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UniProtKB - P18892 (BT1A1_BOVIN)
Protein
Butyrophilin subfamily 1 member A1
Gene
BTN1A1
Organism
Bos taurus (Bovine)
Status
Functioni
May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane. Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity).
By similarityGO - Molecular functioni
- signaling receptor binding Source: GO_Central
GO - Biological processi
- regulation of cytokine production Source: GO_Central
- T cell receptor signaling pathway Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: Butyrophilin subfamily 1 member A1Short name: BT |
Gene namesi | Name:BTN1A1 Synonyms:BTN |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Other locations
Note: Secreted in association with the milk-fat-globule membrane during lactation.By similarity
Plasma Membrane
- external side of plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 242 | ExtracellularSequence analysisAdd BLAST | 216 | |
Transmembranei | 243 – 269 | HelicalSequence analysisAdd BLAST | 27 | |
Topological domaini | 270 – 526 | CytoplasmicSequence analysisAdd BLAST | 257 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | 1 PublicationAdd BLAST | 26 | |
ChainiPRO_0000014526 | 27 – 526 | Butyrophilin subfamily 1 member A1Add BLAST | 500 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 50 ↔ 124 | PROSITE-ProRule annotation | ||
Glycosylationi | 55 | N-linked (GlcNAc...) (complex) asparagine1 Publication | 1 | |
Disulfide bondi | 164 ↔ 218 | PROSITE-ProRule annotation | ||
Glycosylationi | 215 | N-linked (GlcNAc...) (hybrid) asparagine1 Publication | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PeptideAtlasi | P18892 |
PRIDEi | P18892 |
PTM databases
CarbonylDBi | P18892 |
iPTMneti | P18892 |
Expressioni
Tissue specificityi
Expressed in mammary tissue.
Interactioni
Subunit structurei
Seems to associate with xanthine dehydrogenase/oxidase.
By similarityGO - Molecular functioni
- signaling receptor binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000042450 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P18892 |
SMRi | P18892 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 140 | Ig-like V-type 1Add BLAST | 114 | |
Domaini | 148 – 234 | Ig-like V-type 2Add BLAST | 87 | |
Domaini | 285 – 479 | B30.2/SPRYPROSITE-ProRule annotationAdd BLAST | 195 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QSRZ, Eukaryota |
InParanoidi | P18892 |
OrthoDBi | 522383at2759 |
Family and domain databases
CDDi | cd15819, SPRY_PRY_BTN1_2, 1 hit |
Gene3Di | 2.60.120.920, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR003879, Butyrophylin_SPRY IPR013162, CD80_C2-set IPR013320, ConA-like_dom_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR006574, PRY IPR037958, SPRY/PRY_BTN1/2 IPR003877, SPRY_dom |
Pfami | View protein in Pfam PF08205, C2-set_2, 1 hit PF13765, PRY, 1 hit PF00622, SPRY, 1 hit PF07686, V-set, 1 hit |
PRINTSi | PR01407, BUTYPHLNCDUF |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00406, IGv, 1 hit SM00589, PRY, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS50835, IG_LIKE, 2 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P18892-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVFPNSCLA GCLLIFILLQ LPKLDSAPFD VIGPQEPILA VVGEDAELPC
60 70 80 90 100
RLSPNVSAKG MELRWFREKV SPAVFVSREG QEQEGEEMAE YRGRVSLVED
110 120 130 140 150
HIAEGSVAVR IQEVKASDDG EYRCFFRQDE NYEEAIVHLK VAALGSDPHI
160 170 180 190 200
SMKVQESGEI QLECTSVGWY PEPQVQWRTH RGEEFPSMSE SRNPDEEGLF
210 220 230 240 250
TVRASVIIRD SSMKNVSCCI RNLLLGQEKE VEVSIPASFF PRLTPWMVAV
260 270 280 290 300
AVILVVLGLL TIGSIFFTWR LYKERSRQRR NEFSSKEKLL EELKWKRATL
310 320 330 340 350
HAVDVTLDPD TAHPHLFLYE DSKSVRLEDS RQKLPEKPER FDSWPCVMGR
360 370 380 390 400
EAFTSGRHYW EVEVGDRTDW AIGVCRENVM KKGFDPMTPE NGFWAVELYG
410 420 430 440 450
NGYWALTPLR TPLPLAGPPR RVGVFLDYES GDIFFYNMTD GSHIYTFSKA
460 470 480 490 500
SFSGPLRPFF CLWSCGKKPL TICPVTDGLE GVMVVADAKD ISKEIPLSPM
510 520
GEDSASGDIE TLHSKLIPLQ PSQGVP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 16 | F → Y in AAB92578 (Ref. 4) Curated | 1 | |
Sequence conflicti | 35 | Q → P in CAB07533 (Ref. 3) Curated | 1 | |
Sequence conflicti | 230 | E → D (PubMed:2387867).Curated | 1 | |
Sequence conflicti | 230 | E → D (Ref. 4) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M35551 mRNA Translation: AAB39766.1 AF005497 Genomic DNA Translation: AAB62889.1 Z93323 Genomic DNA Translation: CAB07533.1 AF037402 Genomic DNA Translation: AAB92578.2 AY491469 Genomic DNA Translation: AAR85488.1 |
PIRi | A37821 |
RefSeqi | NP_776933.1, NM_174508.2 XP_015315455.1, XM_015459969.1 XP_015324493.1, XM_015469007.1 |
Genome annotation databases
GeneIDi | 282157 |
KEGGi | bta:282157 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M35551 mRNA Translation: AAB39766.1 AF005497 Genomic DNA Translation: AAB62889.1 Z93323 Genomic DNA Translation: CAB07533.1 AF037402 Genomic DNA Translation: AAB92578.2 AY491469 Genomic DNA Translation: AAR85488.1 |
PIRi | A37821 |
RefSeqi | NP_776933.1, NM_174508.2 XP_015315455.1, XM_015459969.1 XP_015324493.1, XM_015469007.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4HH8 | X-ray | 2.30 | A | 27-238 | [»] | |
AlphaFoldDBi | P18892 | |||||
SMRi | P18892 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000042450 |
PTM databases
CarbonylDBi | P18892 |
iPTMneti | P18892 |
Proteomic databases
PeptideAtlasi | P18892 |
PRIDEi | P18892 |
Genome annotation databases
GeneIDi | 282157 |
KEGGi | bta:282157 |
Organism-specific databases
CTDi | 696 |
Phylogenomic databases
eggNOGi | ENOG502QSRZ, Eukaryota |
InParanoidi | P18892 |
OrthoDBi | 522383at2759 |
Family and domain databases
CDDi | cd15819, SPRY_PRY_BTN1_2, 1 hit |
Gene3Di | 2.60.120.920, 1 hit 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR003879, Butyrophylin_SPRY IPR013162, CD80_C2-set IPR013320, ConA-like_dom_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR006574, PRY IPR037958, SPRY/PRY_BTN1/2 IPR003877, SPRY_dom |
Pfami | View protein in Pfam PF08205, C2-set_2, 1 hit PF13765, PRY, 1 hit PF00622, SPRY, 1 hit PF07686, V-set, 1 hit |
PRINTSi | PR01407, BUTYPHLNCDUF |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00406, IGv, 1 hit SM00589, PRY, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS50835, IG_LIKE, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | BT1A1_BOVIN | |
Accessioni | P18892Primary (citable) accession number: P18892 Secondary accession number(s): O18955 Q6RUS3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | July 15, 1998 | |
Last modified: | May 25, 2022 | |
This is version 141 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families