D(1A) dopamine receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• angiotensin receptor binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Binding of losartan to angiotensin AT1 receptors increases dopamine D1 receptor activation."
    Li D., Scott L., Crambert S., Zelenin S., Eklof A.C., Di Ciano L., Ibarra F., Aperia A.
    J. Am. Soc. Nephrol. 23:421-428(2012) [PubMed] [Europe PMC] [Abstract]
• ATPase binding Source: RGDInferred from physical interactionⁱ
  • "Interaction of dopamine D1 receptor with N-ethylmaleimide-sensitive factor is important for the membrane localization of the receptor."
    Chen S., Liu F.
    J. Neurosci. Res. 88:2504-2512(2010) [PubMed] [Europe PMC] [Abstract]
  • "Nearest neighbor analysis of dopamine D1 receptors and Na(+)-K(+)-ATPases in dendritic spines dissected by STED microscopy."
    Blom H., Ronnlund D., Scott L., Spicarova Z., Rantanen V., Widengren J., Aperia A., Brismar H.
    Microsc. Res. Tech. 75:220-228(2012) [PubMed] [Europe PMC] [Abstract]
• D3 dopamine receptor binding Source: RGDInferred from physical interactionⁱ
  • "Aberrant D1 and D3 dopamine receptor transregulation in hypertension."
    Zeng C., Wang D., Asico L.D., Welch W.J., Wilcox C.S., Hopfer U., Eisner G.M., Felder R.A., Jose P.A.
    Hypertension 43:654-660(2004) [PubMed] [Europe PMC] [Abstract]
• dopamine binding Source: RGDInferred from sequence orthologyⁱ
  • "Cholera toxin-sensitive 3',5'-cyclic adenosine monophosphate and calcium signals of the human dopamine-D1 receptor: selective potentiation by protein kinase A."
    Liu Y.F., Civelli O., Zhou Q.Y., Albert P.R.
    Mol. Endocrinol. 6:1815-1824(1992) [PubMed] [Europe PMC] [Abstract]
• dopamine neurotransmitter receptor activity Source: RGDInferred from sequence orthologyⁱ
  • "Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor."
    Tiberi M., Jarvie K.R., Silvia C., Falardeau P., Gingrich J.A., Godinot N., Bertrand L., Yang-Feng T.L., Fremeau R.T. Jr., Caron M.G.
    Proc. Natl. Acad. Sci. U.S.A. 88:7491-7495(1991) [PubMed] [Europe PMC] [Abstract]
  • "Decrease of D2 receptor binding but increase in D2-stimulated G-protein activation, dopamine transporter binding and behavioural sensitization in brains of mice treated with a chronic escalating dose 'binge' cocaine administration paradigm."
    Bailey A., Metaxas A., Yoo J.H., McGee T., Kitchen I.
    Eur. J. Neurosci. 28:759-770(2008) [PubMed] [Europe PMC] [Abstract]
• dopamine neurotransmitter receptor activity, coupled via Gs Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Selective up-regulation of dopamine D1 receptors in dendritic spines by NMDA receptor activation."
    Scott L., Kruse M.S., Forssberg H., Brismar H., Greengard P., Aperia A.
    Proc. Natl. Acad. Sci. U.S.A. 99:1661-1664(2002) [PubMed] [Europe PMC] [Abstract]
  • "Dopaminergic regulation of inhibitory and excitatory transmission in the basolateral amygdala-prefrontal cortical pathway."
    Floresco S.B., Tse M.T.
    J. Neurosci. 27:2045-2057(2007) [PubMed] [Europe PMC] [Abstract]
• drug binding Source: RGDInferred from direct assayⁱ
  • "Dopamine D1/D5 receptors gate the acquisition of novel information through hippocampal long-term potentiation and long-term depression."
    Lemon N., Manahan-Vaughan D.
    J. Neurosci. 26:7723-7729(2006) [PubMed] [Europe PMC] [Abstract]
  • "Dopaminergic regulation of inhibitory and excitatory transmission in the basolateral amygdala-prefrontal cortical pathway."
    Floresco S.B., Tse M.T.
    J. Neurosci. 27:2045-2057(2007) [PubMed] [Europe PMC] [Abstract]
• G-protein alpha-subunit binding Source: RGDInferred from physical interactionⁱ
  • "Rosiglitazone restores renal D1A receptor-Gs protein coupling by reducing receptor hyperphosphorylation in obese rats."
    Trivedi M., Lokhandwala M.F.
    Am. J. Physiol. Renal Physiol. 289:F298-304(2005) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor activity Source: RGDInferred from direct assayⁱ
  • "Selective up-regulation of dopamine D1 receptors in dendritic spines by NMDA receptor activation."
    Scott L., Kruse M.S., Forssberg H., Brismar H., Greengard P., Aperia A.
    Proc. Natl. Acad. Sci. U.S.A. 99:1661-1664(2002) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled serotonin receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• neurotransmitter receptor activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex binding Source: RGDInferred from physical interactionⁱ
  • "Calcyon forms a novel ternary complex with dopamine D1 receptor through PSD-95 protein and plays a role in dopamine receptor internalization."
    Ha C.M., Park D., Han J.K., Jang J.I., Park J.Y., Hwang E.M., Seok H., Chang S.
    J. Biol. Chem. 287:31813-31822(2012) [PubMed] [Europe PMC] [Abstract]
  • "Reduced striatal dopamine D1-D2 receptor heteromer expression and behavioural subsensitivity in juvenile rats."
    Perreault M.L., Hasbi A., Alijaniaram M., O'Dowd B.F., George S.R.
    Neuroscience 225:130-139(2012) [PubMed] [Europe PMC] [Abstract]
• protein phosphatase binding Source: RGDInferred from physical interactionⁱ
  • "Persistent activation of the D1R/Shp-2/Erk1/2 pathway in l-DOPA-induced dyskinesia in the 6-hydroxy-dopamine rat model of Parkinson's disease."
    Fiorentini C., Savoia P., Savoldi D., Barbon A., Missale C.
    Neurobiol. Dis. 54:339-348(2013) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: RGDInferred from physical interactionⁱ
  • "Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor."
    Lee F.J., Xue S., Pei L., Vukusic B., Chery N., Wang Y., Wang Y.T., Niznik H.B., Yu X.M., Liu F.
    Cell 111:219-230(2002) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• activation of adenylate cyclase activity Source: RGDInferred from sequence orthologyⁱ
  • "Loss of G protein gamma 7 alters behavior and reduces striatal alpha(olf) level and cAMP production."
    Schwindinger W.F., Betz K.S., Giger K.E., Sabol A., Bronson S.K., Robishaw J.D.
    J. Biol. Chem. 278:6575-6579(2003) [PubMed] [Europe PMC] [Abstract]
  • Ref.2

    "Cloning and expression of human and rat D1 dopamine receptors."
    Zhou Q.-Y., Grandy D.K., Thambi L., Kushner J.A., van Tol H.H.M., Cone R., Pribnow D., Salon J., Bunzow J.R., Civelli O.
    Nature 347:76-80(1990) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• adenylate cyclase-activating dopamine receptor signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization."
    Fiorentini C., Busi C., Gorruso E., Gotti C., Spano P., Missale C.
    Mol. Pharmacol. 74:59-69(2008) [PubMed] [Europe PMC] [Abstract]
  • "Dopamine D1A receptor regulation of phospholipase C isoform."
    Yu P.Y., Eisner G.M., Yamaguchi I., Mouradian M.M., Felder R.A., Jose P.A.
    J. Biol. Chem. 271:19503-19508(1996) [PubMed] [Europe PMC] [Abstract]
• adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Differential dependence of the D1 and D5 dopamine receptors on the G protein gamma 7 subunit for activation of adenylylcyclase."
    Wang Q., Jolly J.P., Surmeier J.D., Mullah B.M., Lidow M.S., Bergson C.M., Robishaw J.D.
    J. Biol. Chem. 276:39386-39393(2001) [PubMed] [Europe PMC] [Abstract]
  • "Molecular cloning and expression of the gene for a human D1 dopamine receptor."
    Dearry A., Gingrich J.A., Falardeau P., Fremeau R.T. Jr., Bates M.D., Caron M.G.
    Nature 347:72-76(1990) [PubMed] [Europe PMC] [Abstract]
• adult walking behavior Source: RGDInferred from sequence orthologyⁱ
  • "Essential conservation of D1 mutant phenotype at the level of individual topographies of behaviour in mice lacking both D1 and D3 dopamine receptors."
    Wong J.Y., Clifford J.J., Massalas J.S., Kinsella A., Waddington J.L., Drago J.
    Psychopharmacology (Berl.) 167:167-173(2003) [PubMed] [Europe PMC] [Abstract]
  • "Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses."
    Xu M., Moratalla R., Gold L.H., Hiroi N., Koob G.F., Graybiel A.M., Tonegawa S.
    Cell 79:729-742(1994) [PubMed] [Europe PMC] [Abstract]
  • "Dopamine D3 receptor mutant mice exhibit increased behavioral sensitivity to concurrent stimulation of D1 and D2 receptors."
    Xu M., Koeltzow T.E., Santiago G.T., Moratalla R., Cooper D.C., Hu X.T., White N.M., Graybiel A.M., White F.J., Tonegawa S.
    Neuron 19:837-848(1997) [PubMed] [Europe PMC] [Abstract]
• associative learning Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Involvement of D1 dopamine receptors in the cognitive effects of angiotensin IV and des-Phe6 angiotensin IV."
    Braszko J.J.
    Peptides 25:1195-1203(2004) [PubMed] [Europe PMC] [Abstract]
• astrocyte development Source: RGDInferred from sequence orthologyⁱ
  • "Ablation of D1 dopamine receptor-expressing cells generates mice with seizures, dystonia, hyperactivity, and impaired oral behavior."
    Gantois I., Fang K., Jiang L., Babovic D., Lawrence A.J., Ferreri V., Teper Y., Jupp B., Ziebell J., Morganti-Kossmann C.M., O'Brien T.J., Nally R., Schutz G., Waddington J., Egan G.F., Drago J.
    Proc. Natl. Acad. Sci. U.S.A. 104:4182-4187(2007) [PubMed] [Europe PMC] [Abstract]
• behavioral fear response Source: RGDInferred from sequence orthologyⁱ
  • "Prolonged fear responses in mice lacking dopamine D1 receptor."
    El-Ghundi M., O'Dowd B.F., George S.R.
    Brain Res. 892:86-93(2001) [PubMed] [Europe PMC] [Abstract]
• behavioral response to cocaine Source: RGDInferred from mutant phenotypeⁱ
  • "Cocaine-induced sex differences in D1 receptor activation and binding levels after acute cocaine administration."
    Festa E.D., Jenab S., Weiner J., Nazarian A., Niyomchai T., Russo S.J., Kemen L.M., Akhavan A., Wu H.B., Quinones-Jenab V.
    Brain Res. Bull. 68:277-284(2006) [PubMed] [Europe PMC] [Abstract]
• calcium-mediated signaling Source: RGDInferred from direct assayⁱ
  • "Potentiation of NMDA receptor currents by dopamine D1 receptors in prefrontal cortex."
    Chen G., Greengard P., Yan Z.
    Proc. Natl. Acad. Sci. U.S.A. 101:2596-2600(2004) [PubMed] [Europe PMC] [Abstract]
• cellular response to catecholamine stimulus Source: RGDInferred from sequence orthologyⁱ
  • "Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system."
    Sakihama T., Masuda K., Sato T., Doi T., Kodama T., Hamakubo T.
    J. Biotechnol. 135:28-33(2008) [PubMed] [Europe PMC] [Abstract]
• cellular response to dopamine Source: RGDInferred from sequence orthologyⁱ
  • "Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-N-methyl-D-aspartate receptor coupling."
    Sidharthan N.P., Minchin R.F., Butcher N.J.
    J. Biol. Chem. 288:34364-34374(2013) [PubMed] [Europe PMC] [Abstract]
• cellular response to hypoxia Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Post-translational modification of glutamic acid decarboxylase 67 by intermittent hypoxia: evidence for the involvement of dopamine D1 receptor signaling."
    Raghuraman G., Prabhakar N.R., Kumar G.K.
    J. Neurochem. 115:1568-1578(2010) [PubMed] [Europe PMC] [Abstract]
• cellular response to insulin stimulus Source: RGDInferred from expression patternⁱ
  • "Dopamine-mediated inhibition of renal Na,K-ATPase is reduced by insulin."
    Banday A.A., Asghar M., Hussain T., Lokhandwala M.F.
    Hypertension 41:1353-1358(2003) [PubMed] [Europe PMC] [Abstract]
• cerebral cortex GABAergic interneuron migration Source: RGDInferred from sequence orthologyⁱ
  • "Dopamine receptor activation modulates GABA neuron migration from the basal forebrain to the cerebral cortex."
    Crandall J.E., McCarthy D.M., Araki K.Y., Sims J.R., Ren J.Q., Bhide P.G.
    J. Neurosci. 27:3813-3822(2007) [PubMed] [Europe PMC] [Abstract]
• chemical synaptic transmission Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• conditioned taste aversion Source: RGDInferred from sequence orthologyⁱ
  • "Mice lacking dopamine D1 receptors express normal lithium chloride-induced conditioned taste aversion for salt but not sucrose."
    Cannon C.M., Scannell C.A., Palmiter R.D.
    Eur. J. Neurosci. 21:2600-2604(2005) [PubMed] [Europe PMC] [Abstract]
• dentate gyrus development Source: RGDInferred from sequence orthologyⁱ
  • "Ablation of D1 dopamine receptor-expressing cells generates mice with seizures, dystonia, hyperactivity, and impaired oral behavior."
    Gantois I., Fang K., Jiang L., Babovic D., Lawrence A.J., Ferreri V., Teper Y., Jupp B., Ziebell J., Morganti-Kossmann C.M., O'Brien T.J., Nally R., Schutz G., Waddington J., Egan G.F., Drago J.
    Proc. Natl. Acad. Sci. U.S.A. 104:4182-4187(2007) [PubMed] [Europe PMC] [Abstract]
• dopamine receptor signaling pathway Source: RGDInferred from direct assayⁱ
  • "Dopaminergic regulation of inhibitory and excitatory transmission in the basolateral amygdala-prefrontal cortical pathway."
    Floresco S.B., Tse M.T.
    J. Neurosci. 27:2045-2057(2007) [PubMed] [Europe PMC] [Abstract]
• dopamine transport Source: RGDInferred from sequence orthologyⁱ
  • "Galpha(olf) levels are regulated by receptor usage and control dopamine and adenosine action in the striatum."
    Herve D., Le Moine C., Corvol J.C., Belluscio L., Ledent C., Fienberg A.A., Jaber M., Studler J.M., Girault J.A.
    J. Neurosci. 21:4390-4399(2001) [PubMed] [Europe PMC] [Abstract]
• eating behavior Source: RGDInferred from direct assayⁱ
  • "Wake-promoting actions of dopamine D1 and D2 receptor stimulation."
    Isaac S.O., Berridge C.W.
    J. Pharmacol. Exp. Ther. 307:386-394(2003) [PubMed] [Europe PMC] [Abstract]
• feeding behavior Source: RGDInferred from sequence orthologyⁱ
  • "Simultaneous absence of dopamine D1 and D2 receptor-mediated signaling is lethal in mice."
    Kobayashi M., Iaccarino C., Saiardi A., Heidt V., Bozzi Y., Picetti R., Vitale C., Westphal H., Drago J., Borrelli E.
    Proc. Natl. Acad. Sci. U.S.A. 101:11465-11470(2004) [PubMed] [Europe PMC] [Abstract]
• glucose import Source: RGDInferred from sequence orthologyⁱ
  • "Blunted brain metabolic response to ketamine in mice lacking D(1A) dopamine receptors."
    Miyamoto S., Mailman R.B., Lieberman J.A., Duncan G.E.
    Brain Res. 894:167-180(2001) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Galpha(olf) levels are regulated by receptor usage and control dopamine and adenosine action in the striatum."
    Herve D., Le Moine C., Corvol J.C., Belluscio L., Ledent C., Fienberg A.A., Jaber M., Studler J.M., Girault J.A.
    J. Neurosci. 21:4390-4399(2001) [PubMed] [Europe PMC] [Abstract]
  • "G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway."
    Weissman J.T., Ma J.N., Essex A., Gao Y., Burstein E.S.
    Oncogene 23:241-249(2004) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: RGDInferred from sequence orthologyⁱ
  • "Cholera toxin-sensitive 3',5'-cyclic adenosine monophosphate and calcium signals of the human dopamine-D1 receptor: selective potentiation by protein kinase A."
    Liu Y.F., Civelli O., Zhou Q.Y., Albert P.R.
    Mol. Endocrinol. 6:1815-1824(1992) [PubMed] [Europe PMC] [Abstract]
• grooming behavior Source: RGDInferred from direct assayⁱ
  • "Wake-promoting actions of dopamine D1 and D2 receptor stimulation."
    Isaac S.O., Berridge C.W.
    J. Pharmacol. Exp. Ther. 307:386-394(2003) [PubMed] [Europe PMC] [Abstract]
• habituation Source: RGDInferred from sequence orthologyⁱ
  • "Phenotypic resolution of spontaneous and D1-like agonist-induced orofacial movement topographies in congenic dopamine D1A receptor 'knockout' mice."
    Tomiyama K., McNamara F.N., Clifford J.J., Kinsella A., Drago J., Tighe O., Croke D.T., Koshikawa N., Waddington J.L.
    Neuropharmacology 42:644-652(2002) [PubMed] [Europe PMC] [Abstract]
• hippocampus development Source: RGDInferred from sequence orthologyⁱ
  • "Ablation of D1 dopamine receptor-expressing cells generates mice with seizures, dystonia, hyperactivity, and impaired oral behavior."
    Gantois I., Fang K., Jiang L., Babovic D., Lawrence A.J., Ferreri V., Teper Y., Jupp B., Ziebell J., Morganti-Kossmann C.M., O'Brien T.J., Nally R., Schutz G., Waddington J., Egan G.F., Drago J.
    Proc. Natl. Acad. Sci. U.S.A. 104:4182-4187(2007) [PubMed] [Europe PMC] [Abstract]
• histone H3-S10 phosphorylation Source: RGDInferred from sequence orthologyⁱ
  • "A phosphatase cascade by which rewarding stimuli control nucleosomal response."
    Stipanovich A., Valjent E., Matamales M., Nishi A., Ahn J.H., Maroteaux M., Bertran-Gonzalez J., Brami-Cherrier K., Enslen H., Corbille A.G., Filhol O., Nairn A.C., Greengard P., Herve D., Girault J.A.
    Nature 453:879-884(2008) [PubMed] [Europe PMC] [Abstract]
• intracellular protein transport Source: RGDInferred from mutant phenotypeⁱ
  • "Dopamine D1 activation potentiates striatal NMDA receptors by tyrosine phosphorylation-dependent subunit trafficking."
    Hallett P.J., Spoelgen R., Hyman B.T., Standaert D.G., Dunah A.W.
    J. Neurosci. 26:4690-4700(2006) [PubMed] [Europe PMC] [Abstract]
• learning Source: RGDInferred from sequence orthologyⁱ
  • "Dopamine D1 receptors involved in locomotor activity and accumbens neural responses to prediction of reward associated with place."
    Tran A.H., Tamura R., Uwano T., Kobayashi T., Katsuki M., Ono T.
    Proc. Natl. Acad. Sci. U.S.A. 102:2117-2122(2005) [PubMed] [Europe PMC] [Abstract]
• locomotory behavior Source: RGDInferred from mutant phenotypeⁱ
  • "Cocaine-induced sex differences in D1 receptor activation and binding levels after acute cocaine administration."
    Festa E.D., Jenab S., Weiner J., Nazarian A., Niyomchai T., Russo S.J., Kemen L.M., Akhavan A., Wu H.B., Quinones-Jenab V.
    Brain Res. Bull. 68:277-284(2006) [PubMed] [Europe PMC] [Abstract]
• long-term synaptic depression Source: RGDInferred from sequence orthologyⁱ
  • "Genetic evidence for the bidirectional modulation of synaptic plasticity in the prefrontal cortex by D1 receptors."
    Huang Y.Y., Simpson E., Kellendonk C., Kandel E.R.
    Proc. Natl. Acad. Sci. U.S.A. 101:3236-3241(2004) [PubMed] [Europe PMC] [Abstract]
• long-term synaptic potentiation Source: RGDInferred from sequence orthologyⁱ
  • "Distinct roles of D1 and D5 dopamine receptors in motor activity and striatal synaptic plasticity."
    Centonze D., Grande C., Saulle E., Martin A.B., Gubellini P., Pavon N., Pisani A., Bernardi G., Moratalla R., Calabresi P.
    J. Neurosci. 23:8506-8512(2003) [PubMed] [Europe PMC] [Abstract]
  • "Genetic evidence for the bidirectional modulation of synaptic plasticity in the prefrontal cortex by D1 receptors."
    Huang Y.Y., Simpson E., Kellendonk C., Kandel E.R.
    Proc. Natl. Acad. Sci. U.S.A. 101:3236-3241(2004) [PubMed] [Europe PMC] [Abstract]
  • "Dopamine D1-deficient mutant mice do not express the late phase of hippocampal long-term potentiation."
    Matthies H., Becker A., Schroeder H., Kraus J., Hollt V., Krug M.
    Neuroreport 8:3533-3535(1997) [PubMed] [Europe PMC] [Abstract]
• maternal behavior Source: RGDInferred from sequence orthologyⁱ
  • "Ablation of D1 dopamine receptor-expressing cells generates mice with seizures, dystonia, hyperactivity, and impaired oral behavior."
    Gantois I., Fang K., Jiang L., Babovic D., Lawrence A.J., Ferreri V., Teper Y., Jupp B., Ziebell J., Morganti-Kossmann C.M., O'Brien T.J., Nally R., Schutz G., Waddington J., Egan G.F., Drago J.
    Proc. Natl. Acad. Sci. U.S.A. 104:4182-4187(2007) [PubMed] [Europe PMC] [Abstract]
  • "Altered striatal function in a mutant mouse lacking D1A dopamine receptors."
    Drago J., Gerfen C.R., Lachowicz J.E., Steiner H., Hollon T.R., Love P.E., Ooi G.T., Grinberg A., Lee E.J., Huang S.P.
    Proc. Natl. Acad. Sci. U.S.A. 91:12564-12568(1994) [PubMed] [Europe PMC] [Abstract]
• mating behavior Source: RGDInferred from sequence orthologyⁱ
  • "Dopamine-stimulated sexual behavior is testosterone dependent in mice."
    Szczypka M.S., Zhou Q.Y., Palmiter R.D.
    Behav. Neurosci. 112:1229-1235(1998) [PubMed] [Europe PMC] [Abstract]
• memory Source: RGDInferred from sequence orthologyⁱ
  • "Spatial learning deficit in dopamine D(1) receptor knockout mice."
    El-Ghundi M., Fletcher P.J., Drago J., Sibley D.R., O'Dowd B.F., George S.R.
    Eur. J. Pharmacol. 383:95-106(1999) [PubMed] [Europe PMC] [Abstract]
• modification of postsynaptic structure Source: RGDInferred from sequence orthologyⁱ
  • "A critical time window for dopamine actions on the structural plasticity of dendritic spines."
    Yagishita S., Hayashi-Takagi A., Ellis-Davies G.C., Urakubo H., Ishii S., Kasai H.
    Science 345:1616-1620(2014) [PubMed] [Europe PMC] [Abstract]
• muscle contraction Source: RGDInferred from sequence orthologyⁱ
  • "Ablation of D1 dopamine receptor-expressing cells generates mice with seizures, dystonia, hyperactivity, and impaired oral behavior."
    Gantois I., Fang K., Jiang L., Babovic D., Lawrence A.J., Ferreri V., Teper Y., Jupp B., Ziebell J., Morganti-Kossmann C.M., O'Brien T.J., Nally R., Schutz G., Waddington J., Egan G.F., Drago J.
    Proc. Natl. Acad. Sci. U.S.A. 104:4182-4187(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell death Source: RGDInferred from direct assayⁱ
  • "Modulation of Postnatal Neurogenesis by Perinatal Asphyxia: Effect of D1 and D2 Dopamine Receptor Agonists."
    Tapia-Bustos A., Perez-Lobos R., Vio V., Lespay-Rebolledo C., Palacios E., Chiti-Morales A., Bustamante D., Herrera-Marschitz M., Morales P.
    Neurotox Res 31:109-121(2017) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell migration Source: RGDInferred from mutant phenotypeⁱ
  • "Dopamine as a novel anti-migration factor of vascular smooth muscle cells through D1A and D1B receptors."
    Yasunari K., Maeda K., Nakamura M., Yoshikawa J.
    J. Cardiovasc. Pharmacol. 41 Suppl 1:S33-8(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of circadian sleep/wake cycle, sleep Source: RGDInferred from direct assayⁱ
  • "Wake-promoting actions of dopamine D1 and D2 receptor stimulation."
    Isaac S.O., Berridge C.W.
    J. Pharmacol. Exp. Ther. 307:386-394(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of protein kinase activity Source: RGDInferred from mutant phenotypeⁱ
  • "Dopamine as a novel anti-migration factor of vascular smooth muscle cells through D1A and D1B receptors."
    Yasunari K., Maeda K., Nakamura M., Yoshikawa J.
    J. Cardiovasc. Pharmacol. 41 Suppl 1:S33-8(2003) [PubMed] [Europe PMC] [Abstract]
• neuronal action potential Source: RGDInferred from sequence orthologyⁱ
  • "Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles."
    Naccache S.N., Hasson T., Horowitz A.
    Proc. Natl. Acad. Sci. U.S.A. 103:12735-12740(2006) [PubMed] [Europe PMC] [Abstract]
• operant conditioning Source: RGDInferred from mutant phenotypeⁱ
  • "Involvement of D1 dopamine receptors in the cognitive effects of angiotensin IV and des-Phe6 angiotensin IV."
    Braszko J.J.
    Peptides 25:1195-1203(2004) [PubMed] [Europe PMC] [Abstract]
• orbitofrontal cortex development Source: RGDInferred from expression patternⁱ
  • "Expression and function of dopamine receptors in the developing medial frontal cortex and striatum of the rat."
    Sillivan S.E., Konradi C.
    Neuroscience 199:501-514(2011) [PubMed] [Europe PMC] [Abstract]
• peristalsis Source: RGDInferred from sequence orthologyⁱ
  • "Simultaneous absence of dopamine D1 and D2 receptor-mediated signaling is lethal in mice."
    Kobayashi M., Iaccarino C., Saiardi A., Heidt V., Bozzi Y., Picetti R., Vitale C., Westphal H., Drago J., Borrelli E.
    Proc. Natl. Acad. Sci. U.S.A. 101:11465-11470(2004) [PubMed] [Europe PMC] [Abstract]
• phospholipase C-activating dopamine receptor signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Cholera toxin-sensitive 3',5'-cyclic adenosine monophosphate and calcium signals of the human dopamine-D1 receptor: selective potentiation by protein kinase A."
    Liu Y.F., Civelli O., Zhou Q.Y., Albert P.R.
    Mol. Endocrinol. 6:1815-1824(1992) [PubMed] [Europe PMC] [Abstract]
  • "Enhancement of dopamine-induced signaling responses in the forebrain of mice lacking dopamine D3 receptor."
    Mizuo K., Narita M., Miyatake M., Suzuki T.
    Neurosci. Lett. 358:13-16(2004) [PubMed] [Europe PMC] [Abstract]
  • "D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum."
    Rashid A.J., So C.H., Kong M.M., Furtak T., El-Ghundi M., Cheng R., O'Dowd B.F., George S.R.
    Proc. Natl. Acad. Sci. U.S.A. 104:654-659(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell migration Source: RGDInferred from sequence orthologyⁱ
  • "Dopamine receptor activation modulates GABA neuron migration from the basal forebrain to the cerebral cortex."
    Crandall J.E., McCarthy D.M., Araki K.Y., Sims J.R., Ren J.Q., Bhide P.G.
    J. Neurosci. 27:3813-3822(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Cholera toxin-sensitive 3',5'-cyclic adenosine monophosphate and calcium signals of the human dopamine-D1 receptor: selective potentiation by protein kinase A."
    Liu Y.F., Civelli O., Zhou Q.Y., Albert P.R.
    Mol. Endocrinol. 6:1815-1824(1992) [PubMed] [Europe PMC] [Abstract]
• positive regulation of feeding behavior Source: RGDInferred from mutant phenotypeⁱ
  • "Hypothalamic dopaminergic receptor expressions in anorexia of tumor-bearing rats."
    Sato T., Meguid M.M., Fetissov S.O., Chen C., Zhang L.
    Am. J. Physiol. Regul. Integr. Comp. Physiol. 281:R1907-16(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: RGDInferred from sequence orthologyⁱ
  • "Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-N-methyl-D-aspartate receptor coupling."
    Sidharthan N.P., Minchin R.F., Butcher N.J.
    J. Biol. Chem. 288:34364-34374(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of long-term synaptic potentiation Source: RGDInferred from mutant phenotypeⁱ
  • "Dopamine receptor mechanisms mediate corticotropin-releasing factor-induced long-term potentiation in the rat amygdala following cocaine withdrawal."
    Krishnan B., Centeno M., Pollandt S., Fu Y., Genzer K., Liu J., Gallagher J.P., Shinnick-Gallagher P.
    Eur. J. Neurosci. 31:1027-1042(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of membrane potential Source: RGDInferred from mutant phenotypeⁱ
  • "D1 and D4 dopaminergic receptor interplay mediates coincident G protein-independent and dependent regulation of glutamate NMDA receptors in the lateral amygdala."
    Martina M., Bergeron R.
    J. Neurochem. 106:2421-2435(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein phosphorylation Source: RGDInferred from direct assayⁱ
  • "Dopaminergic and cholinergic regulation of Fyn tyrosine kinase phosphorylation in the rat striatum in vivo."
    Mao L.M., Wang J.Q.
    Neuropharmacology 99:491-499(2015) [PubMed] [Europe PMC] [Abstract]
• positive regulation of release of sequestered calcium ion into cytosol Source: RGDInferred from sequence orthologyⁱ
  • "Cholera toxin-sensitive 3',5'-cyclic adenosine monophosphate and calcium signals of the human dopamine-D1 receptor: selective potentiation by protein kinase A."
    Liu Y.F., Civelli O., Zhou Q.Y., Albert P.R.
    Mol. Endocrinol. 6:1815-1824(1992) [PubMed] [Europe PMC] [Abstract]
  • "Characterization of cloned human dopamine D1 receptor-mediated calcium release in 293 cells."
    Lin C.W., Miller T.R., Witte D.G., Bianchi B.R., Stashko M., Manelli A.M., Frail D.E.
    Mol. Pharmacol. 47:131-139(1995) [PubMed] [Europe PMC] [Abstract]
• positive regulation of synaptic transmission, glutamatergic Source: RGDInferred from sequence orthologyⁱ
  • "Modulatory actions of dopamine on NMDA receptor-mediated responses are reduced in D1A-deficient mutant mice."
    Levine M.S., Altemus K.L., Cepeda C., Cromwell H.C., Crawford C., Ariano M.A., Drago J., Sibley D.R., Westphal H.
    J. Neurosci. 16:5870-5882(1996) [PubMed] [Europe PMC] [Abstract]
• postsynaptic modulation of chemical synaptic transmission Source: SynGOInferred from direct assayⁱ
  • "Dopamine-glutamate interactions controlling prefrontal cortical pyramidal cell excitability involve multiple signaling mechanisms."
    Tseng K.Y., O'Donnell P.
    J. Neurosci. 24:5131-5139(2004) [PubMed] [Europe PMC] [Abstract]
• protein import into nucleus Source: RGDInferred from sequence orthologyⁱ
  • "A phosphatase cascade by which rewarding stimuli control nucleosomal response."
    Stipanovich A., Valjent E., Matamales M., Nishi A., Ahn J.H., Maroteaux M., Bertran-Gonzalez J., Brami-Cherrier K., Enslen H., Corbille A.G., Filhol O., Nairn A.C., Greengard P., Herve D., Girault J.A.
    Nature 453:879-884(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of dopamine metabolic process Source: RGDInferred from sequence orthologyⁱ
  • "The role of dopamine receptors in regulating the size of axonal arbors."
    Parish C.L., Finkelstein D.I., Drago J., Borrelli E., Horne M.K.
    J. Neurosci. 21:5147-5157(2001) [PubMed] [Europe PMC] [Abstract]
• regulation of ion transport Source: RGDInferred from direct assayⁱ
  • "Potentiation of NMDA receptor currents by dopamine D1 receptors in prefrontal cortex."
    Chen G., Greengard P., Yan Z.
    Proc. Natl. Acad. Sci. U.S.A. 101:2596-2600(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of long-term neuronal synaptic plasticity Source: RGDInferred from mutant phenotypeⁱ
  • "Dopamine D1/D5 receptors gate the acquisition of novel information through hippocampal long-term potentiation and long-term depression."
    Lemon N., Manahan-Vaughan D.
    J. Neurosci. 26:7723-7729(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of protein phosphorylation Source: RGDInferred from sequence orthologyⁱ
  • "A phosphatase cascade by which rewarding stimuli control nucleosomal response."
    Stipanovich A., Valjent E., Matamales M., Nishi A., Ahn J.H., Maroteaux M., Bertran-Gonzalez J., Brami-Cherrier K., Enslen H., Corbille A.G., Filhol O., Nairn A.C., Greengard P., Herve D., Girault J.A.
    Nature 453:879-884(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of synaptic vesicle exocytosis Source: RGDInferred from sequence orthologyⁱ
  • "Regulation of prefrontal excitatory neurotransmission by dopamine in the nucleus accumbens core."
    Wang W., Dever D., Lowe J., Storey G.P., Bhansali A., Eck E.K., Nitulescu I., Weimer J., Bamford N.S.
    J. Physiol. (Lond.) 590:3743-3769(2012) [PubMed] [Europe PMC] [Abstract]
• regulation of vasoconstriction Source: RGDInferred from mutant phenotypeⁱ
  • "The role of dopamine in a model of trigeminovascular nociception."
    Akerman S., Goadsby P.J.
    J. Pharmacol. Exp. Ther. 314:162-169(2005) [PubMed] [Europe PMC] [Abstract]
• response to activity Source: RGDInferred from expression patternⁱ
  • "Exercise activates redox-sensitive transcription factors and restores renal D1 receptor function in old rats."
    George L., Lokhandwala M.F., Asghar M.
    Am. J. Physiol. Renal Physiol. 297:F1174-80(2009) [PubMed] [Europe PMC] [Abstract]
• response to amino acid Source: RGDInferred from expression patternⁱ
  • "Co-regulation of dopamine D1 receptor and uncoupling protein-2 expression in 3-nitropropionic acid-induced neurotoxicity: neuroprotective role of L-carnitine."
    Binienda Z.K., Ali S.F., Virmani A., Amato A., Salem N., Przybyla B.D.
    Neurosci. Lett. 410:62-65(2006) [PubMed] [Europe PMC] [Abstract]
• response to amphetamine Source: RGDInferred from expression patternⁱ
  • "Amphetamine-induced changes in dopamine receptors in early postnatal rat brain."
    Mukda S., Kaewsuk S., Ebadi M., Govitrapong P.
    Dev. Neurosci. 31:193-201(2009) [PubMed] [Europe PMC] [Abstract]
• response to cocaine Source: RGDInferred from sequence orthologyⁱ
  • "Paradoxical locomotor behavior of dopamine D1 receptor transgenic mice."
    Dracheva S., Xu M., Kelley K.A., Haroutunian V., Holstein G.R., Haun S., Silverstein J.H., Sealfon S.C.
    Exp. Neurol. 157:169-179(1999) [PubMed] [Europe PMC] [Abstract]
  • "Behavioral responses to cocaine and amphetamine administration in mice lacking the dopamine D1 receptor."
    Xu M., Guo Y., Vorhees C.V., Zhang J.
    Brain Res. 852:198-207(2000) [PubMed] [Europe PMC] [Abstract]
  • "The dopamine D1 receptor is a critical mediator for cocaine-induced gene expression."
    Zhang D., Zhang L., Lou D.W., Nakabeppu Y., Zhang J., Xu M.
    J. Neurochem. 82:1453-1464(2002) [PubMed] [Europe PMC] [Abstract]
  • "Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles."
    Naccache S.N., Hasson T., Horowitz A.
    Proc. Natl. Acad. Sci. U.S.A. 103:12735-12740(2006) [PubMed] [Europe PMC] [Abstract]
  • "Lack of self-administration of cocaine in dopamine D1 receptor knock-out mice."
    Caine S.B., Thomsen M., Gabriel K.I., Berkowitz J.S., Gold L.H., Koob G.F., Tonegawa S., Zhang J., Xu M.
    J. Neurosci. 27:13140-13150(2007) [PubMed] [Europe PMC] [Abstract]
  • "D1 receptors mediate dopamine action in the fetal suprachiasmatic nuclei: studies of mice with targeted deletion of the D1 dopamine receptor gene."
    Bender M., Drago J., Rivkees S.A.
    Brain Res. Mol. Brain Res. 49:271-277(1997) [PubMed] [Europe PMC] [Abstract]
• response to drug Source: RGDInferred from expression patternⁱ
  • "Rosiglitazone restores renal D1A receptor-Gs protein coupling by reducing receptor hyperphosphorylation in obese rats."
    Trivedi M., Lokhandwala M.F.
    Am. J. Physiol. Renal Physiol. 289:F298-304(2005) [PubMed] [Europe PMC] [Abstract]
  • "Repeated treatment with antidepressants enhances dopamine D1 receptor gene expression in the rat brain."
    Huzarska M., Zielinski M., Herman Z.S.
    Eur. J. Pharmacol. 532:208-213(2006) [PubMed] [Europe PMC] [Abstract]
• response to estradiol Source: RGDInferred from expression patternⁱ
  • "Estradiol replacement alters expression of genes related to neurotransmission and immune surveillance in the frontal cortex of middle-aged, ovariectomized rats."
    Sarvari M., Kallo I., Hrabovszky E., Solymosi N., Toth K., Liko I., Molnar B., Tihanyi K., Liposits Z.
    Endocrinology 151:3847-3862(2010) [PubMed] [Europe PMC] [Abstract]
• response to ethanol Source: RGDInferred from expression patternⁱ
  • "MicroRNA expression profile and functional analysis reveal that miR-382 is a critical novel gene of alcohol addiction."
    Li J., Li J., Liu X., Qin S., Guan Y., Liu Y., Cheng Y., Chen X., Li W., Wang S., Xiong M., Kuzhikandathil E.V., Ye J.H., Zhang C.
    EMBO Mol Med 5:1402-1414(2013) [PubMed] [Europe PMC] [Abstract]
• response to food Source: RGDInferred from expression patternⁱ
  • "Dopamine D1 receptor gene expression decreases in the nucleus accumbens upon long-term exposure to palatable food and differs depending on diet-induced obesity phenotype in rats."
    Alsio J., Olszewski P.K., Norback A.H., Gunnarsson Z.E., Levine A.S., Pickering C., Schioth H.B.
    Neuroscience 171:779-787(2010) [PubMed] [Europe PMC] [Abstract]
• response to morphine Source: RGDInferred from expression patternⁱ
  • "Mesoaccumbens dopamine signaling alteration underlies behavioral transition from tolerance to sensitization to morphine rewarding properties during morphine withdrawal."
    Sun L., Hu L., Li Y., Cui C.
    Brain Struct Funct 219:1755-1771(2014) [PubMed] [Europe PMC] [Abstract]
• response to nicotine Source: RGDInferred from expression patternⁱ
  • "The epigenetic effect of nicotine on dopamine D1 receptor expression in rat prefrontal cortex."
    Gozen O., Balkan B., Yildirim E., Koylu E.O., Pogun S.
    Synapse 67:545-552(2013) [PubMed] [Europe PMC] [Abstract]
• response to organic cyclic compound Source: RGDInferred from expression patternⁱ
  • "Differential treatment regimen-related effects of cannabinoids on D1 and D2 receptors in adolescent and adult rat brain."
    Dalton V.S., Zavitsanou K.
    J. Chem. Neuroanat. 40:272-280(2010) [PubMed] [Europe PMC] [Abstract]
• response to organonitrogen compound Source: RGDInferred from expression patternⁱ
  • "Transcription factor Nrf2 protects renal dopamine D1 receptor function during oxidative stress."
    Banday A.A., Lokhandwala M.F.
    Hypertension 62:512-517(2013) [PubMed] [Europe PMC] [Abstract]
• response to retinoic acid Source: RGDInferred from expression patternⁱ
  • "Regulation of multiple dopamine signal transduction molecules by retinoids in the developing striatum."
    Wang H.F., Liu F.C.
    Neuroscience 134:97-105(2005) [PubMed] [Europe PMC] [Abstract]
• response to steroid hormone Source: RGDInferred from expression patternⁱ
  • "The anabolic androgenic steroid nandrolone decanoate affects mRNA expression of dopaminergic but not serotonergic receptors."
    Birgner C., Kindlundh-Hogberg A.M., Alsio J., Lindblom J., Schioth H.B., Bergstrom L.
    Brain Res. 1240:221-228(2008) [PubMed] [Europe PMC] [Abstract]
• sensitization Source: RGDInferred from sequence orthologyⁱ
  • "Role of D1-like receptors in amphetamine-induced behavioral sensitization: a study using D1A receptor knockout mice."
    Karper P.E., De la Rosa H., Newman E.R., Krall C.M., Nazarian A., McDougall S.A., Crawford C.A.
    Psychopharmacology (Berl.) 159:407-414(2002) [PubMed] [Europe PMC] [Abstract]
• social behavior Source: RGDInferred from mutant phenotypeⁱ
  • "Requirement for the endocannabinoid system in social interaction impairment induced by coactivation of dopamine D1 and D2 receptors in the piriform cortex."
    Zenko M., Zhu Y., Dremencov E., Ren W., Xu L., Zhang X.
    J. Neurosci. Res. 89:1245-1258(2011) [PubMed] [Europe PMC] [Abstract]
• striatum development Source: RGDInferred from expression patternⁱ
  • "Expression and function of dopamine receptors in the developing medial frontal cortex and striatum of the rat."
    Sillivan S.E., Konradi C.
    Neuroscience 199:501-514(2011) [PubMed] [Europe PMC] [Abstract]
• synapse assembly Source: BHF-UCLInferred from expression patternⁱ
  • "D1- and D2-like dopamine receptors are co-localized on the presynaptic varicosities of striatal and nucleus accumbens neurons in vitro."
    Wong A.C., Shetreat M.E., Clarke J.O., Rayport S.
    Neuroscience 89:221-233(1999) [PubMed] [Europe PMC] [Abstract]
• synaptic transmission, dopaminergic Source: RGDInferred from direct assayⁱ
  • "Dopaminergic regulation of inhibitory and excitatory transmission in the basolateral amygdala-prefrontal cortical pathway."
    Floresco S.B., Tse M.T.
    J. Neurosci. 27:2045-2057(2007) [PubMed] [Europe PMC] [Abstract]
• temperature homeostasis Source: RGDInferred from sequence orthologyⁱ
  • "Hyperthermic and lethal effects of methamphetamine: roles of dopamine D1 and D2 receptors."
    Ito M., Numachi Y., Ohara A., Sora I.
    Neurosci. Lett. 438:327-329(2008) [PubMed] [Europe PMC] [Abstract]
• transmission of nerve impulse Source: RGDInferred from sequence orthologyⁱ
  • "Receptor subtypes involved in the presynaptic and postsynaptic actions of dopamine on striatal interneurons."
    Centonze D., Grande C., Usiello A., Gubellini P., Erbs E., Martin A.B., Pisani A., Tognazzi N., Bernardi G., Moratalla R., Borrelli E., Calabresi P.
    J. Neurosci. 23:6245-6254(2003) [PubMed] [Europe PMC] [Abstract]
• vasodilation Source: InterPro
• visual learning Source: RGDInferred from mutant phenotypeⁱ
  • "Dopamine D1/D5 receptors gate the acquisition of novel information through hippocampal long-term potentiation and long-term depression."
    Lemon N., Manahan-Vaughan D.
    J. Neurosci. 26:7723-7729(2006) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• angiotensin receptor binding Source: RGDInferred from physical interactionⁱ
  • "Binding of losartan to angiotensin AT1 receptors increases dopamine D1 receptor activation."
    Li D., Scott L., Crambert S., Zelenin S., Eklof A.C., Di Ciano L., Ibarra F., Aperia A.
    J. Am. Soc. Nephrol. 23:421-428(2012) [PubMed] [Europe PMC] [Abstract]
• ATPase binding Source: RGDInferred from physical interactionⁱ
  • "Interaction of dopamine D1 receptor with N-ethylmaleimide-sensitive factor is important for the membrane localization of the receptor."
    Chen S., Liu F.
    J. Neurosci. Res. 88:2504-2512(2010) [PubMed] [Europe PMC] [Abstract]
  • "Nearest neighbor analysis of dopamine D1 receptors and Na(+)-K(+)-ATPases in dendritic spines dissected by STED microscopy."
    Blom H., Ronnlund D., Scott L., Spicarova Z., Rantanen V., Widengren J., Aperia A., Brismar H.
    Microsc. Res. Tech. 75:220-228(2012) [PubMed] [Europe PMC] [Abstract]
• D3 dopamine receptor binding Source: RGDInferred from physical interactionⁱ
  • "Aberrant D1 and D3 dopamine receptor transregulation in hypertension."
    Zeng C., Wang D., Asico L.D., Welch W.J., Wilcox C.S., Hopfer U., Eisner G.M., Felder R.A., Jose P.A.
    Hypertension 43:654-660(2004) [PubMed] [Europe PMC] [Abstract]
• G-protein alpha-subunit binding Source: RGDInferred from physical interactionⁱ
  • "Rosiglitazone restores renal D1A receptor-Gs protein coupling by reducing receptor hyperphosphorylation in obese rats."
    Trivedi M., Lokhandwala M.F.
    Am. J. Physiol. Renal Physiol. 289:F298-304(2005) [PubMed] [Europe PMC] [Abstract]
• protein phosphatase binding Source: RGDInferred from physical interactionⁱ
  • "Persistent activation of the D1R/Shp-2/Erk1/2 pathway in l-DOPA-induced dyskinesia in the 6-hydroxy-dopamine rat model of Parkinson's disease."
    Fiorentini C., Savoia P., Savoldi D., Barbon A., Missale C.
    Neurobiol. Dis. 54:339-348(2013) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: RGDInferred from physical interactionⁱ
  • "Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor."
    Lee F.J., Xue S., Pei L., Vukusic B., Chery N., Wang Y., Wang Y.T., Niznik H.B., Yu X.M., Liu F.
    Cell 111:219-230(2002) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MAPNTSTMDE AGLPAERDFS FRILTACFLS LLILSTLLGN TLVCAAVIRF 
        60         70         80         90        100
RHLRSKVTNF FVISLAVSDL LVAVLVMPWK AVAEIAGFWP LGPFCNIWVA 
       110        120        130        140        150
FDIMCSTASI LNLCVISVDR YWAISSPFQY ERKMTPKAAF ILISVAWTLS 
       160        170        180        190        200
VLISFIPVQL SWHKAKPTWP LDGNFTSLED TEDDNCDTRL SRTYAISSSL 
       210        220        230        240        250
ISFYIPVAIM IVTYTSIYRI AQKQIRRISA LERAAVHAKN CQTTAGNGNP 
       260        270        280        290        300
VECAQSESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI SNCMVPFCGS 
       310        320        330        340        350
EETQPFCIDS ITFDVFVWFG WANSSLNPII YAFNADFQKA FSTLLGCYRL 
       360        370        380        390        400
CPTTNNAIET VSINNNGAVV FSSHHEPRGS ISKDCNLVYL IPHAVGSSED 
       410        420        430        440 
LKKEEAGGIA KPLEKLSPAL SVILDYDTDV SLEKIQPVTH SGQHST     

Experimental Info

Sequence databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries
2. SIMILARITY comments
   Index of protein domains and families