPGIQM IIGCSFIRSL
1310 1320 1330 1340 1350
EGGLRIEKDI ITFYKLVTSI ETSRTTQVAN SIEELELSED EYLNIAASVE
1360 1370 1380 1390 1400
TPSFLDQEFA RKNKDLLKEM KEMKYIGENP MEFWKNNKIK CKLNIINPDI
1410 1420 1430 1440 1450
KIMGRPIKHV TPGDEEAMTR QINLLLQMKV IRPSESKHRS TAFIVRSGTE
1460 1470 1480 1490 1500
IDPITGKEKK GKERMVFNYK LLNENTESDQ YSLPGINTII SKVGRSKIYS
1510 1520 1530 1540 1550
KFDLKSGFWQ VAMEEESVPW TAFLAGNKLY EWLVMPFGLK NAPAIFQRKM
1560 1570 1580 1590 1600
DNVFKGTEKF IAVYIDDILV FSETAEQHSQ HLYTMLQLCK ENGLILSPTK
1610 1620 1630 1640 1650
MKIGTPEIDF LGASLGCTKI KLQPHIISKI CDFSDEKLAT PEGMRSWLGI
1660 1670 1680 1690 1700
LSYARNYIQD IGKLVQPLRQ KMAPTGDKRM NPETWKMVRQ IKEKVKNLPD
1710 1720 1730 1740 1750
LQLPPKDSFI IIETDGCMTG WGAVCKWKMS KHDPRSTERI CAYASGSFNP
1760 1770 1780 1790 1800
IKSTIDAEIQ AAIHGLDKFK IYYLDKKELI IRSDCEAIIK FYNKTNENKP
1810 1820 1830 1840 1850
SRVRWLTFSD FLTGLGITVT FEHIDGKHNG LADALSRMIN FIVEKNDESP
1860 1870 1880
YRFTSSVEDA LKVCNDDHGR NLISAVINDI ITVLRR
Length:1,886
Mass (Da):215,662
Last modified:August 1, 1991 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i60E010C132FEDA91
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X52938 Genomic DNA Translation: CAA37110.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S11480

NCBI Reference Sequences

More...
RefSeqi
NP_039820.1, NC_001343.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1489554

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:1489554

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52938 Genomic DNA Translation: CAA37110.1
PIRiS11480
RefSeqiNP_039820.1, NC_001343.1

3D structure databases

SMRiP19199
ModBaseiSearch...

Protein family/group databases

MEROPSiA03.004

Genome annotation databases

GeneIDi1489554
KEGGivg:1489554

Family and domain databases

Gene3Di2.40.70.10, 1 hit
3.30.70.270, 2 hits
InterProiView protein in InterPro
IPR001969, Aspartic_peptidase_AS
IPR043502, DNA/RNA_pol_sf
IPR001995, Peptidase_A2_cat
IPR021109, Peptidase_aspartic_dom_sf
IPR018061, Retropepsins
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR002156, RNaseH_domain
IPR000477, RT_dom
IPR041577, RT_RNaseH_2
IPR001878, Znf_CCHC
IPR036875, Znf_CCHC_sf
PfamiView protein in Pfam
PF17919, RT_RNaseH_2, 1 hit
PF00077, RVP, 1 hit
PF00078, RVT_1, 1 hit
SMARTiView protein in SMART
SM00343, ZnF_C2HC, 1 hit
SUPFAMiSSF56672, SSF56672, 1 hit
SSF57756, SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS50175, ASP_PROT_RETROV, 1 hit
PS00141, ASP_PROTEASE, 1 hit
PS50879, RNASE_H, 1 hit
PS50878, RT_POL, 1 hit
PS50158, ZF_CCHC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOL_COYMV
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P19199
Secondary accession number(s): P19202
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: August 1, 1991
Last modified: June 2, 2021
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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