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Entry version 184 (17 Jun 2020)
Sequence version 3 (02 Nov 2010)
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Protein

Keratin, type I cytoskeletal 15

Gene

KRT15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • scaffold protein binding Source: BHF-UCL
  • structural constituent of cytoskeleton Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

SIGNOR Signaling Network Open Resource

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SIGNORi
P19012

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin, type I cytoskeletal 15
Alternative name(s):
Cytokeratin-15
Short name:
CK-15
Keratin-15
Short name:
K15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRT15
Synonyms:KRTB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000171346.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6421 KRT15

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
148030 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P19012

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Intermediate filament, Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3866

Open Targets

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OpenTargetsi
ENSG00000171346

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30208

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P19012 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRT15

Domain mapping of disease mutations (DMDM)

More...
DMDMi
311033438

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000636571 – 456Keratin, type I cytoskeletal 15Add BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei17PhosphoserineBy similarity1
Modified residuei34PhosphoserineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei48PhosphoserineBy similarity1
Modified residuei56PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki300Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei301PhosphothreonineBy similarity1
Modified residuei323PhosphothreonineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P19012

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P19012

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P19012

PeptideAtlas

More...
PeptideAtlasi
P19012

PRoteomics IDEntifications database

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PRIDEi
P19012

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
3590
53620 [P19012-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P19012

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P19012

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P19012

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level). Expressed homogeneously in all cell layers of the esophagus and exocervix, but detected in the basal cell layer only of oral mucosa, skin and in the basal plus the next two layers of the suprabasal epithelium of the palate.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171346 Expressed in esophagus mucosa and 135 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P19012 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P19012 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000171346 Group enriched (breast, esophagus, skin, vagina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer of two type I and two type II keratins.

Interacts with NOD2 (PubMed:27812135).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P19012
With#Exp.IntAct
ABI2 [Q9NYB9]6EBI-739566,EBI-743598
ABI2 - isoform 2 [Q9NYB9-2]3EBI-739566,EBI-11096309
AMOT [A2BDD9]3EBI-739566,EBI-17286414
AMOT - isoform 2 [Q4VCS5-2]3EBI-739566,EBI-3891843
AMOTL2 - isoform 4 [Q9Y2J4-4]3EBI-739566,EBI-10187270
ANKRD36BP1 [Q96IX9]4EBI-739566,EBI-744859
ARFIP2 [P53365]6EBI-739566,EBI-638194
ATP5PO [P48047]3EBI-739566,EBI-355815
BEX2 [Q9BXY8]3EBI-739566,EBI-745073
C1orf216 [Q8TAB5]4EBI-739566,EBI-747505
C2CD6 [Q53TS8]3EBI-739566,EBI-739879
CARD9 - isoform 2 [Q9H257-2]3EBI-739566,EBI-11530605
CCDC87 [Q9NVE4]3EBI-739566,EBI-749261
CCHCR1 - isoform 3 [Q8TD31-3]6EBI-739566,EBI-10175300
CCNB1IP1 [Q9NPC3]4EBI-739566,EBI-745269
CCNC [P24863]3EBI-739566,EBI-395261
CDK18 [Q07002]3EBI-739566,EBI-746238
CEP57 [Q86XR8]3EBI-739566,EBI-308614
COX5B [P10606]3EBI-739566,EBI-1053725
CREB5 - isoform 3 [Q02930-3]3EBI-739566,EBI-10192698
CYTH4 [Q8WWE8]3EBI-739566,EBI-10277443
DES [P17661]3EBI-739566,EBI-1055572
DEUP1 [Q05D60]6EBI-739566,EBI-748597
DTNB - isoform 5 [O60941-5]3EBI-739566,EBI-11984733
EFHC1 [Q5JVL4]3EBI-739566,EBI-743105
ENKD1 [Q9H0I2]3EBI-739566,EBI-744099
EPC1 [Q9H2F5]3EBI-739566,EBI-769270
FAM110A [Q9BQ89]6EBI-739566,EBI-1752811
GAS8 [O95995]3EBI-739566,EBI-1052570
GFAP [P14136]9EBI-739566,EBI-744302
GLYCTK [Q8IVS8]3EBI-739566,EBI-748515
HAPLN2 [Q9GZV7]3EBI-739566,EBI-11956675
HAUS1 [Q96CS2]3EBI-739566,EBI-2514791
HGS [O14964]6EBI-739566,EBI-740220
HMG20B [Q9P0W2]3EBI-739566,EBI-713401
IKBIP [Q70UQ0]3EBI-739566,EBI-2557212
KANSL1 [Q7Z3B3]5EBI-739566,EBI-740244
KDM1A [O60341]3EBI-739566,EBI-710124
KIAA1217 - isoform 6 [Q5T5P2-6]3EBI-739566,EBI-10188326
KIFC3 [Q9BVG8]3EBI-739566,EBI-2125614
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-739566,EBI-14069005
KLC3 [Q6P597]3EBI-739566,EBI-1643885
KLC4 [Q9NSK0]3EBI-739566,EBI-949319
KRT1 [P04264]7EBI-739566,EBI-298429
KRT2 [P35908]7EBI-739566,EBI-1247312
KRT20 [P35900]5EBI-739566,EBI-742094
KRT4 [P19013]6EBI-739566,EBI-2371606
KRT5 [P13647]6EBI-739566,EBI-702187
KRT6A [P02538]15EBI-739566,EBI-702198
KRT6B [P04259]7EBI-739566,EBI-740907
KRT6C [P48668]3EBI-739566,EBI-2564105
KRT71 [Q3SY84]6EBI-739566,EBI-2952676
KRT72 [Q14CN4]3EBI-739566,EBI-1221280
KRT73 [Q86Y46]3EBI-739566,EBI-2830994
KRT73 - isoform 2 [Q86Y46-2]3EBI-739566,EBI-12039441
KRT74 [Q7RTS7]3EBI-739566,EBI-968660
KRT75 [O95678]3EBI-739566,EBI-2949715
KRT77 [Q0IIN1]3EBI-739566,EBI-2511085
KRT77 [Q7Z794]3EBI-739566,EBI-3045529
KRT78 [Q8N1N4]3EBI-739566,EBI-1056564
KRT79 [Q5XKE5]7EBI-739566,EBI-2514135
KRT8 [P05787]6EBI-739566,EBI-297852
KRT80 [Q6KB66]3EBI-739566,EBI-3046635
KRT80 - isoform 2 [Q6KB66-2]3EBI-739566,EBI-11999246
KRT81 [Q14533]4EBI-739566,EBI-739648
KRT82 [Q9NSB4]3EBI-739566,EBI-1045341
KRT83 [P78385]3EBI-739566,EBI-10221390
KRT85 [P78386]3EBI-739566,EBI-1049371
KRT86 [O43790]7EBI-739566,EBI-9996498
LMO2 [P25791]3EBI-739566,EBI-739696
LMO4 [P61968]6EBI-739566,EBI-2798728
LNX1 [Q8TBB1]5EBI-739566,EBI-739832
MBD3 [O95983]3EBI-739566,EBI-1783068
MGC50722 [Q8IVT4]3EBI-739566,EBI-14086479
MORN3 [Q6PF18]3EBI-739566,EBI-9675802
MOS [P00540]6EBI-739566,EBI-1757866
NEFL [I6L9F6]3EBI-739566,EBI-10178578
NEFL [P07196]3EBI-739566,EBI-475646
NOC4L [Q9BVI4]4EBI-739566,EBI-395927
NUP54 [Q7Z3B4]4EBI-739566,EBI-741048
OIP5 [O43482]4EBI-739566,EBI-536879
PIK3R2 [O00459]3EBI-739566,EBI-346930
PKN1 [Q16512]3EBI-739566,EBI-602382
PPP1R18 [Q6NYC8]6EBI-739566,EBI-2557469
PRPF31 [Q8WWY3]9EBI-739566,EBI-1567797
PSMA1 [P25786]4EBI-739566,EBI-359352
PSMB1 [P20618]7EBI-739566,EBI-372273
RAD51D [O75771]7EBI-739566,EBI-1055693
RAMAC [Q9BTL3]3EBI-739566,EBI-744023
RCOR3 [Q9P2K3]5EBI-739566,EBI-743428
RCOR3 - isoform 2 [Q9P2K3-2]3EBI-739566,EBI-1504830
RIBC1 [Q8N443]3EBI-739566,EBI-10265323
RNF6 [A0A0S2Z4G9]3EBI-739566,EBI-16428950
RPP25 [Q9BUL9]3EBI-739566,EBI-366570
RSPH14 [Q9UHP6]3EBI-739566,EBI-748350
SGF29 [Q96ES7]7EBI-739566,EBI-743117
SMARCD1 [Q96GM5]4EBI-739566,EBI-358489
SMARCE1 [Q969G3]3EBI-739566,EBI-455078
SNAPIN [O95295]3EBI-739566,EBI-296723
SPG21 [Q9NZD8]3EBI-739566,EBI-742688
SSX2IP [Q9Y2D8]3EBI-739566,EBI-2212028
TBC1D21 [Q8IYX1]3EBI-739566,EBI-12018146
TCHP [Q9BT92]5EBI-739566,EBI-740781
TIMM8A [O60220]3EBI-739566,EBI-1049822
TLE5 [Q08117]3EBI-739566,EBI-717810
TMSB4X [Q0P5Q0]3EBI-739566,EBI-10226570
TRIM42 [Q8IWZ5]3EBI-739566,EBI-5235829
TRIML2 [Q8N7C3]3EBI-739566,EBI-11059915
TTC23 - isoform 3 [Q5W5X9-3]3EBI-739566,EBI-9090990
TXLNA [P40222]6EBI-739566,EBI-359793
TXLNB [Q8N3L3]6EBI-739566,EBI-6116822
USP2 [O75604]5EBI-739566,EBI-743272
WAC [Q9BTA9]4EBI-739566,EBI-749118
WAC - isoform 2 [Q9BTA9-2]3EBI-739566,EBI-10298216
ZC2HC1C [Q53FD0]4EBI-739566,EBI-740767
ZC2HC1C - isoform 2 [Q53FD0-2]3EBI-739566,EBI-14104088
ZFYVE26 - isoform 5 [Q68DK2-5]3EBI-739566,EBI-8656416
ZGPAT [Q8N5A5]3EBI-739566,EBI-3439227
ZGPAT - isoform 2 [Q8N5A5-2]3EBI-739566,EBI-10183064
ZNF417 [Q8TAU3]3EBI-739566,EBI-740727
ZNF576 [Q9H609]3EBI-739566,EBI-3921014
ZNF688 [A0A0S2Z5X4]3EBI-739566,EBI-16429014
tax [P14079] from Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A).3EBI-739566,EBI-9675698

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
110064, 149 interactors

Protein interaction database and analysis system

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IntActi
P19012, 155 interactors

Molecular INTeraction database

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MINTi
P19012

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000254043

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P19012 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P19012

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini105 – 417IF rodPROSITE-ProRule annotationAdd BLAST313

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 104HeadAdd BLAST104
Regioni105 – 140Coil 1AAdd BLAST36
Regioni141 – 159Linker 1Add BLAST19
Regioni160 – 251Coil 1BAdd BLAST92
Regioni252 – 271Linker 12Add BLAST20
Regioni272 – 413Coil 2Add BLAST142
Regioni414 – 456TailAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi14 – 103Gly-richAdd BLAST90
Compositional biasi428 – 431Poly-Gly4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFTF Eukaryota
ENOG410Y9IV LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154403

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012560_8_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P19012

KEGG Orthology (KO)

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KOi
K07604

Identification of Orthologs from Complete Genome Data

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OMAi
IRCDMER

Database of Orthologous Groups

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OrthoDBi
798081at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P19012

TreeFam database of animal gene trees

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TreeFami
TF332742

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.5.1160, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR042180 IF_rod_dom_coil1B
IPR002957 Keratin_I

The PANTHER Classification System

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PANTHERi
PTHR23239 PTHR23239, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00038 Filament, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01248 TYPE1KERATIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01391 Filament, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P19012-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTTFLQTSS STFGGGSTRG GSLLAGGGGF GGGSLSGGGG SRSISASSAR
60 70 80 90 100
FVSSGSGGGY GGGMRVCGFG GGAGSVFGGG FGGGVGGGFG GGFGGGDGGL
110 120 130 140 150
LSGNEKITMQ NLNDRLASYL DKVRALEEAN ADLEVKIHDW YQKQTPTSPE
160 170 180 190 200
CDYSQYFKTI EELRDKIMAT TIDNSRVILE IDNARLAADD FRLKYENELA
210 220 230 240 250
LRQGVEADIN GLRRVLDELT LARTDLEMQI EGLNEELAYL KKNHEEEMKE
260 270 280 290 300
FSSQLAGQVN VEMDAAPGVD LTRVLAEMRE QYEAMAEKNR RDVEAWFFSK
310 320 330 340 350
TEELNKEVAS NTEMIQTSKT EITDLRRTMQ ELEIELQSQL SMKAGLENSL
360 370 380 390 400
AETECRYATQ LQQIQGLIGG LEAQLSELRC EMEAQNQEYK MLLDIKTRLE
410 420 430 440 450
QEIATYRSLL EGQDAKMAGI AIREASSGGG GSSSNFHINV EESVDGQVVS

SHKREI
Length:456
Mass (Da):49,212
Last modified:November 2, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i812C1343905EBE41
GO
Isoform 2 (identifier: P19012-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-29: TTFLQTSSSTFGGGSTRGGSLLAGGGG → GTRSRPQPAQNATTANTSRPLKSSGTR
     30-194: Missing.
     417-456: Missing.

Show »
Length:251
Mass (Da):28,602
Checksum:i0EED60B048471B9B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JTG5C9JTG5_HUMAN
Keratin, type I cytoskeletal 15
KRT15
220Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MT21A8MT21_HUMAN
Keratin, type I cytoskeletal 15
KRT15
291Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMX0K7EMX0_HUMAN
Keratin, type I cytoskeletal 15
KRT15
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQK9K7EQK9_HUMAN
Keratin, type I cytoskeletal 15
KRT15
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047429147T → A2 PublicationsCorresponds to variant dbSNP:rs1050784Ensembl.1
Natural variantiVAR_047430416K → R1 PublicationCorresponds to variant dbSNP:rs2305556Ensembl.1
Natural variantiVAR_047431421A → G5 PublicationsCorresponds to variant dbSNP:rs897420Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0565073 – 29TTFLQ…AGGGG → GTRSRPQPAQNATTANTSRP LKSSGTR in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_05650830 – 194Missing in isoform 2. 1 PublicationAdd BLAST165
Alternative sequenceiVSP_056509417 – 456Missing in isoform 2. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X07696 mRNA Translation: CAA30535.1
AF202320 Genomic DNA Translation: AAF27047.1
BT007261 mRNA Translation: AAP35925.1
AK090604 mRNA Translation: BAG52193.1
AK091239 mRNA Translation: BAG52314.1
AC019349 Genomic DNA No translation available.
BC002641 mRNA Translation: AAH02641.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11398.1 [P19012-1]

Protein sequence database of the Protein Information Resource

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PIRi
S01069 KRHU5

NCBI Reference Sequences

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RefSeqi
NP_002266.2, NM_002275.3 [P19012-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000254043; ENSP00000254043; ENSG00000171346 [P19012-1]
ENST00000393976; ENSP00000377546; ENSG00000171346 [P19012-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3866

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3866

UCSC genome browser

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UCSCi
uc002hwy.4 human [P19012-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07696 mRNA Translation: CAA30535.1
AF202320 Genomic DNA Translation: AAF27047.1
BT007261 mRNA Translation: AAP35925.1
AK090604 mRNA Translation: BAG52193.1
AK091239 mRNA Translation: BAG52314.1
AC019349 Genomic DNA No translation available.
BC002641 mRNA Translation: AAH02641.1
CCDSiCCDS11398.1 [P19012-1]
PIRiS01069 KRHU5
RefSeqiNP_002266.2, NM_002275.3 [P19012-1]

3D structure databases

SMRiP19012
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi110064, 149 interactors
IntActiP19012, 155 interactors
MINTiP19012
STRINGi9606.ENSP00000254043

PTM databases

iPTMnetiP19012
PhosphoSitePlusiP19012
SwissPalmiP19012

Polymorphism and mutation databases

BioMutaiKRT15
DMDMi311033438

Proteomic databases

jPOSTiP19012
MassIVEiP19012
PaxDbiP19012
PeptideAtlasiP19012
PRIDEiP19012
ProteomicsDBi3590
53620 [P19012-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
3601 861 antibodies

The DNASU plasmid repository

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DNASUi
3866

Genome annotation databases

EnsembliENST00000254043; ENSP00000254043; ENSG00000171346 [P19012-1]
ENST00000393976; ENSP00000377546; ENSG00000171346 [P19012-1]
GeneIDi3866
KEGGihsa:3866
UCSCiuc002hwy.4 human [P19012-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3866
DisGeNETi3866
EuPathDBiHostDB:ENSG00000171346.13

GeneCards: human genes, protein and diseases

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GeneCardsi
KRT15
HGNCiHGNC:6421 KRT15
HPAiENSG00000171346 Group enriched (breast, esophagus, skin, vagina)
MIMi148030 gene
neXtProtiNX_P19012
OpenTargetsiENSG00000171346
PharmGKBiPA30208

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFTF Eukaryota
ENOG410Y9IV LUCA
GeneTreeiENSGT00940000154403
HOGENOMiCLU_012560_8_1_1
InParanoidiP19012
KOiK07604
OMAiIRCDMER
OrthoDBi798081at2759
PhylomeDBiP19012
TreeFamiTF332742

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope
SIGNORiP19012

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
3866 3 hits in 787 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KRT15 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Keratin_15

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3866
PharosiP19012 Tbio

Protein Ontology

More...
PROi
PR:P19012
RNActiP19012 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000171346 Expressed in esophagus mucosa and 135 other tissues
ExpressionAtlasiP19012 baseline and differential
GenevisibleiP19012 HS

Family and domain databases

Gene3Di1.20.5.1160, 1 hit
InterProiView protein in InterPro
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR042180 IF_rod_dom_coil1B
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK1C15_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P19012
Secondary accession number(s): B3KQY1
, B3KRA2, E0CX14, Q53XV8, Q9BUG4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 2, 2010
Last modified: June 17, 2020
This is version 184 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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