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Protein

NADH-ubiquinone oxidoreductase chain 6

Gene

MT-ND6

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Enzyme and pathway databases

ReactomeiR-GGA-611105 Respiratory electron transport
R-GGA-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 6 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 6
Gene namesi
Name:MT-ND6
Synonyms:MTND6, NADH6, ND6
Encoded oniMitochondrion
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Mitochondrion

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei27 – 47HelicalSequence analysisAdd BLAST21
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001182661 – 173NADH-ubiquinone oxidoreductase chain 6Add BLAST173

Proteomic databases

PaxDbiP18941

Expressioni

Gene expression databases

BgeeiENSGALG00000018357 Expressed in 11 organ(s), highest expression level in heart
ExpressionAtlasiP18941 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000034624

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 6 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYM9 Eukaryota
ENOG410YP23 LUCA
GeneTreeiENSGT00390000003988
HOGENOMiHOG000113881
HOVERGENiHBG007487
InParanoidiP18941
KOiK03884
OMAiYLGGMMV
OrthoDBiEOG091G111J
PhylomeDBiP18941
TreeFamiTF343324

Family and domain databases

InterProiView protein in InterPro
IPR001457 NADH_UbQ/plastoQ_OxRdtase_su6
PfamiView protein in Pfam
PF00499 Oxidored_q3, 1 hit

Sequencei

Sequence statusi: Complete.

P18941-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTYFVIFLGI CFMLGVLAVA SNPSPYYGVV GLVVASVMGC GWLVSLGVSF
60 70 80 90 100
VSLALFLVYL GGMLVVFVYS VSLAADPYPE AWGDWRVVGY GLGFVLVVWM
110 120 130 140 150
GVVLGGLVDF WKVGVVTVDG GGVSFARLDF SGVAVFYSCG VGLFLVAGWG
160 170
LLLALFVVLE LVRGLSRGAI RAV
Length:173
Mass (Da):18,226
Last modified:November 1, 1990 - v1
Checksum:i653B972273CF0064
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52392 Genomic DNA Translation: CAA36637.1
PIRiS10199
RefSeqiNP_006927.1, NC_001323.1

Genome annotation databases

EnsembliENSGALT00000068151; ENSGALP00000047587; ENSGALG00000037838
GeneIDi807640
KEGGigga:807640

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52392 Genomic DNA Translation: CAA36637.1
PIRiS10199
RefSeqiNP_006927.1, NC_001323.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000034624

Proteomic databases

PaxDbiP18941

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000068151; ENSGALP00000047587; ENSGALG00000037838
GeneIDi807640
KEGGigga:807640

Organism-specific databases

CTDi4541

Phylogenomic databases

eggNOGiENOG410IYM9 Eukaryota
ENOG410YP23 LUCA
GeneTreeiENSGT00390000003988
HOGENOMiHOG000113881
HOVERGENiHBG007487
InParanoidiP18941
KOiK03884
OMAiYLGGMMV
OrthoDBiEOG091G111J
PhylomeDBiP18941
TreeFamiTF343324

Enzyme and pathway databases

ReactomeiR-GGA-611105 Respiratory electron transport
R-GGA-6799198 Complex I biogenesis

Miscellaneous databases

PROiPR:P18941

Gene expression databases

BgeeiENSGALG00000018357 Expressed in 11 organ(s), highest expression level in heart
ExpressionAtlasiP18941 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR001457 NADH_UbQ/plastoQ_OxRdtase_su6
PfamiView protein in Pfam
PF00499 Oxidored_q3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNU6M_CHICK
AccessioniPrimary (citable) accession number: P18941
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: September 12, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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