Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Guanine nucleotide-binding protein G(z) subunit alpha

Gene

GNAZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47MagnesiumBy similarity1
Metal bindingi182MagnesiumBy similarity1
Binding sitei327GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 47GTPBy similarity8
Nucleotide bindingi176 – 182GTPBy similarity7
Nucleotide bindingi201 – 205GTPBy similarity5
Nucleotide bindingi270 – 273GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransducer
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-112043 PLC beta mediated events
R-HSA-202040 G-protein activation
R-HSA-418555 G alpha (s) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
SignaLinkiP19086
SIGNORiP19086

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(z) subunit alpha
Alternative name(s):
G(x) alpha chain
Gz-alpha
Gene namesi
Name:GNAZ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000128266.8
HGNCiHGNC:4395 GNAZ
MIMi139160 gene
neXtProtiNX_P19086

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2781
OpenTargetsiENSG00000128266
PharmGKBiPA28775

Polymorphism and mutation databases

BioMutaiGNAZ
DMDMi121005

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCurated
ChainiPRO_00002036962 – 355Guanine nucleotide-binding protein G(z) subunit alphaAdd BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Lipidationi3S-palmitoyl cysteineBy similarity1
Modified residuei179ADP-ribosylarginine; by cholera toxinBy similarity1

Keywords - PTMi

ADP-ribosylation, Lipoprotein, Myristate, Palmitate

Proteomic databases

EPDiP19086
MaxQBiP19086
PaxDbiP19086
PeptideAtlasiP19086
PRIDEiP19086
ProteomicsDBi53630

PTM databases

iPTMnetiP19086
PhosphoSitePlusiP19086
SwissPalmiP19086

Expressioni

Gene expression databases

BgeeiENSG00000128266 Expressed in 165 organ(s), highest expression level in forebrain
CleanExiHS_GNAZ
GenevisibleiP19086 HS

Organism-specific databases

HPAiHPA003011

Interactioni

Subunit structurei

G-proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with ADGRB2 (PubMed:28891236).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109043, 47 interactors
ELMiP19086
IntActiP19086, 12 interactors
MINTiP19086
STRINGi9606.ENSP00000248996

Structurei

3D structure databases

ProteinModelPortaliP19086
SMRiP19086
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-alpha family. G(i/o/t/z) subfamily.Curated

Phylogenomic databases

eggNOGiKOG0082 Eukaryota
ENOG410XNVQ LUCA
GeneTreeiENSGT00760000118851
HOGENOMiHOG000038730
HOVERGENiHBG063184
InParanoidiP19086
KOiK04535
OMAiYRQLVFN
OrthoDBiEOG091G0VUT
PhylomeDBiP19086
TreeFamiTF300673

Family and domain databases

CDDicd00066 G-alpha, 1 hit
Gene3Di1.10.400.10, 1 hit
InterProiView protein in InterPro
IPR001408 Gprotein_alpha_I
IPR001019 Gprotein_alpha_su
IPR011025 GproteinA_insert
IPR027417 P-loop_NTPase
PANTHERiPTHR10218 PTHR10218, 1 hit
PfamiView protein in Pfam
PF00503 G-alpha, 1 hit
PRINTSiPR00318 GPROTEINA
PR00441 GPROTEINAI
SMARTiView protein in SMART
SM00275 G_alpha, 1 hit
SUPFAMiSSF47895 SSF47895, 1 hit
SSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19086-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGCRQSSEEK EAARRSRRID RHLRSESQRQ RREIKLLLLG TSNSGKSTIV
60 70 80 90 100
KQMKIIHSGG FNLEACKEYK PLIIYNAIDS LTRIIRALAA LRIDFHNPDR
110 120 130 140 150
AYDAVQLFAL TGPAESKGEI TPELLGVMRR LWADPGAQAC FSRSSEYHLE
160 170 180 190 200
DNAAYYLNDL ERIAAADYIP TVEDILRSRD MTTGIVENKF TFKELTFKMV
210 220 230 240 250
DVGGQRSERK KWIHCFEGVT AIIFCVELSG YDLKLYEDNQ TSRMAESLRL
260 270 280 290 300
FDSICNNNWF INTSLILFLN KKDLLAEKIR RIPLTICFPE YKGQNTYEEA
310 320 330 340 350
AVYIQRQFED LNRNKETKEI YSHFTCATDT SNIQFVFDAV TDVIIQNNLK

YIGLC
Length:355
Mass (Da):40,924
Last modified:January 23, 2007 - v3
Checksum:iE868FAE7CD2873EB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132W → Y (PubMed:1908722).Curated1
Sequence conflicti230G → A in BAA14180 (PubMed:2115889).Curated1
Sequence conflicti273D → N (PubMed:1908722).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03260 mRNA Translation: AAA52580.1
D90150 Genomic DNA Translation: BAA14180.1
AF493899 mRNA Translation: AAM12613.1
CR456495 mRNA Translation: CAG30381.1
AK312519 mRNA Translation: BAG35418.1
CH471095 Genomic DNA Translation: EAW59559.1
BC078163 mRNA Translation: AAH78163.1
BC096828 mRNA Translation: AAH96828.1
CCDSiCCDS13804.1
PIRiA36628 RGHUGX
RefSeqiNP_002064.1, NM_002073.3
UniGeneiHs.584760

Genome annotation databases

EnsembliENST00000615612; ENSP00000478892; ENSG00000128266
GeneIDi2781
KEGGihsa:2781
UCSCiuc002zwu.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03260 mRNA Translation: AAA52580.1
D90150 Genomic DNA Translation: BAA14180.1
AF493899 mRNA Translation: AAM12613.1
CR456495 mRNA Translation: CAG30381.1
AK312519 mRNA Translation: BAG35418.1
CH471095 Genomic DNA Translation: EAW59559.1
BC078163 mRNA Translation: AAH78163.1
BC096828 mRNA Translation: AAH96828.1
CCDSiCCDS13804.1
PIRiA36628 RGHUGX
RefSeqiNP_002064.1, NM_002073.3
UniGeneiHs.584760

3D structure databases

ProteinModelPortaliP19086
SMRiP19086
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109043, 47 interactors
ELMiP19086
IntActiP19086, 12 interactors
MINTiP19086
STRINGi9606.ENSP00000248996

PTM databases

iPTMnetiP19086
PhosphoSitePlusiP19086
SwissPalmiP19086

Polymorphism and mutation databases

BioMutaiGNAZ
DMDMi121005

Proteomic databases

EPDiP19086
MaxQBiP19086
PaxDbiP19086
PeptideAtlasiP19086
PRIDEiP19086
ProteomicsDBi53630

Protocols and materials databases

DNASUi2781
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000615612; ENSP00000478892; ENSG00000128266
GeneIDi2781
KEGGihsa:2781
UCSCiuc002zwu.2 human

Organism-specific databases

CTDi2781
DisGeNETi2781
EuPathDBiHostDB:ENSG00000128266.8
GeneCardsiGNAZ
HGNCiHGNC:4395 GNAZ
HPAiHPA003011
MIMi139160 gene
neXtProtiNX_P19086
OpenTargetsiENSG00000128266
PharmGKBiPA28775
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0082 Eukaryota
ENOG410XNVQ LUCA
GeneTreeiENSGT00760000118851
HOGENOMiHOG000038730
HOVERGENiHBG063184
InParanoidiP19086
KOiK04535
OMAiYRQLVFN
OrthoDBiEOG091G0VUT
PhylomeDBiP19086
TreeFamiTF300673

Enzyme and pathway databases

ReactomeiR-HSA-112043 PLC beta mediated events
R-HSA-202040 G-protein activation
R-HSA-418555 G alpha (s) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-418597 G alpha (z) signalling events
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
SignaLinkiP19086
SIGNORiP19086

Miscellaneous databases

GeneWikiiGNAZ
GenomeRNAii2781
PROiPR:P19086
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128266 Expressed in 165 organ(s), highest expression level in forebrain
CleanExiHS_GNAZ
GenevisibleiP19086 HS

Family and domain databases

CDDicd00066 G-alpha, 1 hit
Gene3Di1.10.400.10, 1 hit
InterProiView protein in InterPro
IPR001408 Gprotein_alpha_I
IPR001019 Gprotein_alpha_su
IPR011025 GproteinA_insert
IPR027417 P-loop_NTPase
PANTHERiPTHR10218 PTHR10218, 1 hit
PfamiView protein in Pfam
PF00503 G-alpha, 1 hit
PRINTSiPR00318 GPROTEINA
PR00441 GPROTEINAI
SMARTiView protein in SMART
SM00275 G_alpha, 1 hit
SUPFAMiSSF47895 SSF47895, 1 hit
SSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGNAZ_HUMAN
AccessioniPrimary (citable) accession number: P19086
Secondary accession number(s): B2R6C1, Q4QRJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 189 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again