UniProtKB - P18988 (HBB2_PANLE)
Protein
Hemoglobin subunit beta-2
Gene
HBB2
Organism
Panthera leo (Lion)
Status
Functioni
Involved in oxygen transport from the lung to the various peripheral tissues.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 63 | Iron (heme distal ligand) | 1 | |
Metal bindingi | 92 | Iron (heme proximal ligand) | 1 |
GO - Molecular functioni
- heme binding Source: InterPro
- metal ion binding Source: UniProtKB-KW
- oxygen binding Source: InterPro
- oxygen carrier activity Source: UniProtKB-KW
Keywordsi
Biological process | Oxygen transport, Transport |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Hemoglobin subunit beta-2Alternative name(s): Beta-2-globin Hemoglobin beta-2 chain |
Gene namesi | Name:HBB2 |
Organismi | Panthera leo (Lion) |
Taxonomic identifieri | 9689 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Pantherinae › Panthera |
Subcellular locationi
Cytosol
- hemoglobin complex Source: InterPro
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053053 | 1 – 146 | Hemoglobin subunit beta-2Add BLAST | 146 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 17 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 44 | PhosphoserineBy similarity | 1 | |
Modified residuei | 50 | PhosphoserineBy similarity | 1 | |
Modified residuei | 59 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 104 | Asymmetric dimethylarginineBy similarity | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
PRIDEi | P18988 |
Expressioni
Tissue specificityi
Red blood cells.
Interactioni
Subunit structurei
Heterotetramer of two alpha chains and two beta chains.
Family & Domainsi
Sequence similaritiesi
Belongs to the globin family.PROSITE-ProRule annotation
Family and domain databases
CDDi | cd08925 Hb-beta_like, 1 hit |
Gene3Di | 1.10.490.10, 1 hit |
InterProi | View protein in InterPro IPR000971 Globin IPR009050 Globin-like_sf IPR012292 Globin/Proto IPR002337 Haemoglobin_b |
Pfami | View protein in Pfam PF00042 Globin, 1 hit |
PRINTSi | PR00814 BETAHAEM |
SUPFAMi | SSF46458 SSF46458, 1 hit |
PROSITEi | View protein in PROSITE PS01033 GLOBIN, 1 hit |
i Sequence
Sequence statusi: Complete.
P18988-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
GFLSAEEKGL VNGLWSKVNV DEVGGEALGR LLVVYPWTQR FFQSFGDLSS
60 70 80 90 100
ADAIMSNAKV KAHGKKVLNS FSDGLKNIDD LKGAFAKLSE LHCDKLHVDP
110 120 130 140
ENFRLLGNVL VCVLAHHFGH EFNPQVQAAF QKVVAGVASA LAHKYH
Sequence databases
PIRi | S03926 HBJL2 |
Similar proteinsi
Cross-referencesi
Sequence databases
PIRi | S03926 HBJL2 |
3D structure databases
SMRi | P18988 |
ModBasei | Search... |
Proteomic databases
PRIDEi | P18988 |
Family and domain databases
CDDi | cd08925 Hb-beta_like, 1 hit |
Gene3Di | 1.10.490.10, 1 hit |
InterProi | View protein in InterPro IPR000971 Globin IPR009050 Globin-like_sf IPR012292 Globin/Proto IPR002337 Haemoglobin_b |
Pfami | View protein in Pfam PF00042 Globin, 1 hit |
PRINTSi | PR00814 BETAHAEM |
SUPFAMi | SSF46458 SSF46458, 1 hit |
PROSITEi | View protein in PROSITE PS01033 GLOBIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HBB2_PANLE | |
Accessioni | P18988Primary (citable) accession number: P18988 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 8, 2019 | |
This is version 94 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families