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Protein

Peroxidase 2

Gene
N/A
Organism
Cucumis sativus (Cucumber)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Ca2+Note: Binds 2 calcium ions per subunit.
  • heme bNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei34Transition state stabilizerPROSITE-ProRule annotation1
Active sitei38Proton acceptorPROSITE-ProRule annotation1
Metal bindingi39Calcium 1PROSITE-ProRule annotation1
Metal bindingi42Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi44Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi46Calcium 1PROSITE-ProRule annotation1
Metal bindingi48Calcium 1PROSITE-ProRule annotation1
Binding sitei134Substrate; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi164Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi165Calcium 2PROSITE-ProRule annotation1
Metal bindingi210Calcium 2PROSITE-ProRule annotation1
Metal bindingi213Calcium 2PROSITE-ProRule annotation1
Metal bindingi218Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

SABIO-RKiP19135

Protein family/group databases

PeroxiBasei23 CsaPrx07

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase 2 (EC:1.11.1.7)
Alternative name(s):
CUP2
OrganismiCucumis sativus (Cucumber)
Taxonomic identifieri3659 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsCucurbitalesCucurbitaceaeBenincaseaeCucumis

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000055610‹1 – 292Peroxidase 2Add BLAST›292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi7 ↔ 86PROSITE-ProRule annotation
Disulfide bondi40 ↔ 45PROSITE-ProRule annotation
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi92 ↔ 288PROSITE-ProRule annotation
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi171 ↔ 199PROSITE-ProRule annotation
Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP19135

Structurei

3D structure databases

ProteinModelPortaliP19135
SMRiP19135
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Fragment.

P19135-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
TFYDESCPDV SNIVRRVVQQ ALVSDERAGA RLIRLHFHDC FVNGCDGSVL
60 70 80 90 100
LEDQPGVVSE LAAPGNANIT GFNIVNNIKA AVEKACPGVV SCADILAIAS
110 120 130 140 150
VGSVNLAGGP CWEVQLGRRD SRRANLQGAI DGLPSPFENV TQLKRKFDRV
160 170 180 190 200
DLDSTDLVAL SGAHTFGKSR CQFFDRRLNV SNPDSTLNPR YAQQLRQACS
210 220 230 240 250
SGRDTFVNLD PTTPNKFDKN YYTNLQSNTG PLTSDQVLHS TPGEDTVKIV
260 270 280 290
NLFAASQNQF FESFGQSMIN MGNIQPLTGN QGEIRSNCRR LN
Length:292
Mass (Da):31,857
Last modified:November 1, 1990 - v1
Checksum:i98FD89EF01CE6888
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32742 mRNA Translation: AAA33121.1
PIRiS11870

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32742 mRNA Translation: AAA33121.1
PIRiS11870

3D structure databases

ProteinModelPortaliP19135
SMRiP19135
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

PeroxiBasei23 CsaPrx07

Proteomic databases

PRIDEiP19135

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

SABIO-RKiP19135

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPER2_CUCSA
AccessioniPrimary (citable) accession number: P19135
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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