UniProtKB - P19121 (ALBU_CHICK)
Protein
Albumin
Gene
ALB
Organism
Gallus gallus (Chicken)
Status
Functioni
Binds water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 30 | CopperBy similarity | 1 | |
Metal bindingi | 33 | Calcium 1By similarity | 1 | |
Metal bindingi | 40 | Calcium 2By similarity | 1 | |
Metal bindingi | 272 | Calcium 1By similarity | 1 | |
Metal bindingi | 277 | Calcium 1By similarity | 1 | |
Metal bindingi | 277 | ZincBy similarity | 1 | |
Metal bindingi | 280 | Calcium 1By similarity | 1 | |
Metal bindingi | 283 | Calcium 2By similarity | 1 |
GO - Molecular functioni
- DNA binding Source: UniProtKB
- fatty acid binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- pyridoxal phosphate binding Source: UniProtKB
- small molecule binding Source: AgBase
- toxic substance binding Source: UniProtKB
GO - Biological processi
- cellular response to starvation Source: UniProtKB
- maintenance of mitochondrion location Source: UniProtKB
- negative regulation of apoptotic process Source: UniProtKB
- response to virus Source: AgBase
- response to vitamin A Source: AgBase
Keywordsi
Ligand | Calcium, Copper, Lipid-binding, Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: AlbuminAlternative name(s): Alpha-livetin Allergen: Gal d 5 |
Gene namesi | Name:ALB |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: AgBase
Other locations
- cytoplasm Source: GO_Central
- protein-containing complex Source: UniProtKB
- yolk Source: AgBase
Keywords - Cellular componenti
SecretedPathology & Biotechi
Allergenic propertiesi
Can cause allergic reactions in humans. Binds to IgE. Partially heat-labile allergen that may cause both respiratory and food-allergy symptoms in patients with the bird-egg syndrome.1 Publication
Keywords - Diseasei
AllergenProtein family/group databases
Allergomei | 3295, Gal d 5.0101 363, Gal d 5 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | 1 PublicationAdd BLAST | 18 | |
PropeptideiPRO_0000001083 | 19 – 23 | 5 | ||
ChainiPRO_0000001084 | 24 – 615 | AlbuminAdd BLAST | 592 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 80 ↔ 89 | PROSITE-ProRule annotation | ||
Disulfide bondi | 102 ↔ 118 | PROSITE-ProRule annotation | ||
Disulfide bondi | 117 ↔ 128 | PROSITE-ProRule annotation | ||
Disulfide bondi | 152 ↔ 197 | PROSITE-ProRule annotation | ||
Disulfide bondi | 196 ↔ 205 | PROSITE-ProRule annotation | ||
Disulfide bondi | 228 ↔ 274 | PROSITE-ProRule annotation | ||
Disulfide bondi | 273 ↔ 281 | PROSITE-ProRule annotation | ||
Disulfide bondi | 293 ↔ 307 | PROSITE-ProRule annotation | ||
Disulfide bondi | 306 ↔ 317 | PROSITE-ProRule annotation | ||
Disulfide bondi | 344 ↔ 389 | PROSITE-ProRule annotation | ||
Disulfide bondi | 388 ↔ 397 | PROSITE-ProRule annotation | ||
Disulfide bondi | 420 ↔ 466 | PROSITE-ProRule annotation | ||
Disulfide bondi | 465 ↔ 476 | PROSITE-ProRule annotation | ||
Disulfide bondi | 489 ↔ 505 | PROSITE-ProRule annotation | ||
Glycosylationi | 500 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 504 ↔ 515 | PROSITE-ProRule annotation | ||
Disulfide bondi | 542 ↔ 587 | PROSITE-ProRule annotation | ||
Disulfide bondi | 586 ↔ 595 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P19121 |
Expressioni
Tissue specificityi
Plasma.
Interactioni
Protein-protein interaction databases
BioGRIDi | 676457, 1 interactor |
IntActi | P19121, 1 interactor |
STRINGi | 9031.ENSGALP00000019031 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 214 | Albumin 1PROSITE-ProRule annotationAdd BLAST | 193 | |
Domaini | 215 – 407 | Albumin 2PROSITE-ProRule annotationAdd BLAST | 193 | |
Domaini | 408 – 605 | Albumin 3PROSITE-ProRule annotationAdd BLAST | 198 |
Sequence similaritiesi
Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502R7EA, Eukaryota |
InParanoidi | P19121 |
PhylomeDBi | P19121 |
Family and domain databases
CDDi | cd00015, ALBUMIN, 3 hits |
InterProi | View protein in InterPro IPR000264, ALB/AFP/VDB IPR020858, Serum_albumin-like IPR021177, Serum_albumin/AFP/Afamin IPR020857, Serum_albumin_CS IPR014760, Serum_albumin_N |
PANTHERi | PTHR11385, PTHR11385, 1 hit |
Pfami | View protein in Pfam PF00273, Serum_albumin, 3 hits |
PIRSFi | PIRSF002520, Serum_albumin_subgroup, 1 hit |
PRINTSi | PR00803, AFETOPROTEIN PR00802, SERUMALBUMIN |
SMARTi | View protein in SMART SM00103, ALBUMIN, 3 hits |
SUPFAMi | SSF48552, SSF48552, 3 hits |
PROSITEi | View protein in PROSITE PS00212, ALBUMIN_1, 3 hits PS51438, ALBUMIN_2, 3 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P19121-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKWVTLISFI FLFSSATSRN LQRFARDAEH KSEIAHRYND LKEETFKAVA
60 70 80 90 100
MITFAQYLQR CSYEGLSKLV KDVVDLAQKC VANEDAPECS KPLPSIILDE
110 120 130 140 150
ICQVEKLRDS YGAMADCCSK ADPERNECFL SFKVSQPDFV QPYQRPASDV
160 170 180 190 200
ICQEYQDNRV SFLGHFIYSV ARRHPFLYAP AILSFAVDFE HALQSCCKES
210 220 230 240 250
DVGACLDTKE IVMREKAKGV SVKQQYFCGI LKQFGDRVFQ ARQLIYLSQK
260 270 280 290 300
YPKAPFSEVS KFVHDSIGVH KECCEGDMVE CMDDMARMMS NLCSQQDVFS
310 320 330 340 350
GKIKDCCEKP IVERSQCIME AEFDEKPADL PSLVEKYIED KEVCKSFEAG
360 370 380 390 400
HDAFMAEFVY EYSRRHPEFS IQLIMRIAKG YESLLEKCCK TDNPAECYAN
410 420 430 440 450
AQEQLNQHIK ETQDVVKTNC DLLHDHGEAD FLKSILIRYT KKMPQVPTDL
460 470 480 490 500
LLETGKKMTT IGTKCCQLGE DRRMACSEGY LSIVIHDTCR KQETTPINDN
510 520 530 540 550
VSQCCSQLYA NRRPCFTAMG VDTKYVPPPF NPDMFSFDEK LCSAPAEERE
560 570 580 590 600
VGQMKLLINL IKRKPQMTEE QIKTIADGFT AMVDKCCKQS DINTCFGEEG
610
ANLIVQSRAT LGIGA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 24 | F → M AA sequence (PubMed:911327).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X60688 mRNA Translation: CAA43098.1 V00381 Genomic DNA Translation: CAA23680.1 |
PIRi | S15571, ABCHS |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X60688 mRNA Translation: CAA43098.1 V00381 Genomic DNA Translation: CAA23680.1 |
PIRi | S15571, ABCHS |
3D structure databases
SMRi | P19121 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 676457, 1 interactor |
IntActi | P19121, 1 interactor |
STRINGi | 9031.ENSGALP00000019031 |
Protein family/group databases
Allergomei | 3295, Gal d 5.0101 363, Gal d 5 |
Proteomic databases
PaxDbi | P19121 |
Phylogenomic databases
eggNOGi | ENOG502R7EA, Eukaryota |
InParanoidi | P19121 |
PhylomeDBi | P19121 |
Family and domain databases
CDDi | cd00015, ALBUMIN, 3 hits |
InterProi | View protein in InterPro IPR000264, ALB/AFP/VDB IPR020858, Serum_albumin-like IPR021177, Serum_albumin/AFP/Afamin IPR020857, Serum_albumin_CS IPR014760, Serum_albumin_N |
PANTHERi | PTHR11385, PTHR11385, 1 hit |
Pfami | View protein in Pfam PF00273, Serum_albumin, 3 hits |
PIRSFi | PIRSF002520, Serum_albumin_subgroup, 1 hit |
PRINTSi | PR00803, AFETOPROTEIN PR00802, SERUMALBUMIN |
SMARTi | View protein in SMART SM00103, ALBUMIN, 3 hits |
SUPFAMi | SSF48552, SSF48552, 3 hits |
PROSITEi | View protein in PROSITE PS00212, ALBUMIN_1, 3 hits PS51438, ALBUMIN_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ALBU_CHICK | |
Accessioni | P19121Primary (citable) accession number: P19121 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | August 1, 1992 | |
Last modified: | December 2, 2020 | |
This is version 142 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Allergens
Nomenclature of allergens and list of entries