UniProtKB - P19022 (CADH2_HUMAN)

BLAST

>sp|P19022|CADH2_HUMAN Cadherin-2 OS=Homo sapiens OX=9606 GN=CDH2 PE=1 SV=4
MCRIAGALRTLLPLLAALLQASVEASGEIALCKTGFPEDVYSAVLSKDVHEGQPLLNVKF
SNCNGKRKVQYESSEPADFKVDEDGMVYAVRSFPLSSEHAKFLIYAQDKETQEKWQVAVK
LSLKPTLTEESVKESAEVEEIVFPRQFSKHSGHLQRQKRDWVIPPINLPENSRGPFPQEL
VRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINPISGQLSVTKPLDREQIARFHLRAHAV
DINGNQVENPIDIVINVIDMNDNRPEFLHQVWNGTVPEGSKPGTYVMTVTAIDADDPNAL
NGMLRYRIVSQAPSTPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPTY
GLSNTATAVITVTDVNDNPPEFTAMTFYGEVPENRVDIIVANLTVTDKDQPHTPAWNAVY
RISGGDPTGRFAIQTDPNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPLAKGIQHPPQS
TATVSVTVIDVNENPYFAPNPKIIRQEEGLHAGTMLTTFTAQDPDRYMQQNIRYTKLSDP
ANWLKIDPVNGQITTIAVLDRESPNVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDIND
NAPQVLPQEAETCETPDPNSINITALDYDIDPNAGPFAFDLPLSPVTIKRNWTITRLNGD
FAQLNLKIKFLEAGIYEVPIIITDSGNPPKSNISILRVKVCQCDSNGDCTDVDRIVGAGL
GTGAIIAILLCIIILLILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGE
EDQDYDLSQLQQPDTVEPDAIKPVGIRRMDERPIHAEPQYPVRSAAPHPGDIGDFINEGL
KAADNDPTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADM
YGGGDD

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Format
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History
Entry version 184 (12 Sep 2018)
Sequence version 4 (17 Oct 2006)
Previous versions | rss
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Protein

Cadherin-2

Gene

CDH2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	262	Calcium 1By similarity	1
Metal bindingⁱ	262	Calcium 2By similarity	1
Metal bindingⁱ	293	Calcium 3By similarity	1

GO - Molecular functionⁱ

alpha-catenin binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 7650039
beta-catenin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19830702
calcium ion binding Source: InterPro
gamma-catenin binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 7650039
identical protein binding Source: Ensembl
protein kinase binding Source: Ensembl
protein phosphatase binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adherens junction organization Source: Reactome
blood vessel morphogenesis Source: Ensembl
brain morphogenesis Source: Ensembl
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: Ensembl
cell adhesion
Source: ProtInc
Traceable author statementⁱ
- 2384753
cell-cell adhesion mediated by cadherin Source: UniProtKB
cell migration Source: Ensembl
cellular protein metabolic process Source: Reactome
cerebral cortex development Source: Ensembl
glial cell differentiation Source: UniProtKB
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: Ensembl
homeostasis of number of cells Source: Ensembl
homophilic cell adhesion via plasma membrane adhesion molecules Source: Ensembl
negative regulation of canonical Wnt signaling pathway Source: Ensembl
neuroepithelial cell differentiation Source: Ensembl
neuroligin clustering involved in postsynaptic membrane assembly Source: Ensembl
neuronal stem cell population maintenance Source: UniProtKB
positive regulation of MAPK cascade Source: Ensembl
positive regulation of muscle cell differentiation Source: Reactome
positive regulation of synaptic vesicle clustering Source: Ensembl
post-translational protein modification Source: Reactome
protein localization to plasma membrane Source: Ensembl
radial glial cell differentiation Source: Ensembl
regulation of oligodendrocyte progenitor proliferation Source: Ensembl
regulation of postsynaptic density protein 95 clustering Source: Ensembl
striated muscle cell differentiation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell adhesion
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-375170 CDO in myogenesis R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-418990 Adherens junctions interactions R-HSA-8957275 Post-translational protein phosphorylation
SIGNORⁱ	P19022

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cadherin-2 Alternative name(s): CDw325 Neural cadherin Short name: N-cadherin CD_antigen: CD325
Gene namesⁱ	Name:CDH2 Synonyms:CDHN, NCAD
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 18

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000170558.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1759 CDH2
MIMⁱ	114020 gene
neXtProtⁱ	NX_P19022

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	160 – 724	ExtracellularSequence analysisAdd BLAST	565
Transmembraneⁱ	725 – 745	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	746 – 906	CytoplasmicSequence analysisAdd BLAST	161

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1000
Open Targets More...OpenTargetsⁱ	ENSG00000170558
PharmGKBⁱ	PA26293

Chemistry databases

ChEMBLⁱ	CHEMBL1697669

ChEMBLⁱ

CHEMBL1697669

Polymorphism and mutation databases

BioMutaⁱ	CDH2
DMDMⁱ	116241277

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 25	Sequence analysisAdd BLAST	25
PropeptideⁱPRO_0000003731	26 – 159	Add BLAST	134
ChainⁱPRO_0000003732	160 – 906	Cadherin-2Add BLAST	747

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	96	Phosphoserine; by FAM20C1 Publication	1
Modified residueⁱ	135	Phosphoserine; by FAM20C1 Publication	1
Glycosylationⁱ	190	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	273	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	325	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	402	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	572	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	651	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	692	N-linked (GlcNAc...) asparagine1 Publication	1

Post-translational modificationⁱ

Cleaved by MMP24. Ectodomain cleavage leads to the generation of a soluble 90 kDa amino-terminal soluble fragment and a 45 kDa membrane-bound carboxy-terminal fragment 1 (CTF1), which is further cleaved by gamma-secretase into a 35 kDa. Cleavage in neural stem cells by MMP24 affects CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate neural stem cell quiescence (By similarity).By similarity

May be phosphorylated by OBSCN.By similarity

Keywords - PTMⁱ

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	P19022
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P19022
PaxDbⁱ	P19022
PeptideAtlas More...PeptideAtlasⁱ	P19022
PRIDEⁱ	P19022
ProteomicsDBⁱ	53628
TopDownProteomicsⁱ	P19022-1 [P19022-1]

PTM databases

GlyConnectⁱ	733
iPTMnetⁱ	P19022
PhosphoSitePlusⁱ	P19022
UniCarbKBⁱ	P19022

Miscellaneous databases

PMAP-CutDBⁱ	P19022

PMAP-CutDBⁱ

P19022

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000170558 Expressed in 199 organ(s), highest expression level in cardiac ventricle
CleanExⁱ	HS_CDH2
ExpressionAtlasⁱ	P19022 baseline and differential
Genevisibleⁱ	P19022 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB000141 CAB018580 CAB078686 HPA058574

HPAⁱ

CAB000141
CAB018580
CAB078686
HPA058574

Interactionⁱ

Subunit structureⁱ

Interacts with CDCP1 (PubMed:16007225). Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway (By similarity). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN (By similarity). May interact with OBSCN (via protein kinase domain 2) (By similarity).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CTNNB1	P35222	8	EBI-2256711,EBI-491549
JUP	P14923	2	EBI-2256711,EBI-702484

GO - Molecular functionⁱ

alpha-catenin binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 7650039
beta-catenin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19830702
gamma-catenin binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 7650039
identical protein binding Source: Ensembl
protein kinase binding Source: Ensembl
protein phosphatase binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107435, 59 interactors
CORUMⁱ	P19022
Database of interacting proteins More...DIPⁱ	DIP-43894N
IntActⁱ	P19022, 21 interactors
Molecular INTeraction database More...MINTⁱ	P19022
STRINGⁱ	9606.ENSP00000269141

Chemistry databases

BindingDBⁱ

P19022

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P19022
SMRⁱ	P19022
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	160 – 267	Cadherin 1PROSITE-ProRule annotationAdd BLAST	108
Domainⁱ	268 – 382	Cadherin 2PROSITE-ProRule annotationAdd BLAST	115
Domainⁱ	383 – 497	Cadherin 3PROSITE-ProRule annotationAdd BLAST	115
Domainⁱ	498 – 603	Cadherin 4PROSITE-ProRule annotationAdd BLAST	106
Domainⁱ	604 – 714	Cadherin 5PROSITE-ProRule annotationAdd BLAST	111

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	863 – 878	Ser-richAdd BLAST		16

Domainⁱ

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. Calcium-binding sites are occupied sequentially in the order of site 3, then site 2 and site 1 (By similarity).By similarity

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3594 Eukaryota ENOG410XQHI LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118906
HOGENOMⁱ	HOG000231254
HOVERGENⁱ	HBG106438
InParanoidⁱ	P19022
KEGG Orthology (KO) More...KOⁱ	K06736
OMAⁱ	FLEAGIY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01FV
PhylomeDBⁱ	P19022
TreeFamⁱ	TF316817

Family and domain databases

Gene3Dⁱ	4.10.900.10, 1 hit
InterProⁱ	View protein in InterPro IPR002126 Cadherin IPR015919 Cadherin-like IPR020894 Cadherin_CS IPR000233 Cadherin_cytoplasmic-dom IPR014868 Cadherin_pro_dom IPR027397 Catenin_binding_dom_sf IPR030051 CDH2
PANTHERⁱ	PTHR24027:SF79 PTHR24027:SF79, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00028 Cadherin, 5 hits PF01049 Cadherin_C, 1 hit PF08758 Cadherin_pro, 1 hit
PRINTSⁱ	PR00205 CADHERIN
SMARTⁱ	View protein in SMART SM00112 CA, 5 hits SM01055 Cadherin_pro, 1 hit
SUPFAMⁱ	SSF49313 SSF49313, 6 hits
PROSITEⁱ	View protein in PROSITE PS00232 CADHERIN_1, 3 hits PS50268 CADHERIN_2, 5 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: P19022-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCRIAGALRT LLPLLAALLQ ASVEASGEIA LCKTGFPEDV YSAVLSKDVH 
        60         70         80         90        100
EGQPLLNVKF SNCNGKRKVQ YESSEPADFK VDEDGMVYAV RSFPLSSEHA 
       110        120        130        140        150
KFLIYAQDKE TQEKWQVAVK LSLKPTLTEE SVKESAEVEE IVFPRQFSKH 
       160        170        180        190        200
SGHLQRQKRD WVIPPINLPE NSRGPFPQEL VRIRSDRDKN LSLRYSVTGP 
       210        220        230        240        250
GADQPPTGIF IINPISGQLS VTKPLDREQI ARFHLRAHAV DINGNQVENP 
       260        270        280        290        300
IDIVINVIDM NDNRPEFLHQ VWNGTVPEGS KPGTYVMTVT AIDADDPNAL 
       310        320        330        340        350
NGMLRYRIVS QAPSTPSPNM FTINNETGDI ITVAAGLDRE KVQQYTLIIQ 
       360        370        380        390        400
ATDMEGNPTY GLSNTATAVI TVTDVNDNPP EFTAMTFYGE VPENRVDIIV 
       410        420        430        440        450
ANLTVTDKDQ PHTPAWNAVY RISGGDPTGR FAIQTDPNSN DGLVTVVKPI 
       460        470        480        490        500
DFETNRMFVL TVAAENQVPL AKGIQHPPQS TATVSVTVID VNENPYFAPN 
       510        520        530        540        550
PKIIRQEEGL HAGTMLTTFT AQDPDRYMQQ NIRYTKLSDP ANWLKIDPVN 
       560        570        580        590        600
GQITTIAVLD RESPNVKNNI YNATFLASDN GIPPMSGTGT LQIYLLDIND 
       610        620        630        640        650
NAPQVLPQEA ETCETPDPNS INITALDYDI DPNAGPFAFD LPLSPVTIKR 
       660        670        680        690        700
NWTITRLNGD FAQLNLKIKF LEAGIYEVPI IITDSGNPPK SNISILRVKV 
       710        720        730        740        750
CQCDSNGDCT DVDRIVGAGL GTGAIIAILL CIIILLILVL MFVVWMKRRD 
       760        770        780        790        800
KERQAKQLLI DPEDDVRDNI LKYDEEGGGE EDQDYDLSQL QQPDTVEPDA 
       810        820        830        840        850
IKPVGIRRMD ERPIHAEPQY PVRSAAPHPG DIGDFINEGL KAADNDPTAP 
       860        870        880        890        900
PYDSLLVFDY EGSGSTAGSL SSLNSSSSGG EQDYDYLNDW GPRFKKLADM 

YGGGDD

Length:906

Mass (Da):99,809

Last modified:October 17, 2006 - v4

Checksum:ⁱ7267E2A00489DF94

Isoform 2 (identifier: P19022-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-57: MCRIAGALRT...DVHEGQPLLN → MFLLRRYVCIFTEKLKNQAELYVFLS

« Hide

        10         20         30         40         50
MFLLRRYVCI FTEKLKNQAE LYVFLSVKFS NCNGKRKVQY ESSEPADFKV 
        60         70         80         90        100
DEDGMVYAVR SFPLSSEHAK FLIYAQDKET QEKWQVAVKL SLKPTLTEES 
       110        120        130        140        150
VKESAEVEEI VFPRQFSKHS GHLQRQKRDW VIPPINLPEN SRGPFPQELV 
       160        170        180        190        200
RIRSDRDKNL SLRYSVTGPG ADQPPTGIFI INPISGQLSV TKPLDREQIA 
       210        220        230        240        250
RFHLRAHAVD INGNQVENPI DIVINVIDMN DNRPEFLHQV WNGTVPEGSK 
       260        270        280        290        300
PGTYVMTVTA IDADDPNALN GMLRYRIVSQ APSTPSPNMF TINNETGDII 
       310        320        330        340        350
TVAAGLDREK VQQYTLIIQA TDMEGNPTYG LSNTATAVIT VTDVNDNPPE 
       360        370        380        390        400
FTAMTFYGEV PENRVDIIVA NLTVTDKDQP HTPAWNAVYR ISGGDPTGRF 
       410        420        430        440        450
AIQTDPNSND GLVTVVKPID FETNRMFVLT VAAENQVPLA KGIQHPPQST 
       460        470        480        490        500
ATVSVTVIDV NENPYFAPNP KIIRQEEGLH AGTMLTTFTA QDPDRYMQQN 
       510        520        530        540        550
IRYTKLSDPA NWLKIDPVNG QITTIAVLDR ESPNVKNNIY NATFLASDNG 
       560        570        580        590        600
IPPMSGTGTL QIYLLDINDN APQVLPQEAE TCETPDPNSI NITALDYDID 
       610        620        630        640        650
PNAGPFAFDL PLSPVTIKRN WTITRLNGDF AQLNLKIKFL EAGIYEVPII 
       660        670        680        690        700
ITDSGNPPKS NISILRVKVC QCDSNGDCTD VDRIVGAGLG TGAIIAILLC 
       710        720        730        740        750
IIILLILVLM FVVWMKRRDK ERQAKQLLID PEDDVRDNIL KYDEEGGGEE 
       760        770        780        790        800
DQDYDLSQLQ QPDTVEPDAI KPVGIRRMDE RPIHAEPQYP VRSAAPHPGD 
       810        820        830        840        850
IGDFINEGLK AADNDPTAPP YDSLLVFDYE GSGSTAGSLS SLNSSSSGGE 
       860        870 
QDYDYLNDWG PRFKKLADMY GGGDD

Note: No experimental confirmation available.

Show »

Length:875

Mass (Da):97,040

Checksum:ⁱ04DCB2F62C61C998

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
C9J8J8	C9J8J8_HUMAN	Cadherin-2 Cadherin-2	CDH2	191	Annotation score:
C9J126	C9J126_HUMAN	Cadherin-2 Cadherin-2	CDH2	120	Annotation score:
C9JMH2	C9JMH2_HUMAN	Cadherin-2 Cadherin-2	CDH2	73	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	12	Missing in AAB22854 (PubMed:1500442).Curated	1
Sequence conflictⁱ	16	A → L in CAA38213 (PubMed:2216790).Curated	1
Sequence conflictⁱ	164	P → S in AAH36470 (PubMed:15489334).Curated	1
Sequence conflictⁱ	357	N → I in CAA38213 (PubMed:2216790).Curated	1
Sequence conflictⁱ	437	P → Q in AAH36470 (PubMed:15489334).Curated	1
Sequence conflictⁱ	484	V → M in AAH36470 (PubMed:15489334).Curated	1
Sequence conflictⁱ	629	D → G in AAH36470 (PubMed:15489334).Curated	1
Sequence conflictⁱ	867	A → L in AAB22854 (PubMed:1500442).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_028254	21	A → T. Corresponds to variant dbSNP:rs17495042Ensembl.	1
Natural variantⁱVAR_028255	118	A → T. Corresponds to variant dbSNP:rs17445840Ensembl.	1
Natural variantⁱVAR_028256	196	S → T1 PublicationCorresponds to variant dbSNP:rs1041970Ensembl.	1
Natural variantⁱVAR_028257	212	I → L1 PublicationCorresponds to variant dbSNP:rs1041972Ensembl.	1
Natural variantⁱVAR_048503	454	T → A1 PublicationCorresponds to variant dbSNP:rs17857112Ensembl.	1
Natural variantⁱVAR_028258	845	N → S. Corresponds to variant dbSNP:rs2289664Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056448	1 – 57	MCRIA…QPLLN → MFLLRRYVCIFTEKLKNQAE LYVFLS in isoform 2. 1 PublicationAdd BLAST		57

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X54315 mRNA Translation: CAA38213.1 S42303 mRNA Translation: AAB22854.1 AK302831 mRNA Translation: BAH13814.1 AC006249 Genomic DNA No translation available. AC015933 Genomic DNA No translation available. AC110015 Genomic DNA No translation available. EF444966 Genomic DNA Translation: ACA05964.1 CH471088 Genomic DNA Translation: EAX01240.1 BC036470 mRNA Translation: AAH36470.1 M34064 mRNA Translation: AAA03236.1 X57548 mRNA Translation: CAA40773.1 Z27420 Genomic DNA Translation: CAA81799.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11891.1 [P19022-1] CCDS77172.1 [P19022-2]
PIRⁱ	A38870 IJHUCN
NCBI Reference Sequences More...RefSeqⁱ	NP_001295105.1, NM_001308176.1 [P19022-2] NP_001783.2, NM_001792.4 [P19022-1]
UniGeneⁱ	Hs.464829 Hs.606106

Genome annotation databases

Ensemblⁱ	ENST00000269141; ENSP00000269141; ENSG00000170558 [P19022-1] ENST00000399380; ENSP00000382312; ENSG00000170558 [P19022-2]
GeneIDⁱ	1000
KEGGⁱ	hsa:1000
UCSC genome browser More...UCSCⁱ	uc002kwg.3 human [P19022-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P19022	Cadherin 2, type 1, N-cadherin (Neuronal), isoform CRA_b		HUMAN		906	UniRef100_P19022
UPI0002A4716C		HUMAN		821

Protein	Similar proteins		Species	Score	Length	Source
P19022	Cadherin-2	)	MOUSE		906	UniRef90_P15116
Cadherin-2		RHIFE		906
Cadherin-2		RAT		906
Cadherin-2		PONAB		906
Cadherin-2		OTOGA		906
+114
P19022-2	Cadherin 2, type 1, N-cadherin (Neuronal)		PANTR		1075	UniRef90_P19022-2
Cadherin-2 (Fragment)		HUMAN		73
Cadherin 2		PANPA		849
Cadherin-2 isoform 2 (Fragment)		CALJA		109
Cadherin 2		FELCA		957
+78

Protein	Similar proteins		Species	Score	Length	Source
P19022	Cadherin-2	)	MOUSE		906	UniRef50_P15116
Cadherin-2		OTOGA		906
Cadherin-2		RAT		906
Cadherin-2		RHIFE		906
Cadherin-2		PONAB		906
+352

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X54315 mRNA Translation: CAA38213.1 S42303 mRNA Translation: AAB22854.1 AK302831 mRNA Translation: BAH13814.1 AC006249 Genomic DNA No translation available. AC015933 Genomic DNA No translation available. AC110015 Genomic DNA No translation available. EF444966 Genomic DNA Translation: ACA05964.1 CH471088 Genomic DNA Translation: EAX01240.1 BC036470 mRNA Translation: AAH36470.1 M34064 mRNA Translation: AAA03236.1 X57548 mRNA Translation: CAA40773.1 Z27420 Genomic DNA Translation: CAA81799.1
CCDSⁱ	CCDS11891.1 [P19022-1] CCDS77172.1 [P19022-2]
PIRⁱ	A38870 IJHUCN
RefSeqⁱ	NP_001295105.1, NM_001308176.1 [P19022-2] NP_001783.2, NM_001792.4 [P19022-1]
UniGeneⁱ	Hs.464829 Hs.606106

3D structure databases

ProteinModelPortalⁱ	P19022
SMRⁱ	P19022
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107435, 59 interactors
CORUMⁱ	P19022
DIPⁱ	DIP-43894N
IntActⁱ	P19022, 21 interactors
MINTⁱ	P19022
STRINGⁱ	9606.ENSP00000269141

Chemistry databases

BindingDBⁱ	P19022
ChEMBLⁱ	CHEMBL1697669

PTM databases

GlyConnectⁱ	733
iPTMnetⁱ	P19022
PhosphoSitePlusⁱ	P19022
UniCarbKBⁱ	P19022

Polymorphism and mutation databases

BioMutaⁱ	CDH2
DMDMⁱ	116241277

Proteomic databases

EPDⁱ	P19022
MaxQBⁱ	P19022
PaxDbⁱ	P19022
PeptideAtlasⁱ	P19022
PRIDEⁱ	P19022
ProteomicsDBⁱ	53628
TopDownProteomicsⁱ	P19022-1 [P19022-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1000
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000269141; ENSP00000269141; ENSG00000170558 [P19022-1] ENST00000399380; ENSP00000382312; ENSG00000170558 [P19022-2]
GeneIDⁱ	1000
KEGGⁱ	hsa:1000
UCSCⁱ	uc002kwg.3 human [P19022-1]

Organism-specific databases

CTDⁱ	1000
DisGeNETⁱ	1000
EuPathDBⁱ	HostDB:ENSG00000170558.8
GeneCardsⁱ	CDH2
H-InvDBⁱ	HIX0027368
HGNCⁱ	HGNC:1759 CDH2
HPAⁱ	CAB000141 CAB018580 CAB078686 HPA058574
MIMⁱ	114020 gene
neXtProtⁱ	NX_P19022
OpenTargetsⁱ	ENSG00000170558
PharmGKBⁱ	PA26293
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3594 Eukaryota ENOG410XQHI LUCA
GeneTreeⁱ	ENSGT00760000118906
HOGENOMⁱ	HOG000231254
HOVERGENⁱ	HBG106438
InParanoidⁱ	P19022
KOⁱ	K06736
OMAⁱ	FLEAGIY
OrthoDBⁱ	EOG091G01FV
PhylomeDBⁱ	P19022
TreeFamⁱ	TF316817

Enzyme and pathway databases

Reactomeⁱ	R-HSA-375170 CDO in myogenesis R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-418990 Adherens junctions interactions R-HSA-8957275 Post-translational protein phosphorylation
SIGNORⁱ	P19022

Miscellaneous databases

ChiTaRSⁱ	CDH2 human
GeneWikiⁱ	CDH2
GenomeRNAiⁱ	1000
PMAP-CutDBⁱ	P19022
Protein Ontology More...PROⁱ	PR:P19022
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000170558 Expressed in 199 organ(s), highest expression level in cardiac ventricle
CleanExⁱ	HS_CDH2
ExpressionAtlasⁱ	P19022 baseline and differential
Genevisibleⁱ	P19022 HS

Family and domain databases

Gene3Dⁱ	4.10.900.10, 1 hit
InterProⁱ	View protein in InterPro IPR002126 Cadherin IPR015919 Cadherin-like IPR020894 Cadherin_CS IPR000233 Cadherin_cytoplasmic-dom IPR014868 Cadherin_pro_dom IPR027397 Catenin_binding_dom_sf IPR030051 CDH2
PANTHERⁱ	PTHR24027:SF79 PTHR24027:SF79, 1 hit
Pfamⁱ	View protein in Pfam PF00028 Cadherin, 5 hits PF01049 Cadherin_C, 1 hit PF08758 Cadherin_pro, 1 hit
PRINTSⁱ	PR00205 CADHERIN
SMARTⁱ	View protein in SMART SM00112 CA, 5 hits SM01055 Cadherin_pro, 1 hit
SUPFAMⁱ	SSF49313 SSF49313, 6 hits
PROSITEⁱ	View protein in PROSITE PS00232 CADHERIN_1, 3 hits PS50268 CADHERIN_2, 5 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CADH2_HUMAN
Accessionⁱ	P19022Primary (citable) accession number: P19022 Secondary accession number(s): A8MWK3 , B0YIY6, Q14923, Q8N173
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
	Last sequence update:	October 17, 2006
	Last modified:	September 12, 2018
	This is version 184 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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UniProtKB - P19022 (CADH2_HUMAN)

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Cadherin-2

CDH2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

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Organism-specific databases

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Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

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Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

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Keywords - Domaini

Phylogenomic databases

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Computationally mapped potential isoform sequencesi

Experimental Info

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Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ