Rarg

Functionⁱ

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (By similarity). Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function.By similarity2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	90 – 155	Nuclear receptorPROSITE-ProRule annotationAdd BLAST	66
Zinc fingerⁱ	90 – 110	NR C4-typePROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	126 – 150	NR C4-typePROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

DNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 18439490
DNA-binding transcription factor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 18439490
DNA-binding transcription factor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
nuclear receptor transcription coactivator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
retinoic acid receptor activity Source: MGI
retinoid X receptor binding
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18439490
RNA polymerase II regulatory region sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 1655807
signaling receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
steroid hormone receptor activity Source: InterPro
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anterior/posterior pattern specification
Source: MGI
Inferred from mutant phenotypeⁱ
- 11784046
- 8388780
bone development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19389355
bone morphogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 11784046
- 8388780
camera-type eye development
Source: MGI
Inferred from genetic interactionⁱ
- 9376317
cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cellular response to leukemia inhibitory factor
Source: MGI
Inferred from expression patternⁱ
- 20439489
cellular response to retinoic acid
Source: MGI
Inferred from direct assayⁱ
- 2157970
chondrocyte development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19389355
embryonic camera-type eye development
Source: MGI
Inferred from genetic interactionⁱ
- 7607067
embryonic eye morphogenesis
Source: MGI
Inferred from genetic interactionⁱ
- 16207763
embryonic hindlimb morphogenesis
Source: MGI
Inferred from genetic interactionⁱ
- 10075839
epithelium development
Source: MGI
Inferred from mutant phenotypeⁱ
- 8388780
face development
Source: MGI
Inferred from genetic interactionⁱ
- 7607067
gland development
Source: MGI
Inferred from mutant phenotypeⁱ
- 8388780
glandular epithelial cell development
Source: MGI
Inferred from genetic interactionⁱ
- 7607067
growth plate cartilage chondrocyte growth
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19389355
growth plate cartilage development
Source: MGI
Inferred from genetic interactionⁱ
- 19389355
Harderian gland development
Source: MGI
Inferred from mutant phenotypeⁱ
- 8388780
hormone-mediated signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
limb development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19389355
multicellular organism development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
multicellular organism growth
Source: MGI
Inferred from genetic interactionⁱ
- 19389355
negative regulation of apoptotic process
Source: MGI
Inferred from genetic interactionⁱ
- 8681798
negative regulation of cartilage development
Source: MGI
Inferred from mutant phenotypeⁱ
- 10684250
negative regulation of cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 10684250
negative regulation of cell proliferation
Source: MGI
Inferred from genetic interactionⁱ
- 10075839
negative regulation of chondrocyte differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 10684250
negative regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 8152920
neural tube closure
Source: MGI
Inferred from genetic interactionⁱ
- 7607067
positive regulation of apoptotic process
Source: MGI
Inferred from genetic interactionⁱ
- 16207763
positive regulation of cell proliferation
Source: MGI
Inferred from genetic interactionⁱ
- 8681798
positive regulation of gene expression
Source: MGI
Inferred from direct assayⁱ
- 19389355
positive regulation of programmed cell death
Source: MGI
Inferred from genetic interactionⁱ
- 10075839
positive regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
prostate gland epithelium morphogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 8388780
regulation of gene expression
Source: MGI
Inferred from genetic interactionⁱ
- 19389355
regulation of myelination Source: MGI
regulation of myeloid cell differentiation
Source: MGI
Inferred from genetic interactionⁱ
- 23136256
reproductive structure development
Source: MGI
Inferred from mutant phenotypeⁱ
- 8388780
response to lipid
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to retinoic acid Source: MGI
retina development in camera-type eye
Source: MGI
Inferred from genetic interactionⁱ
- 8681798
retinal pigment epithelium development
Source: MGI
Inferred from genetic interactionⁱ
- 8681798
retinoic acid receptor signaling pathway
Source: MGI
Inferred from mutant phenotypeⁱ
- 8388780
trachea cartilage development
Source: MGI
Inferred from mutant phenotypeⁱ
- 8388780
- 9376317

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Receptor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-383280 Nuclear Receptor transcription pathway R-MMU-5362517 Signaling by Retinoic Acid

Reactomeⁱ

R-MMU-383280 Nuclear Receptor transcription pathway
R-MMU-5362517 Signaling by Retinoic Acid

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Retinoic acid receptor gamma Short name: RAR-gamma Alternative name(s): Nuclear receptor subfamily 1 group B member 3
Gene namesⁱ	Name:Rarg Synonyms:Nr1b3
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 15

Organism-specific databases

MGIⁱ	MGI:97858 Rarg

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Rarg and Rarb double null mice exhibit growth retardation 3 weeks after birth. Defects are found in the growth plates with deficiency in cartilage. Growth retardation was noticable in limb sketal elements such as femurs. Early lethality and male sterility due to squamous metaplasia of the seminal vesicles and prostate are also observed. Isoform 2 mutants appear normal. The Rarg and Cyp26b1 double null mutation is able to partially rescue limb skeletal morphology without restoring normal expression of proximo-distal patterning genes.3 Publications

Chemistry databases

ChEMBLⁱ	CHEMBL4177
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	592

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000053474	1 – 458	Retinoic acid receptor gammaAdd BLAST		458

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	34	Omega-N-methylarginineCombined sources	1
Cross-linkⁱ	172	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	401	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMⁱ

Isopeptide bond, Methylation, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P18911
PaxDbⁱ	P18911
PeptideAtlas More...PeptideAtlasⁱ	P18911
PRIDEⁱ	P18911

PTM databases

iPTMnetⁱ	P18911
PhosphoSitePlusⁱ	P18911

Expressionⁱ

Developmental stageⁱ

In E9.5-E12.5 embryos, expression throughout limb bud mesenchyme. This expression overlaps with that of CYP26B1. Also strongly expressed in the caudal and craniofacial regions.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000001288 Expressed in 330 organ(s), highest expression level in cranium
CleanExⁱ	MM_RARG
ExpressionAtlasⁱ	P18911 baseline and differential
Genevisibleⁱ	P18911 MM

Interactionⁱ

Subunit structureⁱ

Homodimer (By similarity). Heterodimer with a RXR molecule (By similarity). Binds DNA preferentially as a RAR/RXR heterodimer (By similarity). Forms a complex with PUS1 and the SRA1 RNA in the nucleus.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Ajuba	Q91XC0	2	EBI-8053650,EBI-1565930

With

Entry

#Exp.

IntAct

Notes

Ajuba

Q91XC0

2

EBI-8053650,EBI-1565930

GO - Molecular functionⁱ

retinoid X receptor binding
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18439490
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	202595, 4 interactors
Database of interacting proteins More...DIPⁱ	DIP-42822N
IntActⁱ	P18911, 2 interactors
Molecular INTeraction database More...MINTⁱ	P18911
STRINGⁱ	10090.ENSMUSP00000048838

Chemistry databases

BindingDBⁱ

P18911

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P18911
SMRⁱ	P18911
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	185 – 419	NR LBDPROSITE-ProRule annotationAdd BLAST		235

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 89	ModulatingAdd BLAST		89
Regionⁱ	156 – 184	HingeAdd BLAST		29

Domainⁱ

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family. NR1 subfamily.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	90 – 110	NR C4-typePROSITE-ProRule annotationAdd BLAST		21
Zinc fingerⁱ	126 – 150	NR C4-typePROSITE-ProRule annotationAdd BLAST		25

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00870000136372
HOGENOMⁱ	HOG000010312
HOVERGENⁱ	HBG005606
InParanoidⁱ	P18911
KEGG Orthology (KO) More...KOⁱ	K08529
OMAⁱ	QKVSKAH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XCQ
PhylomeDBⁱ	P18911
TreeFamⁱ	TF328382

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR003078 Retinoic_acid_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01292 RETNOICACIDR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P18911-1) [UniParc]FASTA Add to basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATNKERLFA PGALGPGSGY PGAGFPFAFP GALRGSPPFE MLSPSFRGLG 
        60         70         80         90        100
QPDLPKEMAS LSVETQSTSS EEMVPSSPSP PPPPRVYKPC FVCNDKSSGY 
       110        120        130        140        150
HYGVSSCEGC KGFFRRSIQK NMVYTCHRDK NCIINKVTRN RCQYCRLQKC 
       160        170        180        190        200
FEVGMSKEAV RNDRNKKKKE VKEEGSPDSY ELSPQLEELI TKVSKAHQET 
       210        220        230        240        250
FPSLCQLGKY TTNSSADHRV QLDLGLWDKF SELATKCIIK IVEFAKRLPG 
       260        270        280        290        300
FTGLSIADQI TLLKAACLDI LMLRICTRYT PEQDTMTFSD GLTLNRTQMH 
       310        320        330        340        350
NAGFGPLTDL VFAFAGQLLP LEMDDTETGL LSAICLICGD RMDLEEPEKV 
       360        370        380        390        400
DKLQEPLLEA LRLYARRRRP SQPYMFPRML MKITDLRGIS TKGAERAITL 
       410        420        430        440        450
KMEIPGPMPP LIREMLENPE MFEDDSSKPG PHPKASSEDE APGGQGKRGQ 

SPQPDQGP

Length:458

Mass (Da):50,891

Last modified:February 5, 2008 - v3

Checksum:ⁱ1D13D2F1482D7194

GO

Isoform 2 (identifier: P18911-2) [UniParc] [UniParc]FASTA Add to basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
1-61: MATNKERLFA...PDLPKEMASL → MYDCMESFVP...FAWAQPASLQ

« Hide

        10         20         30         40         50
MYDCMESFVP GPRRLYGAAG PGAGLLRRAT GSSCFAGLES FAWAQPASLQ 
        60         70         80         90        100
SVETQSTSSE EMVPSSPSPP PPPRVYKPCF VCNDKSSGYH YGVSSCEGCK 
       110        120        130        140        150
GFFRRSIQKN MVYTCHRDKN CIINKVTRNR CQYCRLQKCF EVGMSKEAVR 
       160        170        180        190        200
NDRNKKKKEV KEEGSPDSYE LSPQLEELIT KVSKAHQETF PSLCQLGKYT 
       210        220        230        240        250
TNSSADHRVQ LDLGLWDKFS ELATKCIIKI VEFAKRLPGF TGLSIADQIT 
       260        270        280        290        300
LLKAACLDIL MLRICTRYTP EQDTMTFSDG LTLNRTQMHN AGFGPLTDLV 
       310        320        330        340        350
FAFAGQLLPL EMDDTETGLL SAICLICGDR MDLEEPEKVD KLQEPLLEAL 
       360        370        380        390        400
RLYARRRRPS QPYMFPRMLM KITDLRGIST KGAERAITLK MEIPGPMPPL 
       410        420        430        440 
IREMLENPEM FEDDSSKPGP HPKASSEDEA PGGQGKRGQS PQPDQGP

Show »

Length:447

Mass (Da):49,849

Checksum:ⁱ75E0BCB50BC9AD3B

GO

Isoform 3 (identifier: P18911-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-62: MATNKERLFA...DLPKEMASLS → MHKGDNSGHQ...LSSHAAFHSA

« Hide

        10         20         30         40         50
MHKGDNSGHQ QVPRKRGHGM RVLLLSFCLS SHAAFHSAVE TQSTSSEEMV 
        60         70         80         90        100
PSSPSPPPPP RVYKPCFVCN DKSSGYHYGV SSCEGCKGFF RRSIQKNMVY 
       110        120        130        140        150
TCHRDKNCII NKVTRNRCQY CRLQKCFEVG MSKEAVRNDR NKKKKEVKEE 
       160        170        180        190        200
GSPDSYELSP QLEELITKVS KAHQETFPSL CQLGKYTTNS SADHRVQLDL 
       210        220        230        240        250
GLWDKFSELA TKCIIKIVEF AKRLPGFTGL SIADQITLLK AACLDILMLR 
       260        270        280        290        300
ICTRYTPEQD TMTFSDGLTL NRTQMHNAGF GPLTDLVFAF AGQLLPLEMD 
       310        320        330        340        350
DTETGLLSAI CLICGDRMDL EEPEKVDKLQ EPLLEALRLY ARRRRPSQPY 
       360        370        380        390        400
MFPRMLMKIT DLRGISTKGA ERAITLKMEI PGPMPPLIRE MLENPEMFED 
       410        420        430 
DSSKPGPHPK ASSEDEAPGG QGKRGQSPQP DQGP

Show »

Length:434

Mass (Da):48,708

Checksum:ⁱD0885E92CB7B2966

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D3YZY4	D3YZY4_MOUSE		Retinoic acid receptor gamma Retinoic acid receptor gamma	Rarg	227	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	63	V → E in BAE28323 (PubMed:16141072).Curated	1
Sequence conflictⁱ	78	P → A in BAE28323 (PubMed:16141072).Curated	1
Sequence conflictⁱ	176	S → L in AAH13709 (PubMed:15489334).Curated	1
Sequence conflictⁱ	369 – 372	RPSQ → DPAK in AAA40035 (PubMed:2157970).Curated	4
Sequence conflictⁱ	369 – 372	RPSQ → DPAK in AAA40036 (PubMed:2157970).Curated	4

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_031081	1 – 62	MATNK…MASLS → MHKGDNSGHQQVPRKRGHGM RVLLLSFCLSSHAAFHSA in isoform 3. 1 PublicationAdd BLAST		62
Alternative sequenceⁱVSP_031082	1 – 61	MATNK…EMASL → MYDCMESFVPGPRRLYGAAG PGAGLLRRATGSSCFAGLES FAWAQPASLQ in isoform 2. 2 PublicationsAdd BLAST		61

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X15848 mRNA Translation: CAA33845.1 M34475 mRNA Translation: AAA40036.1 M34476 mRNA Translation: AAA40035.1 AK148064 mRNA Translation: BAE28323.1 BC012923 mRNA Translation: AAH12923.1 BC013709 mRNA Translation: AAH13709.1 M32068 mRNA Translation: AAA40032.1 M32069 mRNA Translation: AAA40033.1 M32070 mRNA Translation: AAA40034.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS27875.1 [P18911-1] CCDS37226.1 [P18911-2]
PIRⁱ	B34714 S05052 A34714
NCBI Reference Sequences More...RefSeqⁱ	NP_001036192.1, NM_001042727.2 [P18911-2] NP_035374.3, NM_011244.4 [P18911-1] XP_006520713.1, XM_006520650.1 [P18911-1] XP_011243827.1, XM_011245525.2 [P18911-1]
UniGeneⁱ	Mm.1273

Genome annotation databases

Ensemblⁱ	ENSMUST00000043172; ENSMUSP00000048838; ENSMUSG00000001288 [P18911-1] ENSMUST00000063339; ENSMUSP00000067266; ENSMUSG00000001288 [P18911-2]
GeneIDⁱ	19411
KEGGⁱ	mmu:19411
UCSC genome browser More...UCSCⁱ	uc007xvc.2 mouse [P18911-2] uc007xvd.2 mouse [P18911-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P18911	Retinoic acid receptor gamma (Fragment)		MOUSE		227	UniRef100_P18911

Protein	Similar proteins		Species	Score	Length	Source
P18911	Retinoic acid receptor gamma (Fragment)		MOUSE		227	UniRef90_P18911
Uncharacterized protein		COLAP		461
Uncharacterized protein		FELCA		459
Uncharacterized protein		PROCO		458
retinoic acid receptor gamma isoform X1		PHYCD		458
+123
P18911-2	LOW QUALITY PROTEIN: retinoic acid receptor gamma		ODORO		584	UniRef90_P18911-2
retinoic acid receptor gamma isoform X4		LEPWE		386
Retinoic acid receptor, gamma		RAT		485
retinoic acid receptor gamma isoform X2		DIPOR		485
retinoic acid receptor gamma isoform X1		MESAU		447
+22
P18911-3	Uncharacterized protein		CAVPO		444	UniRef90_P18911-3
Retinoic acid receptor beta		ALLMI		399
UPI000695C7CE		CHILA		486
UPI00062AB787		OCTDE		444
UPI000981988D		CASCN		433
+1

Protein	Similar proteins		Species	Score	Length	Source
P18911	Retinoic acid receptor gamma-B		DANRE		489	UniRef50_P18911
Retinoic acid receptor gamma (Fragment)		MOUSE		227
Uncharacterized protein		COLAP		461
Uncharacterized protein		FELCA		459
Retinoic acid receptor gamma		SHEEP		458
+523
P18911-2	Retinoic acid receptor alpha	)	HUMAN		462	UniRef50_P10276
Retinoic acid receptor gamma-A		DANRE		499
Retinoic acid receptor alpha isoform 1		MACMU		462
RARA isoform 2		PANTR		462
Retinoic acid receptor alpha		RHIBE		462
+195
P18911-3	Isoform Alpha-2 of Retinoic acid receptor alpha		MOUSE		459	UniRef50_P11416-2
Retinoic acid receptor alpha		CHICK		460
Retinoic acid receptor beta		COTJA		455
Retinoic acid receptor beta	)	HUMAN		455
Retinoic acid receptor gamma		XENLA		476
+599

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X15848 mRNA Translation: CAA33845.1 M34475 mRNA Translation: AAA40036.1 M34476 mRNA Translation: AAA40035.1 AK148064 mRNA Translation: BAE28323.1 BC012923 mRNA Translation: AAH12923.1 BC013709 mRNA Translation: AAH13709.1 M32068 mRNA Translation: AAA40032.1 M32069 mRNA Translation: AAA40033.1 M32070 mRNA Translation: AAA40034.1
CCDSⁱ	CCDS27875.1 [P18911-1] CCDS37226.1 [P18911-2]
PIRⁱ	B34714 S05052 A34714
RefSeqⁱ	NP_001036192.1, NM_001042727.2 [P18911-2] NP_035374.3, NM_011244.4 [P18911-1] XP_006520713.1, XM_006520650.1 [P18911-1] XP_011243827.1, XM_011245525.2 [P18911-1]
UniGeneⁱ	Mm.1273

3D structure databases

ProteinModelPortalⁱ	P18911
SMRⁱ	P18911
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	202595, 4 interactors
DIPⁱ	DIP-42822N
IntActⁱ	P18911, 2 interactors
MINTⁱ	P18911
STRINGⁱ	10090.ENSMUSP00000048838

Chemistry databases

BindingDBⁱ	P18911
ChEMBLⁱ	CHEMBL4177
GuidetoPHARMACOLOGYⁱ	592

PTM databases

iPTMnetⁱ	P18911
PhosphoSitePlusⁱ	P18911

Proteomic databases

MaxQBⁱ	P18911
PaxDbⁱ	P18911
PeptideAtlasⁱ	P18911
PRIDEⁱ	P18911

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000043172; ENSMUSP00000048838; ENSMUSG00000001288 [P18911-1] ENSMUST00000063339; ENSMUSP00000067266; ENSMUSG00000001288 [P18911-2]
GeneIDⁱ	19411
KEGGⁱ	mmu:19411
UCSCⁱ	uc007xvc.2 mouse [P18911-2] uc007xvd.2 mouse [P18911-1]

Organism-specific databases

CTDⁱ	5916
MGIⁱ	MGI:97858 Rarg

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
GeneTreeⁱ	ENSGT00870000136372
HOGENOMⁱ	HOG000010312
HOVERGENⁱ	HBG005606
InParanoidⁱ	P18911
KOⁱ	K08529
OMAⁱ	QKVSKAH
OrthoDBⁱ	EOG091G0XCQ
PhylomeDBⁱ	P18911
TreeFamⁱ	TF328382

Enzyme and pathway databases

Reactomeⁱ	R-MMU-383280 Nuclear Receptor transcription pathway R-MMU-5362517 Signaling by Retinoic Acid

Reactomeⁱ

R-MMU-383280 Nuclear Receptor transcription pathway
R-MMU-5362517 Signaling by Retinoic Acid

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P18911
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000001288 Expressed in 330 organ(s), highest expression level in cranium
CleanExⁱ	MM_RARG
ExpressionAtlasⁱ	P18911 baseline and differential
Genevisibleⁱ	P18911 MM

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR003078 Retinoic_acid_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01292 RETNOICACIDR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RARG_MOUSE
Accessionⁱ	P18911Primary (citable) accession number: P18911 Secondary accession number(s): P20787 , Q3UG86, Q62149, Q91VK5, Q91YX2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
	Last sequence update:	February 5, 2008
	Last modified:	November 7, 2018
	This is version 187 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

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UniProtKB - P18911 (RARG_MOUSE)

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Retinoic acid receptor gamma

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

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GO - Biological processi

Enzyme and pathway databases

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Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Chemistry databases

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Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

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Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

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3D structure databases

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Domains and Repeats

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Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

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Chemistry databases

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Proteomic databases

Protocols and materials databases

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Enzyme and pathway databases

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Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ