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Protein

Histidine decarboxylase

Gene

HDC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the biosynthesis of histamine from histidine.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pyridoxal 5'-phosphate1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.1 mM for histidine1 Publication
  1. Vmax=1880 nmol/min/mg enzyme1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: histamine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes histamine from L-histidine.
Proteins known to be involved in this subpathway in this organism are:
  1. Histidine decarboxylase (HDC)
This subpathway is part of the pathway histamine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes histamine from L-histidine, the pathway histamine biosynthesis and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei81Substrate; via amide nitrogen1
Binding sitei194Substrate1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • histidine decarboxylase activity Source: UniProtKB
  • pyridoxal phosphate binding Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processCatecholamine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS06697-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
4.1.1.22 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-70921 Histidine catabolism

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00822;UER00786

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histidine decarboxylase (EC:4.1.1.22)
Short name:
HDC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HDC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000140287.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4855 HDC

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
142704 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P19113

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi305K → G: Loss of enzyme activity. 1 Publication1
Mutagenesisi334Y → F: Loss of enzyme activity. 1 Publication1
Mutagenesisi354S → G: Strongly decreases affinity for histidine. Strongly increases affinity for L-DOPA and confers enzyme activity toward L-DOPA. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
3067

MalaCards human disease database

More...
MalaCardsi
HDC

Open Targets

More...
OpenTargetsi
ENSG00000140287

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
856 NON RARE IN EUROPE: Tourette syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29233

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00117 L-Histidine
DB00114 Pyridoxal Phosphate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HDC

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1352220

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001469501 – 662Histidine decarboxylaseAdd BLAST662

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei305N6-(pyridoxal phosphate)lysine1

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P19113

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P19113

PeptideAtlas

More...
PeptideAtlasi
P19113

PRoteomics IDEntifications database

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PRIDEi
P19113

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53634

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P19113

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P19113

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P19113

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000140287 Expressed in 122 organ(s), highest expression level in esophagogastric junction muscularis propria

CleanEx database of gene expression profiles

More...
CleanExi
HS_HDC

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P19113 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P19113 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038891

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
DTX2Q86UW96EBI-10200283,EBI-740376

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109317, 2 interactors

Protein interaction database and analysis system

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IntActi
P19113, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000267845

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1662
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P19113

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P19113

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0628 Eukaryota
COG0076 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157938

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000121941

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000944

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P19113

KEGG Orthology (KO)

More...
KOi
K01590

Identification of Orthologs from Complete Genome Data

More...
OMAi
PVYLRHE

Database of Orthologous Groups

More...
OrthoDBi
EOG091G03KI

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P19113

TreeFam database of animal gene trees

More...
TreeFami
TF313863

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.640.10, 1 hit
3.90.1150.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010977 Aromatic_deC
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR021115 Pyridoxal-P_BS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00282 Pyridoxal_deC, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00800 YHDCRBOXLASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53383 SSF53383, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00392 DDC_GAD_HDC_YDC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P19113-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMEPEEYRER GREMVDYICQ YLSTVRERRV TPDVQPGYLR AQLPESAPED
60 70 80 90 100
PDSWDSIFGD IERIIMPGVV HWQSPHMHAY YPALTSWPSL LGDMLADAIN
110 120 130 140 150
CLGFTWASSP ACTELEMNVM DWLAKMLGLP EHFLHHHPSS QGGGVLQSTV
160 170 180 190 200
SESTLIALLA ARKNKILEMK TSEPDADESC LNARLVAYAS DQAHSSVEKA
210 220 230 240 250
GLISLVKMKF LPVDDNFSLR GEALQKAIEE DKQRGLVPVF VCATLGTTGV
260 270 280 290 300
CAFDCLSELG PICAREGLWL HIDAAYAGTA FLCPEFRGFL KGIEYADSFT
310 320 330 340 350
FNPSKWMMVH FDCTGFWVKD KYKLQQTFSV NPIYLRHANS GVATDFMHWQ
360 370 380 390 400
IPLSRRFRSV KLWFVIRSFG VKNLQAHVRH GTEMAKYFES LVRNDPSFEI
410 420 430 440 450
PAKRHLGLVV FRLKGPNCLT ENVLKEIAKA GRLFLIPATI QDKLIIRFTV
460 470 480 490 500
TSQFTTRDDI LRDWNLIRDA ATLILSQHCT SQPSPRVGNL ISQIRGARAW
510 520 530 540 550
ACGTSLQSVS GAGDDPVQAR KIIKQPQRVG AGPMKRENGL HLETLLDPVD
560 570 580 590 600
DCFSEEAPDA TKHKLSSFLF SYLSVQTKKK TVRSLSCNSV PVSAQKPLPT
610 620 630 640 650
EASVKNGGSS RVRIFSRFPE DMMMLKKSAF KKLIKFYSVP SFPECSSQCG
660
LQLPCCPLQA MV
Length:662
Mass (Da):74,141
Last modified:February 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD7611CFAAD60F469
GO
Isoform 2 (identifier: P19113-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     348-380: Missing.

Note: No experimental confirmation available.
Show »
Length:629
Mass (Da):70,059
Checksum:i72BDB69D63CE7606
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YLF0H0YLF0_HUMAN
Histidine decarboxylase
HDC
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti118N → M no nucleotide entry (PubMed:1425659).Curated1
Sequence conflicti148S → Q in CAA38196 (PubMed:2216786).Curated1
Sequence conflicti148S → Q no nucleotide entry (PubMed:1425659).Curated1
Sequence conflicti500W → M no nucleotide entry (PubMed:1425659).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04887331T → M1 PublicationCorresponds to variant dbSNP:rs17740607Ensembl.1
Natural variantiVAR_03647049E → V in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036471285E → K in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1353958864Ensembl.1
Natural variantiVAR_048874553F → L. Corresponds to variant dbSNP:rs16963486Ensembl.1
Natural variantiVAR_033846644E → D. Corresponds to variant dbSNP:rs2073440Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056296348 – 380Missing in isoform 2. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X54297 mRNA Translation: CAA38196.1
M60445 mRNA Translation: AAC41698.1
D16583 Genomic DNA Translation: BAA04015.1
AC009753 Genomic DNA No translation available.
AC022087 Genomic DNA No translation available.
BC130527 mRNA Translation: AAI30528.1
BC144173 mRNA Translation: AAI44174.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10134.1 [P19113-1]
CCDS76754.1 [P19113-2]

Protein sequence database of the Protein Information Resource

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PIRi
A49882

NCBI Reference Sequences

More...
RefSeqi
NP_001293075.1, NM_001306146.1 [P19113-2]
NP_002103.2, NM_002112.3 [P19113-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.1481

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000267845; ENSP00000267845; ENSG00000140287 [P19113-1]
ENST00000543581; ENSP00000440252; ENSG00000140287 [P19113-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3067

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3067

UCSC genome browser

More...
UCSCi
uc001zxz.4 human [P19113-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54297 mRNA Translation: CAA38196.1
M60445 mRNA Translation: AAC41698.1
D16583 Genomic DNA Translation: BAA04015.1
AC009753 Genomic DNA No translation available.
AC022087 Genomic DNA No translation available.
BC130527 mRNA Translation: AAI30528.1
BC144173 mRNA Translation: AAI44174.1
CCDSiCCDS10134.1 [P19113-1]
CCDS76754.1 [P19113-2]
PIRiA49882
RefSeqiNP_001293075.1, NM_001306146.1 [P19113-2]
NP_002103.2, NM_002112.3 [P19113-1]
UniGeneiHs.1481

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4E1OX-ray1.80A/B/C/D/E/F2-477[»]
ProteinModelPortaliP19113
SMRiP19113
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109317, 2 interactors
IntActiP19113, 1 interactor
STRINGi9606.ENSP00000267845

Chemistry databases

DrugBankiDB00117 L-Histidine
DB00114 Pyridoxal Phosphate

PTM databases

CarbonylDBiP19113
iPTMnetiP19113
PhosphoSitePlusiP19113

Polymorphism and mutation databases

BioMutaiHDC
DMDMi1352220

Proteomic databases

EPDiP19113
PaxDbiP19113
PeptideAtlasiP19113
PRIDEiP19113
ProteomicsDBi53634

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
3067
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267845; ENSP00000267845; ENSG00000140287 [P19113-1]
ENST00000543581; ENSP00000440252; ENSG00000140287 [P19113-2]
GeneIDi3067
KEGGihsa:3067
UCSCiuc001zxz.4 human [P19113-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3067
DisGeNETi3067
EuPathDBiHostDB:ENSG00000140287.10

GeneCards: human genes, protein and diseases

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GeneCardsi
HDC
HGNCiHGNC:4855 HDC
HPAiHPA038891
MalaCardsiHDC
MIMi142704 gene
neXtProtiNX_P19113
OpenTargetsiENSG00000140287
Orphaneti856 NON RARE IN EUROPE: Tourette syndrome
PharmGKBiPA29233

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0628 Eukaryota
COG0076 LUCA
GeneTreeiENSGT00940000157938
HOGENOMiHOG000121941
HOVERGENiHBG000944
InParanoidiP19113
KOiK01590
OMAiPVYLRHE
OrthoDBiEOG091G03KI
PhylomeDBiP19113
TreeFamiTF313863

Enzyme and pathway databases

UniPathwayi
UPA00822;UER00786

BioCyciMetaCyc:HS06697-MONOMER
BRENDAi4.1.1.22 2681
ReactomeiR-HSA-70921 Histidine catabolism

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Histidine_decarboxylase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3067

Protein Ontology

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PROi
PR:P19113

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000140287 Expressed in 122 organ(s), highest expression level in esophagogastric junction muscularis propria
CleanExiHS_HDC
ExpressionAtlasiP19113 baseline and differential
GenevisibleiP19113 HS

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR010977 Aromatic_deC
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
IPR021115 Pyridoxal-P_BS
PfamiView protein in Pfam
PF00282 Pyridoxal_deC, 1 hit
PRINTSiPR00800 YHDCRBOXLASE
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00392 DDC_GAD_HDC_YDC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDCHS_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P19113
Secondary accession number(s): A1L4G0, B7ZM01
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: February 1, 1996
Last modified: December 5, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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