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Entry version 154 (02 Jun 2021)
Sequence version 3 (01 Nov 1997)
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Protein

Steroid 17-alpha-hydroxylase/17,20 lyase

Gene

CYP17A1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • A C(21)-steroid + [reduced NADPH--hemoprotein reductase] + O(2) = a 17-alpha-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H(2)O.By similarity EC:1.14.14.19

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

hemeBy similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Regulated predominantly by intracellular cAMP levels. The 17,20-lyase activity is stimulated by cytochrome b5, which acts as an allosteric effector increasing the Vmax of the lyase activity.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Steroid hormone biosynthesis

This protein is involved in Steroid hormone biosynthesis.By similarity
View all proteins of this organism that are known to be involved in Steroid hormone biosynthesis.

Pathwayi: glucocorticoid biosynthesis

This protein is involved in the pathway glucocorticoid biosynthesis, which is part of Steroid biosynthesis.By similarity
View all proteins of this organism that are known to be involved in the pathway glucocorticoid biosynthesis and in Steroid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei202SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi442Iron (heme axial ligand)By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase, Monooxygenase, Oxidoreductase
Biological processSteroidogenesis
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.14.14.19, 6170

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SSC-193048, Androgen biosynthesis
R-SSC-194002, Glucocorticoid biosynthesis

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00788

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Steroid 17-alpha-hydroxylase/17,20 lyase (EC:1.14.14.19By similarity)
Alternative name(s):
17-alpha-hydroxyprogesterone aldolase (EC:1.14.14.32By similarity)
CYPXVII
Cytochrome P450 17A1
Cytochrome P450-C17
Short name:
Cytochrome P450c17
Steroid 17-alpha-monooxygenase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYP17A1
Synonyms:CYP17
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000314985 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14
  • UP000008227 Componenti: Chromosome 14

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:103368, CYP17A1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000519401 – 509Steroid 17-alpha-hydroxylase/17,20 lyaseAdd BLAST509

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P19100

PeptideAtlas

More...
PeptideAtlasi
P19100

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSSSCG00000010591, Expressed in testis and 17 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P19100, baseline

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P19100, SS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9823.ENSSSCP00000011283

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P19100

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0156, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155588

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001570_22_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P19100

Identification of Orthologs from Complete Genome Data

More...
OMAi
ICLPRES

Database of Orthologous Groups

More...
OrthoDBi
702827at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105095

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.630.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001128, Cyt_P450
IPR017972, Cyt_P450_CS
IPR002401, Cyt_P450_E_grp-I
IPR036396, Cyt_P450_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00067, p450, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00463, EP450I
PR00385, P450

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48264, SSF48264, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00086, CYTOCHROME_P450, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P19100-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWVLLVFFLL TLTYLFWPKT KGSGAKYPRS LPVLPVVGSL PFLPRRGHQH
60 70 80 90 100
MNFFKLQDKY GPIFSFRLGS KTTVVIGDHQ LAKEVLLKKG KEFSGRPRVM
110 120 130 140 150
TLDILSDNQK GIAFADHGTS WQLHRKLALS TFSLFKGGNL KLENIINQEI
160 170 180 190 200
KVLCDFLATR NGESIDLAQP LSLAMTNIVS FICFNFSFKK GDPALQAIVN
210 220 230 240 250
FNDGILDAVG KEILYDMFPG IRILPSQTLE NMKQCVRMRN ELLREILENR
260 270 280 290 300
KENYSRNSIT NLLDIMIQAK TNAESNTGGP DHNLKLLSDR HMLATVADIF
310 320 330 340 350
GAGVETSASV VKWIVAFLLH YPLLRKKIQD AIDQNIGFNR APSISDRNQL
360 370 380 390 400
VLLEATIREV LRFRPVSPTL IPHRAIIDSS IGEFTIDKDT DVVVNLWALH
410 420 430 440 450
HNEKEWHRPD LFMPERFLDP TGTQLISPSL SYLPFGAGPR SCVGEMLARQ
460 470 480 490 500
ELFLFTAGLL QRFDLELPDD GQLPCLVGNP SLVLQIDPFK VKIKERQAWK

EAHTEGSTS
Length:509
Mass (Da):57,447
Last modified:November 1, 1997 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9497D185A1B446B4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5G2QXA3A0A5G2QXA3_PIG
Steroid 17-alpha-hydroxylase/17,20 ...
CYP17A1
480Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5G2QTJ5A0A5G2QTJ5_PIG
Steroid 17-alpha-hydroxylase/17,20 ...
CYP17A1
357Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5G2RFT3A0A5G2RFT3_PIG
Steroid 17-alpha-hydroxylase/17,20 ...
CYP17A1
408Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti46 – 53RGHQHMNF → FL no nucleotide entry (PubMed:3025870).Curated8
Sequence conflicti51M → I in CAA77878 (PubMed:1627653).Curated1
Sequence conflicti70S → D no nucleotide entry (PubMed:3025870).Curated1
Sequence conflicti98R → K no nucleotide entry (PubMed:3025870).Curated1
Sequence conflicti108 – 116Missing in CAA77878 (PubMed:1627653).Curated9
Sequence conflicti117H → E no nucleotide entry (PubMed:3025870).Curated1
Sequence conflicti126 – 140KLALS…KGGNL → SLF no nucleotide entry (PubMed:3025870).CuratedAdd BLAST15
Sequence conflicti161 – 191NGESI…SFKKG → VIQNACEMDRLKEI no nucleotide entry (PubMed:3025870).CuratedAdd BLAST31
Sequence conflicti196Q → D no nucleotide entry (PubMed:3025870).Curated1
Sequence conflicti201 – 210FNDGILDAVG → IEEGELT no nucleotide entry (PubMed:3025870).Curated10
Sequence conflicti238M → E no nucleotide entry (PubMed:3025870).Curated1
Sequence conflicti257 – 266NSITNLLDIM → IL no nucleotide entry (PubMed:3025870).Curated10
Sequence conflicti270 – 284Missing no nucleotide entry (PubMed:3025870).CuratedAdd BLAST15
Sequence conflicti291 – 303HMLAT…IFGAG → AC no nucleotide entry (PubMed:3025870).CuratedAdd BLAST13
Sequence conflicti292M → S in CAA77878 (PubMed:1627653).Curated1
Sequence conflicti308A → V no nucleotide entry (PubMed:3025870).Curated1
Sequence conflicti311 – 333VKWIV…QDAID → FIWIQEAIE no nucleotide entry (PubMed:3025870).CuratedAdd BLAST23
Sequence conflicti319 – 321LHY → ATLC in CAA77878 (PubMed:1627653).Curated3
Sequence conflicti330D → E in CAA77878 (PubMed:1627653).Curated1
Sequence conflicti333D → E in CAA77878 (PubMed:1627653).Curated1
Sequence conflicti389D → A no nucleotide entry (PubMed:3025870).Curated1
Sequence conflicti395 – 397NLW → SLF no nucleotide entry (PubMed:3025870).Curated3
Sequence conflicti407H → L in AAA31008 (PubMed:1543750).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M63507 mRNA Translation: AAA31008.1
U41525 U41524 Genomic DNA Translation: AAA84419.1
Z11854, Z11855, Z11856 Genomic DNA Translation: CAA77878.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S22339

NCBI Reference Sequences

More...
RefSeqi
NP_999593.1, NM_214428.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSSCT00000011585; ENSSSCP00000011283; ENSSSCG00000010591
ENSSSCT00005030769; ENSSSCP00005018763; ENSSSCG00005019328
ENSSSCT00005030856; ENSSSCP00005018814; ENSSSCG00005019328
ENSSSCT00015028983; ENSSSCP00015011397; ENSSSCG00015021503
ENSSSCT00025105077; ENSSSCP00025046858; ENSSSCG00025075981
ENSSSCT00035110081; ENSSSCP00035047911; ENSSSCG00035080345
ENSSSCT00040076620; ENSSSCP00040032917; ENSSSCG00040055008
ENSSSCT00045032693; ENSSSCP00045022639; ENSSSCG00045019126
ENSSSCT00055007950; ENSSSCP00055006290; ENSSSCG00055004034
ENSSSCT00060070162; ENSSSCP00060030276; ENSSSCG00060051529
ENSSSCT00065007534; ENSSSCP00065003217; ENSSSCG00065005560
ENSSSCT00070022474; ENSSSCP00070018599; ENSSSCG00070011543

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
403330

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ssc:403330

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63507 mRNA Translation: AAA31008.1
U41525 U41524 Genomic DNA Translation: AAA84419.1
Z11854, Z11855, Z11856 Genomic DNA Translation: CAA77878.1
PIRiS22339
RefSeqiNP_999593.1, NM_214428.1

3D structure databases

SMRiP19100
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011283

Proteomic databases

PaxDbiP19100
PeptideAtlasiP19100

Genome annotation databases

EnsembliENSSSCT00000011585; ENSSSCP00000011283; ENSSSCG00000010591
ENSSSCT00005030769; ENSSSCP00005018763; ENSSSCG00005019328
ENSSSCT00005030856; ENSSSCP00005018814; ENSSSCG00005019328
ENSSSCT00015028983; ENSSSCP00015011397; ENSSSCG00015021503
ENSSSCT00025105077; ENSSSCP00025046858; ENSSSCG00025075981
ENSSSCT00035110081; ENSSSCP00035047911; ENSSSCG00035080345
ENSSSCT00040076620; ENSSSCP00040032917; ENSSSCG00040055008
ENSSSCT00045032693; ENSSSCP00045022639; ENSSSCG00045019126
ENSSSCT00055007950; ENSSSCP00055006290; ENSSSCG00055004034
ENSSSCT00060070162; ENSSSCP00060030276; ENSSSCG00060051529
ENSSSCT00065007534; ENSSSCP00065003217; ENSSSCG00065005560
ENSSSCT00070022474; ENSSSCP00070018599; ENSSSCG00070011543
GeneIDi403330
KEGGissc:403330

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1586
VGNCiVGNC:103368, CYP17A1

Phylogenomic databases

eggNOGiKOG0156, Eukaryota
GeneTreeiENSGT00940000155588
HOGENOMiCLU_001570_22_0_1
InParanoidiP19100
OMAiICLPRES
OrthoDBi702827at2759
TreeFamiTF105095

Enzyme and pathway databases

UniPathwayiUPA00788
BRENDAi1.14.14.19, 6170
ReactomeiR-SSC-193048, Androgen biosynthesis
R-SSC-194002, Glucocorticoid biosynthesis

Gene expression databases

BgeeiENSSSCG00000010591, Expressed in testis and 17 other tissues
ExpressionAtlasiP19100, baseline
GenevisibleiP19100, SS

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128, Cyt_P450
IPR017972, Cyt_P450_CS
IPR002401, Cyt_P450_E_grp-I
IPR036396, Cyt_P450_sf
PfamiView protein in Pfam
PF00067, p450, 1 hit
PRINTSiPR00463, EP450I
PR00385, P450
SUPFAMiSSF48264, SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086, CYTOCHROME_P450, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCP17A_PIG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P19100
Secondary accession number(s): Q29553, Q99030
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1997
Last modified: June 2, 2021
This is version 154 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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