Potassium voltage-gated channel subfamily A member 5

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• alpha-actinin binding Source: RGDInferred from sequence orthologyⁱ
  • "alpha-actinin-2 couples to cardiac Kv1.5 channels, regulating current density and channel localization in HEK cells."
    Maruoka N.D., Steele D.F., Au B.P., Dan P., Zhang X., Moore E.D., Fedida D.
    FEBS Lett. 473:188-194(2000) [PubMed] [Europe PMC] [Abstract]
• delayed rectifier potassium channel activity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.6

    "Heteromultimeric Kv1 channels contribute to myogenic control of arterial diameter."
    Plane F., Johnson R., Kerr P., Wiehler W., Thorneloe K., Ishii K., Chen T., Cole W.
    Circ. Res. 96:216-224(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION.
• outward rectifier potassium channel activity Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Contributions of Kv1.2, Kv1.5 and Kv2.1 subunits to the native delayed rectifier K(+) current in rat mesenteric artery smooth muscle cells."
    Lu Y., Hanna S.T., Tang G., Wang R.
    Life Sci. 71:1465-1473(2002) [PubMed] [Europe PMC] [Abstract]
  • "Expression and characterization of delayed rectifying K+ channels in anterior rat taste buds."
    Liu L., Hansen D.R., Kim I., Gilbertson T.A.
    Am. J. Physiol., Cell Physiol. 289:C868-80(2005) [PubMed] [Europe PMC] [Abstract]
• potassium channel inhibitor activity Source: RGDInferred from sequence orthologyⁱ
  • "Multiple mRNA isoforms encoding the mouse cardiac Kv1-5 delayed rectifier K+ channel."
    Attali B., Lesage F., Ziliani P., Guillemare E., Honore E., Waldmann R., Hugnot J.-P., Mattei M.-G., Lazdunski M., Barhanin J.
    J. Biol. Chem. 268:24283-24289(1993) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: RGDInferred from sequence orthologyⁱ
  • "Association of Src tyrosine kinase with a human potassium channel mediated by SH3 domain."
    Holmes T.C., Fadool D.A., Ren R., Levitan I.B.
    Science 274:2089-2091(1996) [PubMed] [Europe PMC] [Abstract]
• scaffold protein binding Source: RGDInferred from sequence orthologyⁱ
  • "Different isoforms of synapse-associated protein, SAP97, are expressed in the heart and have distinct effects on the voltage-gated K+ channel Kv1.5."
    Godreau D., Vranckx R., Maguy A., Goyenvalle C., Hatem S.N.
    J. Biol. Chem. 278:47046-47052(2003) [PubMed] [Europe PMC] [Abstract]
  • "Four and a half LIM protein 1: a partner for KCNA5 in human atrium."
    Yang Z., Browning C.F., Hallaq H., Yermalitskaya L., Esker J., Hall M.R., Link A.J., Ham A.J., McGrath M.J., Mitchell C.A., Murray K.T.
    Cardiovasc. Res. 78:449-457(2008) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Serotonin inhibits voltage-gated K+ currents in pulmonary artery smooth muscle cells: role of 5-HT2A receptors, caveolin-1, and KV1.5 channel internalization."
    Cogolludo A., Moreno L., Lodi F., Frazziano G., Cobeno L., Tamargo J., Perez-Vizcaino F.
    Circ. Res. 98:931-938(2006) [PubMed] [Europe PMC] [Abstract]
• voltage-gated potassium channel activity Source: RGDInferred from sequence orthologyⁱ
  • "Multiple mRNA isoforms encoding the mouse cardiac Kv1-5 delayed rectifier K+ channel."
    Attali B., Lesage F., Ziliani P., Guillemare E., Honore E., Waldmann R., Hugnot J.-P., Mattei M.-G., Lazdunski M., Barhanin J.
    J. Biol. Chem. 268:24283-24289(1993) [PubMed] [Europe PMC] [Abstract]
• voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization Source: RGDInferred from sequence orthologyⁱ
  • "Novel KCNA5 loss-of-function mutations responsible for atrial fibrillation."
    Yang Y., Li J., Lin X., Yang Y., Hong K., Wang L., Liu J., Li L., Yan D., Liang D., Xiao J., Jin H., Wu J., Zhang Y., Chen Y.H.
    J. Hum. Genet. 54:277-283(2009) [PubMed] [Europe PMC] [Abstract]
  • "Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation."
    Christophersen I.E., Olesen M.S., Liang B., Andersen M.N., Larsen A.P., Nielsen J.B., Haunso S., Olesen S.P., Tveit A., Svendsen J.H., Schmitt N.
    Eur. Heart J. 34:1517-1525(2013) [PubMed] [Europe PMC] [Abstract]
• voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization Source: RGDInferred from sequence orthologyⁱ
  • "Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation."
    Christophersen I.E., Olesen M.S., Liang B., Andersen M.N., Larsen A.P., Nielsen J.B., Haunso S., Olesen S.P., Tveit A., Svendsen J.H., Schmitt N.
    Eur. Heart J. 34:1517-1525(2013) [PubMed] [Europe PMC] [Abstract]
• voltage-gated potassium channel activity involved in SA node cell action potential repolarization Source: RGDInferred from sequence orthologyⁱ
  • "Novel KCNA5 loss-of-function mutations responsible for atrial fibrillation."
    Yang Y., Li J., Lin X., Yang Y., Hong K., Wang L., Liu J., Li L., Yan D., Liang D., Xiao J., Jin H., Wu J., Zhang Y., Chen Y.H.
    J. Hum. Genet. 54:277-283(2009) [PubMed] [Europe PMC] [Abstract]
  • "Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation."
    Christophersen I.E., Olesen M.S., Liang B., Andersen M.N., Larsen A.P., Nielsen J.B., Haunso S., Olesen S.P., Tveit A., Svendsen J.H., Schmitt N.
    Eur. Heart J. 34:1517-1525(2013) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• atrial cardiac muscle cell action potential Source: RGDInferred from sequence orthologyⁱ
  • "Novel KCNA5 loss-of-function mutations responsible for atrial fibrillation."
    Yang Y., Li J., Lin X., Yang Y., Hong K., Wang L., Liu J., Li L., Yan D., Liang D., Xiao J., Jin H., Wu J., Zhang Y., Chen Y.H.
    J. Hum. Genet. 54:277-283(2009) [PubMed] [Europe PMC] [Abstract]
  • "Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation."
    Christophersen I.E., Olesen M.S., Liang B., Andersen M.N., Larsen A.P., Nielsen J.B., Haunso S., Olesen S.P., Tveit A., Svendsen J.H., Schmitt N.
    Eur. Heart J. 34:1517-1525(2013) [PubMed] [Europe PMC] [Abstract]
• membrane hyperpolarization Source: RGDInferred from sequence orthologyⁱ
  • "Acute hypoxia selectively inhibits KCNA5 channels in pulmonary artery smooth muscle cells."
    Platoshyn O., Brevnova E.E., Burg E.D., Yu Y., Remillard C.V., Yuan J.X.
    Am. J. Physiol., Cell Physiol. 290:C907-16(2006) [PubMed] [Europe PMC] [Abstract]
• membrane repolarization during atrial cardiac muscle cell action potential Source: RGDInferred from sequence orthologyⁱ
  • "Novel KCNA5 loss-of-function mutations responsible for atrial fibrillation."
    Yang Y., Li J., Lin X., Yang Y., Hong K., Wang L., Liu J., Li L., Yan D., Liang D., Xiao J., Jin H., Wu J., Zhang Y., Chen Y.H.
    J. Hum. Genet. 54:277-283(2009) [PubMed] [Europe PMC] [Abstract]
  • "Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation."
    Christophersen I.E., Olesen M.S., Liang B., Andersen M.N., Larsen A.P., Nielsen J.B., Haunso S., Olesen S.P., Tveit A., Svendsen J.H., Schmitt N.
    Eur. Heart J. 34:1517-1525(2013) [PubMed] [Europe PMC] [Abstract]
• membrane repolarization during bundle of His cell action potential Source: RGDInferred from sequence orthologyⁱ
  • "Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation."
    Christophersen I.E., Olesen M.S., Liang B., Andersen M.N., Larsen A.P., Nielsen J.B., Haunso S., Olesen S.P., Tveit A., Svendsen J.H., Schmitt N.
    Eur. Heart J. 34:1517-1525(2013) [PubMed] [Europe PMC] [Abstract]
• membrane repolarization during SA node cell action potential Source: RGDInferred from sequence orthologyⁱ
  • "Novel KCNA5 loss-of-function mutations responsible for atrial fibrillation."
    Yang Y., Li J., Lin X., Yang Y., Hong K., Wang L., Liu J., Li L., Yan D., Liang D., Xiao J., Jin H., Wu J., Zhang Y., Chen Y.H.
    J. Hum. Genet. 54:277-283(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cytosolic calcium ion concentration Source: RGDInferred from mutant phenotypeⁱ
  • "Subacute hypoxia decreases voltage-activated potassium channel expression and function in pulmonary artery myocytes."
    Hong Z., Weir E.K., Nelson D.P., Olschewski A.
    Am. J. Respir. Cell Mol. Biol. 31:337-343(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of potassium ion transport Source: RGDInferred from sequence orthologyⁱ
  • "Multiple mRNA isoforms encoding the mouse cardiac Kv1-5 delayed rectifier K+ channel."
    Attali B., Lesage F., Ziliani P., Guillemare E., Honore E., Waldmann R., Hugnot J.-P., Mattei M.-G., Lazdunski M., Barhanin J.
    J. Biol. Chem. 268:24283-24289(1993) [PubMed] [Europe PMC] [Abstract]
• Notch signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature."
    Fouillade C., Baron-Menguy C., Domenga-Denier V., Thibault C., Takamiya K., Huganir R., Joutel A.
    Arterioscler. Thromb. Vasc. Biol. 33:76-86(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of G1/S transition of mitotic cell cycle Source: RGDInferred from direct assayⁱ
  • "Cell cycle-dependent expression of Kv1.5 is involved in myoblast proliferation."
    Villalonga N., Martinez-Marmol R., Roura-Ferrer M., David M., Valenzuela C., Soler C., Felipe A.
    Biochim. Biophys. Acta 1783:728-736(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of myoblast proliferation Source: RGDInferred from direct assayⁱ
  • "Cell cycle-dependent expression of Kv1.5 is involved in myoblast proliferation."
    Villalonga N., Martinez-Marmol R., Roura-Ferrer M., David M., Valenzuela C., Soler C., Felipe A.
    Biochim. Biophys. Acta 1783:728-736(2008) [PubMed] [Europe PMC] [Abstract]
• potassium ion export across plasma membrane Source: RGDInferred from mutant phenotypeⁱ
  • "Contributions of Kv1.2, Kv1.5 and Kv2.1 subunits to the native delayed rectifier K(+) current in rat mesenteric artery smooth muscle cells."
    Lu Y., Hanna S.T., Tang G., Wang R.
    Life Sci. 71:1465-1473(2002) [PubMed] [Europe PMC] [Abstract]
• potassium ion homeostasis Source: RGDInferred from mutant phenotypeⁱ
  • "Contributions of Kv1.2, Kv1.5 and Kv2.1 subunits to the native delayed rectifier K(+) current in rat mesenteric artery smooth muscle cells."
    Lu Y., Hanna S.T., Tang G., Wang R.
    Life Sci. 71:1465-1473(2002) [PubMed] [Europe PMC] [Abstract]
• potassium ion transmembrane transport Source: UniProtKBInferred from direct assayⁱ
  • Ref.6

    "Heteromultimeric Kv1 channels contribute to myogenic control of arterial diameter."
    Plane F., Johnson R., Kerr P., Wiehler W., Thorneloe K., Ishii K., Chen T., Cole W.
    Circ. Res. 96:216-224(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION.
• potassium ion transport Source: RGDInferred from sequence orthologyⁱ
  • "Multiple mRNA isoforms encoding the mouse cardiac Kv1-5 delayed rectifier K+ channel."
    Attali B., Lesage F., Ziliani P., Guillemare E., Honore E., Waldmann R., Hugnot J.-P., Mattei M.-G., Lazdunski M., Barhanin J.
    J. Biol. Chem. 268:24283-24289(1993) [PubMed] [Europe PMC] [Abstract]
  • "Functional differences in Kv1.5 currents expressed in mammalian cell lines are due to the presence of endogenous Kv beta 2.1 subunits."
    Uebele V.N., England S.K., Chaudhary A., Tamkun M.M., Snyders D.J.
    J. Biol. Chem. 271:2406-2412(1996) [PubMed] [Europe PMC] [Abstract]
• protein complex oligomerization Source: RGDInferred from mutant phenotypeⁱ
  • "Contributions of Kv1.2, Kv1.5 and Kv2.1 subunits to the native delayed rectifier K(+) current in rat mesenteric artery smooth muscle cells."
    Lu Y., Hanna S.T., Tang G., Wang R.
    Life Sci. 71:1465-1473(2002) [PubMed] [Europe PMC] [Abstract]
• protein homooligomerization Source: InterPro
• regulation of atrial cardiac muscle cell membrane repolarization Source: RGDInferred from sequence orthologyⁱ
  • "Novel KCNA5 loss-of-function mutations responsible for atrial fibrillation."
    Yang Y., Li J., Lin X., Yang Y., Hong K., Wang L., Liu J., Li L., Yan D., Liang D., Xiao J., Jin H., Wu J., Zhang Y., Chen Y.H.
    J. Hum. Genet. 54:277-283(2009) [PubMed] [Europe PMC] [Abstract]
• regulation of heart rate by cardiac conduction Source: RGDInferred from sequence orthologyⁱ
  • "Novel KCNA5 loss-of-function mutations responsible for atrial fibrillation."
    Yang Y., Li J., Lin X., Yang Y., Hong K., Wang L., Liu J., Li L., Yan D., Liang D., Xiao J., Jin H., Wu J., Zhang Y., Chen Y.H.
    J. Hum. Genet. 54:277-283(2009) [PubMed] [Europe PMC] [Abstract]
  • "Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation."
    Christophersen I.E., Olesen M.S., Liang B., Andersen M.N., Larsen A.P., Nielsen J.B., Haunso S., Olesen S.P., Tveit A., Svendsen J.H., Schmitt N.
    Eur. Heart J. 34:1517-1525(2013) [PubMed] [Europe PMC] [Abstract]
• regulation of membrane potential Source: RGDInferred from mutant phenotypeⁱ
  • "Cell cycle-dependent expression of Kv1.5 is involved in myoblast proliferation."
    Villalonga N., Martinez-Marmol R., Roura-Ferrer M., David M., Valenzuela C., Soler C., Felipe A.
    Biochim. Biophys. Acta 1783:728-736(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of potassium ion transport Source: RGDInferred from sequence orthologyⁱ
  • "Amino-terminal determinants of U-type inactivation of voltage-gated K+ channels."
    Kurata H.T., Soon G.S., Eldstrom J.R., Lu G.W., Steele D.F., Fedida D.
    J. Biol. Chem. 277:29045-29053(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of vasoconstriction Source: RGDInferred from sequence orthologyⁱ
  • "Impairment of hypoxic pulmonary vasoconstriction in mice lacking the voltage-gated potassium channel Kv1.5."
    Archer S.L., London B., Hampl V., Wu X., Nsair A., Puttagunta L., Hashimoto K., Waite R.E., Michelakis E.D.
    FASEB J. 15:1801-1803(2001) [PubMed] [Europe PMC] [Abstract]
• response to hydrogen peroxide Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension."
    Bonnet S., Michelakis E.D., Porter C.J., Andrade-Navarro M.A., Thebaud B., Bonnet S., Haromy A., Harry G., Moudgil R., McMurtry M.S., Weir E.K., Archer S.L.
    Circulation 113:2630-2641(2006) [PubMed] [Europe PMC] [Abstract]
• response to hyperoxia Source: RGDInferred from expression patternⁱ
  • "An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension."
    Bonnet S., Michelakis E.D., Porter C.J., Andrade-Navarro M.A., Thebaud B., Bonnet S., Haromy A., Harry G., Moudgil R., McMurtry M.S., Weir E.K., Archer S.L.
    Circulation 113:2630-2641(2006) [PubMed] [Europe PMC] [Abstract]
• response to hypoxia Source: RGDInferred from expression patternⁱ
  • "Subacute hypoxia decreases voltage-activated potassium channel expression and function in pulmonary artery myocytes."
    Hong Z., Weir E.K., Nelson D.P., Olschewski A.
    Am. J. Respir. Cell Mol. Biol. 31:337-343(2004) [PubMed] [Europe PMC] [Abstract]
• response to mechanical stimulus Source: RGDInferred from expression patternⁱ
  • "Losartan prevents stretch-induced electrical remodeling in cultured atrial neonatal myocytes."
    Saygili E., Rana O.R., Saygili E., Reuter H., Frank K., Schwinger R.H., Muller-Ehmsen J., Zobel C.
    Am. J. Physiol. Heart Circ. Physiol. 292:H2898-905(2007) [PubMed] [Europe PMC] [Abstract]
• response to organic substance Source: RGDInferred from expression patternⁱ
  • "An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension."
    Bonnet S., Michelakis E.D., Porter C.J., Andrade-Navarro M.A., Thebaud B., Bonnet S., Haromy A., Harry G., Moudgil R., McMurtry M.S., Weir E.K., Archer S.L.
    Circulation 113:2630-2641(2006) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• alpha-actinin binding Source: RGDInferred from sequence orthologyⁱ
  • "alpha-actinin-2 couples to cardiac Kv1.5 channels, regulating current density and channel localization in HEK cells."
    Maruoka N.D., Steele D.F., Au B.P., Dan P., Zhang X., Moore E.D., Fedida D.
    FEBS Lett. 473:188-194(2000) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: RGDInferred from sequence orthologyⁱ
  • "Association of Src tyrosine kinase with a human potassium channel mediated by SH3 domain."
    Holmes T.C., Fadool D.A., Ren R., Levitan I.B.
    Science 274:2089-2091(1996) [PubMed] [Europe PMC] [Abstract]
• scaffold protein binding Source: RGDInferred from sequence orthologyⁱ
  • "Different isoforms of synapse-associated protein, SAP97, are expressed in the heart and have distinct effects on the voltage-gated K+ channel Kv1.5."
    Godreau D., Vranckx R., Maguy A., Goyenvalle C., Hatem S.N.
    J. Biol. Chem. 278:47046-47052(2003) [PubMed] [Europe PMC] [Abstract]
  • "Four and a half LIM protein 1: a partner for KCNA5 in human atrium."
    Yang Z., Browning C.F., Hallaq H., Yermalitskaya L., Esker J., Hall M.R., Link A.J., Ham A.J., McGrath M.J., Mitchell C.A., Murray K.T.
    Cardiovasc. Res. 78:449-457(2008) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: RGDInferred from physical interactionⁱ
  • "Serotonin inhibits voltage-gated K+ currents in pulmonary artery smooth muscle cells: role of 5-HT2A receptors, caveolin-1, and KV1.5 channel internalization."
    Cogolludo A., Moreno L., Lodi F., Frazziano G., Cobeno L., Tamargo J., Perez-Vizcaino F.
    Circ. Res. 98:931-938(2006) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MEISLVPLEN GSAMTLRGGG EAGASCVQTP RGECGCPPTS GLNNQSKETL 
        60         70         80         90        100
LRGRTTLEDA NQGGRPLPPM AQELPQPRRL SAEDEEGEGD PGLGTVEEDQ 
       110        120        130        140        150
APQDAGSLHH QRVLINISGL RFETQLGTLA QFPNTLLGDP AKRLHYFDPL 
       160        170        180        190        200
RNEYFFDRNR PSFDGILYYY QSGGRLRRPV NVSLDVFADE IRFYQLGDEA 
       210        220        230        240        250
MERFREDEGF IKEEEKPLPR NEFQRQVWLI FEYPESSGSA RAIAIVSVLV 
       260        270        280        290        300
ILISIITFCL ETLPEFRDER ELLRHPPVPP QPPAPAPGIN GSVSGALSSG 
       310        320        330        340        350
PTVAPLLPRT LADPFFIVET TCVIWFTFEL LVRFFACPSK AEFSRNIMNI 
       360        370        380        390        400
IDVVAIFPYF ITLGTELAEQ QPGGGGQNGQ QAMSLAILRV IRLVRVFRIF 
       410        420        430        440        450
KLSRHSKGLQ ILGKTLQASM RELGLLIFFL FIGVILFSSA VYFAEADNHG 
       460        470        480        490        500
SHFSSIPDAF WWAVVTMTTV GYGDMRPITV GGKIVGSLCA IAGVLTIALP 
       510        520        530        540        550
VPVIVSNFNY FYHRETDHEE QAALKEEQGN QRRESGLDTG GQRKVSCSKA 
       560        570        580        590        600
SFCKTGGSLE SSDSIRRGSC PLEKCHLKAK SNVDLRRSLY ALCLDTSRET 

DL                                                     

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families