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UniProtKB - P19174 (PLCG1_HUMAN)

Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Gene

PLCG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.1 Publication

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Cofactori

Ca2+

Activity regulationi

Activated by phosphorylation on tyrosine residues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei335PROSITE-ProRule annotation1
Active sitei380PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi165 – 176PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionHydrolase, Transducer
Biological processHost-virus interaction, Lipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.4.11 2681
ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
R-HSA-1251932 PLCG1 events in ERBB2 signaling
R-HSA-1489509 DAG and IP3 signaling
R-HSA-167021 PLC-gamma1 signalling
R-HSA-170968 Frs2-mediated activation
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol
R-HSA-186763 Downstream signal transduction
R-HSA-202433 Generation of second messenger molecules
R-HSA-2029485 Role of phospholipids in phagocytosis
R-HSA-210990 PECAM1 interactions
R-HSA-212718 EGFR interacts with phospholipase C-gamma
R-HSA-2424491 DAP12 signaling
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-418890 Role of second messengers in netrin-1 signaling
R-HSA-5218921 VEGFR2 mediated cell proliferation
R-HSA-5637810 Constitutive Signaling by EGFRvIII
R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1
R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2
R-HSA-5654227 Phospholipase C-mediated cascade, FGFR3
R-HSA-5654228 Phospholipase C-mediated cascade, FGFR4
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5655291 Signaling by FGFR4 in disease
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer
R-HSA-8853659 RET signaling
R-HSA-9026527 Activated NTRK2 signals through PLCG1
R-HSA-9034793 Activated NTRK3 signals through PLCG1
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
SignaLinkiP19174
SIGNORiP19174

Protein family/group databases

MoonDBiP19174 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC:3.1.4.11)
Alternative name(s):
PLC-148
Phosphoinositide phospholipase C-gamma-1
Phospholipase C-II
Short name:
PLC-II
Phospholipase C-gamma-1
Short name:
PLC-gamma-1
Gene namesi
Name:PLCG1
Synonyms:PLC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000124181.14
HGNCiHGNC:9065 PLCG1
MIMi172420 gene
neXtProtiNX_P19174

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection

Pathology & Biotechi

Organism-specific databases

DisGeNETi5335
OpenTargetsiENSG00000124181
PharmGKBiPA33392

Chemistry databases

ChEMBLiCHEMBL3964

Polymorphism and mutation databases

BioMutaiPLCG1
DMDMi130225

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000884982 – 12901-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Add BLAST1289

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei506PhosphotyrosineBy similarity1
Modified residuei771Phosphotyrosine; by SYKCombined sources2 Publications1
Modified residuei775PhosphotyrosineCombined sources1
Modified residuei783Phosphotyrosine; by ITK, SYK and TXKCombined sources3 Publications1
Modified residuei977PhosphotyrosineBy similarity1
Modified residuei1221PhosphoserineCombined sources1
Modified residuei1227PhosphoserineCombined sources1
Modified residuei1233PhosphoserineCombined sources1
Modified residuei1248Phosphoserine1 Publication1
Modified residuei1253PhosphotyrosineCombined sources1
Modified residuei1263PhosphoserineCombined sources1
Isoform 2 (identifier: P19174-2)
Modified residuei1222PhosphoserineCombined sources1

Post-translational modificationi

Tyrosine phosphorylated in response to signaling via activated FLT3, KIT and PDGFRA (By similarity). Tyrosine phosphorylated by activated FGFR1, FGFR2, FGFR3 and FGFR4. Tyrosine phosphorylated by activated FLT1 and KDR. Tyrosine phosphorylated by activated PDGFRB. The receptor-mediated activation of PLCG1 involves its phosphorylation by tyrosine kinases, in response to ligation of a variety of growth factor receptors and immune system receptors. For instance, SYK phosphorylates and activates PLCG1 in response to ligation of the B-cell receptor. May be dephosphorylated by PTPRJ. Phosphorylated by ITK and TXK on Tyr-783 upon TCR activation in T-cells.By similarity11 Publications
Ubiquitinated by CBLB in activated T-cells.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP19174
MaxQBiP19174
PaxDbiP19174
PeptideAtlasiP19174
PRIDEiP19174
ProteomicsDBi53635
53636 [P19174-2]

PTM databases

iPTMnetiP19174
PhosphoSitePlusiP19174

Expressioni

Gene expression databases

BgeeiENSG00000124181 Expressed in 221 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_PLCG1
ExpressionAtlasiP19174 baseline and differential
GenevisibleiP19174 HS

Organism-specific databases

HPAiCAB004277
HPA036681
HPA036682

Interactioni

Subunit structurei

Interacts with AGAP2 via its SH3 domain. Interacts (via SH2 domain) with RET. Interacts with FLT1 (tyrosine-phosphorylated) (By similarity). Interacts (via SH2 domain) with FGFR1, FGFR2, FGFR3 and FGFR4 (phosphorylated). Interacts with LAT (phosphorylated) upon TCR activation. Interacts (via SH3 domain) with the Pro-rich domain of TNK1. Associates with BLNK, VAV1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB in activated T-cells; which inhibits phosphorylation. Interacts with SHB. Interacts (via SH3 domain) with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. This interaction is selectively regulated by arginine methylation of KHDRBS1/SAM68. Interacts with INPP5D/SHIP1, THEMIS and CLNK (By similarity). Interacts with AXL, FLT4 and KIT. Interacts with RALGPS1. Interacts (via the SH2 domains) with VIL1 (phosphorylated at C-terminus tyrosine phosphorylation sites). Interacts (via SH2 domain) with PDGFRA and PDGFRB (tyrosine phosphorylated). Interacts with PIP5K1C (By similarity). Interacts with NTRK1 and NTRK2 (phosphorylated upon ligand-binding). Interacts with SYK; activates PLCG1. Interacts with GRB2, LAT and THEMIS upon TCR activation in thymocytes (By similarity). Interacts with TESPA1; the association is increased with prolonged stimulation of the TCR and may facilitate the assembly of the LAT signalosome.By similarity19 Publications
(Microbial infection) Interacts (via SH3 domain) with HEV ORF3 protein.1 Publication

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi111351, 131 interactors
CORUMiP19174
DIPiDIP-100N
IntActiP19174, 118 interactors
MINTiP19174
STRINGi9606.ENSP00000244007

Chemistry databases

BindingDBiP19174

Structurei

Secondary structure

11290
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP19174
SMRiP19174
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19174

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 142PH 1PROSITE-ProRule annotationAdd BLAST116
Domaini152 – 187EF-handPROSITE-ProRule annotationAdd BLAST36
Domaini320 – 464PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST145
Domaini489 – 523PH 2; first partPROSITE-ProRule annotationAdd BLAST35
Domaini550 – 657SH2 1PROSITE-ProRule annotationAdd BLAST108
Domaini668 – 756SH2 2PROSITE-ProRule annotationAdd BLAST89
Domaini791 – 851SH3PROSITE-ProRule annotationAdd BLAST61
Domaini895 – 931PH 2; second partPROSITE-ProRule annotationAdd BLAST37
Domaini953 – 1070PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST118
Domaini1075 – 1177C2PROSITE-ProRule annotationAdd BLAST103

Domaini

The SH3 domain mediates interaction with CLNK (By similarity). The SH3 domain also mediates interaction with RALGPS1.By similarity

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiKOG1264 Eukaryota
ENOG410XPXE LUCA
GeneTreeiENSGT00730000110782
HOVERGENiHBG053611
InParanoidiP19174
KOiK01116
OMAiKENSIWN
OrthoDBiEOG091G07R3
PhylomeDBiP19174
TreeFamiTF313216

Family and domain databases

CDDicd09932 SH2_C-SH2_PLC_gamma_like, 1 hit
cd10341 SH2_N-SH2_PLC_gamma_like, 1 hit
cd11970 SH3_PLCgamma1, 1 hit
Gene3Di2.30.29.30, 1 hit
2.60.40.150, 1 hit
3.20.20.190, 2 hits
3.30.505.10, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR001192 PI-PLC_fam
IPR016279 PLC-gamma
IPR028380 PLC-gamma1
IPR035023 PLC-gamma_C-SH2
IPR035024 PLC-gamma_N-SH2
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR035724 PLCgamma1_SH3
IPR000909 PLipase_C_PInositol-sp_X_dom
IPR001711 PLipase_C_Pinositol-sp_Y
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR10336 PTHR10336, 1 hit
PTHR10336:SF52 PTHR10336:SF52, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF00388 PI-PLC-X, 1 hit
PF00387 PI-PLC-Y, 1 hit
PF00017 SH2, 2 hits
PF00018 SH3_1, 1 hit
PIRSFiPIRSF000952 PLC-gamma, 1 hit
PRINTSiPR00390 PHPHLIPASEC
PR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00233 PH, 3 hits
SM00148 PLCXc, 1 hit
SM00149 PLCYc, 1 hit
SM00252 SH2, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF50044 SSF50044, 1 hit
SSF51695 SSF51695, 1 hit
SSF55550 SSF55550, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS50003 PH_DOMAIN, 2 hits
PS50007 PIPLC_X_DOMAIN, 1 hit
PS50008 PIPLC_Y_DOMAIN, 1 hit
PS50001 SH2, 2 hits
PS50002 SH3, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P19174-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGAASPCAN GCGPGAPSDA EVLHLCRSLE VGTVMTLFYS KKSQRPERKT 
        60         70         80         90        100
FQVKLETRQI TWSRGADKIE GAIDIREIKE IRPGKTSRDF DRYQEDPAFR 
       110        120        130        140        150
PDQSHCFVIL YGMEFRLKTL SLQATSEDEV NMWIKGLTWL MEDTLQAPTP 
       160        170        180        190        200
LQIERWLRKQ FYSVDRNRED RISAKDLKNM LSQVNYRVPN MRFLRERLTD 
       210        220        230        240        250
LEQRSGDITY GQFAQLYRSL MYSAQKTMDL PFLEASTLRA GERPELCRVS 
       260        270        280        290        300
LPEFQQFLLD YQGELWAVDR LQVQEFMLSF LRDPLREIEE PYFFLDEFVT 
       310        320        330        340        350
FLFSKENSVW NSQLDAVCPD TMNNPLSHYW ISSSHNTYLT GDQFSSESSL 
       360        370        380        390        400
EAYARCLRMG CRCIELDCWD GPDGMPVIYH GHTLTTKIKF SDVLHTIKEH 
       410        420        430        440        450
AFVASEYPVI LSIEDHCSIA QQRNMAQYFK KVLGDTLLTK PVEISADGLP 
       460        470        480        490        500
SPNQLKRKIL IKHKKLAEGS AYEEVPTSMM YSENDISNSI KNGILYLEDP 
       510        520        530        540        550
VNHEWYPHYF VLTSSKIYYS EETSSDQGNE DEEEPKEVSS STELHSNEKW 
       560        570        580        590        600
FHGKLGAGRD GRHIAERLLT EYCIETGAPD GSFLVRESET FVGDYTLSFW 
       610        620        630        640        650
RNGKVQHCRI HSRQDAGTPK FFLTDNLVFD SLYDLITHYQ QVPLRCNEFE 
       660        670        680        690        700
MRLSEPVPQT NAHESKEWYH ASLTRAQAEH MLMRVPRDGA FLVRKRNEPN 
       710        720        730        740        750
SYAISFRAEG KIKHCRVQQE GQTVMLGNSE FDSLVDLISY YEKHPLYRKM 
       760        770        780        790        800
KLRYPINEEA LEKIGTAEPD YGALYEGRNP GFYVEANPMP TFKCAVKALF 
       810        820        830        840        850
DYKAQREDEL TFIKSAIIQN VEKQEGGWWR GDYGGKKQLW FPSNYVEEMV 
       860        870        880        890        900
NPVALEPERE HLDENSPLGD LLRGVLDVPA CQIAIRPEGK NNRLFVFSIS 
       910        920        930        940        950
MASVAHWSLD VAADSQEELQ DWVKKIREVA QTADARLTEG KIMERRKKIA 
       960        970        980        990       1000
LELSELVVYC RPVPFDEEKI GTERACYRDM SSFPETKAEK YVNKAKGKKF 
      1010       1020       1030       1040       1050
LQYNRLQLSR IYPKGQRLDS SNYDPLPMWI CGSQLVALNF QTPDKPMQMN 
      1060       1070       1080       1090       1100
QALFMTGRHC GYVLQPSTMR DEAFDPFDKS SLRGLEPCAI SIEVLGARHL 
      1110       1120       1130       1140       1150
PKNGRGIVCP FVEIEVAGAE YDSTKQKTEF VVDNGLNPVW PAKPFHFQIS 
      1160       1170       1180       1190       1200
NPEFAFLRFV VYEEDMFSDQ NFLAQATFPV KGLKTGYRAV PLKNNYSEDL 
      1210       1220       1230       1240       1250
ELASLLIKID IFPAKENGDL SPFSGTSLRE RGSDASGQLF HGRAREGSFE 
      1260       1270       1280       1290
SRYQQPFEDF RISQEHLADH FDSRERRAPR RTRVNGDNRL
Length:1,290
Mass (Da):148,532
Last modified:November 1, 1990 - v1
Checksum:iAE05ABE2A18EDDAC
GO
Isoform 2 (identifier: P19174-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1215-1215: K → KQ

Show »
Length:1,291
Mass (Da):148,660
Checksum:iEDDBB8D4E49B2F3E
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GY63V9GY63_HUMAN
Phosphoinositide phospholipase C
PLCG1
219Annotation score:
V9GYH5V9GYH5_HUMAN
1-phosphatidylinositol 4,5-bisphosp...
PLCG1
133Annotation score:
V9GY71V9GY71_HUMAN
1-phosphatidylinositol 4,5-bisphosp...
PLCG1
108Annotation score:
M0QX77M0QX77_HUMAN
1-phosphatidylinositol 4,5-bisphosp...
PLCG1
50Annotation score:
A0A0D9SEK2A0A0D9SEK2_HUMAN
1-phosphatidylinositol 4,5-bisphosp...
PLCG1
132Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025213209T → N1 PublicationCorresponds to variant dbSNP:rs2229348Ensembl.1
Natural variantiVAR_022130279S → G1 PublicationCorresponds to variant dbSNP:rs2228246Ensembl.1
Natural variantiVAR_025214739S → T1 PublicationCorresponds to variant dbSNP:rs34203315Ensembl.1
Natural variantiVAR_011908813I → T2 PublicationsCorresponds to variant dbSNP:rs753381Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0386921215K → KQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34667 mRNA Translation: AAA36452.1
DQ297143 Genomic DNA Translation: ABB84466.1
AL022394 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75991.1
CH471077 Genomic DNA Translation: EAW75992.1
BC136466 mRNA Translation: AAI36467.1
BC144136 mRNA Translation: AAI44137.1
CCDSiCCDS13313.1 [P19174-2]
CCDS13314.1 [P19174-1]
PIRiA36466
RefSeqiNP_002651.2, NM_002660.2 [P19174-2]
NP_877963.1, NM_182811.1 [P19174-1]
UniGeneiHs.268177

Genome annotation databases

EnsembliENST00000244007; ENSP00000244007; ENSG00000124181 [P19174-2]
ENST00000373271; ENSP00000362368; ENSG00000124181 [P19174-1]
GeneIDi5335
KEGGihsa:5335
UCSCiuc002xjo.2 human [P19174-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34667 mRNA Translation: AAA36452.1
DQ297143 Genomic DNA Translation: ABB84466.1
AL022394 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75991.1
CH471077 Genomic DNA Translation: EAW75992.1
BC136466 mRNA Translation: AAI36467.1
BC144136 mRNA Translation: AAI44137.1
CCDSiCCDS13313.1 [P19174-2]
CCDS13314.1 [P19174-1]
PIRiA36466
RefSeqiNP_002651.2, NM_002660.2 [P19174-2]
NP_877963.1, NM_182811.1 [P19174-1]
UniGeneiHs.268177

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HSQNMR-A790-851[»]
2HSPNMR-A790-851[»]
4EY0X-ray2.80A/B/C/D545-790[»]
4FBNX-ray2.40A545-790[»]
ProteinModelPortaliP19174
SMRiP19174
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111351, 131 interactors
CORUMiP19174
DIPiDIP-100N
IntActiP19174, 118 interactors
MINTiP19174
STRINGi9606.ENSP00000244007

Chemistry databases

BindingDBiP19174
ChEMBLiCHEMBL3964

Protein family/group databases

MoonDBiP19174 Predicted

PTM databases

iPTMnetiP19174
PhosphoSitePlusiP19174

Polymorphism and mutation databases

BioMutaiPLCG1
DMDMi130225

Proteomic databases

EPDiP19174
MaxQBiP19174
PaxDbiP19174
PeptideAtlasiP19174
PRIDEiP19174
ProteomicsDBi53635
53636 [P19174-2]

Protocols and materials databases

DNASUi5335
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244007; ENSP00000244007; ENSG00000124181 [P19174-2]
ENST00000373271; ENSP00000362368; ENSG00000124181 [P19174-1]
GeneIDi5335
KEGGihsa:5335
UCSCiuc002xjo.2 human [P19174-1]

Organism-specific databases

CTDi5335
DisGeNETi5335
EuPathDBiHostDB:ENSG00000124181.14
GeneCardsiPLCG1
HGNCiHGNC:9065 PLCG1
HPAiCAB004277
HPA036681
HPA036682
MIMi172420 gene
neXtProtiNX_P19174
OpenTargetsiENSG00000124181
PharmGKBiPA33392
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1264 Eukaryota
ENOG410XPXE LUCA
GeneTreeiENSGT00730000110782
HOVERGENiHBG053611
InParanoidiP19174
KOiK01116
OMAiKENSIWN
OrthoDBiEOG091G07R3
PhylomeDBiP19174
TreeFamiTF313216

Enzyme and pathway databases

BRENDAi3.1.4.11 2681
ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
R-HSA-1251932 PLCG1 events in ERBB2 signaling
R-HSA-1489509 DAG and IP3 signaling
R-HSA-167021 PLC-gamma1 signalling
R-HSA-170968 Frs2-mediated activation
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol
R-HSA-186763 Downstream signal transduction
R-HSA-202433 Generation of second messenger molecules
R-HSA-2029485 Role of phospholipids in phagocytosis
R-HSA-210990 PECAM1 interactions
R-HSA-212718 EGFR interacts with phospholipase C-gamma
R-HSA-2424491 DAP12 signaling
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-418890 Role of second messengers in netrin-1 signaling
R-HSA-5218921 VEGFR2 mediated cell proliferation
R-HSA-5637810 Constitutive Signaling by EGFRvIII
R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1
R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2
R-HSA-5654227 Phospholipase C-mediated cascade, FGFR3
R-HSA-5654228 Phospholipase C-mediated cascade, FGFR4
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5655291 Signaling by FGFR4 in disease
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer
R-HSA-8853659 RET signaling
R-HSA-9026527 Activated NTRK2 signals through PLCG1
R-HSA-9034793 Activated NTRK3 signals through PLCG1
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
SignaLinkiP19174
SIGNORiP19174

Miscellaneous databases

ChiTaRSiPLCG1 human
EvolutionaryTraceiP19174
GeneWikiiPLCG1
GenomeRNAii5335
PROiPR:P19174
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124181 Expressed in 221 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_PLCG1
ExpressionAtlasiP19174 baseline and differential
GenevisibleiP19174 HS

Family and domain databases

CDDicd09932 SH2_C-SH2_PLC_gamma_like, 1 hit
cd10341 SH2_N-SH2_PLC_gamma_like, 1 hit
cd11970 SH3_PLCgamma1, 1 hit
Gene3Di2.30.29.30, 1 hit
2.60.40.150, 1 hit
3.20.20.190, 2 hits
3.30.505.10, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR001192 PI-PLC_fam
IPR016279 PLC-gamma
IPR028380 PLC-gamma1
IPR035023 PLC-gamma_C-SH2
IPR035024 PLC-gamma_N-SH2
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR035724 PLCgamma1_SH3
IPR000909 PLipase_C_PInositol-sp_X_dom
IPR001711 PLipase_C_Pinositol-sp_Y
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR10336 PTHR10336, 1 hit
PTHR10336:SF52 PTHR10336:SF52, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF00388 PI-PLC-X, 1 hit
PF00387 PI-PLC-Y, 1 hit
PF00017 SH2, 2 hits
PF00018 SH3_1, 1 hit
PIRSFiPIRSF000952 PLC-gamma, 1 hit
PRINTSiPR00390 PHPHLIPASEC
PR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00233 PH, 3 hits
SM00148 PLCXc, 1 hit
SM00149 PLCYc, 1 hit
SM00252 SH2, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF50044 SSF50044, 1 hit
SSF51695 SSF51695, 1 hit
SSF55550 SSF55550, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS50003 PH_DOMAIN, 2 hits
PS50007 PIPLC_X_DOMAIN, 1 hit
PS50008 PIPLC_Y_DOMAIN, 1 hit
PS50001 SH2, 2 hits
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLCG1_HUMAN
AccessioniPrimary (citable) accession number: P19174
Secondary accession number(s): B7ZLY7
, B9EGH4, E1P5W4, Q2V575
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 7, 2018
This is version 230 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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