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Protein

Histidine decarboxylase

Gene

HDC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the biosynthesis of histamine from histidine.1 Publication

Catalytic activityi

L-histidine = histamine + CO2.1 Publication

Cofactori

pyridoxal 5'-phosphate1 Publication

Kineticsi

  1. KM=0.1 mM for histidine1 Publication
  1. Vmax=1880 nmol/min/mg enzyme1 Publication

Pathwayi: histamine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes histamine from L-histidine.
Proteins known to be involved in this subpathway in this organism are:
  1. Histidine decarboxylase (HDC)
This subpathway is part of the pathway histamine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes histamine from L-histidine, the pathway histamine biosynthesis and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei81Substrate; via amide nitrogen1
Binding sitei194Substrate1

GO - Molecular functioni

  • histidine decarboxylase activity Source: UniProtKB
  • pyridoxal phosphate binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processCatecholamine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:HS06697-MONOMER
BRENDAi4.1.1.22 2681
ReactomeiR-HSA-70921 Histidine catabolism
UniPathwayi
UPA00822;UER00786

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine decarboxylase (EC:4.1.1.22)
Short name:
HDC
Gene namesi
Name:HDC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140287.10
HGNCiHGNC:4855 HDC
MIMi142704 gene
neXtProtiNX_P19113

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi305K → G: Loss of enzyme activity. 1 Publication1
Mutagenesisi334Y → F: Loss of enzyme activity. 1 Publication1
Mutagenesisi354S → G: Strongly decreases affinity for histidine. Strongly increases affinity for L-DOPA and confers enzyme activity toward L-DOPA. 1 Publication1

Organism-specific databases

DisGeNETi3067
MalaCardsiHDC
OpenTargetsiENSG00000140287
Orphaneti856 NON RARE IN EUROPE: Tourette syndrome
PharmGKBiPA29233

Chemistry databases

DrugBankiDB00117 L-Histidine
DB00114 Pyridoxal Phosphate

Polymorphism and mutation databases

BioMutaiHDC
DMDMi1352220

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001469501 – 662Histidine decarboxylaseAdd BLAST662

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei305N6-(pyridoxal phosphate)lysine1

Proteomic databases

EPDiP19113
PaxDbiP19113
PeptideAtlasiP19113
PRIDEiP19113
ProteomicsDBi53634

PTM databases

CarbonylDBiP19113
iPTMnetiP19113
PhosphoSitePlusiP19113

Expressioni

Gene expression databases

BgeeiENSG00000140287 Expressed in 122 organ(s), highest expression level in esophagogastric junction muscularis propria
CleanExiHS_HDC
ExpressionAtlasiP19113 baseline and differential
GenevisibleiP19113 HS

Organism-specific databases

HPAiHPA038891

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DTX2Q86UW96EBI-10200283,EBI-740376

Protein-protein interaction databases

BioGridi109317, 2 interactors
IntActiP19113, 1 interactor
STRINGi9606.ENSP00000267845

Structurei

Secondary structure

1662
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP19113
SMRiP19113
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG0628 Eukaryota
COG0076 LUCA
GeneTreeiENSGT00760000119205
HOGENOMiHOG000121941
HOVERGENiHBG000944
InParanoidiP19113
KOiK01590
OMAiPVYLRHE
OrthoDBiEOG091G03KI
PhylomeDBiP19113
TreeFamiTF313863

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR010977 Aromatic_deC
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR021115 Pyridoxal-P_BS
PfamiView protein in Pfam
PF00282 Pyridoxal_deC, 1 hit
PRINTSiPR00800 YHDCRBOXLASE
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00392 DDC_GAD_HDC_YDC, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P19113-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMEPEEYRER GREMVDYICQ YLSTVRERRV TPDVQPGYLR AQLPESAPED
60 70 80 90 100
PDSWDSIFGD IERIIMPGVV HWQSPHMHAY YPALTSWPSL LGDMLADAIN
110 120 130 140 150
CLGFTWASSP ACTELEMNVM DWLAKMLGLP EHFLHHHPSS QGGGVLQSTV
160 170 180 190 200
SESTLIALLA ARKNKILEMK TSEPDADESC LNARLVAYAS DQAHSSVEKA
210 220 230 240 250
GLISLVKMKF LPVDDNFSLR GEALQKAIEE DKQRGLVPVF VCATLGTTGV
260 270 280 290 300
CAFDCLSELG PICAREGLWL HIDAAYAGTA FLCPEFRGFL KGIEYADSFT
310 320 330 340 350
FNPSKWMMVH FDCTGFWVKD KYKLQQTFSV NPIYLRHANS GVATDFMHWQ
360 370 380 390 400
IPLSRRFRSV KLWFVIRSFG VKNLQAHVRH GTEMAKYFES LVRNDPSFEI
410 420 430 440 450
PAKRHLGLVV FRLKGPNCLT ENVLKEIAKA GRLFLIPATI QDKLIIRFTV
460 470 480 490 500
TSQFTTRDDI LRDWNLIRDA ATLILSQHCT SQPSPRVGNL ISQIRGARAW
510 520 530 540 550
ACGTSLQSVS GAGDDPVQAR KIIKQPQRVG AGPMKRENGL HLETLLDPVD
560 570 580 590 600
DCFSEEAPDA TKHKLSSFLF SYLSVQTKKK TVRSLSCNSV PVSAQKPLPT
610 620 630 640 650
EASVKNGGSS RVRIFSRFPE DMMMLKKSAF KKLIKFYSVP SFPECSSQCG
660
LQLPCCPLQA MV
Length:662
Mass (Da):74,141
Last modified:February 1, 1996 - v2
Checksum:iD7611CFAAD60F469
GO
Isoform 2 (identifier: P19113-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-380: Missing.

Note: No experimental confirmation available.
Show »
Length:629
Mass (Da):70,059
Checksum:i72BDB69D63CE7606
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YLF0H0YLF0_HUMAN
Histidine decarboxylase
HDC
178Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118N → M no nucleotide entry (PubMed:1425659).Curated1
Sequence conflicti148S → Q in CAA38196 (PubMed:2216786).Curated1
Sequence conflicti148S → Q no nucleotide entry (PubMed:1425659).Curated1
Sequence conflicti500W → M no nucleotide entry (PubMed:1425659).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04887331T → M1 PublicationCorresponds to variant dbSNP:rs17740607Ensembl.1
Natural variantiVAR_03647049E → V in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036471285E → K in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1353958864Ensembl.1
Natural variantiVAR_048874553F → L. Corresponds to variant dbSNP:rs16963486Ensembl.1
Natural variantiVAR_033846644E → D. Corresponds to variant dbSNP:rs2073440Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056296348 – 380Missing in isoform 2. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54297 mRNA Translation: CAA38196.1
M60445 mRNA Translation: AAC41698.1
D16583 Genomic DNA Translation: BAA04015.1
AC009753 Genomic DNA No translation available.
AC022087 Genomic DNA No translation available.
BC130527 mRNA Translation: AAI30528.1
BC144173 mRNA Translation: AAI44174.1
CCDSiCCDS10134.1 [P19113-1]
CCDS76754.1 [P19113-2]
PIRiA49882
RefSeqiNP_001293075.1, NM_001306146.1 [P19113-2]
NP_002103.2, NM_002112.3 [P19113-1]
UniGeneiHs.1481

Genome annotation databases

EnsembliENST00000267845; ENSP00000267845; ENSG00000140287 [P19113-1]
ENST00000543581; ENSP00000440252; ENSG00000140287 [P19113-2]
GeneIDi3067
KEGGihsa:3067
UCSCiuc001zxz.4 human [P19113-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54297 mRNA Translation: CAA38196.1
M60445 mRNA Translation: AAC41698.1
D16583 Genomic DNA Translation: BAA04015.1
AC009753 Genomic DNA No translation available.
AC022087 Genomic DNA No translation available.
BC130527 mRNA Translation: AAI30528.1
BC144173 mRNA Translation: AAI44174.1
CCDSiCCDS10134.1 [P19113-1]
CCDS76754.1 [P19113-2]
PIRiA49882
RefSeqiNP_001293075.1, NM_001306146.1 [P19113-2]
NP_002103.2, NM_002112.3 [P19113-1]
UniGeneiHs.1481

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4E1OX-ray1.80A/B/C/D/E/F2-477[»]
ProteinModelPortaliP19113
SMRiP19113
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109317, 2 interactors
IntActiP19113, 1 interactor
STRINGi9606.ENSP00000267845

Chemistry databases

DrugBankiDB00117 L-Histidine
DB00114 Pyridoxal Phosphate

PTM databases

CarbonylDBiP19113
iPTMnetiP19113
PhosphoSitePlusiP19113

Polymorphism and mutation databases

BioMutaiHDC
DMDMi1352220

Proteomic databases

EPDiP19113
PaxDbiP19113
PeptideAtlasiP19113
PRIDEiP19113
ProteomicsDBi53634

Protocols and materials databases

DNASUi3067
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267845; ENSP00000267845; ENSG00000140287 [P19113-1]
ENST00000543581; ENSP00000440252; ENSG00000140287 [P19113-2]
GeneIDi3067
KEGGihsa:3067
UCSCiuc001zxz.4 human [P19113-1]

Organism-specific databases

CTDi3067
DisGeNETi3067
EuPathDBiHostDB:ENSG00000140287.10
GeneCardsiHDC
HGNCiHGNC:4855 HDC
HPAiHPA038891
MalaCardsiHDC
MIMi142704 gene
neXtProtiNX_P19113
OpenTargetsiENSG00000140287
Orphaneti856 NON RARE IN EUROPE: Tourette syndrome
PharmGKBiPA29233
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0628 Eukaryota
COG0076 LUCA
GeneTreeiENSGT00760000119205
HOGENOMiHOG000121941
HOVERGENiHBG000944
InParanoidiP19113
KOiK01590
OMAiPVYLRHE
OrthoDBiEOG091G03KI
PhylomeDBiP19113
TreeFamiTF313863

Enzyme and pathway databases

UniPathwayi
UPA00822;UER00786

BioCyciMetaCyc:HS06697-MONOMER
BRENDAi4.1.1.22 2681
ReactomeiR-HSA-70921 Histidine catabolism

Miscellaneous databases

GeneWikiiHistidine_decarboxylase
GenomeRNAii3067
PROiPR:P19113
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140287 Expressed in 122 organ(s), highest expression level in esophagogastric junction muscularis propria
CleanExiHS_HDC
ExpressionAtlasiP19113 baseline and differential
GenevisibleiP19113 HS

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR010977 Aromatic_deC
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR021115 Pyridoxal-P_BS
PfamiView protein in Pfam
PF00282 Pyridoxal_deC, 1 hit
PRINTSiPR00800 YHDCRBOXLASE
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00392 DDC_GAD_HDC_YDC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDCHS_HUMAN
AccessioniPrimary (citable) accession number: P19113
Secondary accession number(s): A1L4G0, B7ZM01
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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