D(1A) dopamine receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• angiotensin receptor binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Binding of losartan to angiotensin AT1 receptors increases dopamine D1 receptor activation."
    Li D., Scott L., Crambert S., Zelenin S., Eklof A.C., Di Ciano L., Ibarra F., Aperia A.
    J Am Soc Nephrol 23:421-428(2012) [PubMed] [Europe PMC] [Abstract]
• ATPase binding Source: RGDInferred from physical interactionⁱ
  • "Interaction of dopamine D1 receptor with N-ethylmaleimide-sensitive factor is important for the membrane localization of the receptor."
    Chen S., Liu F.
    J Neurosci Res 88:2504-2512(2010) [PubMed] [Europe PMC] [Abstract]
  • "Nearest neighbor analysis of dopamine D1 receptors and Na(+)-K(+)-ATPases in dendritic spines dissected by STED microscopy."
    Blom H., Ronnlund D., Scott L., Spicarova Z., Rantanen V., Widengren J., Aperia A., Brismar H.
    Microsc Res Tech 75:220-228(2012) [PubMed] [Europe PMC] [Abstract]
• D3 dopamine receptor binding Source: RGDInferred from physical interactionⁱ
  • "Aberrant D1 and D3 dopamine receptor transregulation in hypertension."
    Zeng C., Wang D., Asico L.D., Welch W.J., Wilcox C.S., Hopfer U., Eisner G.M., Felder R.A., Jose P.A.
    Hypertension 43:654-660(2004) [PubMed] [Europe PMC] [Abstract]
• dopamine binding Source: RGD
• dopamine neurotransmitter receptor activity Source: RGD
• dopamine neurotransmitter receptor activity, coupled via Gs Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Selective up-regulation of dopamine D1 receptors in dendritic spines by NMDA receptor activation."
    Scott L., Kruse M.S., Forssberg H., Brismar H., Greengard P., Aperia A.
    Proc Natl Acad Sci U S A 99:1661-1664(2002) [PubMed] [Europe PMC] [Abstract]
• G-protein alpha-subunit binding Source: RGDInferred from physical interactionⁱ
  • "Rosiglitazone restores renal D1A receptor-Gs protein coupling by reducing receptor hyperphosphorylation in obese rats."
    Trivedi M., Lokhandwala M.F.
    Am J Physiol Renal Physiol 289:F298-304(2005) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor activity Source: RGDInferred from direct assayⁱ
  • "Selective up-regulation of dopamine D1 receptors in dendritic spines by NMDA receptor activation."
    Scott L., Kruse M.S., Forssberg H., Brismar H., Greengard P., Aperia A.
    Proc Natl Acad Sci U S A 99:1661-1664(2002) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled serotonin receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• neurotransmitter receptor activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex binding Source: RGDInferred from physical interactionⁱ
  • "Calcyon forms a novel ternary complex with dopamine D1 receptor through PSD-95 protein and plays a role in dopamine receptor internalization."
    Ha C.M., Park D., Han J.K., Jang J.I., Park J.Y., Hwang E.M., Seok H., Chang S.
    J Biol Chem 287:31813-31822(2012) [PubMed] [Europe PMC] [Abstract]
  • "Reduced striatal dopamine D1-D2 receptor heteromer expression and behavioural subsensitivity in juvenile rats."
    Perreault M.L., Hasbi A., Alijaniaram M., O'Dowd B.F., George S.R.
    Neuroscience 225:130-139(2012) [PubMed] [Europe PMC] [Abstract]
• protein phosphatase binding Source: RGDInferred from physical interactionⁱ
  • "Persistent activation of the D1R/Shp-2/Erk1/2 pathway in l-DOPA-induced dyskinesia in the 6-hydroxy-dopamine rat model of Parkinson's disease."
    Fiorentini C., Savoia P., Savoldi D., Barbon A., Missale C.
    Neurobiol Dis 54:339-348(2013) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: RGDInferred from physical interactionⁱ
  • "Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor."
    Lee F.J., Xue S., Pei L., Vukusic B., Chery N., Wang Y., Wang Y.T., Niznik H.B., Yu X.M., Liu F.
    Cell 111:219-230(2002) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• activation of adenylate cyclase activity Source: RGD
• adenylate cyclase-activating dopamine receptor signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization."
    Fiorentini C., Busi C., Gorruso E., Gotti C., Spano P., Missale C.
    Mol Pharmacol 74:59-69(2008) [PubMed] [Europe PMC] [Abstract]
  • "Dopamine D1A receptor regulation of phospholipase C isoform."
    Yu P.Y., Eisner G.M., Yamaguchi I., Mouradian M.M., Felder R.A., Jose P.A.
    J Biol Chem 271:19503-19508(1996) [PubMed] [Europe PMC] [Abstract]
• adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: RGD
• adult walking behavior Source: RGD
• associative learning Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Involvement of D1 dopamine receptors in the cognitive effects of angiotensin IV and des-Phe6 angiotensin IV."
    Braszko J.J.
    Peptides (N.Y.) 25:1195-1203(2004) [PubMed] [Europe PMC] [Abstract]
• astrocyte development Source: RGD
• behavioral fear response Source: RGD
• behavioral response to cocaine Source: RGDInferred from mutant phenotypeⁱ
  • "Cocaine-induced sex differences in D1 receptor activation and binding levels after acute cocaine administration."
    Festa E.D., Jenab S., Weiner J., Nazarian A., Niyomchai T., Russo S.J., Kemen L.M., Akhavan A., Wu H.B., Quinones-Jenab V.
    Brain Res Bull 68:277-284(2006) [PubMed] [Europe PMC] [Abstract]
• calcium-mediated signaling Source: RGDInferred from direct assayⁱ
  • "Potentiation of NMDA receptor currents by dopamine D1 receptors in prefrontal cortex."
    Chen G., Greengard P., Yan Z.
    Proc Natl Acad Sci U S A 101:2596-2600(2004) [PubMed] [Europe PMC] [Abstract]
• cellular response to catecholamine stimulus Source: RGD
• cellular response to dopamine Source: RGD
• cellular response to hypoxia Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Post-translational modification of glutamic acid decarboxylase 67 by intermittent hypoxia: evidence for the involvement of dopamine D1 receptor signaling."
    Raghuraman G., Prabhakar N.R., Kumar G.K.
    J Neurochem 115:1568-1578(2010) [PubMed] [Europe PMC] [Abstract]
• cellular response to insulin stimulus Source: RGDInferred from expression patternⁱ
  • "Dopamine-mediated inhibition of renal Na,K-ATPase is reduced by insulin."
    Banday A.A., Asghar M., Hussain T., Lokhandwala M.F.
    Hypertension 41:1353-1358(2003) [PubMed] [Europe PMC] [Abstract]
• cerebral cortex GABAergic interneuron migration Source: RGD
• chemical synaptic transmission Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• conditioned taste aversion Source: RGD
• dentate gyrus development Source: RGD
• dopamine receptor signaling pathway Source: RGD
• dopamine transport Source: RGD
• eating behavior Source: RGDInferred from direct assayⁱ
  • "Wake-promoting actions of dopamine D1 and D2 receptor stimulation."
    Isaac S.O., Berridge C.W.
    J Pharmacol Exp Ther 307:386-394(2003) [PubMed] [Europe PMC] [Abstract]
• feeding behavior Source: RGD
• glucose import Source: RGD
• G protein-coupled receptor signaling pathway Source: RGD
• G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: RGD
• grooming behavior Source: RGDInferred from direct assayⁱ
  • "Wake-promoting actions of dopamine D1 and D2 receptor stimulation."
    Isaac S.O., Berridge C.W.
    J Pharmacol Exp Ther 307:386-394(2003) [PubMed] [Europe PMC] [Abstract]
• habituation Source: RGD
• hippocampus development Source: RGD
• histone H3-S10 phosphorylation Source: RGD
• intracellular protein transport Source: RGDInferred from mutant phenotypeⁱ
  • "Dopamine D1 activation potentiates striatal NMDA receptors by tyrosine phosphorylation-dependent subunit trafficking."
    Hallett P.J., Spoelgen R., Hyman B.T., Standaert D.G., Dunah A.W.
    J Neurosci 26:4690-4700(2006) [PubMed] [Europe PMC] [Abstract]
• learning Source: RGD
• locomotory behavior Source: RGDInferred from mutant phenotypeⁱ
  • "Cocaine-induced sex differences in D1 receptor activation and binding levels after acute cocaine administration."
    Festa E.D., Jenab S., Weiner J., Nazarian A., Niyomchai T., Russo S.J., Kemen L.M., Akhavan A., Wu H.B., Quinones-Jenab V.
    Brain Res Bull 68:277-284(2006) [PubMed] [Europe PMC] [Abstract]
• long-term synaptic depression Source: RGD
• long-term synaptic potentiation Source: RGD
• maternal behavior Source: RGD
• mating behavior Source: RGD
• memory Source: RGD
• modification of postsynaptic structure Source: RGD
• muscle contraction Source: RGD
• negative regulation of cell death Source: RGDInferred from direct assayⁱ
  • "Modulation of Postnatal Neurogenesis by Perinatal Asphyxia: Effect of D₁ and D₂ Dopamine Receptor Agonists."
    Tapia-Bustos A., Perez-Lobos R., Vio V., Lespay-Rebolledo C., Palacios E., Chiti-Morales A., Bustamante D., Herrera-Marschitz M., Morales P.
    Neurotox Res 31:109-121(2017) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell migration Source: RGDInferred from mutant phenotypeⁱ
  • "Dopamine as a novel anti-migration factor of vascular smooth muscle cells through D1A and D1B receptors."
    Yasunari K., Maeda K., Nakamura M., Yoshikawa J.
    J Cardiovasc Pharmacol 41 Suppl 1:S33-8(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of circadian sleep/wake cycle, sleep Source: RGDInferred from direct assayⁱ
  • "Wake-promoting actions of dopamine D1 and D2 receptor stimulation."
    Isaac S.O., Berridge C.W.
    J Pharmacol Exp Ther 307:386-394(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of protein kinase activity Source: RGDInferred from mutant phenotypeⁱ
  • "Dopamine as a novel anti-migration factor of vascular smooth muscle cells through D1A and D1B receptors."
    Yasunari K., Maeda K., Nakamura M., Yoshikawa J.
    J Cardiovasc Pharmacol 41 Suppl 1:S33-8(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of synaptic transmission Source: RGDInferred from direct assayⁱ
  • "Dopaminergic regulation of inhibitory and excitatory transmission in the basolateral amygdala-prefrontal cortical pathway."
    Floresco S.B., Tse M.T.
    J Neurosci 27:2045-2057(2007) [PubMed] [Europe PMC] [Abstract]
• neuronal action potential Source: RGD
• operant conditioning Source: RGDInferred from mutant phenotypeⁱ
  • "Involvement of D1 dopamine receptors in the cognitive effects of angiotensin IV and des-Phe6 angiotensin IV."
    Braszko J.J.
    Peptides (N.Y.) 25:1195-1203(2004) [PubMed] [Europe PMC] [Abstract]
• orbitofrontal cortex development Source: RGDInferred from expression patternⁱ
  • "Expression and function of dopamine receptors in the developing medial frontal cortex and striatum of the rat."
    Sillivan S.E., Konradi C.
    Neuroscience 199:501-514(2011) [PubMed] [Europe PMC] [Abstract]
• peristalsis Source: RGD
• phospholipase C-activating dopamine receptor signaling pathway Source: RGD
• positive regulation of cell migration Source: RGD
• positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Source: RGD
• positive regulation of feeding behavior Source: RGDInferred from mutant phenotypeⁱ
  • "Hypothalamic dopaminergic receptor expressions in anorexia of tumor-bearing rats."
    Sato T., Meguid M.M., Fetissov S.O., Chen C., Zhang L.
    Am J Physiol Regul Integr Comp Physiol 281:R1907-16(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: RGD
• positive regulation of long-term synaptic potentiation Source: RGDInferred from mutant phenotypeⁱ
  • "Dopamine receptor mechanisms mediate corticotropin-releasing factor-induced long-term potentiation in the rat amygdala following cocaine withdrawal."
    Krishnan B., Centeno M., Pollandt S., Fu Y., Genzer K., Liu J., Gallagher J.P., Shinnick-Gallagher P.
    Eur J Neurosci 31:1027-1042(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of membrane potential Source: RGDInferred from mutant phenotypeⁱ
  • "D1 and D4 dopaminergic receptor interplay mediates coincident G protein-independent and dependent regulation of glutamate NMDA receptors in the lateral amygdala."
    Martina M., Bergeron R.
    J Neurochem 106:2421-2435(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein phosphorylation Source: RGDInferred from direct assayⁱ
  • "Dopaminergic and cholinergic regulation of Fyn tyrosine kinase phosphorylation in the rat striatum in vivo."
    Mao L.M., Wang J.Q.
    Neuropharmacology 99:491-499(2015) [PubMed] [Europe PMC] [Abstract]
• positive regulation of release of sequestered calcium ion into cytosol Source: RGD
• positive regulation of synaptic transmission, glutamatergic Source: RGD
• postsynaptic modulation of chemical synaptic transmission Source: SynGOInferred from direct assayⁱ
  • "Dopamine-glutamate interactions controlling prefrontal cortical pyramidal cell excitability involve multiple signaling mechanisms."
    Tseng K.Y., O'Donnell P.
    J Neurosci 24:5131-5139(2004) [PubMed] [Europe PMC] [Abstract]
• protein import into nucleus Source: RGD
• regulation of dopamine metabolic process Source: RGD
• regulation of ion transport Source: RGDInferred from direct assayⁱ
  • "Potentiation of NMDA receptor currents by dopamine D1 receptors in prefrontal cortex."
    Chen G., Greengard P., Yan Z.
    Proc Natl Acad Sci U S A 101:2596-2600(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of protein phosphorylation Source: RGD
• regulation of synaptic vesicle exocytosis Source: RGD
• regulation of vasoconstriction Source: RGDInferred from mutant phenotypeⁱ
  • "The role of dopamine in a model of trigeminovascular nociception."
    Akerman S., Goadsby P.J.
    J Pharmacol Exp Ther 314:162-169(2005) [PubMed] [Europe PMC] [Abstract]
• response to activity Source: RGDInferred from expression patternⁱ
  • "Exercise activates redox-sensitive transcription factors and restores renal D1 receptor function in old rats."
    George L., Lokhandwala M.F., Asghar M.
    Am J Physiol Renal Physiol 297:F1174-80(2009) [PubMed] [Europe PMC] [Abstract]
• response to amino acid Source: RGDInferred from expression patternⁱ
  • "Co-regulation of dopamine D1 receptor and uncoupling protein-2 expression in 3-nitropropionic acid-induced neurotoxicity: neuroprotective role of L-carnitine."
    Binienda Z.K., Ali S.F., Virmani A., Amato A., Salem N., Przybyla B.D.
    Neurosci Lett 410:62-65(2006) [PubMed] [Europe PMC] [Abstract]
• response to amphetamine Source: RGDInferred from expression patternⁱ
  • "Amphetamine-induced changes in dopamine receptors in early postnatal rat brain."
    Mukda S., Kaewsuk S., Ebadi M., Govitrapong P.
    Dev Neurosci 31:193-201(2009) [PubMed] [Europe PMC] [Abstract]
• response to cocaine Source: RGD
• response to drug Source: RGDInferred from expression patternⁱ
  • "Rosiglitazone restores renal D1A receptor-Gs protein coupling by reducing receptor hyperphosphorylation in obese rats."
    Trivedi M., Lokhandwala M.F.
    Am J Physiol Renal Physiol 289:F298-304(2005) [PubMed] [Europe PMC] [Abstract]
  • "Repeated treatment with antidepressants enhances dopamine D1 receptor gene expression in the rat brain."
    Huzarska M., Zielinski M., Herman Z.S.
    Eur J Pharmacol 532:208-213(2006) [PubMed] [Europe PMC] [Abstract]
• response to estradiol Source: RGDInferred from expression patternⁱ
  • "Estradiol replacement alters expression of genes related to neurotransmission and immune surveillance in the frontal cortex of middle-aged, ovariectomized rats."
    Sarvari M., Kallo I., Hrabovszky E., Solymosi N., Toth K., Liko I., Molnar B., Tihanyi K., Liposits Z.
    Endocrinology 151:3847-3862(2010) [PubMed] [Europe PMC] [Abstract]
• response to ethanol Source: RGDInferred from expression patternⁱ
  • "MicroRNA expression profile and functional analysis reveal that miR-382 is a critical novel gene of alcohol addiction."
    Li J., Li J., Liu X., Qin S., Guan Y., Liu Y., Cheng Y., Chen X., Li W., Wang S., Xiong M., Kuzhikandathil E.V., Ye J.H., Zhang C.
    EMBO Mol Med 5:1402-1414(2013) [PubMed] [Europe PMC] [Abstract]
• response to food Source: RGDInferred from expression patternⁱ
  • "Dopamine D1 receptor gene expression decreases in the nucleus accumbens upon long-term exposure to palatable food and differs depending on diet-induced obesity phenotype in rats."
    Alsio J., Olszewski P.K., Norback A.H., Gunnarsson Z.E., Levine A.S., Pickering C., Schioth H.B.
    Neuroscience 171:779-787(2010) [PubMed] [Europe PMC] [Abstract]
• response to morphine Source: RGDInferred from expression patternⁱ
  • "Mesoaccumbens dopamine signaling alteration underlies behavioral transition from tolerance to sensitization to morphine rewarding properties during morphine withdrawal."
    Sun L., Hu L., Li Y., Cui C.
    Brain Struct Funct 219:1755-1771(2014) [PubMed] [Europe PMC] [Abstract]
• response to nicotine Source: RGDInferred from expression patternⁱ
  • "The epigenetic effect of nicotine on dopamine D1 receptor expression in rat prefrontal cortex."
    Gozen O., Balkan B., Yildirim E., Koylu E.O., Pogun S.
    Synapse 67:545-552(2013) [PubMed] [Europe PMC] [Abstract]
• response to organic cyclic compound Source: RGDInferred from expression patternⁱ
  • "Differential treatment regimen-related effects of cannabinoids on D1 and D2 receptors in adolescent and adult rat brain."
    Dalton V.S., Zavitsanou K.
    J Chem Neuroanat 40:272-280(2010) [PubMed] [Europe PMC] [Abstract]
• response to organonitrogen compound Source: RGDInferred from expression patternⁱ
  • "Transcription factor Nrf2 protects renal dopamine D1 receptor function during oxidative stress."
    Banday A.A., Lokhandwala M.F.
    Hypertension 62:512-517(2013) [PubMed] [Europe PMC] [Abstract]
• response to retinoic acid Source: RGDInferred from expression patternⁱ
  • "Regulation of multiple dopamine signal transduction molecules by retinoids in the developing striatum."
    Wang H.F., Liu F.C.
    Neuroscience 134:97-105(2005) [PubMed] [Europe PMC] [Abstract]
• response to steroid hormone Source: RGDInferred from expression patternⁱ
  • "The anabolic androgenic steroid nandrolone decanoate affects mRNA expression of dopaminergic but not serotonergic receptors."
    Birgner C., Kindlundh-Hogberg A.M., Alsio J., Lindblom J., Schioth H.B., Bergstrom L.
    Brain Res 1240:221-228(2008) [PubMed] [Europe PMC] [Abstract]
• sensitization Source: RGD
• social behavior Source: RGDInferred from mutant phenotypeⁱ
  • "Requirement for the endocannabinoid system in social interaction impairment induced by coactivation of dopamine D1 and D2 receptors in the piriform cortex."
    Zenko M., Zhu Y., Dremencov E., Ren W., Xu L., Zhang X.
    J Neurosci Res 89:1245-1258(2011) [PubMed] [Europe PMC] [Abstract]
• striatum development Source: RGDInferred from expression patternⁱ
  • "Expression and function of dopamine receptors in the developing medial frontal cortex and striatum of the rat."
    Sillivan S.E., Konradi C.
    Neuroscience 199:501-514(2011) [PubMed] [Europe PMC] [Abstract]
• synapse assembly Source: BHF-UCLInferred from expression patternⁱ
  • "D1- and D2-like dopamine receptors are co-localized on the presynaptic varicosities of striatal and nucleus accumbens neurons in vitro."
    Wong A.C., Shetreat M.E., Clarke J.O., Rayport S.
    Neuroscience 89:221-233(1999) [PubMed] [Europe PMC] [Abstract]
• synaptic transmission, dopaminergic Source: RGD
• temperature homeostasis Source: RGD
• transmission of nerve impulse Source: RGD
• vasodilation Source: InterPro
• visual learning Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• angiotensin receptor binding Source: RGDInferred from physical interactionⁱ
  • "Binding of losartan to angiotensin AT1 receptors increases dopamine D1 receptor activation."
    Li D., Scott L., Crambert S., Zelenin S., Eklof A.C., Di Ciano L., Ibarra F., Aperia A.
    J Am Soc Nephrol 23:421-428(2012) [PubMed] [Europe PMC] [Abstract]
• ATPase binding Source: RGDInferred from physical interactionⁱ
  • "Interaction of dopamine D1 receptor with N-ethylmaleimide-sensitive factor is important for the membrane localization of the receptor."
    Chen S., Liu F.
    J Neurosci Res 88:2504-2512(2010) [PubMed] [Europe PMC] [Abstract]
  • "Nearest neighbor analysis of dopamine D1 receptors and Na(+)-K(+)-ATPases in dendritic spines dissected by STED microscopy."
    Blom H., Ronnlund D., Scott L., Spicarova Z., Rantanen V., Widengren J., Aperia A., Brismar H.
    Microsc Res Tech 75:220-228(2012) [PubMed] [Europe PMC] [Abstract]
• D3 dopamine receptor binding Source: RGDInferred from physical interactionⁱ
  • "Aberrant D1 and D3 dopamine receptor transregulation in hypertension."
    Zeng C., Wang D., Asico L.D., Welch W.J., Wilcox C.S., Hopfer U., Eisner G.M., Felder R.A., Jose P.A.
    Hypertension 43:654-660(2004) [PubMed] [Europe PMC] [Abstract]
• G-protein alpha-subunit binding Source: RGDInferred from physical interactionⁱ
  • "Rosiglitazone restores renal D1A receptor-Gs protein coupling by reducing receptor hyperphosphorylation in obese rats."
    Trivedi M., Lokhandwala M.F.
    Am J Physiol Renal Physiol 289:F298-304(2005) [PubMed] [Europe PMC] [Abstract]
• protein phosphatase binding Source: RGDInferred from physical interactionⁱ
  • "Persistent activation of the D1R/Shp-2/Erk1/2 pathway in l-DOPA-induced dyskinesia in the 6-hydroxy-dopamine rat model of Parkinson's disease."
    Fiorentini C., Savoia P., Savoldi D., Barbon A., Missale C.
    Neurobiol Dis 54:339-348(2013) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: RGDInferred from physical interactionⁱ
  • "Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor."
    Lee F.J., Xue S., Pei L., Vukusic B., Chery N., Wang Y., Wang Y.T., Niznik H.B., Yu X.M., Liu F.
    Cell 111:219-230(2002) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MAPNTSTMDE AGLPAERDFS FRILTACFLS LLILSTLLGN TLVCAAVIRF 
        60         70         80         90        100
RHLRSKVTNF FVISLAVSDL LVAVLVMPWK AVAEIAGFWP LGPFCNIWVA 
       110        120        130        140        150
FDIMCSTASI LNLCVISVDR YWAISSPFQY ERKMTPKAAF ILISVAWTLS 
       160        170        180        190        200
VLISFIPVQL SWHKAKPTWP LDGNFTSLED TEDDNCDTRL SRTYAISSSL 
       210        220        230        240        250
ISFYIPVAIM IVTYTSIYRI AQKQIRRISA LERAAVHAKN CQTTAGNGNP 
       260        270        280        290        300
VECAQSESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI SNCMVPFCGS 
       310        320        330        340        350
EETQPFCIDS ITFDVFVWFG WANSSLNPII YAFNADFQKA FSTLLGCYRL 
       360        370        380        390        400
CPTTNNAIET VSINNNGAVV FSSHHEPRGS ISKDCNLVYL IPHAVGSSED 
       410        420        430        440 
LKKEEAGGIA KPLEKLSPAL SVILDYDTDV SLEKIQPVTH SGQHST     

Experimental Info

Sequence databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries
2. SIMILARITY comments
   Index of protein domains and families