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Protein

Tetraspanin-8

Gene

TSPAN8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-8
Short name:
Tspan-8
Alternative name(s):
Transmembrane 4 superfamily member 3
Tumor-associated antigen CO-029
Gene namesi
Name:TSPAN8
Synonyms:TM4SF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000127324.8
HGNCiHGNC:11855 TSPAN8
MIMi600769 gene
neXtProtiNX_P19075

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 33HelicalSequence analysisAdd BLAST24
Topological domaini34 – 57ExtracellularSequence analysisAdd BLAST24
Transmembranei58 – 72HelicalSequence analysisAdd BLAST15
Topological domaini73 – 83CytoplasmicSequence analysisAdd BLAST11
Transmembranei84 – 109HelicalSequence analysisAdd BLAST26
Topological domaini110 – 205ExtracellularSequence analysisAdd BLAST96
Transmembranei206 – 230HelicalSequence analysisAdd BLAST25
Topological domaini231 – 237CytoplasmicSequence analysis7

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7103
OpenTargetsiENSG00000127324
PharmGKBiPA36556

Polymorphism and mutation databases

BioMutaiTSPAN8
DMDMi116589

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192521 – 237Tetraspanin-8Add BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi118N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP19075
PaxDbiP19075
PeptideAtlasiP19075
PRIDEiP19075
ProteomicsDBi53629

PTM databases

iPTMnetiP19075
PhosphoSitePlusiP19075

Expressioni

Tissue specificityi

Gastric, colon, rectal, and pancreatic carcinomas.

Gene expression databases

BgeeiENSG00000127324
CleanExiHS_TSPAN8
GenevisibleiP19075 HS

Organism-specific databases

HPAiCAB026009
HPA044337

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000247829

Structurei

3D structure databases

ProteinModelPortaliP19075
SMRiP19075
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiP19075
KOiK17349
OMAiIWIRVSK
OrthoDBiEOG091G0K9H
PhylomeDBiP19075
TreeFamiTF352895

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequencei

Sequence statusi: Complete.

P19075-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGVSACIKY SMFTFNFLFW LCGILILALA IWVRVSNDSQ AIFGSEDVGS
60 70 80 90 100
SSYVAVDILI AVGAIIMILG FLGCCGAIKE SRCMLLLFFI GLLLILLLQV
110 120 130 140 150
ATGILGAVFK SKSDRIVNET LYENTKLLSA TGESEKQFQE AIIVFQEEFK
160 170 180 190 200
CCGLVNGAAD WGNNFQHYPE LCACLDKQRP CQSYNGKQVY KETCISFIKD
210 220 230
FLAKNLIIVI GISFGLAVIE ILGLVFSMVL YCQIGNK
Length:237
Mass (Da):26,044
Last modified:November 1, 1990 - v1
Checksum:iD1058F054EE8C14E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06184835V → I1 PublicationCorresponds to variant dbSNP:rs17849952Ensembl.1
Natural variantiVAR_02009373G → A1 PublicationCorresponds to variant dbSNP:rs3763978Ensembl.1
Natural variantiVAR_012054213S → A. Corresponds to variant dbSNP:rs1051334Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35252 mRNA Translation: AAA35709.1
AK313112 mRNA Translation: BAG35934.1
CH471054 Genomic DNA Translation: EAW97257.1
BC005246 mRNA Translation: AAH05246.1
CCDSiCCDS8999.1
PIRiA36056
RefSeqiNP_004607.1, NM_004616.2
XP_006719646.1, XM_006719583.3
XP_016875402.1, XM_017019913.1
UniGeneiHs.170563

Genome annotation databases

EnsembliENST00000247829; ENSP00000247829; ENSG00000127324
ENST00000393330; ENSP00000377003; ENSG00000127324
ENST00000546561; ENSP00000447160; ENSG00000127324
GeneIDi7103
KEGGihsa:7103
UCSCiuc001swj.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTSN8_HUMAN
AccessioniPrimary (citable) accession number: P19075
Secondary accession number(s): B2R7T7, Q9BS78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: June 20, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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