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Protein

Cell division control protein 42

Gene

CDC42

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in development of cell polarity during the cell division cycle, and essential for bud emergence. Affects signaling in the pheromone-response pathway through the STE20 protein kinase. Negatively regulated by the GTPase-activating proteins RGA1, BEM3, and BEM4.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17GTPBy similarity8
Nucleotide bindingi57 – 61GTPBy similarity5
Nucleotide bindingi115 – 118GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: SGD
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • budding cell apical bud growth Source: SGD
  • budding cell isotropic bud growth Source: SGD
  • cell cycle Source: UniProtKB-KW
  • conjugation with cellular fusion Source: SGD
  • establishment of cell polarity Source: SGD
  • invasive growth in response to glucose limitation Source: SGD
  • pheromone-dependent signal transduction involved in conjugation with cellular fusion Source: SGD
  • positive regulation of exocytosis Source: SGD
  • positive regulation of pseudohyphal growth Source: SGD
  • regulation of cell morphogenesis Source: AgBase
  • regulation of exit from mitosis Source: SGD
  • regulation of exocyst localization Source: SGD
  • regulation of initiation of mating projection growth Source: SGD
  • regulation of vacuole fusion, non-autophagic Source: SGD
  • septin ring organization Source: SGD
  • small GTPase mediated signal transduction Source: InterPro

Keywordsi

Biological processCell cycle, Cell division, Pheromone response
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32343-MONOMER
ReactomeiR-SCE-114604 GPVI-mediated activation cascade
R-SCE-1433557 Signaling by SCF-KIT
R-SCE-193648 NRAGE signals death through JNK
R-SCE-194840 Rho GTPase cycle
R-SCE-2029482 Regulation of actin dynamics for phagocytic cup formation
R-SCE-389359 CD28 dependent Vav1 pathway
R-SCE-3928662 EPHB-mediated forward signaling
R-SCE-416482 G alpha (12/13) signalling events
R-SCE-4420097 VEGFA-VEGFR2 Pathway
R-SCE-445144 Signal transduction by L1
R-SCE-5218920 VEGFR2 mediated vascular permeability
R-SCE-5625740 RHO GTPases activate PKNs
R-SCE-5625900 RHO GTPases activate CIT
R-SCE-5626467 RHO GTPases activate IQGAPs
R-SCE-5627123 RHO GTPases activate PAKs
R-SCE-5687128 MAPK6/MAPK4 signaling
R-SCE-6798695 Neutrophil degranulation
R-SCE-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 42
Alternative name(s):
Suppressor of RHO3 protein 2
Gene namesi
Name:CDC42
Synonyms:SRO2
Ordered Locus Names:YLR229C
ORF Names:L8083.13
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR229C
SGDiS000004219 CDC42

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi12G → V: Enhances interaction with RGA1. 1 Publication1
Mutagenesisi58T → A: Temperature-sensitive mutant. 1 Publication1
Mutagenesisi61Q → L: Enhances interaction with RGA1. 1 Publication1
Mutagenesisi71S → P: Temperature-sensitive mutant. 1 Publication1
Mutagenesisi97W → R: Temperature-sensitive mutant. 1 Publication1
Mutagenesisi118D → A: Dramatically reduces interaction with RGA1. 1 Publication1
Mutagenesisi142G → S in CDC42-1; temperature-sensitive mutant. 1 Publication1
Mutagenesisi188C → S: Enhances interaction with RGA1. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001989551 – 188Cell division control protein 42Add BLAST188
PropeptideiPRO_0000281285189 – 191Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei188Cysteine methyl esterBy similarity1
Lipidationi188S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiP19073
PaxDbiP19073
PRIDEiP19073

Interactioni

Subunit structurei

Interacts with AXL2.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi31499, 318 interactors
DIPiDIP-862N
IntActiP19073, 27 interactors
MINTiP19073
STRINGi4932.YLR229C

Structurei

3D structure databases

ProteinModelPortaliP19073
SMRiP19073
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 40Effector regionSequence analysis9

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00760000118978
HOGENOMiHOG000233974
InParanoidiP19073
KOiK04393
OMAiMQTLKCV
OrthoDBiEOG092C4TDG

Family and domain databases

CDDicd01874 Cdc42, 1 hit
InterProiView protein in InterPro
IPR037874 Cdc42
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19073-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTLKCVVVG DGAVGKTCLL ISYTTNQFPA DYVPTVFDNY AVTVMIGDEP
60 70 80 90 100
YTLGLFDTAG QEDYDRLRPL SYPSTDVFLV CFSVISPPSF ENVKEKWFPE
110 120 130 140 150
VHHHCPGVPC LVVGTQIDLR DDKVIIEKLQ RQRLRPITSE QGSRLARELK
160 170 180 190
AVKYVECSAL TQRGLKNVFD EAIVAALEPP VIKKSKKCAI L
Length:191
Mass (Da):21,323
Last modified:November 1, 1997 - v2
Checksum:i30BD644BA9836B2C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti189A → T in CAA36186 (PubMed:2164028).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51906 Genomic DNA Translation: CAA36186.1
U19027 Genomic DNA Translation: AAB67416.1
AY557933 Genomic DNA Translation: AAS56259.1
BK006945 Genomic DNA Translation: DAA09547.1
PIRiS51452
RefSeqiNP_013330.1, NM_001182116.1

Genome annotation databases

EnsemblFungiiYLR229C; YLR229C; YLR229C
GeneIDi850930
KEGGisce:YLR229C

Similar proteinsi

Entry informationi

Entry nameiCDC42_YEAST
AccessioniPrimary (citable) accession number: P19073
Secondary accession number(s): D6VYN1, Q05978
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1997
Last modified: July 18, 2018
This is version 187 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

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