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Protein

Serum albumin

Gene

ALB

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi30CopperBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCopper, Lipid-binding, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serum albumin
Alternative name(s):
Alpha-livetin
Allergen: Gal d 5
Gene namesi
Name:ALB
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE. Partially heat-labile allergen that may cause both respiratory and food-allergy symptoms in patients with the bird-egg syndrome.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3295 Gal d 5.0101
363 Gal d 5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
PropeptideiPRO_000000108319 – 235
ChainiPRO_000000108424 – 615Serum albuminAdd BLAST592

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi80 ↔ 89PROSITE-ProRule annotation
Disulfide bondi102 ↔ 118PROSITE-ProRule annotation
Disulfide bondi117 ↔ 128PROSITE-ProRule annotation
Disulfide bondi152 ↔ 197PROSITE-ProRule annotation
Disulfide bondi196 ↔ 205PROSITE-ProRule annotation
Disulfide bondi228 ↔ 274PROSITE-ProRule annotation
Disulfide bondi273 ↔ 281PROSITE-ProRule annotation
Disulfide bondi293 ↔ 307PROSITE-ProRule annotation
Disulfide bondi306 ↔ 317PROSITE-ProRule annotation
Disulfide bondi344 ↔ 389PROSITE-ProRule annotation
Disulfide bondi388 ↔ 397PROSITE-ProRule annotation
Disulfide bondi420 ↔ 466PROSITE-ProRule annotation
Disulfide bondi465 ↔ 476PROSITE-ProRule annotation
Disulfide bondi489 ↔ 505PROSITE-ProRule annotation
Glycosylationi500N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi504 ↔ 515PROSITE-ProRule annotation
Disulfide bondi542 ↔ 587PROSITE-ProRule annotation
Disulfide bondi586 ↔ 595PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP19121

Miscellaneous databases

PMAP-CutDBiP19121

Expressioni

Tissue specificityi

Plasma.

Interactioni

Protein-protein interaction databases

BioGridi676457, 1 interactor
IntActiP19121, 1 interactor
STRINGi9031.ENSGALP00000019031

Structurei

3D structure databases

ProteinModelPortaliP19121
SMRiP19121
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 214Albumin 1PROSITE-ProRule annotationAdd BLAST193
Domaini215 – 407Albumin 2PROSITE-ProRule annotationAdd BLAST193
Domaini408 – 605Albumin 3PROSITE-ProRule annotationAdd BLAST198

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIRZ Eukaryota
ENOG410Z40H LUCA
HOGENOMiHOG000293137
HOVERGENiHBG004207
InParanoidiP19121
PhylomeDBiP19121

Family and domain databases

CDDicd00015 ALBUMIN, 3 hits
InterProiView protein in InterPro
IPR000264 ALB/AFP/VDB
IPR020858 Serum_albumin-like
IPR021177 Serum_albumin/AFP/Afamin
IPR020857 Serum_albumin_CS
IPR014760 Serum_albumin_N
PANTHERiPTHR11385 PTHR11385, 1 hit
PfamiView protein in Pfam
PF00273 Serum_albumin, 3 hits
PIRSFiPIRSF002520 Serum_albumin_subgroup, 1 hit
PRINTSiPR00803 AFETOPROTEIN
PR00802 SERUMALBUMIN
SMARTiView protein in SMART
SM00103 ALBUMIN, 3 hits
SUPFAMiSSF48552 SSF48552, 3 hits
PROSITEiView protein in PROSITE
PS00212 ALBUMIN_1, 3 hits
PS51438 ALBUMIN_2, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19121-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWVTLISFI FLFSSATSRN LQRFARDAEH KSEIAHRYND LKEETFKAVA
60 70 80 90 100
MITFAQYLQR CSYEGLSKLV KDVVDLAQKC VANEDAPECS KPLPSIILDE
110 120 130 140 150
ICQVEKLRDS YGAMADCCSK ADPERNECFL SFKVSQPDFV QPYQRPASDV
160 170 180 190 200
ICQEYQDNRV SFLGHFIYSV ARRHPFLYAP AILSFAVDFE HALQSCCKES
210 220 230 240 250
DVGACLDTKE IVMREKAKGV SVKQQYFCGI LKQFGDRVFQ ARQLIYLSQK
260 270 280 290 300
YPKAPFSEVS KFVHDSIGVH KECCEGDMVE CMDDMARMMS NLCSQQDVFS
310 320 330 340 350
GKIKDCCEKP IVERSQCIME AEFDEKPADL PSLVEKYIED KEVCKSFEAG
360 370 380 390 400
HDAFMAEFVY EYSRRHPEFS IQLIMRIAKG YESLLEKCCK TDNPAECYAN
410 420 430 440 450
AQEQLNQHIK ETQDVVKTNC DLLHDHGEAD FLKSILIRYT KKMPQVPTDL
460 470 480 490 500
LLETGKKMTT IGTKCCQLGE DRRMACSEGY LSIVIHDTCR KQETTPINDN
510 520 530 540 550
VSQCCSQLYA NRRPCFTAMG VDTKYVPPPF NPDMFSFDEK LCSAPAEERE
560 570 580 590 600
VGQMKLLINL IKRKPQMTEE QIKTIADGFT AMVDKCCKQS DINTCFGEEG
610
ANLIVQSRAT LGIGA
Length:615
Mass (Da):69,918
Last modified:August 1, 1992 - v2
Checksum:iE59E4BBCAEC066C6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24F → M AA sequence (PubMed:911327).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60688 mRNA Translation: CAA43098.1
V00381 Genomic DNA Translation: CAA23680.1
PIRiS15571 ABCHS
UniGeneiGga.4510

Similar proteinsi

Entry informationi

Entry nameiALBU_CHICK
AccessioniPrimary (citable) accession number: P19121
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: August 1, 1992
Last modified: May 23, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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