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Protein

Troponin C, slow skeletal and cardiac muscles

Gene

Tnnc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Miscellaneous

Cardiac muscle Tn-C can bind 3 calcium ions per molecule. Domain I does not bind calcium.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi65 – 761Add BLAST12
Calcium bindingi105 – 1162Add BLAST12
Calcium bindingi141 – 1523Add BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMuscle protein
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-390522 Striated Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin C, slow skeletal and cardiac muscles
Short name:
TN-C
Gene namesi
Name:Tnnc1
Synonyms:Tncc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:98779 Tnnc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000736981 – 161Troponin C, slow skeletal and cardiac musclesAdd BLAST161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei98PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP19123
PaxDbiP19123
PeptideAtlasiP19123
PRIDEiP19123

PTM databases

iPTMnetiP19123
PhosphoSitePlusiP19123

Expressioni

Gene expression databases

BgeeiENSMUSG00000091898 Expressed in 212 organ(s), highest expression level in heart left ventricle
CleanExiMM_TNNC1
ExpressionAtlasiP19123 baseline and differential
GenevisibleiP19123 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204238, 1 interactor
ComplexPortaliCPX-16 Cardiac Troponin complex
IntActiP19123, 5 interactors
MINTiP19123
STRINGi10090.ENSMUSP00000131991

Structurei

3D structure databases

ProteinModelPortaliP19123
SMRiP19123
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 51EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini52 – 87EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini92 – 127EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini128 – 161EF-hand 4PROSITE-ProRule annotationAdd BLAST34

Sequence similaritiesi

Belongs to the troponin C family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118901
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiP19123
KOiK05865
OMAiMNDIYKA
OrthoDBiEOG091G0QHM
PhylomeDBiP19123
TreeFamiTF318191

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P19123-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDDIYKAAVE QLTEEQKNEF KAAFDIFVLG AEDGCISTKE LGKVMRMLGQ
60 70 80 90 100
NPTPEELQEM IDEVDEDGSG TVDFDEFLVM MVRCMKDDSK GKSEEELSDL
110 120 130 140 150
FRMFDKNADG YIDLDELKMM LQATGETITE DDIEELMKDG DKNNDGRIDY
160
DEFLEFMKGV E
Length:161
Mass (Da):18,421
Last modified:November 1, 1990 - v1
Checksum:i34DCC903C157A312
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q8P0E9Q8P0_MOUSE
Troponin C, slow skeletal and cardi...
Tnnc1
106Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04971 Genomic DNA Translation: AAA37492.1
M29793 mRNA Translation: AAA37493.1
BC061172 mRNA Translation: AAH61172.1
CCDSiCCDS36854.1
PIRiA32620
RefSeqiNP_033419.1, NM_009393.2
UniGeneiMm.439921

Genome annotation databases

EnsembliENSMUST00000169169; ENSMUSP00000131991; ENSMUSG00000091898
GeneIDi21924
KEGGimmu:21924
UCSCiuc007sxd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04971 Genomic DNA Translation: AAA37492.1
M29793 mRNA Translation: AAA37493.1
BC061172 mRNA Translation: AAH61172.1
CCDSiCCDS36854.1
PIRiA32620
RefSeqiNP_033419.1, NM_009393.2
UniGeneiMm.439921

3D structure databases

ProteinModelPortaliP19123
SMRiP19123
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204238, 1 interactor
ComplexPortaliCPX-16 Cardiac Troponin complex
IntActiP19123, 5 interactors
MINTiP19123
STRINGi10090.ENSMUSP00000131991

PTM databases

iPTMnetiP19123
PhosphoSitePlusiP19123

Proteomic databases

MaxQBiP19123
PaxDbiP19123
PeptideAtlasiP19123
PRIDEiP19123

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000169169; ENSMUSP00000131991; ENSMUSG00000091898
GeneIDi21924
KEGGimmu:21924
UCSCiuc007sxd.1 mouse

Organism-specific databases

CTDi7134
MGIiMGI:98779 Tnnc1

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118901
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiP19123
KOiK05865
OMAiMNDIYKA
OrthoDBiEOG091G0QHM
PhylomeDBiP19123
TreeFamiTF318191

Enzyme and pathway databases

ReactomeiR-MMU-390522 Striated Muscle Contraction

Miscellaneous databases

PROiPR:P19123
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000091898 Expressed in 212 organ(s), highest expression level in heart left ventricle
CleanExiMM_TNNC1
ExpressionAtlasiP19123 baseline and differential
GenevisibleiP19123 MM

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTNNC1_MOUSE
AccessioniPrimary (citable) accession number: P19123
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: September 12, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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