UniProtKB - P19022 (CADH2_HUMAN)
Cadherin-2
CDH2
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 170 | Calcium 1By similarity | 1 | |
Metal bindingi | 170 | Calcium 2By similarity | 1 | |
Metal bindingi | 226 | Calcium 1By similarity | 1 | |
Metal bindingi | 228 | Calcium 1By similarity | 1 | |
Metal bindingi | 228 | Calcium 2By similarity | 1 | |
Metal bindingi | 259 | Calcium 2By similarity | 1 | |
Metal bindingi | 260 | Calcium 2; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 261 | Calcium 3By similarity | 1 | |
Metal bindingi | 262 | Calcium 1By similarity | 1 | |
Metal bindingi | 262 | Calcium 2By similarity | 1 | |
Metal bindingi | 263 | Calcium 3; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 293 | Calcium 3By similarity | 1 | |
Metal bindingi | 295 | Calcium 2By similarity | 1 | |
Metal bindingi | 301 | Calcium 3; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 353 | Calcium 3By similarity | 1 |
GO - Molecular functioni
- alpha-catenin binding Source: BHF-UCL
- beta-catenin binding Source: UniProtKB
- cadherin binding Source: GO_Central
- calcium ion binding Source: UniProtKB
- gamma-catenin binding Source: BHF-UCL
- identical protein binding Source: Ensembl
- protein kinase binding Source: Ensembl
- protein phosphatase binding Source: Ensembl
GO - Biological processi
- adherens junction organization Source: Reactome
- blood vessel morphogenesis Source: GO_Central
- brain development Source: GO_Central
- brain morphogenesis Source: Ensembl
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: Ensembl
- cell adhesion Source: ProtInc
- cell-cell adhesion Source: UniProtKB
- cell-cell adhesion mediated by cadherin Source: UniProtKB
- cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
- cell-cell junction assembly Source: UniProtKB
- cellular protein metabolic process Source: Reactome
- cerebral cortex development Source: Ensembl
- detection of muscle stretch Source: BHF-UCL
- glial cell differentiation Source: UniProtKB
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: Ensembl
- homeostasis of number of cells Source: Ensembl
- homophilic cell adhesion via plasma membrane adhesion molecules Source: GO_Central
- mesenchymal cell migration Source: Ensembl
- negative regulation of canonical Wnt signaling pathway Source: Ensembl
- neural crest cell development Source: UniProtKB
- neuroepithelial cell differentiation Source: Ensembl
- neuroligin clustering involved in postsynaptic membrane assembly Source: Ensembl
- neuronal stem cell population maintenance Source: UniProtKB
- positive regulation of MAPK cascade Source: Ensembl
- positive regulation of muscle cell differentiation Source: Reactome
- positive regulation of synaptic vesicle clustering Source: Ensembl
- post-translational protein modification Source: Reactome
- protein localization to plasma membrane Source: Ensembl
- radial glial cell differentiation Source: Ensembl
- regulation of axonogenesis Source: GO_Central
- regulation of oligodendrocyte progenitor proliferation Source: Ensembl
- regulation of postsynaptic density protein 95 clustering Source: Ensembl
- regulation of synaptic transmission, glutamatergic Source: GO_Central
- striated muscle cell differentiation Source: Ensembl
- synapse assembly Source: GO_Central
- type B pancreatic cell development Source: UniProtKB
Keywordsi
Biological process | Cell adhesion |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | P19022 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-418990, Adherens junctions interactions R-HSA-525793, Myogenesis R-HSA-8957275, Post-translational protein phosphorylation |
SIGNORi | P19022 |
Names & Taxonomyi
Protein namesi | Recommended name: Cadherin-2Alternative name(s): CDw325 Neural cadherin Short name: N-cadherin1 Publication CD_antigen: CD325 |
Gene namesi | Name:CDH2 Synonyms:CDHN, NCAD |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1759, CDH2 |
MIMi | 114020, gene |
neXtProti | NX_P19022 |
VEuPathDBi | HostDB:ENSG00000170558.8 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein Sequence analysis
- sarcolemma By similarity
Other locations
- Cell junction 1 Publication
- Cell surface By similarity
Note: Colocalizes with TMEM65 at the intercalated disk in cardiomyocytes. Colocalizes with OBSCN at the intercalated disk and at sarcolemma in cardiomyocytes.By similarity
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
Plasma Membrane
- apical plasma membrane Source: Ensembl
- apicolateral plasma membrane Source: Ensembl
- basolateral plasma membrane Source: Ensembl
- catenin complex Source: BHF-UCL
- integral component of plasma membrane Source: UniProtKB
- integral component of postsynaptic specialization membrane Source: GO_Central
- integral component of presynaptic active zone membrane Source: GO_Central
- plasma membrane Source: UniProtKB
- plasma membrane raft Source: Ensembl
- sarcolemma Source: UniProtKB-SubCell
Other locations
- adherens junction Source: UniProtKB
- apical part of cell Source: GO_Central
- cell junction Source: UniProtKB
- cell surface Source: UniProtKB
- cell-cell junction Source: BHF-UCL
- cytoplasm Source: UniProtKB
- fascia adherens Source: Ensembl
- focal adhesion Source: UniProtKB
- intercalated disc Source: BHF-UCL
- lamellipodium Source: UniProtKB
- neuron projection Source: GO_Central
- postsynaptic density Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 160 – 724 | ExtracellularSequence analysisAdd BLAST | 565 | |
Transmembranei | 725 – 745 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 746 – 906 | CytoplasmicSequence analysisAdd BLAST | 161 |
Keywords - Cellular componenti
Cell junction, Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 1000 |
MalaCardsi | CDH2 |
OpenTargetsi | ENSG00000170558 |
PharmGKBi | PA26293 |
Miscellaneous databases
Pharosi | P19022, Tbio |
Chemistry databases
ChEMBLi | CHEMBL1697669 |
Genetic variation databases
BioMutai | CDH2 |
DMDMi | 116241277 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
PropeptideiPRO_0000003731 | 26 – 159 | Add BLAST | 134 | |
ChainiPRO_0000003732 | 160 – 906 | Cadherin-2Add BLAST | 747 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 96 | Phosphoserine; by FAM20C1 Publication | 1 | |
Modified residuei | 135 | Phosphoserine; by FAM20C1 Publication | 1 | |
Glycosylationi | 190 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 273 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 325 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 402 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 572 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 651 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 692 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Cleavage on pair of basic residues, Glycoprotein, PhosphoproteinProteomic databases
EPDi | P19022 |
jPOSTi | P19022 |
MassIVEi | P19022 |
MaxQBi | P19022 |
PaxDbi | P19022 |
PeptideAtlasi | P19022 |
PRIDEi | P19022 |
ProteomicsDBi | 2250 53628 [P19022-1] |
TopDownProteomicsi | P19022-1 [P19022-1] |
PTM databases
GlyConnecti | 733, 11 N-Linked glycans (4 sites) |
GlyGeni | P19022, 9 sites, 1 N-linked glycan (1 site) |
iPTMneti | P19022 |
PhosphoSitePlusi | P19022 |
Expressioni
Gene expression databases
Bgeei | ENSG00000170558, Expressed in cardiac ventricle and 215 other tissues |
ExpressionAtlasi | P19022, baseline and differential |
Genevisiblei | P19022, HS |
Organism-specific databases
HPAi | ENSG00000170558, Tissue enhanced (heart muscle, parathyroid gland) |
Interactioni
Subunit structurei
Homodimer (via extracellular region). Can also form heterodimers with other cadherins (via extracellular region). Dimerization occurs in trans, i.e. with a cadherin chain from another cell (By similarity).
Interacts with CDCP1 (PubMed:16007225).
Interacts with PCDH8; this complex may also include TAOK2 (By similarity). The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway (By similarity).
Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. May interact with OBSCN (via protein kinase domain 2) (By similarity).
By similarity1 PublicationBinary interactionsi
Hide detailsGO - Molecular functioni
- alpha-catenin binding Source: BHF-UCL
- beta-catenin binding Source: UniProtKB
- cadherin binding Source: GO_Central
- gamma-catenin binding Source: BHF-UCL
- identical protein binding Source: Ensembl
- protein kinase binding Source: Ensembl
- protein phosphatase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 107435, 65 interactors |
CORUMi | P19022 |
DIPi | DIP-43894N |
IntActi | P19022, 24 interactors |
MINTi | P19022 |
STRINGi | 9606.ENSP00000269141 |
Chemistry databases
BindingDBi | P19022 |
Miscellaneous databases
RNActi | P19022, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 160 – 267 | Cadherin 1PROSITE-ProRule annotationAdd BLAST | 108 | |
Domaini | 268 – 382 | Cadherin 2PROSITE-ProRule annotationAdd BLAST | 115 | |
Domaini | 383 – 497 | Cadherin 3PROSITE-ProRule annotationAdd BLAST | 115 | |
Domaini | 498 – 603 | Cadherin 4PROSITE-ProRule annotationAdd BLAST | 106 | |
Domaini | 604 – 714 | Cadherin 5PROSITE-ProRule annotationAdd BLAST | 111 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 863 – 878 | Ser-richAdd BLAST | 16 |
Domaini
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000155981 |
HOGENOMi | CLU_005284_2_0_1 |
InParanoidi | P19022 |
OMAi | NVRFQSC |
PhylomeDBi | P19022 |
TreeFami | TF316817 |
Family and domain databases
Gene3Di | 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR000233, Cadherin_cytoplasmic-dom IPR014868, Cadherin_pro_dom IPR027397, Catenin-bd_sf IPR030051, CDH2 |
PANTHERi | PTHR24027, PTHR24027, 1 hit PTHR24027:SF79, PTHR24027:SF79, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF01049, Cadherin_C, 1 hit PF08758, Cadherin_pro, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 5 hits SM01055, Cadherin_pro, 1 hit |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 3 hits PS50268, CADHERIN_2, 5 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MCRIAGALRT LLPLLAALLQ ASVEASGEIA LCKTGFPEDV YSAVLSKDVH
60 70 80 90 100
EGQPLLNVKF SNCNGKRKVQ YESSEPADFK VDEDGMVYAV RSFPLSSEHA
110 120 130 140 150
KFLIYAQDKE TQEKWQVAVK LSLKPTLTEE SVKESAEVEE IVFPRQFSKH
160 170 180 190 200
SGHLQRQKRD WVIPPINLPE NSRGPFPQEL VRIRSDRDKN LSLRYSVTGP
210 220 230 240 250
GADQPPTGIF IINPISGQLS VTKPLDREQI ARFHLRAHAV DINGNQVENP
260 270 280 290 300
IDIVINVIDM NDNRPEFLHQ VWNGTVPEGS KPGTYVMTVT AIDADDPNAL
310 320 330 340 350
NGMLRYRIVS QAPSTPSPNM FTINNETGDI ITVAAGLDRE KVQQYTLIIQ
360 370 380 390 400
ATDMEGNPTY GLSNTATAVI TVTDVNDNPP EFTAMTFYGE VPENRVDIIV
410 420 430 440 450
ANLTVTDKDQ PHTPAWNAVY RISGGDPTGR FAIQTDPNSN DGLVTVVKPI
460 470 480 490 500
DFETNRMFVL TVAAENQVPL AKGIQHPPQS TATVSVTVID VNENPYFAPN
510 520 530 540 550
PKIIRQEEGL HAGTMLTTFT AQDPDRYMQQ NIRYTKLSDP ANWLKIDPVN
560 570 580 590 600
GQITTIAVLD RESPNVKNNI YNATFLASDN GIPPMSGTGT LQIYLLDIND
610 620 630 640 650
NAPQVLPQEA ETCETPDPNS INITALDYDI DPNAGPFAFD LPLSPVTIKR
660 670 680 690 700
NWTITRLNGD FAQLNLKIKF LEAGIYEVPI IITDSGNPPK SNISILRVKV
710 720 730 740 750
CQCDSNGDCT DVDRIVGAGL GTGAIIAILL CIIILLILVL MFVVWMKRRD
760 770 780 790 800
KERQAKQLLI DPEDDVRDNI LKYDEEGGGE EDQDYDLSQL QQPDTVEPDA
810 820 830 840 850
IKPVGIRRMD ERPIHAEPQY PVRSAAPHPG DIGDFINEGL KAADNDPTAP
860 870 880 890 900
PYDSLLVFDY EGSGSTAGSL SSLNSSSSGG EQDYDYLNDW GPRFKKLADM
YGGGDD
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J126 | C9J126_HUMAN | Cadherin-2 | CDH2 | 821 | Annotation score: | ||
C9J8J8 | C9J8J8_HUMAN | Cadherin-2 | CDH2 | 191 | Annotation score: | ||
C9JMH2 | C9JMH2_HUMAN | Cadherin-2 | CDH2 | 691 | Annotation score: | ||
A0A6Q8PHJ8 | A0A6Q8PHJ8_HUMAN | Cadherin-2 | CDH2 | 394 | Annotation score: | ||
A0A6Q8PF58 | A0A6Q8PF58_HUMAN | Cadherin-2 | CDH2 | 733 | Annotation score: | ||
A0A6Q8PG20 | A0A6Q8PG20_HUMAN | Cadherin-2 | CDH2 | 161 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 12 | Missing in AAB22854 (PubMed:1500442).Curated | 1 | |
Sequence conflicti | 16 | A → L in CAA38213 (PubMed:2216790).Curated | 1 | |
Sequence conflicti | 164 | P → S in AAH36470 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 357 | N → I in CAA38213 (PubMed:2216790).Curated | 1 | |
Sequence conflicti | 437 | P → Q in AAH36470 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 484 | V → M in AAH36470 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 629 | D → G in AAH36470 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 867 | A → L in AAB22854 (PubMed:1500442).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028254 | 21 | A → T. Corresponds to variant dbSNP:rs17495042Ensembl. | 1 | |
Natural variantiVAR_028255 | 118 | A → T. Corresponds to variant dbSNP:rs17445840Ensembl. | 1 | |
Natural variantiVAR_028256 | 196 | S → T1 PublicationCorresponds to variant dbSNP:rs1041970Ensembl. | 1 | |
Natural variantiVAR_028257 | 212 | I → L1 PublicationCorresponds to variant dbSNP:rs1041972Ensembl. | 1 | |
Natural variantiVAR_048503 | 454 | T → A1 PublicationCorresponds to variant dbSNP:rs17857112Ensembl. | 1 | |
Natural variantiVAR_028258 | 845 | N → S. Corresponds to variant dbSNP:rs2289664Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056448 | 1 – 57 | MCRIA…QPLLN → MFLLRRYVCIFTEKLKNQAE LYVFLS in isoform 2. 1 PublicationAdd BLAST | 57 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X54315 mRNA Translation: CAA38213.1 S42303 mRNA Translation: AAB22854.1 AK302831 mRNA Translation: BAH13814.1 AC006249 Genomic DNA No translation available. AC015933 Genomic DNA No translation available. AC110015 Genomic DNA No translation available. EF444966 Genomic DNA Translation: ACA05964.1 CH471088 Genomic DNA Translation: EAX01240.1 BC036470 mRNA Translation: AAH36470.1 M34064 mRNA Translation: AAA03236.1 X57548 mRNA Translation: CAA40773.1 Z27420 Genomic DNA Translation: CAA81799.1 |
CCDSi | CCDS11891.1 [P19022-1] CCDS77172.1 [P19022-2] |
PIRi | A38870, IJHUCN |
RefSeqi | NP_001295105.1, NM_001308176.1 [P19022-2] NP_001783.2, NM_001792.4 [P19022-1] |
Genome annotation databases
Ensembli | ENST00000269141; ENSP00000269141; ENSG00000170558 [P19022-1] ENST00000399380; ENSP00000382312; ENSG00000170558 [P19022-2] |
GeneIDi | 1000 |
KEGGi | hsa:1000 |
UCSCi | uc002kwg.3, human [P19022-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X54315 mRNA Translation: CAA38213.1 S42303 mRNA Translation: AAB22854.1 AK302831 mRNA Translation: BAH13814.1 AC006249 Genomic DNA No translation available. AC015933 Genomic DNA No translation available. AC110015 Genomic DNA No translation available. EF444966 Genomic DNA Translation: ACA05964.1 CH471088 Genomic DNA Translation: EAX01240.1 BC036470 mRNA Translation: AAH36470.1 M34064 mRNA Translation: AAA03236.1 X57548 mRNA Translation: CAA40773.1 Z27420 Genomic DNA Translation: CAA81799.1 |
CCDSi | CCDS11891.1 [P19022-1] CCDS77172.1 [P19022-2] |
PIRi | A38870, IJHUCN |
RefSeqi | NP_001295105.1, NM_001308176.1 [P19022-2] NP_001783.2, NM_001792.4 [P19022-1] |
3D structure databases
SMRi | P19022 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107435, 65 interactors |
CORUMi | P19022 |
DIPi | DIP-43894N |
IntActi | P19022, 24 interactors |
MINTi | P19022 |
STRINGi | 9606.ENSP00000269141 |
Chemistry databases
BindingDBi | P19022 |
ChEMBLi | CHEMBL1697669 |
PTM databases
GlyConnecti | 733, 11 N-Linked glycans (4 sites) |
GlyGeni | P19022, 9 sites, 1 N-linked glycan (1 site) |
iPTMneti | P19022 |
PhosphoSitePlusi | P19022 |
Genetic variation databases
BioMutai | CDH2 |
DMDMi | 116241277 |
Proteomic databases
EPDi | P19022 |
jPOSTi | P19022 |
MassIVEi | P19022 |
MaxQBi | P19022 |
PaxDbi | P19022 |
PeptideAtlasi | P19022 |
PRIDEi | P19022 |
ProteomicsDBi | 2250 53628 [P19022-1] |
TopDownProteomicsi | P19022-1 [P19022-1] |
Protocols and materials databases
ABCDi | P19022, 4 sequenced antibodies |
Antibodypediai | 4558, 1659 antibodies |
CPTCi | P19022, 5 antibodies |
DNASUi | 1000 |
Genome annotation databases
Ensembli | ENST00000269141; ENSP00000269141; ENSG00000170558 [P19022-1] ENST00000399380; ENSP00000382312; ENSG00000170558 [P19022-2] |
GeneIDi | 1000 |
KEGGi | hsa:1000 |
UCSCi | uc002kwg.3, human [P19022-1] |
Organism-specific databases
CTDi | 1000 |
DisGeNETi | 1000 |
GeneCardsi | CDH2 |
HGNCi | HGNC:1759, CDH2 |
HPAi | ENSG00000170558, Tissue enhanced (heart muscle, parathyroid gland) |
MalaCardsi | CDH2 |
MIMi | 114020, gene |
neXtProti | NX_P19022 |
OpenTargetsi | ENSG00000170558 |
PharmGKBi | PA26293 |
VEuPathDBi | HostDB:ENSG00000170558.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000155981 |
HOGENOMi | CLU_005284_2_0_1 |
InParanoidi | P19022 |
OMAi | NVRFQSC |
PhylomeDBi | P19022 |
TreeFami | TF316817 |
Enzyme and pathway databases
PathwayCommonsi | P19022 |
Reactomei | R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-418990, Adherens junctions interactions R-HSA-525793, Myogenesis R-HSA-8957275, Post-translational protein phosphorylation |
SIGNORi | P19022 |
Miscellaneous databases
BioGRID-ORCSi | 1000, 46 hits in 877 CRISPR screens |
ChiTaRSi | CDH2, human |
GeneWikii | CDH2 |
GenomeRNAii | 1000 |
Pharosi | P19022, Tbio |
PROi | PR:P19022 |
RNActi | P19022, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170558, Expressed in cardiac ventricle and 215 other tissues |
ExpressionAtlasi | P19022, baseline and differential |
Genevisiblei | P19022, HS |
Family and domain databases
Gene3Di | 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR000233, Cadherin_cytoplasmic-dom IPR014868, Cadherin_pro_dom IPR027397, Catenin-bd_sf IPR030051, CDH2 |
PANTHERi | PTHR24027, PTHR24027, 1 hit PTHR24027:SF79, PTHR24027:SF79, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF01049, Cadherin_C, 1 hit PF08758, Cadherin_pro, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 5 hits SM01055, Cadherin_pro, 1 hit |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 3 hits PS50268, CADHERIN_2, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CADH2_HUMAN | |
Accessioni | P19022Primary (citable) accession number: P19022 Secondary accession number(s): A8MWK3 Q8N173 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | October 17, 2006 | |
Last modified: | February 10, 2021 | |
This is version 202 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries