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Protein

D(3) dopamine receptor

Gene

Drd3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei110AgonistBy similarity1

GO - Molecular functioni

  • adrenergic receptor activity Source: GO_Central
  • D1 dopamine receptor binding Source: RGD
  • dopamine binding Source: RGD
  • dopamine neurotransmitter receptor activity Source: RGD
  • dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: BHF-UCL
  • drug binding Source: BHF-UCL
  • protein domain specific binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-390651 Dopamine receptors
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
D(3) dopamine receptor
Alternative name(s):
Dopamine D3 receptor
Gene namesi
Name:Drd3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi2521 Drd3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 55Helical; Name=1By similarityAdd BLAST23
Transmembranei66 – 88Helical; Name=2By similarityAdd BLAST23
Transmembranei105 – 126Helical; Name=3By similarityAdd BLAST22
Transmembranei150 – 170Helical; Name=4By similarityAdd BLAST21
Transmembranei188 – 209Helical; Name=5By similarityAdd BLAST22
Transmembranei376 – 397Helical; Name=6By similarityAdd BLAST22
Transmembranei413 – 432Helical; Name=7By similarityAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3138
GuidetoPHARMACOLOGYi216

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694001 – 446D(3) dopamine receptorAdd BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi12N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi103 ↔ 181PROSITE-ProRule annotation
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi401 ↔ 404PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated by GRK4.By similarity
Palmitoylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP19020
PRIDEiP19020

PTM databases

iPTMnetiP19020
PhosphoSitePlusiP19020

Expressioni

Tissue specificityi

Mainly in limbic areas of brain.

Gene expression databases

BgeeiENSRNOG00000060806 Expressed in 2 organ(s), highest expression level in Ammon's horn
GenevisibleiP19020 RN

Interactioni

Subunit structurei

Interacts with CLIC6 (PubMed:14499480). Interacts with GRK4. Interacts with PALM. Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031550

Chemistry databases

BindingDBiP19020

Structurei

3D structure databases

ProteinModelPortaliP19020
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni189 – 196Agonist bindingBy similarity8
Regioni388 – 396Agonist bindingBy similarity9

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139331
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP19020
KOiK04146
OMAiFPQQSSC
OrthoDBiEOG091G06VI
PhylomeDBiP19020
TreeFamiTF334382

Family and domain databases

CDDicd15310 7tmA_D3_dopamine_R, 1 hit
InterProiView protein in InterPro
IPR001620 Dopamine_D3_rcpt
IPR000929 Dopamine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00568 DOPAMINED3R
PR00242 DOPAMINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P19020-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPLSQISTH LNSTCGAENS TGVNRARPHA YYALSYCALI LAIIFGNGLV
60 70 80 90 100
CAAVLRERAL QTTTNYLVVS LAVADLLVAT LVMPWVVYLE VTGGVWNFSR
110 120 130 140 150
ICCDVFVTLD VMMCTASILN LCAISIDRYT AVVMPVHYQH GTGQSSCRRV
160 170 180 190 200
ALMITAVWVL AFAVSCPLLF GFNTTGDPSI CSISNPDFVI YSSVVSFYVP
210 220 230 240 250
FGVTVLVYAR IYIVLRQRQR KRILTRQNSQ CISIRPGFPQ QSSCLRLHPI
260 270 280 290 300
RQFSIRARFL SDATGQMEHI EDKQYPQKCQ DPLLSHLQPP SPGQTHGGLK
310 320 330 340 350
RYYSICQDTA LRHPSLEGGA GMSPVERTRN SLSPTMAPKL SLEVRKLSNG
360 370 380 390 400
RLSTSLRLGP LQPRGVPLRE KKATQMVVIV LGAFIVCWLP FFLTHVLNTH
410 420 430 440
CQACHVSPEL YRATTWLGYV NSALNPVIYT TFNVEFRKAF LKILSC
Length:446
Mass (Da):49,516
Last modified:November 1, 1990 - v1
Checksum:i180E36AFF217E9DB
GO
Isoform D3(TM3-del) (identifier: P19020-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     92-100: TGGVWNFSR → HSGGHASSL
     101-446: Missing.

Show »
Length:100
Mass (Da):10,602
Checksum:i3FB0359132B0FE91
GO
Isoform D3(O2-DEL) (identifier: P19020-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     176-193: Missing.

Show »
Length:428
Mass (Da):47,633
Checksum:i0C0BCDE0150177DD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71L → M (PubMed:8333859).Curated1
Sequence conflicti139Q → E in AAA41076 (PubMed:2039532).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00187492 – 100TGGVWNFSR → HSGGHASSL in isoform D3(TM3-del). Curated9
Alternative sequenceiVSP_001875101 – 446Missing in isoform D3(TM3-del). CuratedAdd BLAST346
Alternative sequenceiVSP_001876176 – 193Missing in isoform D3(O2-DEL). CuratedAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53944 mRNA Translation: CAA37887.1
M69194
, M69189, M69190, M69191, M69192, M69193 Genomic DNA Translation: AAA41076.1 Sequence problems.
S63847, S63846 Genomic DNA Translation: AAB27545.1
PIRiS11565 DYRTD3
RefSeqiNP_058836.1, NM_017140.2 [P19020-1]
UniGeneiRn.10356

Genome annotation databases

EnsembliENSRNOT00000089057; ENSRNOP00000073117; ENSRNOG00000060806 [P19020-1]
GeneIDi29238
KEGGirno:29238
UCSCiRGD:2521 rat [P19020-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53944 mRNA Translation: CAA37887.1
M69194
, M69189, M69190, M69191, M69192, M69193 Genomic DNA Translation: AAA41076.1 Sequence problems.
S63847, S63846 Genomic DNA Translation: AAB27545.1
PIRiS11565 DYRTD3
RefSeqiNP_058836.1, NM_017140.2 [P19020-1]
UniGeneiRn.10356

3D structure databases

ProteinModelPortaliP19020
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031550

Chemistry databases

BindingDBiP19020
ChEMBLiCHEMBL3138
GuidetoPHARMACOLOGYi216

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP19020
PhosphoSitePlusiP19020

Proteomic databases

PaxDbiP19020
PRIDEiP19020

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000089057; ENSRNOP00000073117; ENSRNOG00000060806 [P19020-1]
GeneIDi29238
KEGGirno:29238
UCSCiRGD:2521 rat [P19020-1]

Organism-specific databases

CTDi1814
RGDi2521 Drd3

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00890000139331
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP19020
KOiK04146
OMAiFPQQSSC
OrthoDBiEOG091G06VI
PhylomeDBiP19020
TreeFamiTF334382

Enzyme and pathway databases

ReactomeiR-RNO-390651 Dopamine receptors
R-RNO-418594 G alpha (i) signalling events

Miscellaneous databases

PROiPR:P19020

Gene expression databases

BgeeiENSRNOG00000060806 Expressed in 2 organ(s), highest expression level in Ammon's horn
GenevisibleiP19020 RN

Family and domain databases

CDDicd15310 7tmA_D3_dopamine_R, 1 hit
InterProiView protein in InterPro
IPR001620 Dopamine_D3_rcpt
IPR000929 Dopamine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00568 DOPAMINED3R
PR00242 DOPAMINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDRD3_RAT
AccessioniPrimary (citable) accession number: P19020
Secondary accession number(s): P70647
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 7, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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