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Entry version 165 (29 Sep 2021)
Sequence version 2 (01 Feb 1995)
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Protein

Dipeptidyl aminopeptidase B

Gene

DAP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei679Charge relay systemPROSITE-ProRule annotation1
Active sitei756Charge relay systemPROSITE-ProRule annotation1
Active sitei789Charge relay systemPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • protein processing Source: SGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
yeast-dap2, DPP4N_Peptidase_S9

MEROPS protease database

More...
MEROPSi
S09.006

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dipeptidyl aminopeptidase B (EC:3.4.14.-)
Short name:
DPAP B
Alternative name(s):
YSCV
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DAP2
Ordered Locus Names:YHR028C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VIII

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000001070, DAP2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YHR028C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 29CytoplasmicSequence analysisAdd BLAST29
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei30 – 45Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST16
Topological domaini46 – 818LumenalSequence analysisAdd BLAST773

Keywords - Cellular componenti

Membrane, Vacuole

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001224211 – 818Dipeptidyl aminopeptidase BAdd BLAST818

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi372N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi392N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi421N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi738N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P18962

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P18962

PRoteomics IDEntifications database

More...
PRIDEi
P18962

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P18962

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
36459, 84 interactors

Database of interacting proteins

More...
DIPi
DIP-5759N

STRING: functional protein association networks

More...
STRINGi
4932.YHR028C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P18962, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1818
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P18962

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P18962

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2100, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161291

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006105_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P18962

Identification of Orthologs from Complete Genome Data

More...
OMAi
NHGIYGG

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058, AB_hydrolase
IPR002471, Pept_S9_AS
IPR001375, Peptidase_S9
IPR002469, Peptidase_S9B_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00930, DPPIV_N, 1 hit
PF00326, Peptidase_S9, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474, SSF53474, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00708, PRO_ENDOPEP_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P18962-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGGEEEVER IPDELFDTKK KHLLDKLIRV GIILVLLIWG TVLLLKSIPH
60 70 80 90 100
HSNTPDYQEP NSNYTNDGKL KVSFSVVRNN TFQPKYHELQ WISDNKIESN
110 120 130 140 150
DLGLYVTFMN DSYVVKSVYD DSYNSVLLEG KTFIHNGQNL TVESITASPD
160 170 180 190 200
LKRLLIRTNS VQNWRHSTFG SYFVYDKSSS SFEEIGNEVA LAIWSPNSND
210 220 230 240 250
IAYVQDNNIY IYSAISKKTI RAVTNDGSSF LFNGKPDWVY EEEVFEDDKA
260 270 280 290 300
AWWSPTGDYL AFLKIDESEV GEFIIPYYVQ DEKDIYPEMR SIKYPKSGTP
310 320 330 340 350
NPHAELWVYS MKDGTSFHPR ISGNKKDGSL LITEVTWVGN GNVLVKTTDR
360 370 380 390 400
SSDILTVFLI DTIAKTSNVV RNESSNGGWW EITHNTLFIP ANETFDRPHN
410 420 430 440 450
GYVDILPIGG YNHLAYFENS NSSHYKTLTE GKWEVVNGPL AFDSMENRLY
460 470 480 490 500
FISTRKSSTE RHVYYIDLRS PNEIIEVTDT SEDGVYDVSF SSGRRFGLLT
510 520 530 540 550
YKGPKVPYQK IVDFHSRKAE KCDKGNVLGK SLYHLEKNEV LTKILEDYAV
560 570 580 590 600
PRKSFRELNL GKDEFGKDIL VNSYEILPND FDETLSDHYP VFFFAYGGPN
610 620 630 640 650
SQQVVKTFSV GFNEVVASQL NAIVVVVDGR GTGFKGQDFR SLVRDRLGDY
660 670 680 690 700
EARDQISAAS LYGSLTFVDP QKISLFGWSY GGYLTLKTLE KDGGRHFKYG
710 720 730 740 750
MSVAPVTDWR FYDSVYTERY MHTPQENFDG YVESSVHNVT ALAQANRFLL
760 770 780 790 800
MHGTGDDNVH FQNSLKFLDL LDLNGVENYD VHVFPDSDHS IRYHNANVIV
810
FDKLLDWAKR AFDGQFVK
Length:818
Mass (Da):93,404
Last modified:February 1, 1995 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i318F450445375BD3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti83Q → H in CAA33512 (PubMed:2647766).Curated1
Sequence conflicti125S → N in CAA33512 (PubMed:2647766).Curated1
Sequence conflicti182 – 188FEEIGNE → LRRLET in CAA33512 (PubMed:2647766).Curated7
Sequence conflicti200D → N in CAA33512 (PubMed:2647766).Curated1
Sequence conflicti318H → R in AAU09739 (PubMed:17322287).Curated1
Sequence conflicti366 – 375TSNVVRNESS → DFKRGKERKF in CAA33512 (PubMed:2647766).Curated10
Sequence conflicti808 – 818AKRAFDGQFVK → QSVLSMGNLTNELTIYSSSH RDIHKTFSYLHTMYI in CAA33512 (PubMed:2647766).CuratedAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X15484 Genomic DNA Translation: CAA33512.1
U10399 Genomic DNA Translation: AAB68879.1
AY723822 Genomic DNA Translation: AAU09739.1
BK006934 Genomic DNA Translation: DAA06719.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S46780, A30107

NCBI Reference Sequences

More...
RefSeqi
NP_011893.1, NM_001179158.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YHR028C_mRNA; YHR028C; YHR028C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
856423

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YHR028C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15484 Genomic DNA Translation: CAA33512.1
U10399 Genomic DNA Translation: AAB68879.1
AY723822 Genomic DNA Translation: AAU09739.1
BK006934 Genomic DNA Translation: DAA06719.1
PIRiS46780, A30107
RefSeqiNP_011893.1, NM_001179158.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KL4X-ray3.50B26-51[»]
3ZN8electron microscopy12.00S31-44[»]
SMRiP18962
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi36459, 84 interactors
DIPiDIP-5759N
STRINGi4932.YHR028C

Protein family/group databases

ESTHERiyeast-dap2, DPP4N_Peptidase_S9
MEROPSiS09.006

PTM databases

iPTMnetiP18962

Proteomic databases

MaxQBiP18962
PaxDbiP18962
PRIDEiP18962

Genome annotation databases

EnsemblFungiiYHR028C_mRNA; YHR028C; YHR028C
GeneIDi856423
KEGGisce:YHR028C

Organism-specific databases

SGDiS000001070, DAP2
VEuPathDBiFungiDB:YHR028C

Phylogenomic databases

eggNOGiKOG2100, Eukaryota
GeneTreeiENSGT00940000161291
HOGENOMiCLU_006105_0_1_1
InParanoidiP18962
OMAiNHGIYGG

Miscellaneous databases

EvolutionaryTraceiP18962

Protein Ontology

More...
PROi
PR:P18962
RNActiP18962, protein

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058, AB_hydrolase
IPR002471, Pept_S9_AS
IPR001375, Peptidase_S9
IPR002469, Peptidase_S9B_N
PfamiView protein in Pfam
PF00930, DPPIV_N, 1 hit
PF00326, Peptidase_S9, 1 hit
SUPFAMiSSF53474, SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00708, PRO_ENDOPEP_SER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDAP2_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18962
Secondary accession number(s): D3DKX5, E9P957
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: February 1, 1995
Last modified: September 29, 2021
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
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