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Protein

Keratin, type I cytoskeletal 19

Gene

Krt19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle (By similarity).By similarity

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei270Stutter1
Sitei330Stutter1

GO - Molecular functioni

GO - Biological processi

  • cell differentiation involved in embryonic placenta development Source: MGI
  • Notch signaling pathway Source: MGI
  • response to estrogen Source: Ensembl
  • sarcomere organization Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-6805567 Keratinization
R-MMU-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 19
Alternative name(s):
Cytokeratin-19
Short name:
CK-19
Keratin-19
Short name:
K19
Gene namesi
Name:Krt19
Synonyms:Krt1-19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96693 Krt19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636721 – 403Keratin, type I cytoskeletal 19Add BLAST403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7Omega-N-methylarginineBy similarity1
Modified residuei14PhosphoserineBy similarity1
Modified residuei22PhosphoserineBy similarity1
Modified residuei24Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei24Omega-N-methylarginine; alternateCombined sources1
Modified residuei27PhosphoserineBy similarity1
Modified residuei32Omega-N-methylarginineCombined sources1
Modified residuei35PhosphoserineBy similarity1
Modified residuei40PhosphoserineBy similarity1
Modified residuei43Omega-N-methylarginineCombined sources1
Modified residuei51Omega-N-methylarginineCombined sources1
Modified residuei57PhosphoserineBy similarity1
Modified residuei64Omega-N-methylarginineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei75PhosphoserineCombined sources1
Modified residuei326PhosphothreonineBy similarity1
Modified residuei394Phosphotyrosine1 Publication1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiP19001
PRIDEiP19001

PTM databases

iPTMnetiP19001
PhosphoSitePlusiP19001

Expressioni

Developmental stagei

Expressed throughout embryonic development with highest levels at 8.5 dpc. Expression decreases by 11.5 dpc and increases again by 17.5 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000020911
CleanExiMM_KRT19
ExpressionAtlasiP19001 baseline and differential
GenevisibleiP19001 MM

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of DMD (By similarity).By similarity

Protein-protein interaction databases

BioGridi201024, 3 interactors
IntActiP19001, 1 interactor
MINTiP19001
STRINGi10090.ENSMUSP00000007317

Structurei

3D structure databases

ProteinModelPortaliP19001
SMRiP19001
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 394IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 82HeadAdd BLAST82
Regioni83 – 118Coil 1AAdd BLAST36
Regioni119 – 136Linker 1Add BLAST18
Regioni137 – 228Coil 1BAdd BLAST92
Regioni229 – 251Linker 12Add BLAST23
Regioni247 – 393Necessary for interaction with PNNBy similarityAdd BLAST147
Regioni252 – 390Coil 2Add BLAST139
Regioni391 – 403Rod-like helical tailAdd BLAST13

Domaini

This keratin differs from all other IF proteins in lacking the C-terminal tail domain.

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF Eukaryota
ENOG410Y9IV LUCA
GeneTreeiENSGT00900000140820
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiP19001
KOiK07604
OMAiAHYNNLP
OrthoDBiEOG091G087I
PhylomeDBiP19001
TreeFamiTF332742

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

P19001-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSYSYRQTS AMSSFGGTGG GSVRIGSGGV FRAPSIHGGS GGRGVSVSST
60 70 80 90 100
RFVTSSSGSY GGVRGGSFSG TLAVSDGLLS GNEKITMQNL NDRLASYLDK
110 120 130 140 150
VRALEQANGE LEVKIRDWYQ KQGPGPSRDY NHYFKTIEDL RDKILGATID
160 170 180 190 200
NSKIVLQIDN ARLAADDFRT KFETEHALRL SVEADINGLR RVLDELTLAR
210 220 230 240 250
TDLEMQIESL KEELAYLKKN HEEEITALRS QVGGQVSVEV DSTPGVDLAK
260 270 280 290 300
ILSEMRSQYE IMAEKNRKDA EATYLARIEE LNTQVAVHSE QIQISKTEVT
310 320 330 340 350
DLRRTLQGLE IELQSQLSMK AALEGTLAET EARYGVQLSQ IQSVISGFEA
360 370 380 390 400
QLSDVRADIE RQNQEYKQLM DIKSRLEQEI ATYRSLLEGQ EAHYNNLPTP

KAI
Length:403
Mass (Da):44,542
Last modified:November 1, 1990 - v1
Checksum:i8CA8A45FFE288BB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28698 mRNA Translation: AAA60432.1
M36120 Genomic DNA Translation: AAA39371.1
BC034561 mRNA Translation: AAH34561.1
BC085304 mRNA Translation: AAH85304.1
CCDSiCCDS25411.1
PIRiJQ0028
RefSeqiNP_032497.1, NM_008471.3
UniGeneiMm.439699

Genome annotation databases

EnsembliENSMUST00000007317; ENSMUSP00000007317; ENSMUSG00000020911
GeneIDi16669
KEGGimmu:16669
UCSCiuc007lkm.2 mouse

Similar proteinsi

Entry informationi

Entry nameiK1C19_MOUSE
AccessioniPrimary (citable) accession number: P19001
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: June 20, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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