UniProtKB - P19174 (PLCG1_HUMAN)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
PLCG1
Functioni
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, EGFR, FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity).
Plays a role in actin reorganization and cell migration (PubMed:17229814).
By similarity1 PublicationCatalytic activityi
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H+By similarityEC:3.1.4.11By similarityThis reaction proceeds in the forwardBy similarity direction.
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H+By similarityThis reaction proceeds in the forwardBy similarity direction.
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 335 | PROSITE-ProRule annotation | 1 | |
Active sitei | 380 | PROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 165 – 176 | PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium-dependent phospholipase C activity Source: UniProtKB
- calcium ion binding Source: InterPro
- neurotrophin TRKA receptor binding Source: UniProtKB
- phosphatidylinositol phospholipase C activity Source: UniProtKB
- phospholipase C activity Source: Reactome
- protein kinase binding Source: BHF-UCL
GO - Biological processi
- calcium-mediated signaling Source: BHF-UCL
- cell migration Source: BHF-UCL
- cellular response to epidermal growth factor stimulus Source: UniProtKB
- epidermal growth factor receptor signaling pathway Source: BHF-UCL
- Fc-epsilon receptor signaling pathway Source: Reactome
- negative regulation of inflammatory response to antigenic stimulus Source: Reactome
- phosphatidylinositol metabolic process Source: UniProtKB
- phospholipid catabolic process Source: InterPro
- positive regulation of angiogenesis Source: DFLAT
- positive regulation of blood vessel endothelial cell migration Source: DFLAT
- positive regulation of endothelial cell apoptotic process Source: BHF-UCL
- positive regulation of epithelial cell migration Source: UniProtKB
- positive regulation of release of sequestered calcium ion into cytosol Source: BHF-UCL
- positive regulation of vascular endothelial cell proliferation Source: BHF-UCL
- T cell receptor signaling pathway Source: Reactome
Keywordsi
Molecular function | Hydrolase, Transducer |
Biological process | Host-virus interaction, Lipid degradation, Lipid metabolism |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
BRENDAi | 3.1.4.11, 2681 |
PathwayCommonsi | P19174 |
Reactomei | R-HSA-1169408, ISG15 antiviral mechanism R-HSA-1236382, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1251932, PLCG1 events in ERBB2 signaling R-HSA-1489509, DAG and IP3 signaling R-HSA-167021, PLC-gamma1 signalling R-HSA-1855204, Synthesis of IP3 and IP4 in the cytosol R-HSA-186763, Downstream signal transduction R-HSA-201556, Signaling by ALK R-HSA-202433, Generation of second messenger molecules R-HSA-2029485, Role of phospholipids in phagocytosis R-HSA-210990, PECAM1 interactions R-HSA-212718, EGFR interacts with phospholipase C-gamma R-HSA-2424491, DAP12 signaling R-HSA-2871796, FCERI mediated MAPK activation R-HSA-2871809, FCERI mediated Ca+2 mobilization R-HSA-418890, Role of second messengers in netrin-1 signaling R-HSA-5218921, VEGFR2 mediated cell proliferation R-HSA-5637810, Constitutive Signaling by EGFRvIII R-HSA-5654219, Phospholipase C-mediated cascade: FGFR1 R-HSA-5654221, Phospholipase C-mediated cascade, FGFR2 R-HSA-5654227, Phospholipase C-mediated cascade, FGFR3 R-HSA-5654228, Phospholipase C-mediated cascade, FGFR4 R-HSA-5655253, Signaling by FGFR2 in disease R-HSA-5655291, Signaling by FGFR4 in disease R-HSA-5655302, Signaling by FGFR1 in disease R-HSA-8853338, Signaling by FGFR3 point mutants in cancer R-HSA-8853659, RET signaling R-HSA-9026527, Activated NTRK2 signals through PLCG1 R-HSA-9027277, Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9034793, Activated NTRK3 signals through PLCG1 R-HSA-9664323, FCGR3A-mediated IL10 synthesis R-HSA-9664565, Signaling by ERBB2 KD Mutants R-HSA-9665348, Signaling by ERBB2 ECD mutants R-HSA-9665686, Signaling by ERBB2 TMD/JMD mutants R-HSA-9725370, Signaling by ALK fusions and activated point mutants |
SignaLinki | P19174 |
SIGNORi | P19174 |
Protein family/group databases
MoonDBi | P19174, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Curated (EC:3.1.4.11By similarity)Alternative name(s): PLC-148 Phosphoinositide phospholipase C-gamma-1 Phospholipase C-II Short name: PLC-II Phospholipase C-gamma-1 Short name: PLC-gamma-1 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9065, PLCG1 |
MIMi | 172420, gene |
neXtProti | NX_P19174 |
VEuPathDBi | HostDB:ENSG00000124181 |
Subcellular locationi
Other locations
- lamellipodium 1 Publication
- ruffle 1 Publication
Note: Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.1 Publication
Cytosol
- cytosol Source: UniProtKB
Nucleus
- COP9 signalosome Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
- ruffle membrane Source: ARUK-UCL
Other locations
- cell projection Source: BHF-UCL
- cytoplasm Source: MGI
- lamellipodium Source: UniProtKB
- ruffle Source: UniProtKB
Keywords - Cellular componenti
Cell projectionPathology & Biotechi
Organism-specific databases
DisGeNETi | 5335 |
OpenTargetsi | ENSG00000124181 |
PharmGKBi | PA33392 |
Miscellaneous databases
Pharosi | P19174, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3964 |
Genetic variation databases
BioMutai | PLCG1 |
DMDMi | 130225 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000088498 | 2 – 1290 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1Add BLAST | 1289 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | ||
Modified residuei | 506 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 771 | Phosphotyrosine; by SYKCombined sources2 Publications | 1 | ||
Modified residuei | 775 | PhosphotyrosineCombined sources | 1 | ||
Modified residuei | 783 | Phosphotyrosine; by ITK, SYK and TXKCombined sources3 Publications | 1 | ||
Modified residuei | 977 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 1221 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1227 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1233 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 1248 | Phosphoserine1 Publication | 1 | ||
Modified residuei | 1253 | PhosphotyrosineCombined sources | 1 | ||
Modified residuei | 1263 | PhosphoserineCombined sources | 1 | ||
Isoform 2 (identifier: P19174-2) | |||||
Modified residuei | 1222 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-1738 |
EPDi | P19174 |
jPOSTi | P19174 |
MassIVEi | P19174 |
MaxQBi | P19174 |
PaxDbi | P19174 |
PeptideAtlasi | P19174 |
PRIDEi | P19174 |
ProteomicsDBi | 53635 [P19174-1] 53636 [P19174-2] |
PTM databases
GlyGeni | P19174, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P19174 |
PhosphoSitePlusi | P19174 |
Expressioni
Gene expression databases
Bgeei | ENSG00000124181, Expressed in left lobe of thyroid gland and 232 other tissues |
ExpressionAtlasi | P19174, baseline and differential |
Genevisiblei | P19174, HS |
Organism-specific databases
HPAi | ENSG00000124181, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with AGAP2 via its SH3 domain.
Interacts (via SH2 domain) with RET.
Interacts with FLT1 (tyrosine-phosphorylated) (By similarity).
Interacts (via SH2 domain) with FGFR1, FGFR2, FGFR3 and FGFR4 (phosphorylated).
Interacts with LAT (phosphorylated) upon TCR activation.
Interacts (via SH3 domain) with the Pro-rich domain of TNK1. Associates with BLNK, VAV1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion.
Interacts with CBLB in activated T-cells; which inhibits phosphorylation.
Interacts with SHB.
Interacts (via SH3 domain) with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. This interaction is selectively regulated by arginine methylation of KHDRBS1/SAM68.
Interacts with INPP5D/SHIP1, THEMIS and CLNK (By similarity).
Interacts with AXL, FLT4 and KIT.
Interacts with RALGPS1.
Interacts (via the SH2 domains) with VIL1 (phosphorylated at C-terminus tyrosine phosphorylation sites).
Interacts (via SH2 domain) with PDGFRA and PDGFRB (tyrosine phosphorylated).
Interacts with PIP5K1C (By similarity).
Interacts with NTRK1 and NTRK2 (phosphorylated upon ligand-binding).
Interacts with SYK; activates PLCG1.
Interacts with GRB2, LAT and THEMIS upon TCR activation in thymocytes (By similarity).
Interacts with TESPA1; the association is increased with prolonged stimulation of the TCR and may facilitate the assembly of the LAT signalosome.
By similarity19 Publications(Microbial infection) Interacts (via SH3 domain) with HEV ORF3 protein.
1 PublicationBinary interactionsi
P19174
GO - Molecular functioni
- neurotrophin TRKA receptor binding Source: UniProtKB
- protein kinase binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 111351, 174 interactors |
CORUMi | P19174 |
DIPi | DIP-100N |
IntActi | P19174, 136 interactors |
MINTi | P19174 |
STRINGi | 9606.ENSP00000244007 |
Chemistry databases
BindingDBi | P19174 |
Miscellaneous databases
RNActi | P19174, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P19174 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P19174 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 142 | PH 1PROSITE-ProRule annotationAdd BLAST | 116 | |
Domaini | 152 – 187 | EF-handPROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 320 – 464 | PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST | 145 | |
Domaini | 489 – 523 | PH 2; first partPROSITE-ProRule annotationAdd BLAST | 35 | |
Domaini | 550 – 657 | SH2 1PROSITE-ProRule annotationAdd BLAST | 108 | |
Domaini | 668 – 756 | SH2 2PROSITE-ProRule annotationAdd BLAST | 89 | |
Domaini | 791 – 851 | SH3PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 895 – 931 | PH 2; second partPROSITE-ProRule annotationAdd BLAST | 37 | |
Domaini | 953 – 1070 | PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST | 118 | |
Domaini | 1071 – 1194 | C2PROSITE-ProRule annotationAdd BLAST | 124 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 522 – 544 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 1271 – 1290 | DisorderedSequence analysisAdd BLAST | 20 |
Domaini
Keywords - Domaini
Repeat, SH2 domain, SH3 domainPhylogenomic databases
eggNOGi | KOG1264, Eukaryota |
GeneTreei | ENSGT00940000158901 |
HOGENOMi | CLU_002738_5_0_1 |
InParanoidi | P19174 |
OMAi | FNPVPFW |
OrthoDBi | 368239at2759 |
PhylomeDBi | P19174 |
TreeFami | TF313216 |
Family and domain databases
CDDi | cd09932, SH2_C-SH2_PLC_gamma_like, 1 hit cd10341, SH2_N-SH2_PLC_gamma_like, 1 hit cd11970, SH3_PLCgamma1, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 2 hits 3.30.505.10, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR001192, PI-PLC_fam IPR016279, PLC-gamma IPR028380, PLC-gamma1 IPR035023, PLC-gamma_C-SH2 IPR035024, PLC-gamma_N-SH2 IPR017946, PLC-like_Pdiesterase_TIM-brl IPR035724, PLCgamma1_SH3 IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR10336, PTHR10336, 1 hit PTHR10336:SF173, PTHR10336:SF173, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit PF00017, SH2, 2 hits PF00018, SH3_1, 1 hit |
PIRSFi | PIRSF000952, PLC-gamma, 1 hit |
PRINTSi | PR00390, PHPHLIPASEC PR00401, SH2DOMAIN |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00233, PH, 3 hits SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit SM00252, SH2, 2 hits SM00326, SH3, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF49562, SSF49562, 1 hit SSF50044, SSF50044, 1 hit SSF51695, SSF51695, 1 hit SSF55550, SSF55550, 2 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 1 hit PS50003, PH_DOMAIN, 2 hits PS50007, PIPLC_X_DOMAIN, 1 hit PS50008, PIPLC_Y_DOMAIN, 1 hit PS50001, SH2, 2 hits PS50002, SH3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGAASPCAN GCGPGAPSDA EVLHLCRSLE VGTVMTLFYS KKSQRPERKT
60 70 80 90 100
FQVKLETRQI TWSRGADKIE GAIDIREIKE IRPGKTSRDF DRYQEDPAFR
110 120 130 140 150
PDQSHCFVIL YGMEFRLKTL SLQATSEDEV NMWIKGLTWL MEDTLQAPTP
160 170 180 190 200
LQIERWLRKQ FYSVDRNRED RISAKDLKNM LSQVNYRVPN MRFLRERLTD
210 220 230 240 250
LEQRSGDITY GQFAQLYRSL MYSAQKTMDL PFLEASTLRA GERPELCRVS
260 270 280 290 300
LPEFQQFLLD YQGELWAVDR LQVQEFMLSF LRDPLREIEE PYFFLDEFVT
310 320 330 340 350
FLFSKENSVW NSQLDAVCPD TMNNPLSHYW ISSSHNTYLT GDQFSSESSL
360 370 380 390 400
EAYARCLRMG CRCIELDCWD GPDGMPVIYH GHTLTTKIKF SDVLHTIKEH
410 420 430 440 450
AFVASEYPVI LSIEDHCSIA QQRNMAQYFK KVLGDTLLTK PVEISADGLP
460 470 480 490 500
SPNQLKRKIL IKHKKLAEGS AYEEVPTSMM YSENDISNSI KNGILYLEDP
510 520 530 540 550
VNHEWYPHYF VLTSSKIYYS EETSSDQGNE DEEEPKEVSS STELHSNEKW
560 570 580 590 600
FHGKLGAGRD GRHIAERLLT EYCIETGAPD GSFLVRESET FVGDYTLSFW
610 620 630 640 650
RNGKVQHCRI HSRQDAGTPK FFLTDNLVFD SLYDLITHYQ QVPLRCNEFE
660 670 680 690 700
MRLSEPVPQT NAHESKEWYH ASLTRAQAEH MLMRVPRDGA FLVRKRNEPN
710 720 730 740 750
SYAISFRAEG KIKHCRVQQE GQTVMLGNSE FDSLVDLISY YEKHPLYRKM
760 770 780 790 800
KLRYPINEEA LEKIGTAEPD YGALYEGRNP GFYVEANPMP TFKCAVKALF
810 820 830 840 850
DYKAQREDEL TFIKSAIIQN VEKQEGGWWR GDYGGKKQLW FPSNYVEEMV
860 870 880 890 900
NPVALEPERE HLDENSPLGD LLRGVLDVPA CQIAIRPEGK NNRLFVFSIS
910 920 930 940 950
MASVAHWSLD VAADSQEELQ DWVKKIREVA QTADARLTEG KIMERRKKIA
960 970 980 990 1000
LELSELVVYC RPVPFDEEKI GTERACYRDM SSFPETKAEK YVNKAKGKKF
1010 1020 1030 1040 1050
LQYNRLQLSR IYPKGQRLDS SNYDPLPMWI CGSQLVALNF QTPDKPMQMN
1060 1070 1080 1090 1100
QALFMTGRHC GYVLQPSTMR DEAFDPFDKS SLRGLEPCAI SIEVLGARHL
1110 1120 1130 1140 1150
PKNGRGIVCP FVEIEVAGAE YDSTKQKTEF VVDNGLNPVW PAKPFHFQIS
1160 1170 1180 1190 1200
NPEFAFLRFV VYEEDMFSDQ NFLAQATFPV KGLKTGYRAV PLKNNYSEDL
1210 1220 1230 1240 1250
ELASLLIKID IFPAKENGDL SPFSGTSLRE RGSDASGQLF HGRAREGSFE
1260 1270 1280 1290
SRYQQPFEDF RISQEHLADH FDSRERRAPR RTRVNGDNRL
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketV9GY63 | V9GY63_HUMAN | Phosphoinositide phospholipase C | PLCG1 | 219 | Annotation score: | ||
V9GYH5 | V9GYH5_HUMAN | 1-phosphatidylinositol 4,5-bisphosp... | PLCG1 | 133 | Annotation score: | ||
V9GY71 | V9GY71_HUMAN | 1-phosphatidylinositol 4,5-bisphosp... | PLCG1 | 108 | Annotation score: | ||
A0A0D9SEK2 | A0A0D9SEK2_HUMAN | 1-phosphatidylinositol 4,5-bisphosp... | PLCG1 | 132 | Annotation score: | ||
M0QX77 | M0QX77_HUMAN | 1-phosphatidylinositol 4,5-bisphosp... | PLCG1 | 50 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_025213 | 209 | T → N1 PublicationCorresponds to variant dbSNP:rs2229348Ensembl. | 1 | |
Natural variantiVAR_022130 | 279 | S → G1 PublicationCorresponds to variant dbSNP:rs2228246Ensembl. | 1 | |
Natural variantiVAR_025214 | 739 | S → T1 PublicationCorresponds to variant dbSNP:rs34203315Ensembl. | 1 | |
Natural variantiVAR_011908 | 813 | I → T2 PublicationsCorresponds to variant dbSNP:rs753381Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038692 | 1215 | K → KQ in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M34667 mRNA Translation: AAA36452.1 DQ297143 Genomic DNA Translation: ABB84466.1 AL022394 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75991.1 CH471077 Genomic DNA Translation: EAW75992.1 BC136466 mRNA Translation: AAI36467.1 BC144136 mRNA Translation: AAI44137.1 |
CCDSi | CCDS13313.1 [P19174-2] CCDS13314.1 [P19174-1] |
PIRi | A36466 |
RefSeqi | NP_002651.2, NM_002660.2 [P19174-2] NP_877963.1, NM_182811.1 [P19174-1] |
Genome annotation databases
Ensembli | ENST00000244007; ENSP00000244007; ENSG00000124181 [P19174-2] ENST00000373271; ENSP00000362368; ENSG00000124181 |
GeneIDi | 5335 |
KEGGi | hsa:5335 |
UCSCi | uc002xjo.2, human [P19174-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M34667 mRNA Translation: AAA36452.1 DQ297143 Genomic DNA Translation: ABB84466.1 AL022394 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75991.1 CH471077 Genomic DNA Translation: EAW75992.1 BC136466 mRNA Translation: AAI36467.1 BC144136 mRNA Translation: AAI44137.1 |
CCDSi | CCDS13313.1 [P19174-2] CCDS13314.1 [P19174-1] |
PIRi | A36466 |
RefSeqi | NP_002651.2, NM_002660.2 [P19174-2] NP_877963.1, NM_182811.1 [P19174-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1HSQ | NMR | - | A | 790-851 | [»] | |
2HSP | NMR | - | A | 790-851 | [»] | |
4EY0 | X-ray | 2.80 | A/B/C/D | 545-790 | [»] | |
4FBN | X-ray | 2.40 | A | 545-790 | [»] | |
7NXE | X-ray | 2.10 | A | 545-772 | [»] | |
SMRi | P19174 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111351, 174 interactors |
CORUMi | P19174 |
DIPi | DIP-100N |
IntActi | P19174, 136 interactors |
MINTi | P19174 |
STRINGi | 9606.ENSP00000244007 |
Chemistry databases
BindingDBi | P19174 |
ChEMBLi | CHEMBL3964 |
Protein family/group databases
MoonDBi | P19174, Predicted |
PTM databases
GlyGeni | P19174, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P19174 |
PhosphoSitePlusi | P19174 |
Genetic variation databases
BioMutai | PLCG1 |
DMDMi | 130225 |
Proteomic databases
CPTACi | CPTAC-1738 |
EPDi | P19174 |
jPOSTi | P19174 |
MassIVEi | P19174 |
MaxQBi | P19174 |
PaxDbi | P19174 |
PeptideAtlasi | P19174 |
PRIDEi | P19174 |
ProteomicsDBi | 53635 [P19174-1] 53636 [P19174-2] |
Protocols and materials databases
ABCDi | P19174, 1 sequenced antibody |
Antibodypediai | 3796, 1167 antibodies from 42 providers |
DNASUi | 5335 |
Genome annotation databases
Ensembli | ENST00000244007; ENSP00000244007; ENSG00000124181 [P19174-2] ENST00000373271; ENSP00000362368; ENSG00000124181 |
GeneIDi | 5335 |
KEGGi | hsa:5335 |
UCSCi | uc002xjo.2, human [P19174-1] |
Organism-specific databases
CTDi | 5335 |
DisGeNETi | 5335 |
GeneCardsi | PLCG1 |
HGNCi | HGNC:9065, PLCG1 |
HPAi | ENSG00000124181, Low tissue specificity |
MIMi | 172420, gene |
neXtProti | NX_P19174 |
OpenTargetsi | ENSG00000124181 |
PharmGKBi | PA33392 |
VEuPathDBi | HostDB:ENSG00000124181 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1264, Eukaryota |
GeneTreei | ENSGT00940000158901 |
HOGENOMi | CLU_002738_5_0_1 |
InParanoidi | P19174 |
OMAi | FNPVPFW |
OrthoDBi | 368239at2759 |
PhylomeDBi | P19174 |
TreeFami | TF313216 |
Enzyme and pathway databases
BRENDAi | 3.1.4.11, 2681 |
PathwayCommonsi | P19174 |
Reactomei | R-HSA-1169408, ISG15 antiviral mechanism R-HSA-1236382, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1251932, PLCG1 events in ERBB2 signaling R-HSA-1489509, DAG and IP3 signaling R-HSA-167021, PLC-gamma1 signalling R-HSA-1855204, Synthesis of IP3 and IP4 in the cytosol R-HSA-186763, Downstream signal transduction R-HSA-201556, Signaling by ALK R-HSA-202433, Generation of second messenger molecules R-HSA-2029485, Role of phospholipids in phagocytosis R-HSA-210990, PECAM1 interactions R-HSA-212718, EGFR interacts with phospholipase C-gamma R-HSA-2424491, DAP12 signaling R-HSA-2871796, FCERI mediated MAPK activation R-HSA-2871809, FCERI mediated Ca+2 mobilization R-HSA-418890, Role of second messengers in netrin-1 signaling R-HSA-5218921, VEGFR2 mediated cell proliferation R-HSA-5637810, Constitutive Signaling by EGFRvIII R-HSA-5654219, Phospholipase C-mediated cascade: FGFR1 R-HSA-5654221, Phospholipase C-mediated cascade, FGFR2 R-HSA-5654227, Phospholipase C-mediated cascade, FGFR3 R-HSA-5654228, Phospholipase C-mediated cascade, FGFR4 R-HSA-5655253, Signaling by FGFR2 in disease R-HSA-5655291, Signaling by FGFR4 in disease R-HSA-5655302, Signaling by FGFR1 in disease R-HSA-8853338, Signaling by FGFR3 point mutants in cancer R-HSA-8853659, RET signaling R-HSA-9026527, Activated NTRK2 signals through PLCG1 R-HSA-9027277, Erythropoietin activates Phospholipase C gamma (PLCG) R-HSA-9034793, Activated NTRK3 signals through PLCG1 R-HSA-9664323, FCGR3A-mediated IL10 synthesis R-HSA-9664565, Signaling by ERBB2 KD Mutants R-HSA-9665348, Signaling by ERBB2 ECD mutants R-HSA-9665686, Signaling by ERBB2 TMD/JMD mutants R-HSA-9725370, Signaling by ALK fusions and activated point mutants |
SignaLinki | P19174 |
SIGNORi | P19174 |
Miscellaneous databases
BioGRID-ORCSi | 5335, 19 hits in 1052 CRISPR screens |
ChiTaRSi | PLCG1, human |
EvolutionaryTracei | P19174 |
GeneWikii | PLCG1 |
GenomeRNAii | 5335 |
Pharosi | P19174, Tchem |
PROi | PR:P19174 |
RNActi | P19174, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000124181, Expressed in left lobe of thyroid gland and 232 other tissues |
ExpressionAtlasi | P19174, baseline and differential |
Genevisiblei | P19174, HS |
Family and domain databases
CDDi | cd09932, SH2_C-SH2_PLC_gamma_like, 1 hit cd10341, SH2_N-SH2_PLC_gamma_like, 1 hit cd11970, SH3_PLCgamma1, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 2.60.40.150, 1 hit 3.20.20.190, 2 hits 3.30.505.10, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR001192, PI-PLC_fam IPR016279, PLC-gamma IPR028380, PLC-gamma1 IPR035023, PLC-gamma_C-SH2 IPR035024, PLC-gamma_N-SH2 IPR017946, PLC-like_Pdiesterase_TIM-brl IPR035724, PLCgamma1_SH3 IPR000909, PLipase_C_PInositol-sp_X_dom IPR001711, PLipase_C_Pinositol-sp_Y IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR10336, PTHR10336, 1 hit PTHR10336:SF173, PTHR10336:SF173, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF00388, PI-PLC-X, 1 hit PF00387, PI-PLC-Y, 1 hit PF00017, SH2, 2 hits PF00018, SH3_1, 1 hit |
PIRSFi | PIRSF000952, PLC-gamma, 1 hit |
PRINTSi | PR00390, PHPHLIPASEC PR00401, SH2DOMAIN |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00233, PH, 3 hits SM00148, PLCXc, 1 hit SM00149, PLCYc, 1 hit SM00252, SH2, 2 hits SM00326, SH3, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF49562, SSF49562, 1 hit SSF50044, SSF50044, 1 hit SSF51695, SSF51695, 1 hit SSF55550, SSF55550, 2 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 1 hit PS50003, PH_DOMAIN, 2 hits PS50007, PIPLC_X_DOMAIN, 1 hit PS50008, PIPLC_Y_DOMAIN, 1 hit PS50001, SH2, 2 hits PS50002, SH3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PLCG1_HUMAN | |
Accessioni | P19174Primary (citable) accession number: P19174 Secondary accession number(s): B7ZLY7 Q2V575 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | November 1, 1990 | |
Last modified: | February 23, 2022 | |
This is version 252 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references