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Entry version 180 (16 Oct 2019)
Sequence version 3 (02 Nov 2010)
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Protein

Keratin, type I cytoskeletal 15

Gene

KRT15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • scaffold protein binding Source: BHF-UCL
  • structural constituent of cytoskeleton Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

SIGNOR Signaling Network Open Resource

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SIGNORi
P19012

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin, type I cytoskeletal 15
Alternative name(s):
Cytokeratin-15
Short name:
CK-15
Keratin-15
Short name:
K15
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRT15
Synonyms:KRTB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:6421 KRT15

Online Mendelian Inheritance in Man (OMIM)

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MIMi
148030 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P19012

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Intermediate filament, Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3866

Open Targets

More...
OpenTargetsi
ENSG00000171346

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA30208

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P19012

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRT15

Domain mapping of disease mutations (DMDM)

More...
DMDMi
311033438

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000636571 – 456Keratin, type I cytoskeletal 15Add BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei17PhosphoserineBy similarity1
Modified residuei34PhosphoserineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei48PhosphoserineBy similarity1
Modified residuei56PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki300Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei301PhosphothreonineBy similarity1
Modified residuei323PhosphothreonineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P19012

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P19012

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P19012

PeptideAtlas

More...
PeptideAtlasi
P19012

PRoteomics IDEntifications database

More...
PRIDEi
P19012

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
3590
53620 [P19012-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P19012

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P19012

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P19012

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level). Expressed homogeneously in all cell layers of the esophagus and exocervix, but detected in the basal cell layer only of oral mucosa, skin and in the basal plus the next two layers of the suprabasal epithelium of the palate.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171346 Expressed in 136 organ(s), highest expression level in esophagus mucosa

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P19012 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P19012 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA023910
HPA024554

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer of two type I and two type II keratins.

Interacts with NOD2 (PubMed:27812135).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ABI2Q9NYB94EBI-739566,EBI-743598
AMOTQ4VCS5-23EBI-739566,EBI-3891843
AMOTL2Q9Y2J4-43EBI-739566,EBI-10187270
ANKRD36BP1Q96IX94EBI-739566,EBI-744859
ARFIP2P533655EBI-739566,EBI-638194
ATP5POP480473EBI-739566,EBI-355815
BEX2Q9BXY83EBI-739566,EBI-745073
C1orf216Q8TAB54EBI-739566,EBI-747505
C2CD6Q53TS83EBI-739566,EBI-739879
CCDC87Q9NVE43EBI-739566,EBI-749261
CCHCR1Q8TD31-35EBI-739566,EBI-10175300
CCNB1IP1Q9NPC33EBI-739566,EBI-745269
CCNCP248633EBI-739566,EBI-395261
CEP57Q86XR83EBI-739566,EBI-308614
COX5BP106063EBI-739566,EBI-1053725
CREB5Q02930-33EBI-739566,EBI-10192698
CYTH4Q8WWE83EBI-739566,EBI-10277443
DEUP1Q05D606EBI-739566,EBI-748597
EFHC1Q5JVL43EBI-739566,EBI-743105
EPC1Q9H2F53EBI-739566,EBI-769270
FAM110AQ9BQ895EBI-739566,EBI-1752811
GFAPP141368EBI-739566,EBI-744302
GLYCTKQ8IVS83EBI-739566,EBI-748515
HAUS1Q96CS23EBI-739566,EBI-2514791
HGSO149645EBI-739566,EBI-740220
HMG20BQ9P0W23EBI-739566,EBI-713401
IKBIPQ70UQ03EBI-739566,EBI-2557212
KANSL1Q7Z3B34EBI-739566,EBI-740244
KIAA1217Q5T5P2-63EBI-739566,EBI-10188326
KIFC3Q9BVG83EBI-739566,EBI-2125614
KLC3Q6P5973EBI-739566,EBI-1643885
KLC4Q9NSK03EBI-739566,EBI-949319
KRT1P042646EBI-739566,EBI-298429
KRT2P359086EBI-739566,EBI-1247312
KRT20P359004EBI-739566,EBI-742094
KRT4P190135EBI-739566,EBI-2371606
KRT5P136475EBI-739566,EBI-702187
KRT6AP0253813EBI-739566,EBI-702198
KRT6BP042596EBI-739566,EBI-740907
KRT6CP486683EBI-739566,EBI-2564105
KRT71Q3SY845EBI-739566,EBI-2952676
KRT73Q86Y463EBI-739566,EBI-2830994
KRT77Q0IIN13EBI-739566,EBI-2511085
KRT79Q5XKE55EBI-739566,EBI-2514135
KRT8P057875EBI-739566,EBI-297852
KRT80Q6KB663EBI-739566,EBI-3046635
KRT81Q145333EBI-739566,EBI-739648
KRT86O437905EBI-739566,EBI-9996498
LMO2P257913EBI-739566,EBI-739696
LMO4P619685EBI-739566,EBI-2798728
LNX1Q8TBB13EBI-739566,EBI-739832
MBD3O959833EBI-739566,EBI-1783068
MORN3Q6PF183EBI-739566,EBI-9675802
MOSP005405EBI-739566,EBI-1757866
NEFLI6L9F63EBI-739566,EBI-10178578
NEFLP071963EBI-739566,EBI-475646
NOC4LQ9BVI44EBI-739566,EBI-395927
NUP54Q7Z3B43EBI-739566,EBI-741048
OIP5O434823EBI-739566,EBI-536879
PIK3R2O004593EBI-739566,EBI-346930
PKN1Q165123EBI-739566,EBI-602382
PPP1R18Q6NYC85EBI-739566,EBI-2557469
PRPF31Q8WWY38EBI-739566,EBI-1567797
PSMA1P257864EBI-739566,EBI-359352
PSMB1P206185EBI-739566,EBI-372273
RAD51DO757716EBI-739566,EBI-1055693
RCOR3Q9P2K35EBI-739566,EBI-743428
RIBC1Q8N4433EBI-739566,EBI-10265323
RNF6A0A0S2Z4G93EBI-739566,EBI-16428950
SGF29Q96ES76EBI-739566,EBI-743117
SMARCD1Q96GM53EBI-739566,EBI-358489
SMARCE1Q969G33EBI-739566,EBI-455078
SPG21Q9NZD83EBI-739566,EBI-742688
SSX2IPQ9Y2D83EBI-739566,EBI-2212028
taxP140793EBI-739566,EBI-9675698From Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A).
TCHPQ9BT924EBI-739566,EBI-740781
TIMM8AO602203EBI-739566,EBI-1049822
TLE5Q081173EBI-739566,EBI-717810
TMSB4XQ0P5Q03EBI-739566,EBI-10226570
TRIM42Q8IWZ53EBI-739566,EBI-5235829
TXLNAP402225EBI-739566,EBI-359793
TXLNBQ8N3L35EBI-739566,EBI-6116822
USP2O756045EBI-739566,EBI-743272
WACQ9BTA94EBI-739566,EBI-749118
WACQ9BTA9-23EBI-739566,EBI-10298216
ZC2HC1CQ53FD04EBI-739566,EBI-740767
ZFYVE26Q68DK2-53EBI-739566,EBI-8656416
ZGPATQ8N5A53EBI-739566,EBI-3439227
ZGPATQ8N5A5-23EBI-739566,EBI-10183064
ZNF417Q8TAU33EBI-739566,EBI-740727
ZNF576Q9H6093EBI-739566,EBI-3921014
ZNF688A0A0S2Z5X43EBI-739566,EBI-16429014

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110064, 148 interactors

Protein interaction database and analysis system

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IntActi
P19012, 155 interactors

Molecular INTeraction database

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MINTi
P19012

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000254043

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P19012

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini105 – 417IF rodPROSITE-ProRule annotationAdd BLAST313

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 104HeadAdd BLAST104
Regioni105 – 140Coil 1AAdd BLAST36
Regioni141 – 159Linker 1Add BLAST19
Regioni160 – 251Coil 1BAdd BLAST92
Regioni252 – 271Linker 12Add BLAST20
Regioni272 – 413Coil 2Add BLAST142
Regioni414 – 456TailAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi14 – 103Gly-richAdd BLAST90
Compositional biasi428 – 431Poly-Gly4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IFTF Eukaryota
ENOG410Y9IV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154403

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000230975

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P19012

KEGG Orthology (KO)

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KOi
K07604

Identification of Orthologs from Complete Genome Data

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OMAi
IRCDMER

Database of Orthologous Groups

More...
OrthoDBi
798081at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P19012

TreeFam database of animal gene trees

More...
TreeFami
TF332742

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.5.1160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR042180 IF_rod_dom_coil1B
IPR002957 Keratin_I

The PANTHER Classification System

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PANTHERi
PTHR23239 PTHR23239, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00038 Filament, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01248 TYPE1KERATIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01391 Filament, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P19012-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTTFLQTSS STFGGGSTRG GSLLAGGGGF GGGSLSGGGG SRSISASSAR
60 70 80 90 100
FVSSGSGGGY GGGMRVCGFG GGAGSVFGGG FGGGVGGGFG GGFGGGDGGL
110 120 130 140 150
LSGNEKITMQ NLNDRLASYL DKVRALEEAN ADLEVKIHDW YQKQTPTSPE
160 170 180 190 200
CDYSQYFKTI EELRDKIMAT TIDNSRVILE IDNARLAADD FRLKYENELA
210 220 230 240 250
LRQGVEADIN GLRRVLDELT LARTDLEMQI EGLNEELAYL KKNHEEEMKE
260 270 280 290 300
FSSQLAGQVN VEMDAAPGVD LTRVLAEMRE QYEAMAEKNR RDVEAWFFSK
310 320 330 340 350
TEELNKEVAS NTEMIQTSKT EITDLRRTMQ ELEIELQSQL SMKAGLENSL
360 370 380 390 400
AETECRYATQ LQQIQGLIGG LEAQLSELRC EMEAQNQEYK MLLDIKTRLE
410 420 430 440 450
QEIATYRSLL EGQDAKMAGI AIREASSGGG GSSSNFHINV EESVDGQVVS

SHKREI
Length:456
Mass (Da):49,212
Last modified:November 2, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i812C1343905EBE41
GO
Isoform 2 (identifier: P19012-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-29: TTFLQTSSSTFGGGSTRGGSLLAGGGG → GTRSRPQPAQNATTANTSRPLKSSGTR
     30-194: Missing.
     417-456: Missing.

Note: No experimental confirmation available.
Show »
Length:251
Mass (Da):28,602
Checksum:i0EED60B048471B9B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JTG5C9JTG5_HUMAN
Keratin, type I cytoskeletal 15
KRT15
220Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MT21A8MT21_HUMAN
Keratin, type I cytoskeletal 15
KRT15
291Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMX0K7EMX0_HUMAN
Keratin, type I cytoskeletal 15
KRT15
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQK9K7EQK9_HUMAN
Keratin, type I cytoskeletal 15
KRT15
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047429147T → A2 PublicationsCorresponds to variant dbSNP:rs1050784Ensembl.1
Natural variantiVAR_047430416K → R1 PublicationCorresponds to variant dbSNP:rs2305556Ensembl.1
Natural variantiVAR_047431421A → G5 PublicationsCorresponds to variant dbSNP:rs897420Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0565073 – 29TTFLQ…AGGGG → GTRSRPQPAQNATTANTSRP LKSSGTR in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_05650830 – 194Missing in isoform 2. 1 PublicationAdd BLAST165
Alternative sequenceiVSP_056509417 – 456Missing in isoform 2. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X07696 mRNA Translation: CAA30535.1
AF202320 Genomic DNA Translation: AAF27047.1
BT007261 mRNA Translation: AAP35925.1
AK090604 mRNA Translation: BAG52193.1
AK091239 mRNA Translation: BAG52314.1
AC019349 Genomic DNA No translation available.
BC002641 mRNA Translation: AAH02641.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11398.1 [P19012-1]

Protein sequence database of the Protein Information Resource

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PIRi
S01069 KRHU5

NCBI Reference Sequences

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RefSeqi
NP_002266.2, NM_002275.3 [P19012-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000254043; ENSP00000254043; ENSG00000171346 [P19012-1]
ENST00000393976; ENSP00000377546; ENSG00000171346 [P19012-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3866

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3866

UCSC genome browser

More...
UCSCi
uc002hwy.4 human [P19012-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07696 mRNA Translation: CAA30535.1
AF202320 Genomic DNA Translation: AAF27047.1
BT007261 mRNA Translation: AAP35925.1
AK090604 mRNA Translation: BAG52193.1
AK091239 mRNA Translation: BAG52314.1
AC019349 Genomic DNA No translation available.
BC002641 mRNA Translation: AAH02641.1
CCDSiCCDS11398.1 [P19012-1]
PIRiS01069 KRHU5
RefSeqiNP_002266.2, NM_002275.3 [P19012-1]

3D structure databases

SMRiP19012
ModBaseiSearch...

Protein-protein interaction databases

BioGridi110064, 148 interactors
IntActiP19012, 155 interactors
MINTiP19012
STRINGi9606.ENSP00000254043

PTM databases

iPTMnetiP19012
PhosphoSitePlusiP19012
SwissPalmiP19012

Polymorphism and mutation databases

BioMutaiKRT15
DMDMi311033438

Proteomic databases

jPOSTiP19012
MassIVEiP19012
PaxDbiP19012
PeptideAtlasiP19012
PRIDEiP19012
ProteomicsDBi3590
53620 [P19012-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3866

Genome annotation databases

EnsembliENST00000254043; ENSP00000254043; ENSG00000171346 [P19012-1]
ENST00000393976; ENSP00000377546; ENSG00000171346 [P19012-1]
GeneIDi3866
KEGGihsa:3866
UCSCiuc002hwy.4 human [P19012-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3866
DisGeNETi3866

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KRT15
HGNCiHGNC:6421 KRT15
HPAiHPA023910
HPA024554
MIMi148030 gene
neXtProtiNX_P19012
OpenTargetsiENSG00000171346
PharmGKBiPA30208

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFTF Eukaryota
ENOG410Y9IV LUCA
GeneTreeiENSGT00940000154403
HOGENOMiHOG000230975
InParanoidiP19012
KOiK07604
OMAiIRCDMER
OrthoDBi798081at2759
PhylomeDBiP19012
TreeFamiTF332742

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope
SIGNORiP19012

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KRT15 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Keratin_15

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3866
PharosiP19012

Protein Ontology

More...
PROi
PR:P19012

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000171346 Expressed in 136 organ(s), highest expression level in esophagus mucosa
ExpressionAtlasiP19012 baseline and differential
GenevisibleiP19012 HS

Family and domain databases

Gene3Di1.20.5.1160, 1 hit
InterProiView protein in InterPro
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR042180 IF_rod_dom_coil1B
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK1C15_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P19012
Secondary accession number(s): B3KQY1
, B3KRA2, E0CX14, Q53XV8, Q9BUG4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 2, 2010
Last modified: October 16, 2019
This is version 180 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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