Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NADH-ubiquinone oxidoreductase chain 4L

Gene

mt:ND4L

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionTranslocase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4L (EC:7.1.1.2)
Alternative name(s):
NADH dehydrogenase subunit 4L
Gene namesi
Name:mt:ND4L
Synonyms:ND4L
Encoded oniMitochondrion
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Mitochondrion

Organism-specific databases

FlyBaseiFBgn0013683 mt:ND4L

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Transmembranei28 – 48HelicalSequence analysisAdd BLAST21
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001184171 – 96NADH-ubiquinone oxidoreductase chain 4LAdd BLAST96

Proteomic databases

PaxDbiP18934

Expressioni

Gene expression databases

BgeeiFBgn0013683 Expressed in 3 organ(s), highest expression level in head
ExpressionAtlasiP18934 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0100184

Structurei

3D structure databases

ProteinModelPortaliP18934
SMRiP18934
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4L family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4669 Eukaryota
COG0713 LUCA
InParanoidiP18934
OMAiLCLEGMM
OrthoDBiEOG091G0ZRL
PhylomeDBiP18934

Family and domain databases

InterProiView protein in InterPro
IPR001133 NADH_UbQ_OxRdtase_chain4L/K
IPR039428 NUOK/Mnh_C1-like
PANTHERiPTHR11434 PTHR11434, 1 hit
PfamiView protein in Pfam
PF00420 Oxidored_q2, 1 hit

Sequencei

Sequence statusi: Complete.

P18934-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIMILYWSLP MILFILGLFC FVSNRKHLLS MLLSLEFIVL MLFFMLFIYL
60 70 80 90
NMLNYESYFS MMFLTFSVCE GALGLSILVS MIRTHGNDYF QSFSIM
Length:96
Mass (Da):11,359
Last modified:November 1, 1990 - v1
Checksum:iD383557D738A175B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37275 Genomic DNA Translation: AAA69712.1
AF200828 Genomic DNA Translation: AAF77235.1
AF200829 Genomic DNA Translation: AAF77247.1
AJ400907 Genomic DNA Translation: CAB91060.1
U37541 Genomic DNA Translation: AAC47820.1
KJ947872 Genomic DNA Translation: AIC64013.1
PIRiS01188
RefSeqiYP_009047275.1, NC_024511.2

Genome annotation databases

EnsemblMetazoaiFBtr0100880; FBpp0100184; FBgn0013683
GeneIDi19893552
KEGGidme:ND4L

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37275 Genomic DNA Translation: AAA69712.1
AF200828 Genomic DNA Translation: AAF77235.1
AF200829 Genomic DNA Translation: AAF77247.1
AJ400907 Genomic DNA Translation: CAB91060.1
U37541 Genomic DNA Translation: AAC47820.1
KJ947872 Genomic DNA Translation: AIC64013.1
PIRiS01188
RefSeqiYP_009047275.1, NC_024511.2

3D structure databases

ProteinModelPortaliP18934
SMRiP18934
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0100184

Proteomic databases

PaxDbiP18934

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0100880; FBpp0100184; FBgn0013683
GeneIDi19893552
KEGGidme:ND4L

Organism-specific databases

CTDi4539
FlyBaseiFBgn0013683 mt:ND4L

Phylogenomic databases

eggNOGiKOG4669 Eukaryota
COG0713 LUCA
InParanoidiP18934
OMAiLCLEGMM
OrthoDBiEOG091G0ZRL
PhylomeDBiP18934

Miscellaneous databases

GenomeRNAii19893552
PROiPR:P18934

Gene expression databases

BgeeiFBgn0013683 Expressed in 3 organ(s), highest expression level in head
ExpressionAtlasiP18934 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR001133 NADH_UbQ_OxRdtase_chain4L/K
IPR039428 NUOK/Mnh_C1-like
PANTHERiPTHR11434 PTHR11434, 1 hit
PfamiView protein in Pfam
PF00420 Oxidored_q2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNU4LM_DROME
AccessioniPrimary (citable) accession number: P18934
Secondary accession number(s): Q7HM98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again