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Protein

Peptidyl-glycine alpha-amidating monooxygenase

Gene

PAM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by EDTA, phenylglyoxal and diethyl pyrocarbonate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi102Copper ABy similarity1
Metal bindingi103Copper ABy similarity1
Metal bindingi167Copper ABy similarity1
Metal bindingi237Copper BBy similarity1
Metal bindingi239Copper BBy similarity1
Metal bindingi309Copper BBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase, Monooxygenase, Multifunctional enzyme, Oxidoreductase
LigandCopper, Metal-binding, Vitamin C, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.14.17.3 2681
4.3.2.5 2681

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P19021

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P19021

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peptidyl-glycine alpha-amidating monooxygenase
Short name:
PAM
Including the following 2 domains:
Peptidylglycine alpha-hydroxylating monooxygenase (EC:1.14.17.3)
Short name:
PHM
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC:4.3.2.5)
Alternative name(s):
Peptidylamidoglycolate lyase
Short name:
PAL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PAM
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000145730.20

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8596 PAM

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
170270 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P19021

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini31 – 863IntragranularSequence analysisAdd BLAST833
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei864 – 887HelicalSequence analysisAdd BLAST24
Topological domaini888 – 973CytoplasmicSequence analysisAdd BLAST86

Keywords - Cellular componenti

Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5066

Open Targets

More...
OpenTargetsi
ENSG00000145730

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32926

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2544

Drug and drug target database

More...
DrugBanki
DB04150 Threonine Derivative
DB00126 Vitamin C

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PAM

Domain mapping of disease mutations (DMDM)

More...
DMDMi
23503036

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20CuratedAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000636121 – 30Curated10
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000636231 – 973Peptidyl-glycine alpha-amidating monooxygenaseAdd BLAST943

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi42 ↔ 181By similarity
Disulfide bondi76 ↔ 121By similarity
Disulfide bondi109 ↔ 126By similarity
Disulfide bondi222 ↔ 329By similarity
Disulfide bondi288 ↔ 310By similarity
Disulfide bondi631 ↔ 652By similarity
Disulfide bondi699 ↔ 710By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi762N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei918PhosphoserineCombined sources1
Modified residuei929PhosphoserineCombined sources1
Modified residuei942PhosphoserineCombined sources1
Modified residuei943Phosphothreonine1 Publication1
Modified residuei946Phosphoserine; by UHMK1; in vitroCombined sources1 Publication1
Modified residuei957PhosphoserineBy similarity1
Isoform 4 (identifier: P19021-4)
Modified residuei875Sulfotyrosine1 Publication1
Isoform 3 (identifier: P19021-3)
Modified residuei893Sulfotyrosine1 Publication1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P19021

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P19021

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P19021

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P19021

PeptideAtlas

More...
PeptideAtlasi
P19021

PRoteomics IDEntifications database

More...
PRIDEi
P19021

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53622
53623 [P19021-2]
53624 [P19021-3]
53625 [P19021-4]
53626 [P19021-5]
53627 [P19021-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P19021

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P19021

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000145730 Expressed in 239 organ(s), highest expression level in endometrium

CleanEx database of gene expression profiles

More...
CleanExi
HS_PAM

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P19021 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P19021 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB026119
HPA042260

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Interacts with RASSF9 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111101, 25 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P19021

Protein interaction database and analysis system

More...
IntActi
P19021, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000306100

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P19021

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P19021

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P19021

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati498 – 541NHL 1Add BLAST44
Repeati567 – 608NHL 2Add BLAST42
Repeati617 – 662NHL 3Add BLAST46
Repeati670 – 714NHL 4Add BLAST45
Repeati766 – 809NHL 5Add BLAST44

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 494Peptidylglycine alpha-hydroxylating monooxygenaseBy similarityAdd BLAST494
Regioni495 – 817Peptidyl-alpha-hydroxyglycine alpha-amidating lyaseBy similarityAdd BLAST323
Regioni925 – 942Interaction with RASSF9By similarityAdd BLAST18

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.Curated
In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3567 Eukaryota
ENOG410XS0X LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156369

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004218

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P19021

KEGG Orthology (KO)

More...
KOi
K00504
K18200

Identification of Orthologs from Complete Genome Data

More...
OMAi
SCHYKKY

Database of Orthologous Groups

More...
OrthoDBi
476471at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P19021

TreeFam database of animal gene trees

More...
TreeFami
TF320698

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 1 hit
2.60.120.230, 1 hit
2.60.120.310, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR014784 Cu2_ascorb_mOase-like_C
IPR020611 Cu2_ascorb_mOase_CS-1
IPR014783 Cu2_ascorb_mOase_CS-2
IPR000323 Cu2_ascorb_mOase_N
IPR036939 Cu2_ascorb_mOase_N_sf
IPR024548 Cu2_monoox_C
IPR001258 NHL_repeat
IPR013017 NHL_repeat_subgr
IPR000720 PHM/PAL
IPR008977 PHM/PNGase_F_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03712 Cu2_monoox_C, 1 hit
PF01082 Cu2_monooxygen, 1 hit
PF01436 NHL, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00790 PAMONOXGNASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49742 SSF49742, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00084 CU2_MONOOXYGENASE_1, 1 hit
PS00085 CU2_MONOOXYGENASE_2, 1 hit
PS51125 NHL, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 6 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P19021-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGRVPSLLV LLVFPSSCLA FRSPLSVFKR FKETTRPFSN ECLGTTRPVV
60 70 80 90 100
PIDSSDFALD IRMPGVTPKQ SDTYFCMSMR IPVDEEAFVI DFKPRASMDT
110 120 130 140 150
VHHMLLFGCN MPSSTGSYWF CDEGTCTDKA NILYAWARNA PPTRLPKGVG
160 170 180 190 200
FRVGGETGSK YFVLQVHYGD ISAFRDNNKD CSGVSLHLTR LPQPLIAGMY
210 220 230 240 250
LMMSVDTVIP AGEKVVNSDI SCHYKNYPMH VFAYRVHTHH LGKVVSGYRV
260 270 280 290 300
RNGQWTLIGR QSPQLPQAFY PVGHPVDVSF GDLLAARCVF TGEGRTEATH
310 320 330 340 350
IGGTSSDEMC NLYIMYYMEA KHAVSFMTCT QNVAPDMFRT IPPEANIPIP
360 370 380 390 400
VKSDMVMMHE HHKETEYKDK IPLLQQPKRE EEEVLDQGDF YSLLSKLLGE
410 420 430 440 450
REDVVHVHKY NPTEKAESES DLVAEIANVV QKKDLGRSDA REGAEHERGN
460 470 480 490 500
AILVRDRIHK FHRLVSTLRP PESRVFSLQQ PPPGEGTWEP EHTGDFHMEE
510 520 530 540 550
ALDWPGVYLL PGQVSGVALD PKNNLVIFHR GDHVWDGNSF DSKFVYQQIG
560 570 580 590 600
LGPIEEDTIL VIDPNNAAVL QSSGKNLFYL PHGLSIDKDG NYWVTDVALH
610 620 630 640 650
QVFKLDPNNK EGPVLILGRS MQPGSDQNHF CQPTDVAVDP GTGAIYVSDG
660 670 680 690 700
YCNSRIVQFS PSGKFITQWG EESSGSSPLP GQFTVPHSLA LVPLLGQLCV
710 720 730 740 750
ADRENGRIQC FKTDTKEFVR EIKHSSFGRN VFAISYIPGL LFAVNGKPHF
760 770 780 790 800
GDQEPVQGFV MNFSNGEIID IFKPVRKHFD MPHDIVASED GTVYIGDAHT
810 820 830 840 850
NTVWKFTLTE KLEHRSVKKA GIEVQEIKEA EAVVETKMEN KPTSSELQKM
860 870 880 890 900
QEKQKLIKEP GSGVPVVLIT TLLVIPVVVL LAIAIFIRWK KSRAFGDSEH
910 920 930 940 950
KLETSSGRVL GRFRGKGSGG LNLGNFFASR KGYSRKGFDR LSTEGSDQEK
960 970
EDDGSESEEE YSAPLPALAP SSS
Length:973
Mass (Da):108,332
Last modified:September 19, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A089B657F56EE39
GO
Isoform 2 (identifier: P19021-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     388-494: Missing.

Show »
Length:866
Mass (Da):96,258
Checksum:i41F0822F95AC3B0E
GO
Isoform 3 (identifier: P19021-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     829-896: Missing.

Note: Soluble.1 Publication
Show »
Length:905
Mass (Da):100,818
Checksum:i5A5EAAC529E267AE
GO
Isoform 4 (identifier: P19021-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     829-914: Missing.

Note: Soluble.1 Publication
Show »
Length:887
Mass (Da):98,762
Checksum:i5F3E355C256FF35C
GO
Isoform 5 (identifier: P19021-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     896-896: G → GA

Show »
Length:974
Mass (Da):108,403
Checksum:iF6D51C73F6E264A3
GO
Isoform 6 (identifier: P19021-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     897-914: Missing.

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Length:955
Mass (Da):106,276
Checksum:iEE05609B9A7F1772
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BYD9H7BYD9_HUMAN
Peptidyl-glycine alpha-amidating mo...
PAM
679Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9I4H0Y9I4_HUMAN
Peptidyl-glycine alpha-amidating mo...
PAM
250Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RG20D6RG20_HUMAN
Peptidyl-glycine alpha-amidating mo...
PAM
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W8D9F8W8D9_HUMAN
Peptidyl-glycine alpha-amidating mo...
PAM
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAQ2D6RAQ2_HUMAN
Peptidyl-glycine alpha-amidating mo...
PAM
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RCD5D6RCD5_HUMAN
Peptidyl-glycine alpha-amidating mo...
PAM
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RDU2D6RDU2_HUMAN
Peptidyl-glycine alpha-amidating mo...
PAM
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RF09D6RF09_HUMAN
Peptidyl-glycine alpha-amidating mo...
PAM
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R961D6R961_HUMAN
Peptidyl-glycine alpha-amidating mo...
PAM
28Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD01439 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti26S → P in BAF82847 (PubMed:14702039).Curated1
Sequence conflicti574G → E in AAA36414 (PubMed:2357221).Curated1
Sequence conflicti774P → L in BAF82847 (PubMed:14702039).Curated1
Sequence conflicti830 – 831Missing in AAB32775 (PubMed:7999037).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05569449V → L. Corresponds to variant dbSNP:rs2230458Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001227388 – 494Missing in isoform 2. 2 PublicationsAdd BLAST107
Alternative sequenceiVSP_001229829 – 914Missing in isoform 4. 1 PublicationAdd BLAST86
Alternative sequenceiVSP_001228829 – 896Missing in isoform 3. 1 PublicationAdd BLAST68
Alternative sequenceiVSP_038691896G → GA in isoform 5. 1 Publication1
Alternative sequenceiVSP_042209897 – 914Missing in isoform 6. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M37721 mRNA Translation: AAA36414.1
S75037 mRNA Translation: AAB32775.1
S75038 mRNA Translation: AAB32776.1
AB095007 mRNA Translation: BAC22594.1
AK290158 mRNA Translation: BAF82847.1
BT007419 mRNA Translation: AAP36087.1
AC008779 Genomic DNA No translation available.
AC010250 Genomic DNA No translation available.
AC113373 Genomic DNA No translation available.
CH471086 Genomic DNA Translation: EAW49085.1
BC018127 mRNA Translation: AAH18127.1
AF010472 mRNA Translation: AAD01439.1 Different initiation.
AF035320 mRNA Translation: AAB88190.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4092.1 [P19021-3]
CCDS4093.1 [P19021-2]
CCDS4094.1 [P19021-4]
CCDS43348.1 [P19021-5]
CCDS54885.1 [P19021-1]

Protein sequence database of the Protein Information Resource

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PIRi
A35477 URHUAP

NCBI Reference Sequences

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RefSeqi
NP_000910.2, NM_000919.3 [P19021-5]
NP_001170777.1, NM_001177306.1 [P19021-1]
NP_001306872.1, NM_001319943.1
NP_620121.1, NM_138766.2 [P19021-3]
NP_620176.1, NM_138821.2 [P19021-2]
NP_620177.1, NM_138822.2 [P19021-4]
XP_016864986.1, XM_017009497.1 [P19021-5]
XP_016864990.1, XM_017009501.1
XP_016864994.1, XM_017009505.1 [P19021-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.369430

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000304400; ENSP00000306100; ENSG00000145730 [P19021-5]
ENST00000346918; ENSP00000282992; ENSG00000145730 [P19021-4]
ENST00000348126; ENSP00000314638; ENSG00000145730 [P19021-2]
ENST00000438793; ENSP00000396493; ENSG00000145730 [P19021-1]
ENST00000455264; ENSP00000403461; ENSG00000145730 [P19021-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5066

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5066

UCSC genome browser

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UCSCi
uc003kns.4 human [P19021-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37721 mRNA Translation: AAA36414.1
S75037 mRNA Translation: AAB32775.1
S75038 mRNA Translation: AAB32776.1
AB095007 mRNA Translation: BAC22594.1
AK290158 mRNA Translation: BAF82847.1
BT007419 mRNA Translation: AAP36087.1
AC008779 Genomic DNA No translation available.
AC010250 Genomic DNA No translation available.
AC113373 Genomic DNA No translation available.
CH471086 Genomic DNA Translation: EAW49085.1
BC018127 mRNA Translation: AAH18127.1
AF010472 mRNA Translation: AAD01439.1 Different initiation.
AF035320 mRNA Translation: AAB88190.1
CCDSiCCDS4092.1 [P19021-3]
CCDS4093.1 [P19021-2]
CCDS4094.1 [P19021-4]
CCDS43348.1 [P19021-5]
CCDS54885.1 [P19021-1]
PIRiA35477 URHUAP
RefSeqiNP_000910.2, NM_000919.3 [P19021-5]
NP_001170777.1, NM_001177306.1 [P19021-1]
NP_001306872.1, NM_001319943.1
NP_620121.1, NM_138766.2 [P19021-3]
NP_620176.1, NM_138821.2 [P19021-2]
NP_620177.1, NM_138822.2 [P19021-4]
XP_016864986.1, XM_017009497.1 [P19021-5]
XP_016864990.1, XM_017009501.1
XP_016864994.1, XM_017009505.1 [P19021-3]
UniGeneiHs.369430

3D structure databases

ProteinModelPortaliP19021
SMRiP19021
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111101, 25 interactors
CORUMiP19021
IntActiP19021, 2 interactors
STRINGi9606.ENSP00000306100

Chemistry databases

BindingDBiP19021
ChEMBLiCHEMBL2544
DrugBankiDB04150 Threonine Derivative
DB00126 Vitamin C

PTM databases

iPTMnetiP19021
PhosphoSitePlusiP19021

Polymorphism and mutation databases

BioMutaiPAM
DMDMi23503036

Proteomic databases

EPDiP19021
jPOSTiP19021
MaxQBiP19021
PaxDbiP19021
PeptideAtlasiP19021
PRIDEiP19021
ProteomicsDBi53622
53623 [P19021-2]
53624 [P19021-3]
53625 [P19021-4]
53626 [P19021-5]
53627 [P19021-6]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5066
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304400; ENSP00000306100; ENSG00000145730 [P19021-5]
ENST00000346918; ENSP00000282992; ENSG00000145730 [P19021-4]
ENST00000348126; ENSP00000314638; ENSG00000145730 [P19021-2]
ENST00000438793; ENSP00000396493; ENSG00000145730 [P19021-1]
ENST00000455264; ENSP00000403461; ENSG00000145730 [P19021-3]
GeneIDi5066
KEGGihsa:5066
UCSCiuc003kns.4 human [P19021-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5066
DisGeNETi5066
EuPathDBiHostDB:ENSG00000145730.20

GeneCards: human genes, protein and diseases

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GeneCardsi
PAM
HGNCiHGNC:8596 PAM
HPAiCAB026119
HPA042260
MIMi170270 gene
neXtProtiNX_P19021
OpenTargetsiENSG00000145730
PharmGKBiPA32926

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3567 Eukaryota
ENOG410XS0X LUCA
GeneTreeiENSGT00940000156369
HOVERGENiHBG004218
InParanoidiP19021
KOiK00504
K18200
OMAiSCHYKKY
OrthoDBi476471at2759
PhylomeDBiP19021
TreeFamiTF320698

Enzyme and pathway databases

BRENDAi1.14.17.3 2681
4.3.2.5 2681
SignaLinkiP19021
SIGNORiP19021

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PAM human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Peptidylglycine_alpha-amidating_monooxygenase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5066

Protein Ontology

More...
PROi
PR:P19021

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000145730 Expressed in 239 organ(s), highest expression level in endometrium
CleanExiHS_PAM
ExpressionAtlasiP19021 baseline and differential
GenevisibleiP19021 HS

Family and domain databases

Gene3Di2.120.10.30, 1 hit
2.60.120.230, 1 hit
2.60.120.310, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR014784 Cu2_ascorb_mOase-like_C
IPR020611 Cu2_ascorb_mOase_CS-1
IPR014783 Cu2_ascorb_mOase_CS-2
IPR000323 Cu2_ascorb_mOase_N
IPR036939 Cu2_ascorb_mOase_N_sf
IPR024548 Cu2_monoox_C
IPR001258 NHL_repeat
IPR013017 NHL_repeat_subgr
IPR000720 PHM/PAL
IPR008977 PHM/PNGase_F_dom_sf
PfamiView protein in Pfam
PF03712 Cu2_monoox_C, 1 hit
PF01082 Cu2_monooxygen, 1 hit
PF01436 NHL, 3 hits
PRINTSiPR00790 PAMONOXGNASE
SUPFAMiSSF49742 SSF49742, 2 hits
PROSITEiView protein in PROSITE
PS00084 CU2_MONOOXYGENASE_1, 1 hit
PS00085 CU2_MONOOXYGENASE_2, 1 hit
PS51125 NHL, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAMD_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P19021
Secondary accession number(s): A6NMR0
, A8K293, O43211, O95080, Q16252, Q16253, Q54A45, Q86U53, Q8WVC7, Q9UCG0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: September 19, 2002
Last modified: January 16, 2019
This is version 209 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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