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UniProtKB - P18901 (DRD1_RAT)
Protein
D(1A) dopamine receptor
Gene
Drd1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
GO - Molecular functioni
- angiotensin receptor binding Source: RGD
- ATPase binding Source: RGD
- D3 dopamine receptor binding Source: RGD
- dopamine binding Source: RGD
- dopamine neurotransmitter receptor activity Source: RGD
- dopamine neurotransmitter receptor activity, coupled via Gs Source: RGD
- G-protein alpha-subunit binding Source: RGD
- G protein-coupled receptor activity Source: RGD
- G protein-coupled serotonin receptor activity Source: GO_Central
- heterocyclic compound binding Source: RGD
- neurotransmitter receptor activity Source: GO_Central
- protein-containing complex binding Source: RGD
- protein phosphatase binding Source: RGD
- signaling receptor binding Source: RGD
GO - Biological processi
- activation of adenylate cyclase activity Source: RGD
- adenylate cyclase-activating dopamine receptor signaling pathway Source: BHF-UCL
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: RGD
- adult walking behavior Source: RGD
- associative learning Source: RGD
- astrocyte development Source: RGD
- behavioral fear response Source: RGD
- behavioral response to cocaine Source: RGD
- calcium-mediated signaling Source: RGD
- cellular response to catecholamine stimulus Source: RGD
- cellular response to dopamine Source: RGD
- cellular response to hypoxia Source: RGD
- cellular response to insulin stimulus Source: RGD
- cerebral cortex GABAergic interneuron migration Source: RGD
- chemical synaptic transmission Source: GO_Central
- conditioned taste aversion Source: RGD
- dentate gyrus development Source: RGD
- dopamine receptor signaling pathway Source: RGD
- dopamine transport Source: RGD
- eating behavior Source: RGD
- feeding behavior Source: RGD
- glucose import Source: RGD
- G protein-coupled receptor signaling pathway Source: RGD
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: RGD
- grooming behavior Source: RGD
- habituation Source: RGD
- hippocampus development Source: RGD
- histone H3-S10 phosphorylation Source: RGD
- intracellular protein transport Source: RGD
- learning Source: RGD
- locomotory behavior Source: RGD
- long-term synaptic depression Source: RGD
- long-term synaptic potentiation Source: RGD
- maternal behavior Source: RGD
- mating behavior Source: RGD
- memory Source: RGD
- modification of postsynaptic structure Source: RGD
- muscle contraction Source: RGD
- negative regulation of cell death Source: RGD
- negative regulation of cell migration Source: RGD
- negative regulation of circadian sleep/wake cycle, sleep Source: RGD
- negative regulation of protein kinase activity Source: RGD
- negative regulation of synaptic transmission Source: RGD
- neuronal action potential Source: RGD
- operant conditioning Source: RGD
- orbitofrontal cortex development Source: RGD
- peristalsis Source: RGD
- phospholipase C-activating dopamine receptor signaling pathway Source: RGD
- positive regulation of cell migration Source: RGD
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Source: RGD
- positive regulation of feeding behavior Source: RGD
- positive regulation of gene expression Source: RGD
- positive regulation of long-term synaptic potentiation Source: RGD
- positive regulation of membrane potential Source: RGD
- positive regulation of protein phosphorylation Source: RGD
- positive regulation of release of sequestered calcium ion into cytosol Source: RGD
- positive regulation of synaptic transmission, glutamatergic Source: RGD
- postsynaptic modulation of chemical synaptic transmission Source: SynGO
- protein import into nucleus Source: RGD
- regulation of dopamine metabolic process Source: RGD
- regulation of ion transport Source: RGD
- regulation of protein phosphorylation Source: RGD
- regulation of synaptic vesicle exocytosis Source: RGD
- regulation of vasoconstriction Source: RGD
- response to activity Source: RGD
- response to amino acid Source: RGD
- response to amphetamine Source: RGD
- response to cocaine Source: RGD
- response to estradiol Source: RGD
- response to ethanol Source: RGD
- response to food Source: RGD
- response to morphine Source: RGD
- response to nicotine Source: RGD
- response to organic cyclic compound Source: RGD
- response to organonitrogen compound Source: RGD
- response to retinoic acid Source: RGD
- response to steroid hormone Source: RGD
- response to xenobiotic stimulus Source: RGD
- sensitization Source: RGD
- social behavior Source: RGD
- striatum development Source: RGD
- synapse assembly Source: BHF-UCL
- synaptic transmission, dopaminergic Source: RGD
- temperature homeostasis Source: RGD
- transmission of nerve impulse Source: RGD
- vasodilation Source: InterPro
- visual learning Source: RGD
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: D(1A) dopamine receptorAlternative name(s): Dopamine D1 receptor |
Gene namesi | Name:Drd1 Synonyms:Drd1a |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2518, Drd1 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication
Other locations
- dendrite By similarity
- dendritic spine By similarity
Note: Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14.1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: RGD
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Nucleus
- nucleus Source: RGD
Plasma Membrane
- caveola Source: RGD
- ciliary membrane Source: RGD
- integral component of plasma membrane Source: GO_Central
- integral component of postsynaptic membrane Source: SynGO
- integral component of presynaptic membrane Source: SynGO
- plasma membrane Source: BHF-UCL
Other locations
- axon Source: RGD
- axon terminus Source: RGD
- cell surface Source: RGD
- cilium Source: RGD
- cytoplasm Source: RGD
- dendrite Source: RGD
- dendritic shaft Source: RGD
- dendritic spine Source: RGD
- dendritic spine head Source: RGD
- dendritic spine neck Source: RGD
- endomembrane system Source: RGD
- GABA-ergic synapse Source: RGD
- glutamatergic synapse Source: SynGO
- integral component of membrane Source: RGD
- membrane Source: RGD
- neuronal cell body Source: RGD
- non-motile cilium Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 22 | ExtracellularSequence analysisAdd BLAST | 22 | |
Transmembranei | 23 – 48 | Helical; Name=1Sequence analysisAdd BLAST | 26 | |
Topological domaini | 49 – 59 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 60 – 86 | Helical; Name=2Sequence analysisAdd BLAST | 27 | |
Topological domaini | 87 – 95 | ExtracellularSequence analysis | 9 | |
Transmembranei | 96 – 118 | Helical; Name=3Sequence analysisAdd BLAST | 23 | |
Topological domaini | 119 – 137 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 138 – 162 | Helical; Name=4Sequence analysisAdd BLAST | 25 | |
Topological domaini | 163 – 192 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 193 – 218 | Helical; Name=5Sequence analysisAdd BLAST | 26 | |
Topological domaini | 219 – 272 | CytoplasmicSequence analysisAdd BLAST | 54 | |
Transmembranei | 273 – 299 | Helical; Name=6Sequence analysisAdd BLAST | 27 | |
Topological domaini | 300 – 312 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 313 – 337 | Helical; Name=7Sequence analysisAdd BLAST | 25 | |
Topological domaini | 338 – 446 | CytoplasmicSequence analysisAdd BLAST | 109 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Endoplasmic reticulum, Membrane, SynapsePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 333 | F → A: Loss of interaction with DNAJC14. Abolishes transport to the cell surface. 1 Publication | 1 | |
Mutagenesisi | 337 | F → A: Loss of interaction with DNAJC14. Abolishes transport to the cell surface. 1 Publication | 1 | |
Mutagenesisi | 341 | F → A: Loss of interaction with DNAJC14. Abolishes transport to the cell surface. 1 Publication | 1 |
Chemistry databases
ChEMBLi | CHEMBL265 |
DrugCentrali | P18901 |
GuidetoPHARMACOLOGYi | 214 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069378 | 1 – 446 | D(1A) dopamine receptorAdd BLAST | 446 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 4 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 95 ↔ 186 | PROSITE-ProRule annotation | ||
Lipidationi | 347 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 351 | S-palmitoyl cysteineBy similarity | 1 |
Post-translational modificationi
N-glycosylated.1 Publication
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | P18901 |
PTM databases
GlyGeni | P18901, 1 site |
iPTMneti | P18901 |
PhosphoSitePlusi | P18901 |
Expressioni
Tissue specificityi
Brain, in the striatum, the nucleus accumbens, and the olfactory tubercle.
Interactioni
Subunit structurei
Interacts with DNAJC14 via its C-terminus (PubMed:11331877).
Interacts with DRD2 (By similarity).
By similarity1 PublicationGO - Molecular functioni
- angiotensin receptor binding Source: RGD
- ATPase binding Source: RGD
- D3 dopamine receptor binding Source: RGD
- G-protein alpha-subunit binding Source: RGD
- protein phosphatase binding Source: RGD
- signaling receptor binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 246496, 5 interactors |
CORUMi | P18901 |
DIPi | DIP-49024N |
IntActi | P18901, 2 interactors |
STRINGi | 10116.ENSRNOP00000034820 |
Chemistry databases
BindingDBi | P18901 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
InParanoidi | P18901 |
PhylomeDBi | P18901 |
Family and domain databases
InterProi | View protein in InterPro IPR001413, Dopamine_D1_rcpt IPR000929, Dopamine_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00565, DOPAMINED1AR PR00242, DOPAMINER PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P18901-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPNTSTMDE AGLPAERDFS FRILTACFLS LLILSTLLGN TLVCAAVIRF
60 70 80 90 100
RHLRSKVTNF FVISLAVSDL LVAVLVMPWK AVAEIAGFWP LGPFCNIWVA
110 120 130 140 150
FDIMCSTASI LNLCVISVDR YWAISSPFQY ERKMTPKAAF ILISVAWTLS
160 170 180 190 200
VLISFIPVQL SWHKAKPTWP LDGNFTSLED TEDDNCDTRL SRTYAISSSL
210 220 230 240 250
ISFYIPVAIM IVTYTSIYRI AQKQIRRISA LERAAVHAKN CQTTAGNGNP
260 270 280 290 300
VECAQSESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI SNCMVPFCGS
310 320 330 340 350
EETQPFCIDS ITFDVFVWFG WANSSLNPII YAFNADFQKA FSTLLGCYRL
360 370 380 390 400
CPTTNNAIET VSINNNGAVV FSSHHEPRGS ISKDCNLVYL IPHAVGSSED
410 420 430 440
LKKEEAGGIA KPLEKLSPAL SVILDYDTDV SLEKIQPVTH SGQHST
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V933 | G3V933_RAT | D(1A) dopamine receptor | Drd1 Drd1a, rCG_24308 | 446 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 91 | L → F (PubMed:1402930).Curated | 1 | |
Sequence conflicti | 93 | P → S (PubMed:1402930).Curated | 1 | |
Sequence conflicti | 165 | A → T (PubMed:2168520).Curated | 1 | |
Sequence conflicti | 190 | L → F (PubMed:2168520).Curated | 1 | |
Sequence conflicti | 227 | R → G (PubMed:2168520).Curated | 1 | |
Sequence conflicti | 253 | C → W (PubMed:2168520).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M35077 mRNA Translation: AAA70428.1 S46131 Genomic DNA Translation: AAB23803.1 |
PIRi | A36049, DYRTD1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M35077 mRNA Translation: AAA70428.1 S46131 Genomic DNA Translation: AAB23803.1 |
PIRi | A36049, DYRTD1 |
3D structure databases
AlphaFoldDBi | P18901 |
SMRi | P18901 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 246496, 5 interactors |
CORUMi | P18901 |
DIPi | DIP-49024N |
IntActi | P18901, 2 interactors |
STRINGi | 10116.ENSRNOP00000034820 |
Chemistry databases
BindingDBi | P18901 |
ChEMBLi | CHEMBL265 |
DrugCentrali | P18901 |
GuidetoPHARMACOLOGYi | 214 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P18901, 1 site |
iPTMneti | P18901 |
PhosphoSitePlusi | P18901 |
Proteomic databases
PaxDbi | P18901 |
Organism-specific databases
RGDi | 2518, Drd1 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
InParanoidi | P18901 |
PhylomeDBi | P18901 |
Miscellaneous databases
PROi | PR:P18901 |
Family and domain databases
InterProi | View protein in InterPro IPR001413, Dopamine_D1_rcpt IPR000929, Dopamine_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00565, DOPAMINED1AR PR00242, DOPAMINER PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DRD1_RAT | |
Accessioni | P18901Primary (citable) accession number: P18901 Secondary accession number(s): P21669 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | May 1, 1991 | |
Last modified: | May 25, 2022 | |
This is version 166 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families