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UniProtKB - P19079 (CDD_BACSU)
Protein
Cytidine deaminase
Gene
cdd
Organism
Bacillus subtilis (strain 168)
Status
Functioni
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
Catalytic activityi
Cofactori
Zn2+Note: Binds 1 zinc ion per subunit.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 53 | Zinc; catalytic | 1 | |
Active sitei | 55 | Proton donor | 1 | |
Metal bindingi | 86 | Zinc; catalytic | 1 | |
Metal bindingi | 89 | Zinc; catalytic | 1 |
GO - Molecular functioni
- cytidine deaminase activity Source: GO_Central
- deoxycytidine deaminase activity Source: RHEA
- zinc ion binding Source: GO_Central
GO - Biological processi
- cytidine deamination Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
BioCyci | BSUB:BSU25300-MONOMER |
BRENDAi | 3.5.4.5, 658 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytidine deaminase (EC:3.5.4.5)Short name: CDA Alternative name(s): Cytidine aminohydrolase |
Gene namesi | Name:cdd Ordered Locus Names:BSU25300 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 53 | C → H: Loss of activity. Reduces activity 500-fold, without effect on zinc binding; when associated with Q-56. 1 Publication | 1 | |
Mutagenesisi | 56 | R → A: No effect on zinc binding. Strongly reduces Vmax. 1 Publication | 1 | |
Mutagenesisi | 56 | R → D: Loss of activity. Reduces zinc binding by 80%. 1 Publication | 1 | |
Mutagenesisi | 56 | R → Q: No effect on zinc binding. Strongly reduces Vmax. Reduces activity 500-fold; when associated with H-53. 1 Publication | 1 |
Chemistry databases
DrugBanki | DB03562, Tetrahydrodeoxyuridine |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000171678 | 1 – 136 | Cytidine deaminaseAdd BLAST | 136 |
Proteomic databases
PaxDbi | P19079 |
Interactioni
Subunit structurei
Homotetramer.
2 PublicationsProtein-protein interaction databases
STRINGi | 224308.BSU25300 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P19079 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P19079 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 128 | CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST | 128 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 42 – 44 | Substrate binding | 3 |
Sequence similaritiesi
Belongs to the cytidine and deoxycytidylate deaminase family.Curated
Phylogenomic databases
eggNOGi | COG0295, Bacteria |
InParanoidi | P19079 |
OMAi | CGACRQS |
PhylomeDBi | P19079 |
Family and domain databases
InterProi | View protein in InterPro IPR016192, APOBEC/CMP_deaminase_Zn-bd IPR002125, CMP_dCMP_dom IPR006262, Cyt_deam_tetra IPR016193, Cytidine_deaminase-like |
Pfami | View protein in Pfam PF00383, dCMP_cyt_deam_1, 1 hit |
SUPFAMi | SSF53927, SSF53927, 1 hit |
TIGRFAMsi | TIGR01354, cyt_deam_tetra, 1 hit |
PROSITEi | View protein in PROSITE PS00903, CYT_DCMP_DEAMINASES_1, 1 hit PS51747, CYT_DCMP_DEAMINASES_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P19079-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNRQELITEA LKARDMAYAP YSKFQVGAAL LTKDGKVYRG CNIENAAYSM
60 70 80 90 100
CNCAERTALF KAVSEGDTEF QMLAVAADTP GPVSPCGACR QVISELCTKD
110 120 130
VIVVLTNLQG QIKEMTVEEL LPGAFSSEDL HDERKL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18532 Genomic DNA Translation: AAB59993.1 X17430 Genomic DNA Translation: CAB57856.1 D84432 Genomic DNA Translation: BAA12481.1 K02174 Genomic DNA Translation: AAB05347.1 AL009126 Genomic DNA Translation: CAB14459.1 U29177 Genomic DNA Translation: AAA70045.1 |
PIRi | JE0022 |
RefSeqi | NP_390408.1, NC_000964.3 WP_003230049.1, NZ_JNCM01000036.1 |
Genome annotation databases
EnsemblBacteriai | CAB14459; CAB14459; BSU_25300 |
GeneIDi | 937885 |
KEGGi | bsu:BSU25300 |
PATRICi | fig|224308.179.peg.2750 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18532 Genomic DNA Translation: AAB59993.1 X17430 Genomic DNA Translation: CAB57856.1 D84432 Genomic DNA Translation: BAA12481.1 K02174 Genomic DNA Translation: AAB05347.1 AL009126 Genomic DNA Translation: CAB14459.1 U29177 Genomic DNA Translation: AAA70045.1 |
PIRi | JE0022 |
RefSeqi | NP_390408.1, NC_000964.3 WP_003230049.1, NZ_JNCM01000036.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1JTK | X-ray | 2.04 | A/B | 1-136 | [»] | |
1UWZ | X-ray | 1.99 | A/B | 1-136 | [»] | |
1UX0 | X-ray | 1.99 | A/B | 1-136 | [»] | |
1UX1 | X-ray | 2.36 | A/B/C/D | 1-136 | [»] | |
SMRi | P19079 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 224308.BSU25300 |
Chemistry databases
DrugBanki | DB03562, Tetrahydrodeoxyuridine |
Proteomic databases
PaxDbi | P19079 |
Genome annotation databases
EnsemblBacteriai | CAB14459; CAB14459; BSU_25300 |
GeneIDi | 937885 |
KEGGi | bsu:BSU25300 |
PATRICi | fig|224308.179.peg.2750 |
Phylogenomic databases
eggNOGi | COG0295, Bacteria |
InParanoidi | P19079 |
OMAi | CGACRQS |
PhylomeDBi | P19079 |
Enzyme and pathway databases
BioCyci | BSUB:BSU25300-MONOMER |
BRENDAi | 3.5.4.5, 658 |
Miscellaneous databases
EvolutionaryTracei | P19079 |
Family and domain databases
InterProi | View protein in InterPro IPR016192, APOBEC/CMP_deaminase_Zn-bd IPR002125, CMP_dCMP_dom IPR006262, Cyt_deam_tetra IPR016193, Cytidine_deaminase-like |
Pfami | View protein in Pfam PF00383, dCMP_cyt_deam_1, 1 hit |
SUPFAMi | SSF53927, SSF53927, 1 hit |
TIGRFAMsi | TIGR01354, cyt_deam_tetra, 1 hit |
PROSITEi | View protein in PROSITE PS00903, CYT_DCMP_DEAMINASES_1, 1 hit PS51747, CYT_DCMP_DEAMINASES_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CDD_BACSU | |
Accessioni | P19079Primary (citable) accession number: P19079 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | November 1, 1990 | |
Last modified: | February 23, 2022 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families