UniProtKB - P18891 (LECF_ALEAU)
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>sp|P18891|LECF_ALEAU Fucose-specific lectin OS=Aleuria aurantia OX=5188 PE=1 SV=3 MPTEFLYTSKIAAISWAATGGRQQRVYFQDLNGKIREAQRGGDNPWTGGSSQNVIGEAKL FSPLAAVTWKSAQGIQIRVYCVNKDNILSEFVYDGSKWITGQLGSVGVKVGSNSKLAALQ WGGSESAPPNIRVYYQKSNGSGSSIHEYVWSGKWTAGASFGSTVPGTGIGATAIGPGRLR IYYQATDNKIREHCWDSNSWYVGGFSASASAGVSIAAISWGSTPNIRVYWQKGREELYEA AYGGSWNTPGQIKDASRPTPSLPDTFIAANSSGNIDISVFFQASGVSLQQWQWISGKGWS IGAVVPTGTPAGWHelp videoAdd a publicationFeedback
Fucose-specific lectin
Annotation score:4 out of 5
<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>Select a section on the left to see content.
<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni
<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
- Ref.1"Primary structure of a fucose-specific lectin obtained from a mushroom, Aleuria aurantia."
Fukumori F., Takeuchi N., Hagiwara T., Ohbayashi H., Endo T., Kochibe N., Nagata Y., Kobata A.
J. Biochem. 107:190-196(1990) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, DEVELOPMENTAL STAGE. - Ref.3"Cloning and expression of a functional fucose-specific lectin from an orange peel mushroom, Aleuria aurantia."
Fukumori F., Takeuchi N., Hagiwara T., Ito K., Kochibe N., Kobata A., Nagata Y.
FEBS Lett. 250:153-156(1989) [PubMed] [Europe PMC] [Abstract] - Ref.4"Purification and properties of a novel fucose-specific hemagglutinin of Aleuria aurantia."
Kochibe N., Furukawa K.
Biochemistry 19:2841-2846(1980) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBUNIT. - Ref.5"Carbohydrate binding specificity of a fucose-specific lectin from Aspergillus oryzae: a novel probe for core fucose."
Matsumura K., Higashida K., Ishida H., Hata Y., Yamamoto K., Shigeta M., Mizuno-Horikawa Y., Wang X., Miyoshi E., Gu J., Taniguchi N.
J. Biol. Chem. 282:15700-15708(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION. - Ref.6"Detection of a high affinity binding site in recombinant Aleuria aurantia lectin."
Olausson J., Tibell L., Jonsson B.H., Paahlsson P.
Glycoconj. J. 25:753-762(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, DOMAIN. - Ref.7"Comparative analysis of oligosaccharide specificities of fucose-specific lectins from Aspergillus oryzae and Aleuria aurantia using frontal affinity chromatography."
Matsumura K., Higashida K., Hata Y., Kominami J., Nakamura-Tsuruta S., Hirabayashi J.
Anal. Biochem. 386:217-221(2009) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION. - Ref.8"Development of recombinant Aleuria aurantia lectins with altered binding specificities to fucosylated glycans."
Romano P.R., Mackay A., Vong M., DeSa J., Lamontagne A., Comunale M.A., Hafner J., Block T., Lec R., Mehta A.
Biochem. Biophys. Res. Commun. 414:84-89(2011) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, MUTAGENESIS OF ASN-225. - Ref.9"Production and characterization of a monomeric form and a single-site form of Aleuria aurantia lectin."
Olausson J., Astroem E., Jonsson B.H., Tibell L.A., Paahlsson P.
Glycobiology 21:34-44(2011) [PubMed] [Europe PMC] [Abstract]Cited for: SUBUNIT, MUTAGENESIS OF TYR-7 AND SER-284, FUNCTION. - Ref.10"Aleuria aurantia lectin exhibits antifungal activity against Mucor racemosus."
Amano K., Katayama H., Saito A., Ando A., Nagata Y.
Biosci. Biotechnol. Biochem. 76:967-970(2012) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION. - Ref.11"Elucidating the selectivity of recombinant forms of Aleuria aurantia lectin using weak affinity chromatography."
Bergstroem M., Astroem E., Paahlsson P., Ohlson S.
J. Chromatogr. B 885:66-72(2012) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION. - Ref.14"Development and application of a novel recombinant Aleuria aurantia lectin with enhanced core fucose binding for identification of glycoprotein biomarkers of hepatocellular carcinoma."
Norton P., Comunale M.A., Herrera H., Wang M., Houser J., Wimmerova M., Romano P.R., Mehta A.
Proteomics 16:3126-3136(2016) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, MUTAGENESIS OF ASN-225, BIOTECHNOLOGY. - Ref.16"Crystal structure of fucose-specific lectin from Aleuria aurantia binding ligands at three of its five sugar recognition sites."
Fujihashi M., Peapus D.H., Kamiya N., Nagata Y., Miki K.
Biochemistry 42:11093-11099(2003) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2.24 ANGSTROMS) OF 2-313 IN COMPLEX WITH FUCOSE AND BETA-L-FUCOSE, FUNCTION, DOMAIN. - Ref.17"Crystal structure of fungal lectin: six-bladed beta-propeller fold and novel fucose recognition mode for Aleuria aurantia lectin."
Wimmerova M., Mitchell E., Sanchez J.F., Gautier C., Imberty A.
J. Biol. Chem. 278:27059-27067(2003) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 2-313 IN COMPLEX WITH FUCOSE AND BETA-L-FUCOSE, FUNCTION, DOMAIN.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei | 25 | Carbohydrate 1Combined sources <p>Manually validated information inferred from a combination of experimental and computational evidence.</p> <p><a href="/manual/evidences#ECO:0000244">More...</a></p> Manual assertion inferred from combination of experimental and computational evidencei 2 PublicationsManual assertion based on experiment ini
| 1 | |
Binding sitei | 37 | Carbohydrate 1Combined sources Manual assertion inferred from combination of experimental and computational evidencei 2 PublicationsManual assertion based on experiment ini
| 1 | |
Binding sitei | 73 | FucoseCombined sources Manual assertion inferred from combination of experimental and computational evidencei 1 Publication<p>Manually curated information which has been inferred by a curator based on his/her scientific knowledge or on the scientific content of an article.</p> <p><a href="/manual/evidences#ECO:0000305">More...</a></p> Manual assertion inferred by curator fromi
| 1 | |
Binding sitei | 78 | Carbohydrate 2Combined sources Manual assertion inferred from combination of experimental and computational evidencei 2 PublicationsManual assertion based on experiment ini
| 1 | |
Binding sitei | 90 | Carbohydrate 2Combined sources Manual assertion inferred from combination of experimental and computational evidencei 2 PublicationsManual assertion based on experiment ini
| 1 | |
Binding sitei | 93 | beta-L-fucose 1Combined sources Manual assertion inferred from combination of experimental and computational evidencei 2 PublicationsManual assertion based on experiment ini
| 1 | |
Binding sitei | 98 | Carbohydrate 1Combined sources Manual assertion inferred from combination of experimental and computational evidencei 2 PublicationsManual assertion based on experiment ini
| 1 | |
Binding sitei | 102 | Carbohydrate 2; via amide nitrogenCombined sources Manual assertion inferred from combination of experimental and computational evidencei 2 PublicationsManual assertion based on experiment ini
| 1 | |
Binding sitei | 105 | Carbohydrate 3; via carbonyl oxygenCombined sources Manual assertion inferred from combination of experimental and computational evidencei | 1 | |
Binding sitei | 132 | Carbohydrate 4Combined sources Manual assertion inferred from combination of experimental and computational evidencei 1 PublicationManual assertion inferred by curator fromi
| 1 | |
Binding sitei | 147 | Carbohydrate 4Combined sources Manual assertion inferred from combination of experimental and computational evidencei 1 PublicationManual assertion inferred by curator fromi
| 1 | |
Binding sitei | 150 | Carbohydrate 2Combined sources Manual assertion inferred from combination of experimental and computational evidencei 1 PublicationManual assertion inferred by curator fromi
| 1 | |
Binding sitei | 154 | Carbohydrate 2Combined sources Manual assertion inferred from combination of experimental and computational evidencei 2 PublicationsManual assertion based on experiment ini
| 1 | |
Binding sitei | 195 | Carbohydrate 4Combined sources Manual assertion inferred from combination of experimental and computational evidencei 1 PublicationManual assertion inferred by curator fromi
| 1 | |
Binding sitei | 200 | Carbohydrate 4Combined sources Manual assertion inferred from combination of experimental and computational evidencei 1 PublicationManual assertion inferred by curator fromi
| 1 | |
Binding sitei | 204 | Carbohydrate 4; via amide nitrogenCombined sources Manual assertion inferred from combination of experimental and computational evidencei 2 PublicationsManual assertion based on experiment ini
| 1 | |
Binding sitei | 227 | Carbohydrate 3Combined sources Manual assertion inferred from combination of experimental and computational evidencei 1 PublicationManual assertion inferred by curator fromi
| 1 | |
Binding sitei | 239 | Carbohydrate 5Combined sources Manual assertion inferred from combination of experimental and computational evidencei 1 PublicationManual assertion inferred by curator fromi
| 1 | |
Binding sitei | 299 | Carbohydrate 3Combined sources Manual assertion inferred from combination of experimental and computational evidencei 1 PublicationManual assertion inferred by curator fromi
| 1 |
<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni
- carbohydrate binding Source: UniProtKB-KW
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi
Ligand | Lectin |
Protein family/group databases
UniLectin database of carbohydrate-binding proteins More...UniLectini | P18891 |
<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi | Recommended name: Fucose-specific lectin1 Publication<p>Manually curated information that is based on statements in scientific articles for which there is no experimental support.</p> <p><a href="/manual/evidences#ECO:0000303">More...</a></p> Manual assertion based on opinion ini
Alternative name(s): Aleuria aurantia lectin1 Publication Manual assertion based on opinion ini
Short name: AAL1 Publication Manual assertion based on opinion ini
|
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>Organismi | Aleuria aurantia (Orange peel mushroom) |
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri | 5188 [NCBI] |
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineagei | cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › Pezizomycetes › Pezizales › Pyronemataceae › Aleuria |
<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi
<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei
Manual assertion based on experiment ini
- Ref.12"A lectin-coupled, targeted proteomic mass spectrometry (MRM MS) platform for identification of multiple liver cancer biomarkers in human plasma."
Ahn Y.H., Shin P.M., Oh N.R., Park G.W., Kim H., Yoo J.S.
J. Proteomics 75:5507-5515(2012) [PubMed] [Europe PMC] [Abstract]Cited for: BIOTECHNOLOGY. - Ref.13
- Ref.14"Development and application of a novel recombinant Aleuria aurantia lectin with enhanced core fucose binding for identification of glycoprotein biomarkers of hepatocellular carcinoma."
Norton P., Comunale M.A., Herrera H., Wang M., Houser J., Wimmerova M., Romano P.R., Mehta A.
Proteomics 16:3126-3136(2016) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, MUTAGENESIS OF ASN-225, BIOTECHNOLOGY.
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi | 7 | Y → R: Impairs homodimerization. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 225 | N → Q: Leads to increased binding to fucosylated glycans. 2 Publications Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 284 | S → D: Impairs homodimerization. 1 Publication Manual assertion based on experiment ini
| 1 |
<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methioninei | Removed1 Publication Manual assertion based on experiment ini
| |||
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000084401 | 2 – 313 | Fucose-specific lectinAdd BLAST | 312 |
Proteomic databases
PRoteomics IDEntifications database More...PRIDEi | P18891 |
<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni
<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei
Manual assertion based on experiment ini
- Ref.1"Primary structure of a fucose-specific lectin obtained from a mushroom, Aleuria aurantia."
Fukumori F., Takeuchi N., Hagiwara T., Ohbayashi H., Endo T., Kochibe N., Nagata Y., Kobata A.
J. Biochem. 107:190-196(1990) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, DEVELOPMENTAL STAGE.
Keywords - Developmental stagei
Fruiting body<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni
<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei
Forms homodimers (PubMed:2193930, PubMed:7397108, PubMed:20798114, PubMed:12732625). The two AAL monomers are associated via interactions between N-terminal and C-terminal peptides (PubMed:12732625). Tyr-7 interacts via aromatic ring stacking with its counterpart on the other monomer, whereas Ser-284 interacts via hydrogen bonding with Asp-264 on the other monomer (PubMed:12732625).
4 PublicationsManual assertion based on experiment ini
- Ref.1"Primary structure of a fucose-specific lectin obtained from a mushroom, Aleuria aurantia."
Fukumori F., Takeuchi N., Hagiwara T., Ohbayashi H., Endo T., Kochibe N., Nagata Y., Kobata A.
J. Biochem. 107:190-196(1990) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, DEVELOPMENTAL STAGE. - Ref.4"Purification and properties of a novel fucose-specific hemagglutinin of Aleuria aurantia."
Kochibe N., Furukawa K.
Biochemistry 19:2841-2846(1980) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBUNIT. - Ref.9"Production and characterization of a monomeric form and a single-site form of Aleuria aurantia lectin."
Olausson J., Astroem E., Jonsson B.H., Tibell L.A., Paahlsson P.
Glycobiology 21:34-44(2011) [PubMed] [Europe PMC] [Abstract]Cited for: SUBUNIT, MUTAGENESIS OF TYR-7 AND SER-284, FUNCTION. - Ref.17"Crystal structure of fungal lectin: six-bladed beta-propeller fold and novel fucose recognition mode for Aleuria aurantia lectin."
Wimmerova M., Mitchell E., Sanchez J.F., Gautier C., Imberty A.
J. Biol. Chem. 278:27059-27067(2003) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 2-313 IN COMPLEX WITH FUCOSE AND BETA-L-FUCOSE, FUNCTION, DOMAIN.
<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei
Secondary structure
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the <a href="http://www.uniprot.org/help/structure_section">'Structure'</a> section is used to indicate the positions of experimentally determined beta strands within the protein sequence.<p><a href='/help/strand' target='_top'>More...</a></p>Beta strandi | 11 – 16 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 6 | |
Beta strandi | 23 – 30 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 8 | |
Beta strandi | 33 – 41 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 9 | |
<p>This subsection of the <a href="http://www.uniprot.org/help/structure_section">'Structure'</a> section is used to indicate the positions of experimentally determined helical regions within the protein sequence.<p><a href='/help/helix' target='_top'>More...</a></p>Helixi | 51 – 53 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 3 | |
Beta strandi | 54 – 57 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 4 | |
Beta strandi | 65 – 71 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 7 | |
Beta strandi | 74 – 82 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 9 | |
Beta strandi | 87 – 96 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 10 | |
Beta strandi | 98 – 100 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 3 | |
Helixi | 102 – 106 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 5 | |
Beta strandi | 117 – 122 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 6 | |
Beta strandi | 124 – 127 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 4 | |
Beta strandi | 130 – 135 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 6 | |
Beta strandi | 143 – 164 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 22 | |
Beta strandi | 169 – 175 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 7 | |
Beta strandi | 178 – 185 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 8 | |
Beta strandi | 188 – 198 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 11 | |
Beta strandi | 200 – 202 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 3 | |
Beta strandi | 214 – 220 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 7 | |
<p>This subsection of the <a href="http://www.uniprot.org/help/structure_section">'Structure'</a> section is used to indicate the positions of experimentally determined hydrogen-bonded turns within the protein sequence. These elements correspond to the DSSP secondary structure code ‘T’.<p><a href='/help/turn' target='_top'>More...</a></p>Turni | 221 – 224 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 4 | |
Beta strandi | 225 – 231 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 7 | |
Beta strandi | 237 – 246 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 10 | |
Beta strandi | 250 – 252 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 3 | |
Beta strandi | 268 – 272 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 5 | |
Turni | 273 – 275 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 3 | |
Beta strandi | 276 – 283 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 8 | |
Turni | 284 – 286 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 3 | |
Beta strandi | 287 – 294 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 8 | |
Turni | 295 – 297 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 3 | |
Beta strandi | 298 – 301 | Combined sources Manual assertion inferred from combination of experimental and computational evidencei | 4 |
3D structure databases
SWISS-MODEL Repository - a database of annotated 3D protein structure models More...SMRi | P18891 |
Database of comparative protein structure models More...ModBasei | Search... |
Protein Data Bank in Europe - Knowledge Base More...PDBe-KBi | Search... |
Miscellaneous databases
Relative evolutionary importance of amino acids within a protein sequence More...EvolutionaryTracei | P18891 |
<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati | 5 – 57 | 13 Publications Manual assertion inferred by curator fromi
| 53 | |
Repeati | 58 – 109 | 23 Publications Manual assertion inferred by curator fromi
| 52 | |
Repeati | 110 – 162 | 33 Publications Manual assertion inferred by curator fromi
| 53 | |
Repeati | 163 – 208 | 43 Publications Manual assertion inferred by curator fromi
| 46 | |
Repeati | 209 – 260 | 53 Publications Manual assertion inferred by curator fromi
| 52 | |
Repeati | 261 – 304 | 63 Publications Manual assertion inferred by curator fromi
| 44 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni | 5 – 304 | 6 X approximate tandem repeats3 Publications Manual assertion inferred by curator fromi
| 300 | |
Regioni | 242 – 246 | Fucose bindingCombined sources Manual assertion inferred from combination of experimental and computational evidencei 1 PublicationManual assertion inferred by curator fromi
| 5 |
<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini
Manual assertion based on experiment ini
- Ref.6"Detection of a high affinity binding site in recombinant Aleuria aurantia lectin."
Olausson J., Tibell L., Jonsson B.H., Paahlsson P.
Glycoconj. J. 25:753-762(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, DOMAIN. - Ref.16"Crystal structure of fucose-specific lectin from Aleuria aurantia binding ligands at three of its five sugar recognition sites."
Fujihashi M., Peapus D.H., Kamiya N., Nagata Y., Miki K.
Biochemistry 42:11093-11099(2003) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2.24 ANGSTROMS) OF 2-313 IN COMPLEX WITH FUCOSE AND BETA-L-FUCOSE, FUNCTION, DOMAIN. - Ref.17"Crystal structure of fungal lectin: six-bladed beta-propeller fold and novel fucose recognition mode for Aleuria aurantia lectin."
Wimmerova M., Mitchell E., Sanchez J.F., Gautier C., Imberty A.
J. Biol. Chem. 278:27059-27067(2003) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 2-313 IN COMPLEX WITH FUCOSE AND BETA-L-FUCOSE, FUNCTION, DOMAIN.
<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi
Keywords - Domaini
RepeatFamily and domain databases
Integrated resource of protein families, domains and functional sites More...InterProi | View protein in InterPro IPR012475 Fungal_lectin |
Pfam protein domain database More...Pfami | View protein in Pfam PF07938 Fungal_lectin, 1 hit |
<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei
<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.
<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.
10 20 30 40 50
MPTEFLYTSK IAAISWAATG GRQQRVYFQD LNGKIREAQR GGDNPWTGGS
60 70 80 90 100
SQNVIGEAKL FSPLAAVTWK SAQGIQIRVY CVNKDNILSE FVYDGSKWIT
110 120 130 140 150
GQLGSVGVKV GSNSKLAALQ WGGSESAPPN IRVYYQKSNG SGSSIHEYVW
160 170 180 190 200
SGKWTAGASF GSTVPGTGIG ATAIGPGRLR IYYQATDNKI REHCWDSNSW
210 220 230 240 250
YVGGFSASAS AGVSIAAISW GSTPNIRVYW QKGREELYEA AYGGSWNTPG
260 270 280 290 300
QIKDASRPTP SLPDTFIAAN SSGNIDISVF FQASGVSLQQ WQWISGKGWS
310
IGAVVPTGTP AGW
Sequence databases
Select the link destinations: EMBL nucleotide sequence database More...EMBLiGenBank nucleotide sequence database More...GenBankiDNA Data Bank of Japan; a nucleotide sequence database More...DDBJiLinks Updated | D00573 mRNA Translation: BAA00451.1 D85776 Genomic DNA Translation: BAA12871.1 |
Protein sequence database of the Protein Information Resource More...PIRi | JX0096 |
<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D00573 mRNA Translation: BAA00451.1 D85776 Genomic DNA Translation: BAA12871.1 |
PIRi | JX0096 |
3D structure databases
Select the link destinations: Protein Data Bank Europe More...PDBeiProtein Data Bank RCSB More...RCSB PDBiProtein Data Bank Japan More...PDBjiLinks Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1IUB | X-ray | 2.31 | A | 2-313 | [»] | |
1IUC | X-ray | 2.24 | A | 2-313 | [»] | |
1OFZ | X-ray | 1.50 | A/B | 2-313 | [»] | |
5MXC | X-ray | 1.14 | A | 1-313 | [»] | |
6GKE | X-ray | 1.08 | A | 2-313 | [»] | |
SMRi | P18891 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein family/group databases
UniLectini | P18891 |
Proteomic databases
PRIDEi | P18891 |
Miscellaneous databases
EvolutionaryTracei | P18891 |
Family and domain databases
InterProi | View protein in InterPro IPR012475 Fungal_lectin |
Pfami | View protein in Pfam PF07938 Fungal_lectin, 1 hit |
ProtoNet; Automatic hierarchical classification of proteins More...ProtoNeti | Search... |
MobiDB: a database of protein disorder and mobility annotations More...MobiDBi | Search... |
<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi
<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei | LECF_ALEAU | |
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>Accessioni | P18891Primary (citable) accession number: P18891 | |
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | January 23, 2007 | |
Last modified: | September 18, 2019 | |
This is version 76 of the entry and version 3 of the sequence. See complete history. | ||
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families - PDB cross-references
Index of Protein Data Bank (PDB) cross-references