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Protein

Vitellogenin-4

Gene

vit-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development.Curated

GO - Molecular functioni

Keywordsi

Molecular functionStorage protein

Names & Taxonomyi

Protein namesi
Recommended name:
Vitellogenin-4
Gene namesi
Name:vit-4
ORF Names:F59D8.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF59D8.2 ; CE26817 ; WBGene00006928 ; vit-4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000004153516 – 1603Vitellogenin-4Add BLAST1588

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi1266N-linked (GlcNAc...) asparagine2 Publications1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP18947
PaxDbiP18947
PeptideAtlasiP18947
PRIDEiP18947

PTM databases

iPTMnetiP18947

Expressioni

Tissue specificityi

Synthesized in Caenorhabditis only by 32 cells building the intestine of adult hermaphroditic individuals; they are cotranslationally secreted into the body cavity and subsequently taken up by the gonad.

Gene expression databases

BgeeiWBGene00006928 Expressed in 2 organ(s), highest expression level in adult organism

Interactioni

Protein-protein interaction databases

STRINGi6239.F59D8.2

Structurei

3D structure databases

ProteinModelPortaliP18947
SMRiP18947
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 685VitellogeninPROSITE-ProRule annotationAdd BLAST662
Domaini1306 – 1507VWFDPROSITE-ProRule annotationAdd BLAST202

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4338 Eukaryota
ENOG411104F LUCA
GeneTreeiENSGT00530000064273
HOGENOMiHOG000004768
InParanoidiP18947
OMAiMASTHIT
OrthoDBiEOG091G00HR
PhylomeDBiP18947

Family and domain databases

Gene3Di1.25.10.20, 1 hit
2.30.230.10, 1 hit
InterProiView protein in InterPro
IPR015819 Lipid_transp_b-sht_shell
IPR001747 Lipid_transpt_N
IPR011030 Lipovitellin_superhlx_dom
IPR015816 Vitellinogen_b-sht_N
IPR015255 Vitellinogen_open_b-sht
IPR001846 VWF_type-D
PfamiView protein in Pfam
PF09172 DUF1943, 1 hit
PF01347 Vitellogenin_N, 1 hit
PF00094 VWD, 1 hit
SMARTiView protein in SMART
SM01169 DUF1943, 1 hit
SM00638 LPD_N, 1 hit
SM00216 VWD, 1 hit
SUPFAMiSSF48431 SSF48431, 1 hit
SSF56968 SSF56968, 2 hits
PROSITEiView protein in PROSITE
PS51211 VITELLOGENIN, 1 hit
PS51233 VWFD, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18947-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSIIIASLV ALAIAASPAL DRTFSPKSEY VYKFDGLLLS GLPTTFSDAS
60 70 80 90 100
QTLISCRTRL QAVDDRYIHL QLIDIQYSAS HIPQSEQWPK IESLEQRELS
110 120 130 140 150
DELKELLELP FRAQIRNGLV SEIQFSSEDA EWSKNAKRSI LNLFSLRKSA
160 170 180 190 200
PVDEMSQDQK DMESDKDSLF FNVHEKTMEG DCEVAYTIVQ EGGKTIYTKS
210 220 230 240 250
VNFDKCITRP ETAYGLRFGS ECKECEKEGQ FVQPQTVYTY TFKNEKLQES
260 270 280 290 300
EVNSIYTLNV NGQEVVKSET RAKVTFVEES KINREIKKVS GPKEEIVYSM
310 320 330 340 350
ENEKLIEQFY KQGDKAEVNP FKAIEIEQKV EQLEEIFRQI QEHEQNTPET
360 370 380 390 400
VHLIARAVRM FRMCTIEELK KVHTTIYTKA EKKVQLVIET TLAVAGTKNT
410 420 430 440 450
IQHLIHHFEK KSITPLRAAE LLKSVQETLY PSEHIADLLI QLAQSPLSEK
460 470 480 490 500
YEPLRQSAWL AAGSVVRGFA SKTQDLPLIR PASRQTKEKY VRVFMQHFRN
510 520 530 540 550
ADSTYEKVLA LKTLGNAGID LSVYELVQLI QDPRQPLSIR TEAVDALRLL
560 570 580 590 600
KDVMPRKIQK VLLPVYKNRQ NKPELRMAAL WRMMHTIPEE PVLAHIVSQM
610 620 630 640 650
ENESNQHVAA FTYNVLRQFS KSTNPCYQQL AVRCSKVLLF TRYQPQEQML
660 670 680 690 700
STYSQLPLFN SEWLSGVQFD FATIFEKNAF LPKEVQASFE TVFGGNWNKY
710 720 730 740 750
FAQVGFSQQN FEQVILKTLE KLSLYGKQSD ELRSRRVQSG IQMLQEIVKK
760 770 780 790 800
MNIRPRVQQT DSQNAHAVFY LRYKEMDYIV LPIDMETIDN VVEKYVRNGE
810 820 830 840 850
FDIKSLLTFL TNDSKFELHR ALFFYEAERR IPTTIGMPLT ISGKMPTILS
860 870 880 890 900
INGKVSIELE KLGARLVLDI VPTVATTHVT EMRFWYPVIE QGVKSLQSAR
910 920 930 940 950
LHTPLRFEST VELKKNTLEI THKFVVPENK KTTVSVHTRP VAFIRVPKNQ
960 970 980 990 1000
DSEYVEAEEK TISHSQYQMS TEEIDRQYET FGLRINAQGN VLSQWTLPMV
1010 1020 1030 1040 1050
LMTEQDFEFT LENKNRPVEF TARVTIGNLE KTDLSEIKFD KIFEKEFDLE
1060 1070 1080 1090 1100
NNESENRRQY FHKMIREIQS EQGFKNLITL KLEAPQQMYW NTELRTVCDK
1110 1120 1130 1140 1150
WIRMCKVEMD ARRSPIEHEN KEWTLRTELL AARPQMPSSL RQLREQPHRE
1160 1170 1180 1190 1200
VQLALNAKWG SSKKSEITFN AQLEQSTEQK KFLRNIEREY KGIPEYELLI
1210 1220 1230 1240 1250
KAARLNQVNV VSEYKLTPES EYTFSRIFDL IKAYNFWTVS EKRVQNEDRR
1260 1270 1280 1290 1300
VVLQLSVEPL SRQYMNMTIQ TPEQEVELKN VRIPRVVLPT IARRAMFQQT
1310 1320 1330 1340 1350
WEKTGATCKV DQSEVSTFDN VIYRAPLTTC YSLVAKDCSE QPRFAVLAKK
1360 1370 1380 1390 1400
INKNSEELLV KVVRREEEIV VKKSDDKFLV KVDGKKVNPT ELEQYNIEIL
1410 1420 1430 1440 1450
GDNLIVIRLP HGEVRFDGYT VKTNMPSVAS QNQLCGLCGN NDGERDNEFM
1460 1470 1480 1490 1500
TADNYETEDV EEFHRSYLLK NEECEVEKDR ISEKKNYKNK WNREEKKSDY
1510 1520 1530 1540 1550
ESSSDYESNY DEKETEKELV KKTLIKEFSN RVCFSIEPVS ECRRGLESEK
1560 1570 1580 1590 1600
TSNKKIRFTC MPRHSKNARR FLKEAREQTV ADLVDFPVSF VESVKIPTAC

VAY
Length:1,603
Mass (Da):186,309
Last modified:March 28, 2003 - v3
Checksum:iE303170325BC99BB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti169L → V in AAA28163 (Ref. 2) Curated1
Sequence conflicti183 – 187EVAYT → RSRLH in AAA28163 (Ref. 2) Curated5
Sequence conflicti275T → S in AAA28163 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081486 Genomic DNA Translation: CCD71958.1
M11498 Genomic DNA Translation: AAA28163.1
X02754 Genomic DNA Translation: CAA26531.1
PIRiA43084
RefSeqiNP_508612.1, NM_076211.5
UniGeneiCel.21335

Genome annotation databases

EnsemblMetazoaiF59D8.2; F59D8.2; WBGene00006928
GeneIDi180646
KEGGicel:CELE_F59D8.2
UCSCiF59D8.2 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081486 Genomic DNA Translation: CCD71958.1
M11498 Genomic DNA Translation: AAA28163.1
X02754 Genomic DNA Translation: CAA26531.1
PIRiA43084
RefSeqiNP_508612.1, NM_076211.5
UniGeneiCel.21335

3D structure databases

ProteinModelPortaliP18947
SMRiP18947
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F59D8.2

PTM databases

iPTMnetiP18947

Proteomic databases

EPDiP18947
PaxDbiP18947
PeptideAtlasiP18947
PRIDEiP18947

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF59D8.2; F59D8.2; WBGene00006928
GeneIDi180646
KEGGicel:CELE_F59D8.2
UCSCiF59D8.2 c. elegans

Organism-specific databases

CTDi180646
WormBaseiF59D8.2 ; CE26817 ; WBGene00006928 ; vit-4

Phylogenomic databases

eggNOGiKOG4338 Eukaryota
ENOG411104F LUCA
GeneTreeiENSGT00530000064273
HOGENOMiHOG000004768
InParanoidiP18947
OMAiMASTHIT
OrthoDBiEOG091G00HR
PhylomeDBiP18947

Miscellaneous databases

PROiPR:P18947

Gene expression databases

BgeeiWBGene00006928 Expressed in 2 organ(s), highest expression level in adult organism

Family and domain databases

Gene3Di1.25.10.20, 1 hit
2.30.230.10, 1 hit
InterProiView protein in InterPro
IPR015819 Lipid_transp_b-sht_shell
IPR001747 Lipid_transpt_N
IPR011030 Lipovitellin_superhlx_dom
IPR015816 Vitellinogen_b-sht_N
IPR015255 Vitellinogen_open_b-sht
IPR001846 VWF_type-D
PfamiView protein in Pfam
PF09172 DUF1943, 1 hit
PF01347 Vitellogenin_N, 1 hit
PF00094 VWD, 1 hit
SMARTiView protein in SMART
SM01169 DUF1943, 1 hit
SM00638 LPD_N, 1 hit
SM00216 VWD, 1 hit
SUPFAMiSSF48431 SSF48431, 1 hit
SSF56968 SSF56968, 2 hits
PROSITEiView protein in PROSITE
PS51211 VITELLOGENIN, 1 hit
PS51233 VWFD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVIT4_CAEEL
AccessioniPrimary (citable) accession number: P18947
Secondary accession number(s): Q9BPP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: March 28, 2003
Last modified: September 12, 2018
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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