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UniProtKB - P18887 (XRCC1_HUMAN)

Entry version 220 (23 Feb 2022)
Sequence version 3 (23 Feb 2022)
Previous versions | rss
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Protein

DNA repair protein XRCC1

Gene

XRCC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP-ribosyltransferase PARP1 activity.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repair

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P18887

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-110381, Resolution of AP sites via the single-nucleotide replacement pathway
R-HSA-5649702, APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
R-HSA-5685939, HDR through MMEJ (alt-NHEJ)
R-HSA-5696397, Gap-filling DNA repair synthesis and ligation in GG-NER
R-HSA-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P18887

SIGNOR Signaling Network Open Resource

More...SIGNORi		P18887

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA repair protein XRCC1Curated
Alternative name(s):
X-ray repair cross-complementing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:XRCC1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12828, XRCC1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		194360, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P18887

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000073050

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spinocerebellar ataxia, autosomal recessive, 26 (SCAR26)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR26 is a progressive disease characterized by gait and limb ataxia, loss of independent ambulation, oculomotor apraxia, and peripheral neuropathy with distal muscle weakness and areflexia.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_079140431K → N in SCAR26; may result in aberrant splicing. 1 PublicationCorresponds to variant dbSNP:rs761564262EnsemblClinVar.1
Natural variantiVAR_079141465 – 633Missing in SCAR26. 1 PublicationAdd BLAST169

Keywords - Diseasei

Neurodegeneration

Organism-specific databases

DisGeNET

More...DisGeNETi		7515

MalaCards human disease database

More...MalaCardsi		XRCC1
MIMi617633, phenotype

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA369

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P18887, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		XRCC1

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373290

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000660441 – 633DNA repair protein XRCC1Add BLAST633

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei140PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki176Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki176Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei198PhosphothreonineCombined sources1
Modified residuei199PhosphoserineCombined sources1
Modified residuei202PhosphothreonineCombined sources1
Modified residuei204PhosphoserineCombined sources1
Modified residuei226PhosphoserineCombined sources1
Modified residuei241PhosphoserineCombined sources1
Modified residuei257PhosphothreonineCombined sources1
Modified residuei259PhosphoserineCombined sources1
Modified residuei266PhosphoserineCombined sources1
Modified residuei281PhosphothreonineCombined sources1
Modified residuei371Phosphoserine; by PRKDC1 Publication1
Modified residuei408PhosphoserineCombined sources1
Modified residuei409PhosphoserineCombined sources1
Modified residuei410PhosphoserineCombined sources1
Modified residuei421PhosphoserineCombined sources1
Modified residuei446PhosphoserineCombined sources1
Modified residuei447PhosphoserineCombined sources1
Modified residuei453PhosphothreonineCombined sources1
Modified residuei457PhosphothreonineCombined sources1
Modified residuei461PhosphoserineCombined sources1
Modified residuei485PhosphoserineCombined sources1 Publication1
Modified residuei488PhosphothreonineCombined sources1 Publication1
Modified residuei518Phosphoserine1 Publication1
Modified residuei519Phosphothreonine1 Publication1
Modified residuei523Phosphothreonine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.5 Publications
Sumoylated.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P18887

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P18887

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P18887

MaxQB - The MaxQuant DataBase

More...MaxQBi		P18887

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P18887

PeptideAtlas

More...PeptideAtlasi		P18887

PRoteomics IDEntifications database

More...PRIDEi		P18887

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53619

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P18887, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P18887

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P18887

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000073050, Expressed in ventricular zone and 233 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P18887, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P18887, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000073050, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3).

Interacts with APTX and APLF.

Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1.

9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113349, 120 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P18887

Database of interacting proteins

More...DIPi		DIP-39067N

Protein interaction database and analysis system

More...IntActi		P18887, 65 interactors

Molecular INTeraction database

More...MINTi		P18887

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000262887

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P18887, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1633
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P18887

Small Angle Scattering Biological Data Bank

More...SASBDBi		P18887

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P18887

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P18887

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini315 – 403BRCT 1PROSITE-ProRule annotationAdd BLAST89
Domaini538 – 629BRCT 2PROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni221 – 313DisorderedSequence analysisAdd BLAST93
Regioni400 – 462DisorderedSequence analysisAdd BLAST63
Regioni471 – 490DisorderedSequence analysisAdd BLAST20
Regioni498 – 536DisorderedSequence analysisAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi221 – 239Polar residuesSequence analysisAdd BLAST19
Compositional biasi240 – 256Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi263 – 283Pro residuesSequence analysisAdd BLAST21
Compositional biasi428 – 444Polar residuesSequence analysisAdd BLAST17

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3226, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_030026_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P18887

Database of Orthologous Groups

More...OrthoDBi		539462at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P18887

TreeFam database of animal gene trees

More...TreeFami		TF101201

Family and domain databases

Conserved Domains Database

More...CDDi		cd17725, BRCT_XRCC1_rpt1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.10190, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001357, BRCT_dom
IPR036420, BRCT_dom_sf
IPR045080, BRCT_XRCC1_rpt1
IPR008979, Galactose-bd-like_sf
IPR002706, Xrcc1_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00533, BRCT, 1 hit
PF16589, BRCT_2, 1 hit
PF01834, XRCC1_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00292, BRCT, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49785, SSF49785, 1 hit
SSF52113, SSF52113, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50172, BRCT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P18887-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEIRLRHVV SCSSQDSTHC AENLLKADTY RKWRAAKAGE KTISVVLQLE 
        60         70         80         90        100
KEEQIHSVDI GNDGSAFVEV LVGSSAGGAG EQDYEVLLVT SSFMSPSESR 
       110        120        130        140        150
SGSNPNRVRM FGPDKLVRAA AEKRWDRVKI VCSQPYSKDS PFGLSFVRFH 
       160        170        180        190        200
SPPDKDEAEA PSQKVTVTKL GQFRVKEEDE SANSLRPGAL FFSRINKTSP 
       210        220        230        240        250
VTASDPAGPS YAAATLQASS AASSASPVSR AIGSTSKPQE SPKGKRKLDL 
       260        270        280        290        300
NQEEKKTPSK PPAQLSPSVP KRPKLPAPTR TPATAPVPAR AQGAVTGKPR 
       310        320        330        340        350
GEGTEPRRPR AGPEELGKIL QGVVVVLSGF QNPFRSELRD KALELGAKYR 
       360        370        380        390        400
PDWTRDSTHL ICAFANTPKY SQVLGLGGRI VRKEWVLDCH RMRRRLPSQR 
       410        420        430        440        450
YLMAGPGSSS EEDEASHSGG SGDEAPKLPQ KQPQTKTKPT QAAGPSSPQK 
       460        470        480        490        500
PPTPEETKAA SPVLQEDIDI EGVQSEGQDN GAEDSGDTED ELRRVAEQKE 
       510        520        530        540        550
HRLPPGQEEN GEDPYAGSTD ENTDSEEHQE PPDLPVPELP DFFQGKHFFL 
       560        570        580        590        600
YGEFPGDERR KLIRYVTAFN GELEDYMSDR VQFVITAQEW DPSFEEALMD 
       610        620        630 
NPSLAFVRPR WIYSCNEKQK LLPHQLYGVV PQA
Length:633
Mass (Da):69,498
Last modified:February 23, 2022 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i76174967D034F89F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H8D7F5H8D7_HUMAN
DNA repair protein XRCC1
XRCC1
602Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYS5M0QYS5_HUMAN
DNA repair protein XRCC1
XRCC1
292Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1U8M0R1U8_HUMAN
DNA repair protein XRCC1
XRCC1
210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0D2M0R0D2_HUMAN
DNA repair protein XRCC1
XRCC1
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZ96M0QZ96_HUMAN
DNA repair protein XRCC1
XRCC1
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Carriers of the polymorphic Gln-399 allele may be at greater risk for tobacco- and age-related DNA damage.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0147737R → L. Corresponds to variant dbSNP:rs2307186Ensembl.1
Natural variantiVAR_01477410V → M. Corresponds to variant dbSNP:rs2307171Ensembl.1
Natural variantiVAR_01616872V → A1 PublicationCorresponds to variant dbSNP:rs25496EnsemblClinVar.1
Natural variantiVAR_029228107R → H. Corresponds to variant dbSNP:rs2228487EnsemblClinVar.1
Natural variantiVAR_014775157E → K. Corresponds to variant dbSNP:rs2307180Ensembl.1
Natural variantiVAR_014776161P → L1 PublicationCorresponds to variant dbSNP:rs2307191EnsemblClinVar.1
Natural variantiVAR_013400194R → W2 PublicationsCorresponds to variant dbSNP:rs1799782EnsemblClinVar.1
Natural variantiVAR_013401280R → H2 PublicationsCorresponds to variant dbSNP:rs25489Ensembl.1
Natural variantiVAR_014777298K → N. Corresponds to variant dbSNP:rs2307188Ensembl.1
Natural variantiVAR_018775304T → A1 PublicationCorresponds to variant dbSNP:rs25490EnsemblClinVar.1
Natural variantiVAR_014778309P → S1 PublicationCorresponds to variant dbSNP:rs25491Ensembl.1
Natural variantiVAR_036277350R → W in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs754041352Ensembl.1
Natural variantiVAR_011487399Q → R5 PublicationsCorresponds to variant dbSNP:rs25487EnsemblClinVar.1
Natural variantiVAR_079140431K → N in SCAR26; may result in aberrant splicing. 1 PublicationCorresponds to variant dbSNP:rs761564262EnsemblClinVar.1
Natural variantiVAR_079141465 – 633Missing in SCAR26. 1 PublicationAdd BLAST169
Natural variantiVAR_014779485S → Y. Corresponds to variant dbSNP:rs2307184Ensembl.1
Natural variantiVAR_016169514P → L. Corresponds to variant dbSNP:rs25474Ensembl.1
Natural variantiVAR_014780559R → Q. Corresponds to variant dbSNP:rs2307167Ensembl.1
Natural variantiVAR_014781560R → W. Corresponds to variant dbSNP:rs2307166Ensembl.1
Natural variantiVAR_061727576Y → N1 PublicationCorresponds to variant dbSNP:rs2682557Ensembl.1
Natural variantiVAR_014782576Y → S1 PublicationCorresponds to variant dbSNP:rs2307177Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M36089 mRNA Translation: AAA63270.1
AF512504 Genomic DNA Translation: AAM34791.1
CR456728 mRNA Translation: CAG33009.1
AC018758 Genomic DNA Translation: AAG09061.1
KC877750 Genomic DNA No translation available.
L34079 Genomic DNA No translation available.
BC023593 mRNA Translation: AAH23593.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12624.1

Protein sequence database of the Protein Information Resource

More...PIRi		A36353

NCBI Reference Sequences

More...RefSeqi		NP_006288.2, NM_006297.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000262887; ENSP00000262887; ENSG00000073050

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7515

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7515

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000262887.10; ENSP00000262887.5; NM_006297.3; NP_006288.2

UCSC genome browser

More...UCSCi		uc002owt.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36089 mRNA Translation: AAA63270.1
AF512504 Genomic DNA Translation: AAM34791.1
CR456728 mRNA Translation: CAG33009.1
AC018758 Genomic DNA Translation: AAG09061.1
KC877750 Genomic DNA No translation available.
L34079 Genomic DNA No translation available.
BC023593 mRNA Translation: AAH23593.1
CCDSiCCDS12624.1
PIRiA36353
RefSeqiNP_006288.2, NM_006297.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CDZX-ray3.20A538-633[»]
1XNANMR-A1-183[»]
1XNTNMR-A1-183[»]
2D8MNMR-A305-420[»]
2W3OX-ray1.85C/D515-522[»]
3K75X-ray2.95B/C1-183[»]
3K77X-ray2.60A/B/C/D/E/F/G/H1-155[»]
3LQCX-ray2.35A1-183[»]
5E6QX-ray2.31A241-276[»]
5W7XX-ray2.00E/F/G/H514-522[»]
5W7YX-ray2.10C/D514-521[»]
BMRBiP18887
SASBDBiP18887
SMRiP18887
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113349, 120 interactors
CORUMiP18887
DIPiDIP-39067N
IntActiP18887, 65 interactors
MINTiP18887
STRINGi9606.ENSP00000262887

PTM databases

GlyGeniP18887, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP18887
PhosphoSitePlusiP18887

Genetic variation databases

BioMutaiXRCC1
DMDMi317373290

Proteomic databases

EPDiP18887
jPOSTiP18887
MassIVEiP18887
MaxQBiP18887
PaxDbiP18887
PeptideAtlasiP18887
PRIDEiP18887
ProteomicsDBi53619

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1863, 559 antibodies from 44 providers

The DNASU plasmid repository

More...DNASUi		7515

Genome annotation databases

EnsembliENST00000262887; ENSP00000262887; ENSG00000073050
GeneIDi7515
KEGGihsa:7515
MANE-SelectiENST00000262887.10; ENSP00000262887.5; NM_006297.3; NP_006288.2
UCSCiuc002owt.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7515
DisGeNETi7515

GeneCards: human genes, protein and diseases

More...GeneCardsi		XRCC1
HGNCiHGNC:12828, XRCC1
HPAiENSG00000073050, Low tissue specificity
MalaCardsiXRCC1
MIMi194360, gene
617633, phenotype
neXtProtiNX_P18887
PharmGKBiPA369
VEuPathDBiHostDB:ENSG00000073050

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3226, Eukaryota
HOGENOMiCLU_030026_0_0_1
InParanoidiP18887
OrthoDBi539462at2759
PhylomeDBiP18887
TreeFamiTF101201

Enzyme and pathway databases

PathwayCommonsiP18887
ReactomeiR-HSA-110381, Resolution of AP sites via the single-nucleotide replacement pathway
R-HSA-5649702, APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
R-HSA-5685939, HDR through MMEJ (alt-NHEJ)
R-HSA-5696397, Gap-filling DNA repair synthesis and ligation in GG-NER
R-HSA-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
SignaLinkiP18887
SIGNORiP18887

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7515, 110 hits in 1053 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		XRCC1, human
EvolutionaryTraceiP18887

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		XRCC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7515
PharosiP18887, Tbio

Protein Ontology

More...PROi		PR:P18887
RNActiP18887, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000073050, Expressed in ventricular zone and 233 other tissues
ExpressionAtlasiP18887, baseline and differential
GenevisibleiP18887, HS

Family and domain databases

CDDicd17725, BRCT_XRCC1_rpt1, 1 hit
Gene3Di3.40.50.10190, 2 hits
InterProiView protein in InterPro
IPR001357, BRCT_dom
IPR036420, BRCT_dom_sf
IPR045080, BRCT_XRCC1_rpt1
IPR008979, Galactose-bd-like_sf
IPR002706, Xrcc1_N
PfamiView protein in Pfam
PF00533, BRCT, 1 hit
PF16589, BRCT_2, 1 hit
PF01834, XRCC1_N, 1 hit
SMARTiView protein in SMART
SM00292, BRCT, 2 hits
SUPFAMiSSF49785, SSF49785, 1 hit
SSF52113, SSF52113, 2 hits
PROSITEiView protein in PROSITE
PS50172, BRCT, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXRCC1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18887
Secondary accession number(s): Q6IBS4, Q9HCB1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: February 23, 2022
Last modified: February 23, 2022
This is version 220 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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