Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutathione S-transferase P 1

Gene

Gstp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Can metabolize 1-chloro-2,4-dinitrobenzene. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity).By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei8Glutathione1 Publication1
Binding sitei14Glutathione1 Publication1
Binding sitei39Glutathione1 Publication1
Binding sitei45Glutathione1 Publication1

GO - Molecular functioni

  • dinitrosyl-iron complex binding Source: MGI
  • drug binding Source: BHF-UCL
  • glutathione binding Source: MGI
  • glutathione peroxidase activity Source: MGI
  • glutathione transferase activity Source: MGI
  • JUN kinase binding Source: BHF-UCL
  • kinase regulator activity Source: BHF-UCL
  • protein kinase binding Source: MGI
  • S-nitrosoglutathione binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BRENDAi2.5.1.18 3474
ReactomeiR-MMU-156590 Glutathione conjugation
R-MMU-3299685 Detoxification of Reactive Oxygen Species
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase P 1 (EC:2.5.1.18)
Short name:
Gst P1
Alternative name(s):
GST YF-YF
GST class-pi
GST-piB
Preadipocyte growth factor
Gene namesi
Name:Gstp1
Synonyms:Gstpib
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:95865 Gstp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001859032 – 210Glutathione S-transferase P 1Add BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4Phosphotyrosine; by EGFRBy similarity1
Modified residuei62PhosphothreonineBy similarity1
Modified residuei103N6-succinyllysineCombined sources1
Modified residuei116N6-succinyllysineCombined sources1
Modified residuei128N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP19157
MaxQBiP19157
PaxDbiP19157
PeptideAtlasiP19157
PRIDEiP19157
TopDownProteomicsiP19157

2D gel databases

REPRODUCTION-2DPAGEiP19157
SWISS-2DPAGEiP19157

PTM databases

iPTMnetiP19157
PhosphoSitePlusiP19157
SwissPalmiP19157

Expressioni

Tissue specificityi

Ubiquitously expressed.

Gene expression databases

BgeeiENSMUSG00000060803 Expressed in 63 organ(s), highest expression level in liver
CleanExiMM_GSTP1
GenevisibleiP19157 MM

Interactioni

Subunit structurei

Homodimer. Interacts with CDK5 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Prdx6O087092EBI-2309446,EBI-444895

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200101, 3 interactors
IntActiP19157, 7 interactors
MINTiP19157
STRINGi10090.ENSMUSP00000129565

Structurei

Secondary structure

1210
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP19157
SMRiP19157
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19157

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 81GST N-terminalAdd BLAST80
Domaini83 – 204GST C-terminalAdd BLAST122

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni52 – 53Glutathione binding1 Publication2
Regioni65 – 66Glutathione binding1 Publication2

Sequence similaritiesi

Belongs to the GST superfamily. Pi family.Curated

Phylogenomic databases

eggNOGiKOG1695 Eukaryota
ENOG4111VAU LUCA
GeneTreeiENSGT00550000074559
HOGENOMiHOG000115733
HOVERGENiHBG108324
InParanoidiP19157
KOiK00799
OMAiLRCKYAT
OrthoDBiEOG091G0K2E
PhylomeDBiP19157
TreeFamiTF105321

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR003082 GST_pi
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF14497 GST_C_3, 1 hit
PF02798 GST_N, 1 hit
PRINTSiPR01268 GSTRNSFRASEP
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19157-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPYTIVYFP VRGRCEAMRM LLADQGQSWK EEVVTIDTWM QGLLKPTCLY
60 70 80 90 100
GQLPKFEDGD LTLYQSNAIL RHLGRSLGLY GKNQREAAQM DMVNDGVEDL
110 120 130 140 150
RGKYVTLIYT NYENGKNDYV KALPGHLKPF ETLLSQNQGG KAFIVGDQIS
160 170 180 190 200
FADYNLLDLL LIHQVLAPGC LDNFPLLSAY VARLSARPKI KAFLSSPEHV
210
NRPINGNGKQ
Length:210
Mass (Da):23,609
Last modified:January 23, 2007 - v2
Checksum:iDAC7762F4E34FF27
GO

Mass spectrometryi

Molecular mass is 23478.8±2 Da from positions 2 - 210. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53451 mRNA Translation: CAA37529.1
X76143 Genomic DNA No translation available.
U15654 Genomic DNA Translation: AAA64837.1
D30687 mRNA Translation: BAA06349.1
BC002048 mRNA Translation: AAH02048.1
BC061109 mRNA Translation: AAH61109.1
AK079144 mRNA Translation: BAC37560.1
CCDSiCCDS29411.1
PIRiS12709 B55140
RefSeqiNP_038569.1, NM_013541.1
UniGeneiMm.299292

Genome annotation databases

EnsembliENSMUST00000169613; ENSMUSP00000129565; ENSMUSG00000060803
ENSMUST00000180480; ENSMUSP00000138073; ENSMUSG00000097830
GeneIDi14870
KEGGimmu:14870
UCSCiuc008fyf.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGSTP1_MOUSE
AccessioniPrimary (citable) accession number: P19157
Secondary accession number(s): Q8BNY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 181 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again