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Protein

Protein phosphatase 1 regulatory subunit 1A

Gene

Ppp1r1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.

GO - Molecular functioni

GO - Biological processi

  • glycogen metabolic process Source: UniProtKB-KW
  • intracellular signal transduction Source: GO_Central

Keywordsi

Molecular functionProtein phosphatase inhibitor
Biological processCarbohydrate metabolism, Glycogen metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 1A
Alternative name(s):
Protein phosphatase inhibitor 1
Short name:
I-1
Short name:
IPP-1
Gene namesi
Name:Ppp1r1a
Synonyms:Ipp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi62018 Ppp1r1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000714801 – 171Protein phosphatase 1 regulatory subunit 1AAdd BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei35Phosphothreonine; by PKABy similarity1
Modified residuei43PhosphoserineBy similarity1
Modified residuei46PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Modified residuei67PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation of Thr-35 is required for activity.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP19103
PRIDEiP19103

PTM databases

iPTMnetiP19103
PhosphoSitePlusiP19103

Expressioni

Gene expression databases

BgeeiENSRNOG00000036827 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiP19103 RN

Interactioni

Subunit structurei

Interacts with PPP1R15A.By similarity

Protein-protein interaction databases

ELMiP19103
STRINGi10116.ENSRNOP00000052146

Structurei

3D structure databases

SMRiP19103
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni9 – 12Essential for activity4
Regioni42 – 54Essential for activityCuratedAdd BLAST13
Regioni143 – 171Interaction with PPP1R15ABy similarityAdd BLAST29

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410J0ZP Eukaryota
ENOG41125ZM LUCA
GeneTreeiENSGT00730000110965
HOGENOMiHOG000115665
HOVERGENiHBG096069
InParanoidiP19103
KOiK08050
OMAiAECIPKT
OrthoDBiEOG091G1A3V
PhylomeDBiP19103
TreeFamiTF332576

Family and domain databases

InterProiView protein in InterPro
IPR008466 PPP1R1A/B/C
PANTHERiPTHR15417 PTHR15417, 1 hit
PfamiView protein in Pfam
PF05395 DARPP-32, 1 hit

Sequencei

Sequence statusi: Complete.

P19103-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPDNSPRKI QFTVPLLEPH LDPEAAEQIR RRRPTPATLV LTSDQSSPEV
60 70 80 90 100
DEDRIPNPLL KSTLSMSPRQ RKKMTRTTPT MKELQTMVEH HLGQQKQGEE
110 120 130 140 150
PEGATESTGN QESCPPGIPD TGSASRPDTS GTAQKPAESK PKTQEQRGVE
160 170
PSTEDLSAHM LPLDSQGASL V
Length:171
Mass (Da):18,738
Last modified:November 1, 1990 - v1
Checksum:i4D26478008245956
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05592 mRNA Translation: AAA41933.1
AJ276593 mRNA Translation: CAB77674.1
AY648296 mRNA Translation: AAT66740.1
BC078820 mRNA Translation: AAH78820.1
PIRiA37110
RefSeqiNP_073167.1, NM_022676.3
UniGeneiRn.9756

Genome annotation databases

EnsembliENSRNOT00000055271; ENSRNOP00000052146; ENSRNOG00000036827
GeneIDi58977
KEGGirno:58977

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05592 mRNA Translation: AAA41933.1
AJ276593 mRNA Translation: CAB77674.1
AY648296 mRNA Translation: AAT66740.1
BC078820 mRNA Translation: AAH78820.1
PIRiA37110
RefSeqiNP_073167.1, NM_022676.3
UniGeneiRn.9756

3D structure databases

SMRiP19103
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ELMiP19103
STRINGi10116.ENSRNOP00000052146

PTM databases

iPTMnetiP19103
PhosphoSitePlusiP19103

Proteomic databases

PaxDbiP19103
PRIDEiP19103

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000055271; ENSRNOP00000052146; ENSRNOG00000036827
GeneIDi58977
KEGGirno:58977

Organism-specific databases

CTDi5502
RGDi62018 Ppp1r1a

Phylogenomic databases

eggNOGiENOG410J0ZP Eukaryota
ENOG41125ZM LUCA
GeneTreeiENSGT00730000110965
HOGENOMiHOG000115665
HOVERGENiHBG096069
InParanoidiP19103
KOiK08050
OMAiAECIPKT
OrthoDBiEOG091G1A3V
PhylomeDBiP19103
TreeFamiTF332576

Miscellaneous databases

PROiPR:P19103

Gene expression databases

BgeeiENSRNOG00000036827 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiP19103 RN

Family and domain databases

InterProiView protein in InterPro
IPR008466 PPP1R1A/B/C
PANTHERiPTHR15417 PTHR15417, 1 hit
PfamiView protein in Pfam
PF05395 DARPP-32, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPPR1A_RAT
AccessioniPrimary (citable) accession number: P19103
Secondary accession number(s): Q6DSU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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